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ONTOLOGY REPORT - ANNOTATIONS


Term:pazopanib
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Accession:CHEBI:71219 term browser browse the term
Definition:A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
Synonyms:exact_synonym: 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
 related_synonym: Formula=C21H23N7O2S;   GW 78603;   GW786034;   InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);   InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N;   SMILES=C1=C(C(=CC(=C1)NC=2N=CC=C(N2)N(C=3C=CC=4C(C3)=NN(C4C)C)C)S(N)(=O)=O)C;   pazopanibum
 xref: CAS:444731-52-6;   Drug_Central:4118;   LINCS:LSM-1114
 xref_mesh: MESH:C516667
 xref: PMID:21394443;   PMID:21766486;   PMID:21811833;   PMID:22112314;   PMID:22190407;   PMID:22233389;   PMID:22341567;   PMID:22359392;   PMID:22595799;   PMID:22679111;   PMID:22688250;   PMID:22716487;   PMID:22733110;   PMID:22733795;   PMID:22759480;   PMID:22766517;   PMID:22830347;   PMID:22861374;   PMID:22917595;   PMID:22984765;   PMID:23054212;   PMID:23064954;   PMID:23072642;   PMID:23088634;   PMID:23135778;   Patent:US2008293691;   Patent:WO2006020564;   Patent:WO2007064753;   Patent:WO2007143483;   Patent:WO2011058179;   Patent:WO2011069053;   Patent:WO2011150044;   Patent:WO2012106302;   Reaxys:11646488;   Wikipedia:Pazopanib
 cyclic_relationship: is_conjugate_base_of CHEBI:71218


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pazopanib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Akr1b10 aldo-keto reductase family 1 member B10 JBrowse link 4 61,813,265 61,830,371 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Pgr progesterone receptor JBrowse link 8 7,128,656 7,187,796 RGD:6480464
G Thra thyroid hormone receptor alpha JBrowse link 10 86,657,285 86,684,935 RGD:6480464
G Thrb thyroid hormone receptor beta JBrowse link 15 8,890,578 9,239,815 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      application 19373
        pharmaceutical 19243
          drug 19243
            antineoplastic agent 16922
              pazopanib 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    main group molecular entity 19664
                      s-block molecular entity 19406
                        hydrogen molecular entity 19397
                          hydrides 18386
                            inorganic hydride 17221
                              pnictogen hydride 17184
                                nitrogen hydride 17020
                                  azane 16716
                                    ammonia 16715
                                      organic amino compound 16714
                                        aromatic amine 13627
                                          aminopyrimidine 1102
                                            pazopanib 12
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