The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.
saxagliptin results in decreased activity of DPP4 protein saxagliptin inhibits the reaction [Rotenone results in increased expression of DPP4 protein] saxagliptin results in decreased expression of DPP4 protein
saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 protein]
saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 protein]
saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]
saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein]
saxagliptin results in increased expression of NFE2L2 protein saxagliptin inhibits the reaction [Rotenone results in increased expression of NFE2L2 protein]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 protein]
saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein]