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ONTOLOGY REPORT - ANNOTATIONS


Term:tofacitinib
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Accession:CHEBI:71200 term browser browse the term
Definition:A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.
Synonyms:exact_synonym: 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
 related_synonym: CP 690550;   Formula=C16H20N6O;   InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1;   InChIKey=UJLAWZDWDVHWOW-YPMHNXCESA-N;   SMILES=C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N;   Tasocitinib;   tofacitinibum
 alt_id: MESH:C479163
 xref: CAS:477600-75-2 "ChemIDplus";   CAS:477600-75-2 "KEGG DRUG";   Drug_Central:4713 "DrugCentral";   KEGG:D09970;   LINCS:LSM-1227
 xref_mesh: MESH:C479163
 xref: PDBeChem:MI1;   PMID:21952978 "Europe PMC";   PMID:21971513 "Europe PMC";   PMID:22006202 "Europe PMC";   PMID:22147632 "Europe PMC";   PMID:22233204 "Europe PMC";   PMID:22357358 "Europe PMC";   PMID:22460142 "Europe PMC";   PMID:22474037 "Europe PMC";   PMID:22525048 "Europe PMC";   PMID:22576568 "Europe PMC";   PMID:22591402 "Europe PMC";   PMID:22607178 "Europe PMC";   PMID:22607938 "Europe PMC";   PMID:22682022 "Europe PMC";   PMID:22802024 "Europe PMC";   PMID:22873530 "Europe PMC";   PMID:22873531 "Europe PMC";   PMID:22894574 "Europe PMC";   PMID:22899318 "Europe PMC";   PMID:22916341 "Europe PMC";   PMID:22924949 "Europe PMC";   PMID:22960764 "Europe PMC";   PMID:23055694 "Europe PMC";   PMID:23150969 "Europe PMC";   PMID:23150970 "Europe PMC";   PMID:23150971 "Europe PMC";   Patent:WO2007012953;   Patent:WO2007107318;   Patent:WO2010123919;   Reaxys:11647225 "Reaxys";   Wikipedia:Tofacitinib


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tofacitinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Ampd2 adenosine monophosphate deaminase 2 JBrowse link 2 210,861,624 210,874,348 RGD:6480464
G Bst2 bone marrow stromal cell antigen 2 JBrowse link 16 19,938,781 19,942,353 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Cxcl11 C-X-C motif chemokine ligand 11 JBrowse link 14 17,195,395 17,198,170 RGD:6480464
G Cxcl13 C-X-C motif chemokine ligand 13 JBrowse link 14 15,253,146 15,258,221 RGD:6480464
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:6480464
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:6480464
G Ifi27 interferon, alpha-inducible protein 27 JBrowse link 6 127,327,959 127,334,430 RGD:6480464
G Ifi35 interferon-induced protein 35 JBrowse link 10 89,358,376 89,366,628 RGD:6480464
G Ifi44 interferon-induced protein 44 JBrowse link 2 256,897,765 256,915,591 RGD:6480464
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 JBrowse link 1 252,906,234 252,911,377 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:6480464
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:6480464
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6480464
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:6480464
G Irf7 interferon regulatory factor 7 JBrowse link 1 214,249,388 214,252,909 RGD:6480464
G Irf9 interferon regulatory factor 9 JBrowse link 15 34,282,936 34,288,981 RGD:6480464
G Isg15 ISG15 ubiquitin-like modifier JBrowse link 5 173,624,862 173,629,124 RGD:6480464
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6480464
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6480464
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Klhl31 kelch-like family member 31 JBrowse link 8 84,945,444 84,968,811 RGD:6480464
G Krt16 keratin 16 JBrowse link 10 88,149,210 88,152,167 RGD:6480464
G Lhcgr luteinizing hormone/choriogonadotropin receptor JBrowse link 6 12,493,182 12,554,482 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mt-co1 mitochondrially encoded cytochrome c oxidase I JBrowse link MT 5,323 6,867 RGD:6480464
G Mx2 MX dynamin like GTPase 2 JBrowse link 11 38,035,306 38,066,185 RGD:6480464
G Nfatc1 nuclear factor of activated T-cells 1 JBrowse link 18 77,203,517 77,322,690 RGD:6480464
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:6480464
G Oas1a 2'-5' oligoadenylate synthetase 1A JBrowse link 12 41,200,680 41,211,393 RGD:6480464
G Oas2 2'-5' oligoadenylate synthetase 2 JBrowse link 12 41,341,417 41,363,124 RGD:6480464
G Osm oncostatin M JBrowse link 14 84,457,487 84,469,426 RGD:6480464
G Prdm16 PR/SET domain 16 JBrowse link 5 171,662,277 171,711,561 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:6480464
G Rorc RAR-related orphan receptor C JBrowse link 2 195,612,471 195,636,797 RGD:6480464
G Rsad2 radical S-adenosyl methionine domain containing 2 JBrowse link 6 45,655,947 45,669,083 RGD:6480464
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:6480464
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:6480464
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Stat2 signal transducer and activator of transcription 2 JBrowse link 7 2,691,064 2,707,530 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:6480464
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:6480464
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:6480464
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:6480464
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6480464
G Usp18 ubiquitin specific peptidase 18 JBrowse link 4 153,812,312 153,834,374 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    chemical entity 19667
      group 19582
        pseudohalo group 2767
          cyano group 2767
            nitrile 2767
              tofacitinib 77
                tofacitinib citrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        tertiary amino compound 8521
                                          tofacitinib 77
                                            tofacitinib citrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.