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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenazopyridine
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Accession:CHEBI:71416 term browser browse the term
Definition:A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.
Synonyms:exact_synonym: 3-(phenyldiazenyl)pyridine-2,6-diamine
 related_synonym: 2,6-Diamino-3-(phenylazo)pyridine;   2,6-Diamino-3-phenylazopyridine;   3-(Phenylazo)-2,6-pyridinediamine;   Formula=C11H11N5;   InChI=1S/C11H11N5/c12-10-7-6-9(11(13)14-10)16-15-8-4-2-1-3-5-8/h1-7H,(H4,12,13,14);   InChIKey=QPFYXYFORQJZEC-UHFFFAOYSA-N;   SMILES=Nc1ccc(N=Nc2ccccc2)c(N)n1;   fenazopiridina;   phenazopyridinum
 alt_id: CHEBI:8057
 xref: Beilstein:184497;   CAS:94-78-0;   DrugBank:DB01438;   HMDB:HMDB0015506;   KEGG:C07429;   KEGG:D08346;   LINCS:LSM-3705
 xref_mesh: MESH:D010621
 xref: PMID:19300288;   PMID:19744778;   PMID:20196783;   PMID:20467292;   PMID:20636989;   PMID:20976818;   PMID:21147318;   PMID:21376167;   PMID:21681956;   PMID:21789523;   PMID:21856805;   PMID:22110938;   PMID:22987905;   PMID:23030327;   PMID:28166217;   Patent:US2009247628;   Patent:WO2008033466;   Patent:WO2010071878;   Reaxys:184497;   Wikipedia:Phenazopyridine
 cyclic_relationship: is_conjugate_base_of CHEBI:71420



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phenazopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Phenazopyridine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Utrn utrophin increases expression ISO Phenazopyridine results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        aetiopathogenetic role 19264
          carcinogenic agent 18536
            phenazopyridine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19744
                        hydrogen molecular entity 19736
                          hydrides 19102
                            inorganic hydride 17893
                              pnictogen hydride 17876
                                nitrogen hydride 17766
                                  azane 17518
                                    ammonia 17517
                                      organic amino compound 17517
                                        aromatic amine 14924
                                          aminopyridine 369
                                            diaminopyridine 6
                                              phenazopyridine 2
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