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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:saxagliptin
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Accession:CHEBI:71272 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.
Synonyms:exact_synonym: (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
 related_synonym: (1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile;   BMS-477118;   Formula=C18H25N3O2;   InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1;   InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N;   SMILES=[H][C@]12C[C@@H](C#N)N(C(=O)[C@@H](N)C34CC5CC(CC(O)(C5)C3)C4)[C@@]1([H])C2
 xref: CAS:361442-04-8;   DrugBank:DB06335;   Drug_Central:4114;   HMDB:HMDB0015634;   KEGG:D08996
 xref_mesh: MESH:C502994
 xref: PMID:22001114;   PMID:22066527;   PMID:22081481;   PMID:22098472;   PMID:22132773;   PMID:22149373;   PMID:22192246;   PMID:22221000;   PMID:22232748;   PMID:22248301;   PMID:22292415;   PMID:22313154;   PMID:22313172;   PMID:22334441;   PMID:22349123;   PMID:22475049;   PMID:22496391;   PMID:22564773;   PMID:22668067;   PMID:22776778;   PMID:22823746;   PMID:22828124;   PMID:22932707;   PMID:22943617;   PMID:23137182;   Patent:US2005222242;   Patent:US2007172525;   Patent:WO2007078726;   Patent:WO2009022009;   Patent:WO2011125011;   Reaxys:10201614;   Wikipedia:Saxagliptin

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saxagliptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] CTD PMID:25446674 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in decreased expression of BDNF protein] CTD PMID:25446674 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of CASP3 protein] CTD PMID:25446674 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of CYCS protein] CTD PMID:25446674 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases activity
multiple interactions
decreases expression		 ISO
EXP		 saxagliptin results in decreased activity of DPP4 protein
saxagliptin inhibits the reaction [Rotenone results in increased expression of DPP4 protein]
saxagliptin results in decreased expression of DPP4 protein		 CTD PMID:21186796, PMID:21388136, PMID:25446674 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 protein] CTD PMID:31629700 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 protein] CTD PMID:31629700 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of ICAM1 protein] CTD PMID:25446674 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein] CTD PMID:31629700 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein] CTD PMID:31629700 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of MPO protein] CTD PMID:25446674 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA] CTD PMID:31629700 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions		 EXP saxagliptin results in increased expression of NFE2L2 protein
saxagliptin inhibits the reaction [Rotenone results in increased expression of NFE2L2 protein]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 protein]		 CTD PMID:25446674, PMID:31629700 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of NOS2 protein] CTD PMID:25446674 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein] CTD PMID:31629700 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of RELA protein] CTD PMID:25446674 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:25446674 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of TNF protein] CTD PMID:25446674 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        pseudohalo group 2881
          cyano group 2881
            nitrile 2881
              saxagliptin 18
                saxagliptin hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                monocarboxylic acid amide 14551
                                                  saxagliptin 18
                                                    saxagliptin hydrate 0
paths to the root

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