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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tofacitinib
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Accession:CHEBI:71200 term browser browse the term
Definition:A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.
Synonyms:exact_synonym: 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
 related_synonym: CP 690550;   Formula=C16H20N6O;   InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1;   InChIKey=UJLAWZDWDVHWOW-YPMHNXCESA-N;   SMILES=C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N;   Tasocitinib;   tofacitinibum
 alt_id: MESH:C479163
 xref: CAS:477600-75-2;   Drug_Central:4713;   KEGG:D09970;   LINCS:LSM-1227
 xref_mesh: MESH:C479163
 xref: PDBeChem:MI1;   PMID:21952978;   PMID:21971513;   PMID:22006202;   PMID:22147632;   PMID:22233204;   PMID:22357358;   PMID:22460142;   PMID:22474037;   PMID:22525048;   PMID:22576568;   PMID:22591402;   PMID:22607178;   PMID:22607938;   PMID:22682022;   PMID:22802024;   PMID:22873530;   PMID:22873531;   PMID:22894574;   PMID:22899318;   PMID:22916341;   PMID:22924949;   PMID:22960764;   PMID:23055694;   PMID:23150969;   PMID:23150970;   PMID:23150971;   Patent:WO2007012953;   Patent:WO2007107318;   Patent:WO2010123919;   Reaxys:11647225;   Wikipedia:Tofacitinib


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tofacitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO tofacitinib inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of AHR mRNA] CTD PMID:21383241 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of AKT1 protein] CTD PMID:21383241 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ampd2 adenosine monophosphate deaminase 2 multiple interactions
decreases expression
ISO [tofacitinib results in decreased expression of AMPD2 protein] which affects the abundance of Adenosine CTD PMID:25496463 NCBI chr 2:210,861,624...210,874,348
Ensembl chr 2:210,861,625...210,874,304
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO tofacitinib results in decreased expression of BST2 mRNA CTD PMID:25487280 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO tofacitinib results in decreased expression of CCL2 mRNA
Cycloheximide inhibits the reaction [tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; tofacitinib inhibits the reaction [OSM protein results in increased expression of CCL2 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL2 protein]
CTD PMID:22121136, PMID:23968543, PMID:25398374 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Cycloheximide inhibits the reaction [tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:22121136 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO tofacitinib results in increased expression of CCND1 mRNA CTD PMID:26300391 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ctsk cathepsin K decreases expression ISO tofacitinib results in decreased expression of CTSK protein CTD PMID:21937456 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression
multiple interactions
decreases secretion
ISO
EXP
tofacitinib results in decreased expression of CXCL10 mRNA
Cycloheximide inhibits the reaction [tofacitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 protein]]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 protein]
tofacitinib inhibits the reaction [IFNG protein results in increased expression of CXCL10 mRNA]
tofacitinib results in decreased secretion of CXCL10 protein
CTD PMID:22121136, PMID:22899318, PMID:22941906, PMID:24213371, PMID:25398374, PMID:25487280 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 decreases expression
multiple interactions
ISO tofacitinib results in decreased expression of CXCL11 mRNA
tofacitinib inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]
CTD PMID:22941906 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO tofacitinib results in decreased expression of CXCL13 mRNA CTD PMID:25398374 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions
decreases expression
ISO tofacitinib inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]
tofacitinib results in decreased expression of CXCL9 mRNA
CTD PMID:22941906, PMID:24213371 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of tofacitinib CTD PMID:31414593 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of tofacitinib CTD PMID:31414593 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of tofacitinib CTD PMID:31414593 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Gli1 GLI family zinc finger 1 increases expression ISO tofacitinib results in increased expression of GLI1 mRNA CTD PMID:25487280 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO tofacitinib results in decreased expression of IFI27 mRNA CTD PMID:25487280 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO tofacitinib results in decreased expression of IFI35 mRNA CTD PMID:25487280 NCBI chr10:89,358,376...89,366,628
Ensembl chr10:89,358,376...89,366,626
