Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pazopanib
go back to main search page
Accession:CHEBI:71219 term browser browse the term
Definition:A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
Synonyms:exact_synonym: 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
 related_synonym: Formula=C21H23N7O2S;   GW 78603;   GW786034;   InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);   InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N;   SMILES=C1=C(C(=CC(=C1)NC=2N=CC=C(N2)N(C=3C=CC=4C(C3)=NN(C4C)C)C)S(N)(=O)=O)C;   pazopanibum
 xref: CAS:444731-52-6;   Drug_Central:4118;   LINCS:LSM-1114
 xref_mesh: MESH:C516667
 xref: PMID:21394443;   PMID:21766486;   PMID:21811833;   PMID:22112314;   PMID:22190407;   PMID:22233389;   PMID:22341567;   PMID:22359392;   PMID:22595799;   PMID:22679111;   PMID:22688250;   PMID:22716487;   PMID:22733110;   PMID:22733795;   PMID:22759480;   PMID:22766517;   PMID:22830347;   PMID:22861374;   PMID:22917595;   PMID:22984765;   PMID:23054212;   PMID:23064954;   PMID:23072642;   PMID:23088634;   PMID:23135778;   Patent:US2008293691;   Patent:WO2006020564;   Patent:WO2007064753;   Patent:WO2007143483;   Patent:WO2011058179;   Patent:WO2011069053;   Patent:WO2011150044;   Patent:WO2012106302;   Reaxys:11646488;   Wikipedia:Pazopanib
 cyclic_relationship: is_conjugate_base_of CHEBI:71218


show annotations for term's descendants           Sort by:
pazopanib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO pazopanib results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO pazopanib results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO pazopanib inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA] CTD PMID:29356861 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Ar androgen receptor multiple interactions ISO pazopanib binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO pazopanib results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO pazopanib results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO pazopanib results in increased expression of CYP2B6 mRNA CTD PMID:29356861 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO pazopanib results in increased expression of CYP2C8 mRNA CTD PMID:29356861
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO pazopanib results in increased expression of CYP3A4 mRNA CTD PMID:29356861 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO pazopanib results in increased secretion of IL1B protein CTD PMID:33271325 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO pazopanib results in decreased phosphorylation of MAPK1 protein
mirdametinib promotes the reaction [pazopanib results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:27560553 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO pazopanib results in decreased phosphorylation of MAPK3 protein
mirdametinib promotes the reaction [pazopanib results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:27560553 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]] CTD PMID:29356861 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; pazopanib inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; pazopanib inhibits the reaction [T0901317 results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO pazopanib binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Prtn3 proteinase 3 increases expression ISO pazopanib results in increased expression of PRTN3 protein CTD PMID:33271325 NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO pazopanib binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO pazopanib binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      application 19615
        pharmaceutical 19493
          drug 19493
            antineoplastic agent 17687
              pazopanib 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    main group molecular entity 19755
                      s-block molecular entity 19605
                        hydrogen molecular entity 19595
                          hydrides 19072
                            inorganic hydride 17983
                              pnictogen hydride 17970
                                nitrogen hydride 17867
                                  azane 17653
                                    ammonia 17652
                                      organic amino compound 17652
                                        aromatic amine 15026
                                          aminopyrimidine 1725
                                            pazopanib 18
paths to the root