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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phlorotannin
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Accession:CHEBI:71222 term browser browse the term
Definition:A type of tannin usually found in brown algae such as kelps and rockweeds. Unlike the hydrolysable or condensed tannins, these compounds are oligomers of phloroglucinol.
Synonyms:related_synonym: phlorotannins
 xref: Wikipedia:Phlorotannin


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dieckol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 EXP dieckol results in decreased expression of and results in decreased phosphorylation of AKT1 protein
dieckol results in decreased phosphorylation of AKT1 protein		 CTD PMID:31291034 PMID:36683349 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA]
dieckol results in increased expression of BAX protein		 CTD PMID:33051972 PMID:33347706 PMID:36683349 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BCL2 mRNA]
dieckol results in decreased expression of BCL2 protein		 CTD PMID:33051972 PMID:33347706 PMID:36683349 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions		 EXP
ISO		 dieckol results in increased activity of CASP3 protein
dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CASP3 mRNA]		 CTD PMID:31291034 PMID:33347706 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases activity EXP dieckol results in increased activity of CASP8 protein CTD PMID:31291034 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity
increases expression
multiple interactions		 EXP
ISO		 dieckol results in increased activity of CASP9 protein
dieckol results in increased expression of CASP9 protein
dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CASP9 mRNA]		 CTD PMID:31291034 PMID:33347706 PMID:36683349 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions
decreases activity		 ISO
EXP		 dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CAT protein]
dieckol results in decreased activity of CAT protein		 CTD PMID:33051972 PMID:33347706 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP dieckol results in decreased expression of CCND1 protein CTD PMID:33051972 PMID:36683349 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDH1 cadherin 1 increases expression EXP dieckol results in increased expression of CDH1 protein CTD PMID:31291034 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDH2 cadherin 2 decreases expression EXP dieckol results in decreased expression of CDH2 protein CTD PMID:31291034 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP dieckol results in decreased expression of CDK4 protein CTD PMID:36683349 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP dieckol results in decreased expression of CDK6 protein CTD PMID:36683349 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression EXP dieckol results in decreased expression of CXCL8 protein CTD PMID:33051972 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP dieckol inhibits the reaction [Particulate Matter results in increased phosphorylation of FOS protein] CTD PMID:33164846 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GSR protein] CTD PMID:33347706 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G IL18 interleukin 18 multiple interactions ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL18 mRNA] CTD PMID:33347706 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL1B mRNA]; dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL1B protein]
dieckol inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]
dieckol results in decreased expression of IL1B protein		 CTD PMID:33051972 PMID:33164846 PMID:33347706 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO
EXP		 dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL6 mRNA]; dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL6 protein]
dieckol inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]		 CTD PMID:33164846 PMID:33347706 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP dieckol inhibits the reaction [Particulate Matter results in increased phosphorylation of JUN protein] CTD PMID:33164846 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP dieckol inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein] CTD PMID:33164846 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP dieckol inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein] CTD PMID:33164846 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MMP1 matrix metallopeptidase 1 decreases expression
multiple interactions		 EXP dieckol results in decreased expression of MMP1 mRNA; dieckol results in decreased expression of MMP1 protein
dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP1 protein]		 CTD PMID:19330880 PMID:33164846 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MMP13 matrix metallopeptidase 13 decreases expression
multiple interactions		 EXP dieckol results in decreased expression of MMP13 mRNA; dieckol results in decreased expression of MMP13 protein
dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP13 protein]		 CTD PMID:19330880 PMID:33164846 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP2 protein] CTD PMID:33164846 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP3 matrix metallopeptidase 3 decreases expression EXP dieckol results in decreased expression of MMP3 mRNA; dieckol results in decreased expression of MMP3 protein CTD PMID:19330880 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609 		JBrowse link
G MMP8 matrix metallopeptidase 8 multiple interactions EXP dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP8 protein] CTD PMID:33164846 NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression
multiple interactions		 EXP dieckol results in decreased expression of MMP9 protein
dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP9 protein]		 CTD PMID:31291034 PMID:33164846 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation EXP dieckol results in decreased phosphorylation of MTOR protein CTD PMID:31291034 PMID:36683349 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP dieckol inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein] CTD PMID:33164846 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO dieckol affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFKBIA protein]; dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of NFKBIA protein] CTD PMID:33347706 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression EXP dieckol results in decreased expression of NOS2 mRNA; dieckol results in decreased expression of NOS2 protein CTD PMID:19330880 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP dieckol results in decreased expression of PCNA protein CTD PMID:33051972 PMID:36683349 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PLAU plasminogen activator, urokinase decreases expression EXP dieckol results in decreased expression of PLAU protein CTD PMID:31291034 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 EXP
ISO		 dieckol results in decreased expression of PTGS2 mRNA; dieckol results in decreased expression of PTGS2 protein
dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]		 CTD PMID:19330880 PMID:33347706 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP dieckol inhibits the reaction [Particulate Matter results in increased expression of RELA protein] CTD PMID:33164846 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 decreases expression EXP dieckol results in decreased expression of RPS6KB1 protein CTD PMID:31291034 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFB1 mRNA] CTD PMID:33347706 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF mRNA]; dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF protein]
dieckol inhibits the reaction [Particulate Matter results in increased expression of TNF protein]
dieckol results in decreased expression of TNF protein		 CTD PMID:33051972 PMID:33164846 PMID:33347706 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TRP53 mRNA] CTD PMID:33347706 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TWIST1 twist family bHLH transcription factor 1 decreases expression EXP dieckol results in decreased expression of TWIST1 protein CTD PMID:31291034 NCBI chr 7:19,113,047...19,117,636
Ensembl chr 7:19,020,991...19,117,636 		JBrowse link
G VIM vimentin decreases expression EXP dieckol results in decreased expression of VIM protein CTD PMID:31291034 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
eckol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP eckol results in decreased phosphorylation of and results in decreased activity of AKT1 protein CTD PMID:21514314 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G CASP8 caspase 8 multiple interactions EXP [eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein CTD PMID:21514314 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP eckol results in decreased expression of CTNNB1 protein CTD PMID:21514314 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CYBB cytochrome b-245 beta chain decreases expression EXP eckol results in decreased expression of CYBB protein CTD PMID:21514314 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G FOXO3 forkhead box O3 increases phosphorylation
multiple interactions		 EXP eckol results in increased phosphorylation of FOXO3 protein
FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]		 CTD PMID:24700636 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP eckol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:21514314 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP eckol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:21514314 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MSI1 musashi RNA binding protein 1 decreases expression EXP eckol results in decreased expression of MSI1 protein CTD PMID:21514314 NCBI chr12:120,339,662...120,369,164
Ensembl chr12:120,341,330...120,369,164 		JBrowse link
G NES nestin decreases expression EXP eckol results in decreased expression of NES protein CTD PMID:21514314 NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407 		JBrowse link
G PROM1 prominin 1 decreases expression EXP eckol results in decreased expression of PROM1 protein CTD PMID:21514314 NCBI chr 4:15,968,228...16,084,023
Ensembl chr 4:15,963,076...16,084,378 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase decreases activity EXP eckol results in decreased activity of RAF1 protein CTD PMID:21514314 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases expression		 EXP eckol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of SOD2 protein]; FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]
eckol results in increased expression of SOD2 mRNA; eckol results in increased expression of SOD2 protein		 CTD PMID:24700636 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SOX2 SRY-box transcription factor 2 decreases expression EXP eckol results in decreased expression of SOX2 protein CTD PMID:21514314 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            astringent 12083
              tannin 308
                phlorotannin 50
                  6,6'-bieckol 0
                  7-phloroeckol 0
                  dieckol 41
                  eckol + 13
                  eckstolonol 0
                  fucodiphloroethol G 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic aromatic compound 23910
                                  phenols 21095
                                    polyphenol 10053
                                      tannin 308
                                        phlorotannin 50
                                          6,6'-bieckol 0
                                          7-phloroeckol 0
                                          dieckol 41
                                          eckol + 13
                                          eckstolonol 0
                                          fucodiphloroethol G 0
paths to the root