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO tofacitinib results in decreased expression of IFI44 mRNA CTD PMID:25487280 NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO tofacitinib results in decreased expression of IFIT3 mRNA CTD PMID:25487280 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ifng interferon gamma multiple interactions ISO tofacitinib inhibits the reaction [IFNG protein results in increased expression of CXCL10 mRNA]; tofacitinib inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]; tofacitinib inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IFNG protein]
tofacitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein]
CTD PMID:21383241, PMID:22941906, PMID:24213371 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO tofacitinib inhibits the reaction [IL6 protein results in increased expression of IL10 mRNA]; tofacitinib inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL10 protein] CTD PMID:21383241, PMID:24285838 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il15 interleukin 15 multiple interactions ISO tofacitinib inhibits the reaction [IL15 protein results in increased phosphorylation of STAT5A protein]; tofacitinib inhibits the reaction [IL15 protein results in increased phosphorylation of STAT5B protein] CTD PMID:21155605 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il17a interleukin 17A multiple interactions ISO tofacitinib inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of and results in increased secretion of IL17A protein] CTD PMID:26738536 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
tofacitinib inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; tofacitinib inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; tofacitinib inhibits the reaction [IL1B protein results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]
tofacitinib inhibits the reaction [TNF protein affects the expression of IL1B mRNA]
tofacitinib results in decreased expression of IL1B mRNA
CTD PMID:21383241, PMID:21937456, PMID:22899318, PMID:22941906 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO tofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of AKT1 protein]; tofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5A protein]; tofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5B protein] CTD PMID:21155605, PMID:21383241 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il21 interleukin 21 multiple interactions ISO tofacitinib inhibits the reaction [IL21 protein results in increased phosphorylation of STAT3 protein]
tofacitinib inhibits the reaction [IL21 protein results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [IL21 protein results in increased phosphorylation of STAT3 protein]
CTD PMID:21383241 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO tofacitinib inhibits the reaction [[IL6 protein co-treated with IL23A protein] results in increased expression of IL23R mRNA]; tofacitinib inhibits the reaction [[IL6 protein co-treated with IL23A protein] results in increased expression of RORC mRNA]; tofacitinib inhibits the reaction [IL23A protein results in increased phosphorylation of STAT3 protein] CTD PMID:21383241, PMID:21937456 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il23r interleukin 23 receptor multiple interactions ISO tofacitinib inhibits the reaction [[IL6 protein co-treated with IL23A protein] results in increased expression of IL23R mRNA] CTD PMID:21383241 NCBI chr 4:98,203,788...98,306,729
Ensembl chr 4:98,203,958...98,305,173
JBrowse link
G Il4 interleukin 4 multiple interactions ISO tofacitinib inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein] CTD PMID:21383241 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO
EXP
tofacitinib results in decreased expression of IL6 mRNA
tofacitinib inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [IL6 protein results in increased expression of SAA1 mRNA]; tofacitinib inhibits the reaction [IL6 protein results in increased expression of SAA2 mRNA]; tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; tofacitinib inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein]; tofacitinib inhibits the reaction [OSM protein results in increased expression of IL6 mRNA]
tofacitinib results in decreased expression of and results in decreased secretion of IL6 protein
tofacitinib inhibits the reaction [[IL6 protein co-treated with IL23A protein] results in increased expression of IL23R mRNA]; tofacitinib inhibits the reaction [[IL6 protein co-treated with IL23A protein] results in increased expression of RORC mRNA]; tofacitinib inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of AHR mRNA]; tofacitinib inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of RORC mRNA]; tofacitinib inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; tofacitinib inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; tofacitinib inhibits the reaction [IL6 protein results in increased expression of IL10 mRNA]; tofacitinib inhibits the reaction [IL6 protein results in increased expression of IL6 mRNA]; tofacitinib inhibits the reaction [IL6 protein results in increased expression of TNFSF11 mRNA]; tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; tofacitinib inhibits the reaction [OSM protein results in increased expression of IL6 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of IL6 protein]; tofacitinib promotes the reaction [IL6 protein results in increased expression of MMP9 mRNA]
