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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phlorotannin
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Accession:CHEBI:71222 term browser browse the term
Definition:A type of tannin usually found in brown algae such as kelps and rockweeds. Unlike the hydrolysable or condensed tannins, these compounds are oligomers of phloroglucinol.
Synonyms:related_synonym: phlorotannins
 xref: Wikipedia:Phlorotannin


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dieckol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO dieckol results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:31291034 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BAX mRNA]
dieckol results in increased expression of BAX protein		 CTD PMID:33051972 PMID:33347706 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BCL2 mRNA]
dieckol results in decreased expression of BCL2 protein		 CTD PMID:33051972 PMID:33347706 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO dieckol results in increased activity of CASP3 protein
dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CASP3 mRNA]		 CTD PMID:31291034 PMID:33347706 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO dieckol results in increased activity of CASP8 protein CTD PMID:31291034 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO dieckol results in increased activity of CASP9 protein
dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CASP9 mRNA]		 CTD PMID:31291034 PMID:33347706 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CAT protein]
dieckol results in decreased activity of CAT protein		 CTD PMID:33051972 PMID:33347706 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO dieckol results in decreased expression of CCND1 protein CTD PMID:33051972 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO dieckol results in increased expression of CDH1 protein CTD PMID:31291034 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO dieckol results in decreased expression of CDH2 protein CTD PMID:31291034 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO dieckol inhibits the reaction [Particulate Matter results in increased phosphorylation of FOS protein] CTD PMID:33164846 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GSR protein] CTD PMID:33347706 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL18 mRNA] CTD PMID:33347706 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL1B mRNA]; dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL1B protein]
dieckol inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]
dieckol results in decreased expression of IL1B protein		 CTD PMID:33051972 PMID:33164846 PMID:33347706 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL6 mRNA]; dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL6 protein]
dieckol inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]		 CTD PMID:33164846 PMID:33347706 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO dieckol inhibits the reaction [Particulate Matter results in increased phosphorylation of JUN protein] CTD PMID:33164846 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO dieckol inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein] CTD PMID:33164846 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO dieckol inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein] CTD PMID:33164846 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression
multiple interactions		 ISO dieckol results in decreased expression of MMP1 mRNA; dieckol results in decreased expression of MMP1 protein
dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP1 protein]		 CTD PMID:19330880 PMID:33164846 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression
multiple interactions		 ISO dieckol results in decreased expression of MMP13 mRNA; dieckol results in decreased expression of MMP13 protein
dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP13 protein]		 CTD PMID:19330880 PMID:33164846 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP2 protein] CTD PMID:33164846 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO dieckol results in decreased expression of MMP3 mRNA; dieckol results in decreased expression of MMP3 protein CTD PMID:19330880 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp8 matrix metallopeptidase 8 multiple interactions ISO dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP8 protein] CTD PMID:33164846 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO dieckol results in decreased expression of MMP9 protein
dieckol inhibits the reaction [Particulate Matter results in increased expression of MMP9 protein]		 CTD PMID:31291034 PMID:33164846 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO dieckol results in decreased phosphorylation of MTOR protein CTD PMID:31291034 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO dieckol inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein] CTD PMID:33164846 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO dieckol affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFKBIA protein]; dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of NFKBIA protein] CTD PMID:33347706 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO dieckol results in decreased expression of NOS2 mRNA; dieckol results in decreased expression of NOS2 protein CTD PMID:19330880 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO dieckol results in decreased expression of PCNA protein CTD PMID:33051972 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO dieckol results in decreased expression of PLAU protein CTD PMID:31291034 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 ISO dieckol results in decreased expression of PTGS2 mRNA; dieckol results in decreased expression of PTGS2 protein
dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]		 CTD PMID:19330880 PMID:33347706 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO dieckol inhibits the reaction [Particulate Matter results in increased expression of RELA protein] CTD PMID:33164846 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO dieckol results in decreased expression of RPS6KB1 protein CTD PMID:31291034 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TGFB1 mRNA] CTD PMID:33347706 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF mRNA]; dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF protein]
dieckol inhibits the reaction [Particulate Matter results in increased expression of TNF protein]
dieckol results in decreased expression of TNF protein		 CTD PMID:33051972 PMID:33164846 PMID:33347706 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO dieckol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TRP53 mRNA] CTD PMID:33347706 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 decreases expression ISO dieckol results in decreased expression of TWIST1 protein CTD PMID:31291034 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Vim vimentin decreases expression ISO dieckol results in decreased expression of VIM protein CTD PMID:31291034 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
eckol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of AKT1 protein CTD PMID:21514314 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein CTD PMID:21514314 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO eckol results in decreased expression of CTNNB1 protein CTD PMID:21514314 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO eckol results in decreased expression of CYBB protein CTD PMID:21514314 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation
multiple interactions		 ISO eckol results in increased phosphorylation of FOXO3 protein
FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]		 CTD PMID:24700636 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:21514314 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:21514314 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Msi1 musashi RNA-binding protein 1 decreases expression ISO eckol results in decreased expression of MSI1 protein CTD PMID:21514314 NCBI chr12:41,158,301...41,251,134
Ensembl chr12:41,158,599...41,191,076 		JBrowse link
G Nes nestin decreases expression ISO eckol results in decreased expression of NES protein CTD PMID:21514314 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Prom1 prominin 1 decreases expression ISO eckol results in decreased expression of PROM1 protein CTD PMID:21514314 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases activity ISO eckol results in decreased activity of RAF1 protein CTD PMID:21514314 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression		 ISO eckol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of SOD2 protein]; FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]
eckol results in increased expression of SOD2 mRNA; eckol results in increased expression of SOD2 protein		 CTD PMID:24700636 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO eckol results in decreased expression of SOX2 protein CTD PMID:21514314 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      application 19770
        pharmaceutical 19645
          drug 19645
            astringent 10836
              tannin 243
                phlorotannin 47
                  6,6'-bieckol 0
                  7-phloroeckol 0
                  dieckol 38
                  eckol + 13
                  eckstolonol 0
                  fucodiphloroethol G 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19889
                        carbon atom 19894
                          organic molecular entity 19882
                            organic molecule 19830
                              organic cyclic compound 19603
                                organic aromatic compound 19444
                                  phenols 18667
                                    polyphenol 9167
                                      tannin 243
                                        phlorotannin 47
                                          6,6'-bieckol 0
                                          7-phloroeckol 0
                                          dieckol 38
                                          eckol + 13
                                          eckstolonol 0
                                          fucodiphloroethol G 0
paths to the root