CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: omacetaxine mepesuccinate
Accession: CHEBI:71019
browse the term
Definition: A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
Synonyms: related_synonym: (2'R,3S,4S,5R)-(-)-homoharringtonine; CGX-635; Formula=C29H39NO9; Homoharringtonine; InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1; InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N; SMILES=[H][C@@]12[C@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21; Synribo; mepesuccinate d'omacetaxine; mepesuccinato de omacetaxina; omacetaxini mepesuccinas
xref: Beilstein:5687925; CAS:26833-87-4; Drug_Central:4677; KEGG:D08956; LINCS:LSM-3716
xref_mesh: MESH:C001652
xref: PDBeChem:HMT; PMID:20971952; PMID:21152934; PMID:21258877; PMID:21294709; PMID:21415308; PMID:21418889; PMID:21468038; PMID:21509439; PMID:21845438; PMID:21916787; PMID:22040954; PMID:22054289; PMID:22075327; PMID:22289991; PMID:22391162; PMID:22580751; PMID:22714632; PMID:22896000; PMID:22898909; PMID:22917222; PMID:22967374; PMID:23053254; PMID:23059828; PMID:23086639; PMID:23109844; PMID:23456623; Patent:US2010240887; Patent:WO2007089878; Reaxys:5687925; Wikipedia:Omacetaxine_mepesuccinate
G
Ahi1
Abelson helper integration site 1
increases expression
ISO
Homoharringtonine results in increased expression of AHI1 protein alternative form
CTD
PMID:19379585
NCBI chr 1:16,478,127...16,601,769
Ensembl chr 1:16,478,127...16,601,769
G
Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of AKT1 protein
CTD
PMID:31726078
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
G
Bad
BCL2-associated agonist of cell death
increases expression
ISO
Homoharringtonine results in increased expression of BAD protein
CTD
PMID:31726078
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Homoharringtonine results in increased expression of BAX protein
CTD
PMID:31726078
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Homoharringtonine results in decreased expression of BCL2 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Casp3
caspase 3
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP3 protein Homoharringtonine results in increased cleavage of CASP3 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp7
caspase 7
increases cleavage
ISO
Homoharringtonine results in increased cleavage of CASP7 protein
CTD
PMID:31726078
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
G
Casp9
caspase 9
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP9 protein Homoharringtonine results in increased cleavage of CASP9 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
G
Ccna2
cyclin A2
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNA2 protein
CTD
PMID:31726078
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
G
Ccnb1
cyclin B1
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNB1 protein
CTD
PMID:31726078
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
G
Ccne1
cyclin E1
increases expression
ISO
Homoharringtonine results in increased expression of CCNE1 protein
CTD
PMID:31726078
NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
G
Cdk1
cyclin-dependent kinase 1
increases expression
ISO
Homoharringtonine results in increased expression of CDK1 protein
CTD
PMID:31726078
NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
G
Cdk2
cyclin dependent kinase 2
increases expression
ISO
Homoharringtonine results in increased expression of CDK2 protein
CTD
PMID:31726078
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
G
Ephb4
EPH receptor B4
multiple interactions decreases expression
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein]
CTD
PMID:31726078
NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK1 protein
CTD
PMID:31726078
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK3 protein
CTD
PMID:31726078
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
G
Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
Homoharringtonine results in decreased expression of MCL1 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr 2:197,786,212...197,788,992
G
Mki67
marker of proliferation Ki-67
decreases expression
ISO
Homoharringtonine results in decreased expression of MKI67 protein
CTD
PMID:31726078
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
G
Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MTOR protein
CTD
PMID:31726078
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
decreases expression
ISO
Homoharringtonine results in decreased expression of PIK3CA protein
CTD
PMID:31726078
NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
G
Pten
phosphatase and tensin homolog
increases expression
ISO
Homoharringtonine results in increased expression of PTEN protein
CTD
PMID:31726078
NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
G
Tyr
tyrosinase
increases expression
ISO
Homoharringtonine results in increased expression of TYR mRNA
CTD
PMID:21071833
NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all