CTD PMID:21383241, PMID:21548952, PMID:21844139, PMID:21937456, PMID:22121136, PMID:22899318, PMID:22941906, PMID:24285838, PMID:31048000 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor multiple interactions ISO tofacitinib inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased phosphorylation of STAT3 protein] CTD PMID:21548952 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO tofacitinib results in decreased expression of IRF7 mRNA CTD PMID:22941906, PMID:25487280 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Irf9 interferon regulatory factor 9 decreases expression ISO tofacitinib results in decreased expression of IRF9 mRNA CTD PMID:25487280 NCBI chr15:34,282,936...34,288,981
Ensembl chr15:34,282,936...34,288,138
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO tofacitinib results in decreased expression of ISG15 mRNA CTD PMID:25487280 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Jak1 Janus kinase 1 decreases activity
multiple interactions
ISO tofacitinib results in decreased activity of JAK1 protein
tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK1 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK1 protein]
CTD PMID:21548952, PMID:23968543, PMID:24883332 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Jak2 Janus kinase 2 affects response to substance
multiple interactions
decreases activity
ISO JAK2 gene mutant form affects the susceptibility to tofacitinib
tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK2 protein]
tofacitinib results in decreased activity of JAK2 protein
CTD PMID:21548952, PMID:21844139, PMID:23968543, PMID:26300391 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jak3 Janus kinase 3 decreases activity
multiple interactions
ISO tofacitinib results in decreased activity of JAK3 protein
tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK3 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK3 protein]
CTD PMID:21548952, PMID:23689514, PMID:23968543, PMID:24883332, PMID:26300391, PMID:26738536 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO tofacitinib promotes the reaction [TNF protein affects the localization of JUN protein] CTD PMID:22941906 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klhl31 kelch-like family member 31 increases expression ISO tofacitinib results in increased expression of KLHL31 mRNA CTD PMID:25487280 NCBI chr 8:84,945,444...84,968,811
Ensembl chr 8:84,945,444...84,968,811
JBrowse link
G Krt16 keratin 16 decreases expression ISO tofacitinib results in decreased expression of KRT16 mRNA CTD PMID:27059729 NCBI chr10:88,149,210...88,152,167
Ensembl chr10:88,149,345...88,152,064
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions EXP tofacitinib inhibits the reaction [PRL protein results in increased expression of LHCGR mRNA] CTD PMID:27708194 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of MAPK1 protein] CTD PMID:21548952 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of MAPK3 protein] CTD PMID:21548952 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of MAPK8 protein] CTD PMID:21548952 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of MAPK9 protein] CTD PMID:21548952 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO tofacitinib results in decreased expression of MMP1 mRNA CTD PMID:25398374 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO tofacitinib results in decreased expression of MMP3 mRNA CTD PMID:25398374 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tofacitinib promotes the reaction [IL6 protein results in increased expression of MMP9 mRNA] CTD PMID:24285838 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO tofacitinib results in increased expression of COX1 protein CTD PMID:25487280 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression ISO tofacitinib results in decreased expression of MX1 mRNA CTD PMID:25487280 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO tofacitinib promotes the reaction [TNF protein affects the localization of NFATC1 protein] CTD PMID:22941906 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO tofacitinib inhibits the reaction [TNF protein affects the localization of NFKB2 protein] CTD PMID:22941906 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO tofacitinib results in decreased expression of OAS1 mRNA CTD PMID:25487280 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 decreases expression ISO tofacitinib results in decreased expression of OAS2 mRNA CTD PMID:25487280 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
JBrowse link
G Osm oncostatin M multiple interactions ISO tofacitinib inhibits the reaction [OSM protein results in increased expression of IL6 mRNA]; tofacitinib inhibits the reaction [OSM protein results in increased expression of TNFSF11 mRNA]
