Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pazopanib
go back to main search page
Accession:CHEBI:71219 term browser browse the term
Definition:A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
Synonyms:exact_synonym: 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
 related_synonym: Formula=C21H23N7O2S;   GW 78603;   GW786034;   InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);   InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N;   SMILES=C1=C(C(=CC(=C1)NC=2N=CC=C(N2)N(C=3C=CC=4C(C3)=NN(C4C)C)C)S(N)(=O)=O)C;   pazopanibum
 xref: CAS:444731-52-6;   Drug_Central:4118;   LINCS:LSM-1114
 xref_mesh: MESH:C516667
 xref: PMID:21394443;   PMID:21766486;   PMID:21811833;   PMID:22112314;   PMID:22190407;   PMID:22233389;   PMID:22341567;   PMID:22359392;   PMID:22595799;   PMID:22679111;   PMID:22688250;   PMID:22716487;   PMID:22733110;   PMID:22733795;   PMID:22759480;   PMID:22766517;   PMID:22830347;   PMID:22861374;   PMID:22917595;   PMID:22984765;   PMID:23054212;   PMID:23064954;   PMID:23072642;   PMID:23088634;   PMID:23135778;   Patent:US2008293691;   Patent:WO2006020564;   Patent:WO2007064753;   Patent:WO2007143483;   Patent:WO2011058179;   Patent:WO2011069053;   Patent:WO2011150044;   Patent:WO2012106302;   Reaxys:11646488;   Wikipedia:Pazopanib
 cyclic_relationship: is_conjugate_base_of CHEBI:71218


show annotations for term's descendants           Sort by:
pazopanib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO pazopanib results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 PMID:28437613 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO pazopanib results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO pazopanib inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA] CTD PMID:29356861 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847 		JBrowse link
G Ar androgen receptor multiple interactions ISO pazopanib binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO pazopanib results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO pazopanib results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO pazopanib results in increased expression of CYP2B6 mRNA CTD PMID:29356861 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO pazopanib results in increased expression of CYP2C8 mRNA CTD PMID:29356861
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO pazopanib results in increased expression of CYP3A4 mRNA CTD PMID:29356861 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO pazopanib results in increased secretion of IL1B protein CTD PMID:33271325 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions 		ISO pazopanib results in decreased phosphorylation of MAPK1 protein
mirdametinib promotes the reaction [pazopanib results in decreased phosphorylation of MAPK1 protein] 		CTD PMID:27560553 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions 		ISO pazopanib results in decreased phosphorylation of MAPK3 protein
mirdametinib promotes the reaction [pazopanib results in decreased phosphorylation of MAPK3 protein] 		CTD PMID:27560553 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]] CTD PMID:29356861 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression 		ISO NFE2L2 protein affects the reaction [pazopanib results in decreased activity of TERT protein]; NFE2L2 protein affects the reaction [pazopanib results in increased expression of SERPINE1 mRNA]; NFE2L2 protein affects the reaction [pazopanib results in increased expression of SERPINE1 protein]; NFE2L2 protein affects the reaction [pazopanib results in increased expression of TP53 mRNA]; NFE2L2 protein affects the reaction [pazopanib results in increased expression of TP53 protein]
pazopanib results in increased expression of NFE2L2 protein 		CTD PMID:38613465 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pazopanib inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; pazopanib inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; pazopanib inhibits the reaction [T0901317 results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO pazopanib binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Prtn3 proteinase 3 increases expression ISO pazopanib results in increased expression of PRTN3 protein CTD PMID:33271325 NCBI chr 7:10,472,750...10,482,037
Ensembl chr 7:10,472,755...10,482,474 		JBrowse link
G Serpine1 serpin family E member 1 increases expression
multiple interactions 		ISO pazopanib results in increased expression of SERPINE1 mRNA; pazopanib results in increased expression of SERPINE1 protein
NFE2L2 protein affects the reaction [pazopanib results in increased expression of SERPINE1 mRNA]; NFE2L2 protein affects the reaction [pazopanib results in increased expression of SERPINE1 protein] 		CTD PMID:38613465 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Terf2 telomeric repeat binding factor 2 increases expression ISO pazopanib results in increased expression of TERF2 mRNA CTD PMID:38613465 NCBI chr19:51,887,221...51,915,756
Ensembl chr19:51,887,221...51,915,566 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity
multiple interactions
decreases expression 		ISO pazopanib results in decreased activity of TERT protein
NFE2L2 protein affects the reaction [pazopanib results in decreased activity of TERT protein]
pazopanib results in decreased expression of TERT mRNA 		CTD PMID:38613465 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO pazopanib binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO pazopanib binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		ISO NFE2L2 protein affects the reaction [pazopanib results in increased expression of TP53 mRNA]; NFE2L2 protein affects the reaction [pazopanib results in increased expression of TP53 protein]
pazopanib results in increased expression of TP53 mRNA; pazopanib results in increased expression of TP53 protein 		CTD PMID:38613465 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            antineoplastic agent 18066
              pazopanib 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        aromatic amine 15832
                                          aminopyrimidine 3913
                                            pazopanib 23
paths to the root