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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:asenapine
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Accession:CHEBI:71253 term browser browse the term
Definition:A racemate consisting of equal amounts of (R,R)- and (S,S)-asenapine. Used as its maleate salt for the acute treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features.
Synonyms:exact_synonym: rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
 related_synonym: (3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole;   asenapina;   asenapinum;   trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole
 xref: CAS:65576-45-6
 xref_mesh: MESH:C522667
 xref: PMID:21474903;   PMID:21557265;   PMID:21628604;   PMID:21755540;   PMID:21875607;   PMID:22156709;   PMID:22182459;   PMID:22198448;   PMID:22198451;   PMID:22332980;   PMID:22344545;   PMID:22362425;   PMID:22454251;   PMID:22494521;   PMID:22700206;   PMID:22726414;   PMID:22745558;   PMID:22849428;   PMID:22868059;   PMID:22877962;   PMID:22896826;   PMID:22900950;   PMID:22936407;   PMID:23095277;   PMID:23121334;   Patent:US2005119248;   Patent:US2006084692;   Patent:US2006229352;   Patent:WO2012038975;   Patent:WO2012040845;   Patent:WO2012123325;   Reaxys:3654823;   Wikipedia:Asenapine
 cyclic_relationship: is_conjugate_base_of CHEBI:71249



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asenapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
decreases expression
ISO Asenapine results in decreased activity of CYP1A2 protein
Asenapine results in decreased expression of CYP1A2 mRNA
CTD PMID:32941854 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      chemical substance 13303
        mixture 12454
          racemate 10537
            asenapine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        tertiary amino compound 8848
                                          5-chloro-2-methyl-2,3,3a,12b-tetrahydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole 1
                                            (S,S)-asenapine 1
                                              asenapine 1
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