tofacitinib inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein]; tofacitinib inhibits the reaction [OSM protein results in increased expression of CCL2 mRNA]; tofacitinib inhibits the reaction [OSM protein results in increased expression of IL6 mRNA]; tofacitinib inhibits the reaction [OSM protein results in increased expression of S100A7 protein]; tofacitinib inhibits the reaction [OSM protein results in increased expression of SAA1 mRNA]; tofacitinib inhibits the reaction [OSM protein results in increased expression of SAA2 mRNA]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK1 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of JAK3 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK1 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK2 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of JAK3 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of MAPK1 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of MAPK3 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of MAPK8 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of MAPK9 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of STAT3 protein]
CTD PMID:21548952, PMID:21937456, PMID:23968543, PMID:25252914 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Prdm16 PR/SET domain 16 increases expression ISO tofacitinib results in increased expression of PRDM16 protein CTD PMID:25487280 NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316
JBrowse link
G Prl prolactin multiple interactions EXP tofacitinib inhibits the reaction [PRL protein results in increased expression of LHCGR mRNA]; tofacitinib inhibits the reaction [PRL protein results in increased phosphorylation of STAT5A protein]; tofacitinib inhibits the reaction [PRL protein results in increased phosphorylation of STAT5B protein] CTD PMID:27708194 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions ISO tofacitinib inhibits the reaction [TNF protein affects the localization of RELB protein] CTD PMID:22941906 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO tofacitinib inhibits the reaction [[IL6 protein co-treated with IL23A protein] results in increased expression of RORC mRNA]; tofacitinib inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of RORC mRNA] CTD PMID:21383241 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO tofacitinib results in decreased expression of RSAD2 mRNA CTD PMID:25487280 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A increases expression ISO tofacitinib results in increased expression of SDHA protein CTD PMID:25487280 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Sele selectin E decreases expression EXP tofacitinib results in decreased expression of SELE mRNA CTD PMID:22899318 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selp selectin P decreases expression EXP tofacitinib results in decreased expression of SELP mRNA CTD PMID:22899318 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Sfrp5 secreted frizzled-related protein 5 increases expression ISO tofacitinib results in increased expression of SFRP5 mRNA CTD PMID:25487280 NCBI chr 1:261,442,108...261,446,570
Ensembl chr 1:261,442,108...261,446,570
JBrowse link
G Shh sonic hedgehog signaling molecule increases expression ISO tofacitinib results in increased expression of SHH mRNA CTD PMID:25487280 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO tofacitinib results in decreased expression of SOCS3 mRNA CTD PMID:25487280 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions
decreases phosphorylation
ISO tofacitinib results in decreased expression of STAT1 mRNA; tofacitinib results in decreased expression of STAT1 protein modified form
tofacitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [TNF protein results in increased phosphorylation of STAT1 protein]
tofacitinib inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [IL21 protein results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]
tofacitinib results in decreased phosphorylation of STAT1 protein
CTD PMID:21383241, PMID:21548952, PMID:22121136, PMID:22941906, PMID:23968543, PMID:25398374, PMID:25487280, PMID:27059729, PMID:28365849 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO tofacitinib inhibits the reaction [IFNA1 protein affects the localization of and results in increased phosphorylation of STAT2 protein]; tofacitinib inhibits the reaction [IFNG protein affects the localization of and results in increased phosphorylation of STAT2 protein] CTD PMID:22941906 NCBI chr 7:2,691,064...2,707,530
Ensembl chr 7:2,691,369...2,707,741
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity
multiple interactions
decreases expression
decreases phosphorylation
ISO tofacitinib results in decreased activity of STAT3 protein
tofacitinib inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [IL21 protein results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; tofacitinib inhibits the reaction [OSM protein results in increased phosphorylation of STAT3 protein]
tofacitinib inhibits the reaction [IL1B protein results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [IL21 protein results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [IL23A protein results in increased phosphorylation of STAT3 protein]; tofacitinib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
tofacitinib results in decreased expression of STAT3 protein modified form
tofacitinib results in decreased phosphorylation of STAT3 protein
