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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:saxagliptin
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Accession:CHEBI:71272 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.
Synonyms:exact_synonym: (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
 related_synonym: (1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile;   BMS 477118;   Formula=C18H25N3O2;   InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1;   InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N;   SMILES=[H][C@]12C[C@@H](C#N)N(C(=O)[C@@H](N)C34CC5CC(CC(O)(C5)C3)C4)[C@@]1([H])C2
 xref: CAS:361442-04-8;   DrugBank:DB06335;   Drug_Central:4114;   HMDB:HMDB0015634;   KEGG:D08996
 xref_mesh: MESH:C502994
 xref: PMID:22001114;   PMID:22066527;   PMID:22081481;   PMID:22098472;   PMID:22132773;   PMID:22149373;   PMID:22192246;   PMID:22221000;   PMID:22232748;   PMID:22248301;   PMID:22292415;   PMID:22313154;   PMID:22313172;   PMID:22334441;   PMID:22349123;   PMID:22475049;   PMID:22496391;   PMID:22564773;   PMID:22668067;   PMID:22776778;   PMID:22823746;   PMID:22828124;   PMID:22932707;   PMID:22943617;   PMID:23137182;   Patent:US2005222242;   Patent:US2007172525;   Patent:WO2007078726;   Patent:WO2009022009;   Patent:WO2011125011;   Reaxys:10201614;   Wikipedia:Saxagliptin


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saxagliptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] CTD PMID:25446674 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in decreased expression of BDNF protein] CTD PMID:25446674 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in increased expression of CASP3 protein] CTD PMID:25446674 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in increased expression of CYCS protein] CTD PMID:25446674 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases activity
decreases expression
multiple interactions		 ISO saxagliptin results in decreased activity of DPP4 protein
saxagliptin results in decreased expression of DPP4 protein
saxagliptin inhibits the reaction [Rotenone results in increased expression of DPP4 protein]		 CTD PMID:21186796 PMID:21388136 PMID:25446674 NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 protein] CTD PMID:31629700 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 protein] CTD PMID:31629700 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in increased expression of ICAM1 protein] CTD PMID:25446674 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein] CTD PMID:31629700 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein] CTD PMID:31629700 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in increased expression of MPO protein] CTD PMID:25446674 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA] CTD PMID:31629700 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions		 ISO saxagliptin results in increased expression of NFE2L2 protein
saxagliptin inhibits the reaction [Rotenone results in increased expression of NFE2L2 protein]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 protein]		 CTD PMID:25446674 PMID:31629700 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in increased expression of NOS2 protein] CTD PMID:25446674 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein] CTD PMID:31629700 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in increased expression of RELA protein] CTD PMID:25446674 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:25446674 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO saxagliptin inhibits the reaction [Rotenone results in increased expression of TNF protein] CTD PMID:25446674 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      group 22072
        pseudohalo group 4678
          cyano group 4678
            nitrile 4667
              saxagliptin 18
                saxagliptin hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      carboacyl group 18277
                                        univalent carboacyl group 18277
                                          carbamoyl group 18088
                                            carboxamide 18106
                                              monocarboxylic acid amide 15820
                                                saxagliptin 18
                                                  saxagliptin hydrate 0
paths to the root