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ONTOLOGY REPORT - ANNOTATIONS
Term:carglumic acid
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Accession:CHEBI:71028 term browser browse the term
Definition:A urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia.
Synonyms:exact_synonym: N-carbamoyl-L-glutamic acid
 related_synonym: (2S)-2-(carbamoylamino)pentanedioic acid;   Carbaglu;   Carbamino-L-glutamic acid;   Carbamylglutamic acid;   Formula=C6H10N2O5;   InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1;   InChIKey=LCQLHJZYVOQKHU-VKHMYHEASA-N;   L-N-Carbamoylglutamic acid;   SMILES=NC(=O)N[C@@H](CCC(O)=O)C(O)=O;   Ureidoglutaric acid;   acide carglumique;   acido carglumico;   acidum carglumicum
 xref: CAS:1188-38-1 "ChemIDplus";   CAS:1188-38-1 "KEGG COMPOUND";   CAS:1188-38-1 "KEGG DRUG";   DrugBank:DB06775;   Drug_Central:3068 "DrugCentral";   HMDB:HMDB0015673;   KEGG:C05829;   KEGG:D07130
 xref_mesh: MESH:C006895
 xref: MetaCyc:N-CARBAMYL-L-GLUTAMATE;   PMID:15055204 "Europe PMC";   PMID:17421020 "Europe PMC";   PMID:18234091 "Europe PMC";   PMID:18516804 "Europe PMC";   PMID:18604903 "Europe PMC";   PMID:20410539 "Europe PMC";   PMID:21207059 "Europe PMC";   PMID:21225012 "Europe PMC";   PMID:21403788 "Europe PMC";   PMID:21941437 "Europe PMC";   PMID:22858088 "Europe PMC";   Reaxys:1727929 "Reaxys";   Wikipedia:Carglumic_acid

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carglumic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:6480464
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6480464
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      application 19336
        pharmaceutical 19211
          drug 19211
            orphan drug 71
              carglumic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        carboacyl group 17074
                                          univalent carboacyl group 17074
                                            carbamoyl group 16804
                                              carboxamide 16804
                                                N-acyl-amino acid 4935
                                                  N-acyl-L-amino acid 1868
                                                    N-acyl-L-alpha-amino acid 44
                                                      N-acyl-L-glutamic acid 40
                                                        carglumic acid 4
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