CTD PMID:21383241, PMID:21548952, PMID:21844139, PMID:21937456, PMID:22121136, PMID:22348037, PMID:23968543, PMID:24285838, PMID:25252914, PMID:25398374, PMID:25487280, PMID:26244872, PMID:27059729 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases phosphorylation
multiple interactions
ISO
EXP
tofacitinib results in decreased phosphorylation of STAT5A protein
tofacitinib inhibits the reaction [PRL protein results in increased phosphorylation of STAT5A protein]
tofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5A protein]
tofacitinib inhibits the reaction [IL15 protein results in increased phosphorylation of STAT5A protein]
CTD PMID:21155605, PMID:22705984, PMID:26244872, PMID:27708194 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases phosphorylation
multiple interactions
ISO
EXP
tofacitinib results in decreased phosphorylation of STAT5B protein; tofacitinib results in decreased phosphorylation of STAT5B protein mutant form
tofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5B protein]
tofacitinib inhibits the reaction [PRL protein results in increased phosphorylation of STAT5B protein]
tofacitinib inhibits the reaction [IL15 protein results in increased phosphorylation of STAT5B protein]
CTD PMID:21155605, PMID:22705984, PMID:26244872, PMID:27708194, PMID:29200404 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO tofacitinib inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein] CTD PMID:21383241 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO tofacitinib inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of AHR mRNA]; tofacitinib inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of RORC mRNA] CTD PMID:21383241 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cycloheximide inhibits the reaction [tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Cycloheximide inhibits the reaction [tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Cycloheximide inhibits the reaction [tofacitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 protein]]; tofacitinib inhibits the reaction [TNF protein affects the expression of IL1B mRNA]; tofacitinib inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of STAT1 protein]; tofacitinib inhibits the reaction [TNF protein affects the localization of NFKB2 protein]; tofacitinib inhibits the reaction [TNF protein affects the localization of RELB protein]; tofacitinib inhibits the reaction [TNF protein results in decreased expression of UCP1 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CXCL10 protein]; tofacitinib inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of IFIT1 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased phosphorylation of STAT1 protein]; tofacitinib promotes the reaction [TNF protein affects the localization of JUN protein]; tofacitinib promotes the reaction [TNF protein affects the localization of NFATC1 protein]
tofacitinib inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; tofacitinib inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of IL6 protein]; tofacitinib inhibits the reaction [TNF protein results in increased expression of TNFSF11 mRNA]
CTD PMID:21383241, PMID:21937456, PMID:22121136, PMID:22941906, PMID:25487280 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO tofacitinib results in decreased expression of TNFSF10 mRNA CTD PMID:25487280 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases expression
ISO
EXP
tofacitinib results in decreased expression of and results in decreased secretion of TNFSF11 protein
tofacitinib results in decreased expression of TNFSF11 protein
tofacitinib results in decreased expression of TNFSF11 mRNA
tofacitinib inhibits the reaction [IL6 protein results in increased expression of TNFSF11 mRNA]; tofacitinib inhibits the reaction [OSM protein results in increased expression of TNFSF11 mRNA]; tofacitinib inhibits the reaction [TNF protein results in increased expression of TNFSF11 mRNA]
CTD PMID:21937456, PMID:22899318 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Ucp1 uncoupling protein 1 increases expression
multiple interactions
ISO tofacitinib results in increased expression of UCP1 mRNA; tofacitinib results in increased expression of UCP1 protein
cyclopamine inhibits the reaction [tofacitinib results in increased expression of UCP1 mRNA]; tofacitinib inhibits the reaction [TNF protein results in decreased expression of UCP1 mRNA]
CTD PMID:25487280 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO tofacitinib results in decreased expression of USP18 mRNA CTD PMID:25487280 NCBI chr 4:153,812,312...153,834,374
Ensembl chr 4:153,805,993...153,834,430
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO tofacitinib results in increased expression of VEGFA mRNA CTD PMID:26300391 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        pseudohalo group 2881
          cyano group 2881
            nitrile 2881
              tofacitinib 80
                tofacitinib citrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        tertiary amino compound 8629
                                          tofacitinib 80
                                            tofacitinib citrate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.