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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carglumic acid
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Accession:CHEBI:71028 term browser browse the term
Definition:A urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia.
Synonyms:exact_synonym: N-carbamoyl-L-glutamic acid
 related_synonym: (2S)-2-(carbamoylamino)pentanedioic acid;   Carbaglu;   Carbamino-L-glutamic acid;   Carbamylglutamic acid;   Formula=C6H10N2O5;   InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1;   InChIKey=LCQLHJZYVOQKHU-VKHMYHEASA-N;   L-N-Carbamoylglutamic acid;   SMILES=NC(=O)N[C@@H](CCC(O)=O)C(O)=O;   Ureidoglutaric acid;   acide carglumique;   acido carglumico;   acidum carglumicum
 xref: CAS:1188-38-1;   DrugBank:DB06775;   Drug_Central:3068;   HMDB:HMDB0015673;   KEGG:C05829;   KEGG:D07130
 xref_mesh: MESH:C006895
 xref: MetaCyc:N-CARBAMYL-L-GLUTAMATE;   PMID:15055204;   PMID:17421020;   PMID:18234091;   PMID:18516804;   PMID:18604903;   PMID:20410539;   PMID:21207059;   PMID:21225012;   PMID:21403788;   PMID:21941437;   PMID:22858088;   Reaxys:1727929;   Wikipedia:Carglumic_acid

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carglumic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of ATG5 mRNA] CTD PMID:31369747 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 protein] CTD PMID:31369747 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B protein] CTD PMID:31369747 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 protein] CTD PMID:31369747 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        pharmaceutical 19375
          drug 19375
            orphan drug 72
              carglumic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      carboxylic acid 18153
                                        carboacyl group 17410
                                          univalent carboacyl group 17410
                                            carbamoyl group 17192
                                              carboxamide 17192
                                                N-acyl-amino acid 10046
                                                  N-acyl-L-amino acid 1929
                                                    N-acyl-L-alpha-amino acid 44
                                                      N-acyl-L-glutamic acid 40
                                                        carglumic acid 4
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