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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazine-2-carboxylic acid
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Accession:CHEBI:71311 term browser browse the term
Definition:The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.
Synonyms:related_synonym: 2-Carboxypyrazine;   2-Pyrazinecarboxylic acid;   Formula=C5H4N2O2;   InChI=1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9);   InChIKey=NIPZZXUFJPQHNH-UHFFFAOYSA-N;   Paradiazinecarboxylic acid;   Pyrazinemonocarboxylic acid;   Pyrazinic acid;   Pyrazinoic acid;   SMILES=OC(=O)c1cnccn1;   pyrazinecarboxylic acid
 xref: CAS:98-97-5;   KEGG:C19915
 xref_mesh: MESH:C005296
 xref: MetaCyc:PYRAZINOIC-ACID;   PDBeChem:VGL;   PMID:19298694;   PMID:19963078;   PMID:20099263;   PMID:20382083;   PMID:20429806;   PMID:20879713;   PMID:21283666;   PMID:21775138;   PMID:21835980;   PMID:21876062;   PMID:22004792;   PMID:22074423;   PMID:22236853;   PMID:22372927;   PMID:22613684;   PMID:23101013;   PMID:28166217;   Reaxys:112305;   Wikipedia:Pyrazinoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:71266

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pyrazine-2-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases activity EXP pyrazinoic acid metabolite results in decreased activity of ACMSD protein CTD PMID:12224625 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734
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G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP
pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 PMID:21074513 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] CTD PMID:12472777 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        antimicrobial agent 17376
          antibacterial agent 13452
            antibacterial drug 3188
              antimycobacterial drug 997
                antitubercular agent 584
                  pyrazine-2-carboxylic acid 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic group 18613
                              organic divalent group 18604
                                organodiyl group 18604
                                  carbonyl group 18521
                                    carbonyl compound 18521
                                      carboxylic acid 18196
                                        pyrazinecarboxylic acid 41
                                          pyrazine-2-carboxylic acid 3
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