CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pazopanib
Accession: CHEBI:71219
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Definition: A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
Synonyms: exact_synonym: 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
related_synonym: Formula=C21H23N7O2S; GW 78603; GW786034; InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25); InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N; SMILES=C1=C(C(=CC(=C1)NC=2N=CC=C(N2)N(C=3C=CC=4C(C3)=NN(C4C)C)C)S(N)(=O)=O)C; pazopanibum
xref: CAS:444731-52-6; Drug_Central:4118; LINCS:LSM-1114
xref_mesh: MESH:C516667
xref: PMID:21394443; PMID:21766486; PMID:21811833; PMID:22112314; PMID:22190407; PMID:22233389; PMID:22341567; PMID:22359392; PMID:22595799; PMID:22679111; PMID:22688250; PMID:22716487; PMID:22733110; PMID:22733795; PMID:22759480; PMID:22766517; PMID:22830347; PMID:22861374; PMID:22917595; PMID:22984765; PMID:23054212; PMID:23064954; PMID:23072642; PMID:23088634; PMID:23135778; Patent:US2008293691; Patent:WO2006020564; Patent:WO2007064753; Patent:WO2007143483; Patent:WO2011058179; Patent:WO2011069053; Patent:WO2011150044; Patent:WO2012106302; Reaxys:11646488; Wikipedia:Pazopanib
cyclic_relationship: is_conjugate_base_of CHEBI:71218
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity
ISO
pazopanib results in decreased activity of ABCB11 protein
CTD
PMID:20829430 PMID:23956101 PMID:28437613
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb4
ATP binding cassette subfamily B member 4
decreases activity
ISO
pazopanib results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Akr1b10
aldo-keto reductase family 1 member B10
multiple interactions
ISO
pazopanib inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA]
CTD
PMID:29356861
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Ar
androgen receptor
multiple interactions
ISO
pazopanib binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
pazopanib results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
pazopanib results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
pazopanib results in increased expression of CYP2B6 mRNA
CTD
PMID:29356861
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
increases expression
ISO
pazopanib results in increased expression of CYP2C8 mRNA
CTD
PMID:29356861
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
pazopanib results in increased expression of CYP3A4 mRNA
CTD
PMID:29356861
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Il1b
interleukin 1 beta
increases secretion
ISO
pazopanib results in increased secretion of IL1B protein
CTD
PMID:33271325
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation multiple interactions
ISO
pazopanib results in decreased phosphorylation of MAPK1 protein mirdametinib promotes the reaction [pazopanib results in decreased phosphorylation of MAPK1 protein]
CTD
PMID:27560553
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation multiple interactions
ISO
pazopanib results in decreased phosphorylation of MAPK3 protein mirdametinib promotes the reaction [pazopanib results in decreased phosphorylation of MAPK3 protein]
CTD
PMID:27560553
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Ncoa1
nuclear receptor coactivator 1
multiple interactions
ISO
pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]
CTD
PMID:29356861
NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; pazopanib inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; pazopanib inhibits the reaction [T0901317 results in increased activity of NR1I2 protein]
CTD
PMID:29356861
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Pgr
progesterone receptor
multiple interactions
ISO
pazopanib binds to and results in decreased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Prtn3
proteinase 3
increases expression
ISO
pazopanib results in increased expression of PRTN3 protein
CTD
PMID:33271325
NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
pazopanib binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Thrb
thyroid hormone receptor beta
multiple interactions
ISO
pazopanib binds to and results in decreased activity of THRB protein
CTD
PMID:25752796
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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