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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carglumic acid
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Accession:CHEBI:71028 term browser browse the term
Definition:A urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia.
Synonyms:exact_synonym: N-carbamoyl-L-glutamic acid
 related_synonym: (2S)-2-(carbamoylamino)pentanedioic acid;   Carbaglu;   Carbamino-L-glutamic acid;   Carbamylglutamic acid;   Formula=C6H10N2O5;   InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1;   InChIKey=LCQLHJZYVOQKHU-VKHMYHEASA-N;   L-N-Carbamoylglutamic acid;   SMILES=NC(=O)N[C@@H](CCC(O)=O)C(O)=O;   Ureidoglutaric acid;   acide carglumique;   acido carglumico;   acidum carglumicum
 xref: CAS:1188-38-1;   DrugBank:DB06775;   Drug_Central:3068;   HMDB:HMDB0015673;   KEGG:C05829;   KEGG:D07130
 xref_mesh: MESH:C006895
 xref: MetaCyc:N-CARBAMYL-L-GLUTAMATE;   PMID:15055204;   PMID:17421020;   PMID:18234091;   PMID:18516804;   PMID:18604903;   PMID:20410539;   PMID:21207059;   PMID:21225012;   PMID:21403788;   PMID:21941437;   PMID:22858088;   Reaxys:1727929;   Wikipedia:Carglumic_acid


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carglumic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of ATG5 mRNA] CTD PMID:31369747 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Becn1 beclin 1 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 protein] CTD PMID:31369747 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B protein] CTD PMID:31369747 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 protein] CTD PMID:31369747 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        pharmaceutical 19304
          drug 19304
            orphan drug 72
              carglumic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        carboacyl group 17416
                                          univalent carboacyl group 17416
                                            carbamoyl group 17213
                                              carboxamide 17213
                                                N-acyl-amino acid 10050
                                                  N-acyl-L-amino acid 1950
                                                    N-acyl-L-alpha-amino acid 44
                                                      N-acyl-L-glutamic acid 40
                                                        carglumic acid 4
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