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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:saxagliptin
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Accession:CHEBI:71272 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.
Synonyms:exact_synonym: (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
 related_synonym: (1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile;   BMS 477118;   Formula=C18H25N3O2;   InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1;   InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N;   SMILES=[H][C@]12C[C@@H](C#N)N(C(=O)[C@@H](N)C34CC5CC(CC(O)(C5)C3)C4)[C@@]1([H])C2
 xref: CAS:361442-04-8;   DrugBank:DB06335;   Drug_Central:4114;   HMDB:HMDB0015634;   KEGG:D08996
 xref_mesh: MESH:C502994
 xref: PMID:22001114;   PMID:22066527;   PMID:22081481;   PMID:22098472;   PMID:22132773;   PMID:22149373;   PMID:22192246;   PMID:22221000;   PMID:22232748;   PMID:22248301;   PMID:22292415;   PMID:22313154;   PMID:22313172;   PMID:22334441;   PMID:22349123;   PMID:22475049;   PMID:22496391;   PMID:22564773;   PMID:22668067;   PMID:22776778;   PMID:22823746;   PMID:22828124;   PMID:22932707;   PMID:22943617;   PMID:23137182;   Patent:US2005222242;   Patent:US2007172525;   Patent:WO2007078726;   Patent:WO2009022009;   Patent:WO2011125011;   Reaxys:10201614;   Wikipedia:Saxagliptin


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saxagliptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] CTD PMID:25446674 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in decreased expression of BDNF protein] CTD PMID:25446674 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of CASP3 protein] CTD PMID:25446674 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of CYCS protein] CTD PMID:25446674 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases activity
multiple interactions
decreases expression
ISO
EXP
saxagliptin results in decreased activity of DPP4 protein
saxagliptin inhibits the reaction [Rotenone results in increased expression of DPP4 protein]
saxagliptin results in decreased expression of DPP4 protein
CTD PMID:21186796 PMID:21388136 PMID:25446674 NCBI chr 3:46,962,243...47,043,870
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 protein] CTD PMID:31629700 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of HMOX1 protein] CTD PMID:31629700 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of ICAM1 protein] CTD PMID:25446674 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein] CTD PMID:31629700 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein] CTD PMID:31629700 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of MPO protein] CTD PMID:25446674 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA] CTD PMID:31629700 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
EXP saxagliptin results in increased expression of NFE2L2 protein
saxagliptin inhibits the reaction [Rotenone results in increased expression of NFE2L2 protein]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 mRNA]; saxagliptin promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 protein]
CTD PMID:25446674 PMID:31629700 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of NOS2 protein] CTD PMID:25446674 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein] CTD PMID:31629700 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of RELA protein] CTD PMID:25446674 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:25446674 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP saxagliptin inhibits the reaction [Rotenone results in increased expression of TNF protein] CTD PMID:25446674 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      group 19733
        pseudohalo group 3489
          cyano group 3489
            nitrile 3489
              saxagliptin 18
                saxagliptin hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  saxagliptin 18
                                                    saxagliptin hydrate 0
paths to the root