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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:omacetaxine mepesuccinate
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Accession:CHEBI:71019 term browser browse the term
Definition:A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
Synonyms:related_synonym: (2'R,3S,4S,5R)-(-)-homoharringtonine;   CGX-635;   Formula=C29H39NO9;   Homoharringtonine;   InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1;   InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N;   SMILES=[H][C@@]12[C@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21;   Synribo;   mepesuccinate d'omacetaxine;   mepesuccinato de omacetaxina;   omacetaxini mepesuccinas
 xref: CAS:26833-87-4;   Drug_Central:4677;   KEGG:D08956;   LINCS:LSM-3716
 xref_mesh: MESH:C001652
 xref: PDBeChem:HMT;   PMID:20971952;   PMID:21152934;   PMID:21258877;   PMID:21294709;   PMID:21415308;   PMID:21418889;   PMID:21468038;   PMID:21509439;   PMID:21845438;   PMID:21916787;   PMID:22040954;   PMID:22054289;   PMID:22075327;   PMID:22289991;   PMID:22391162;   PMID:22580751;   PMID:22714632;   PMID:22896000;   PMID:22898909;   PMID:22917222;   PMID:22967374;   PMID:23053254;   PMID:23059828;   PMID:23086639;   PMID:23109844;   PMID:23456623;   Patent:US2010240887;   Patent:WO2007089878;   Reaxys:5687925;   Wikipedia:Omacetaxine_mepesuccinate


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omacetaxine mepesuccinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 increases expression ISO Homoharringtonine results in increased expression of AHI1 protein alternative form CTD PMID:19379585 NCBI chr 1:15,762,485...15,891,213
Ensembl chr 1:17,582,006...17,711,774 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of AKT1 protein CTD PMID:31726078 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Homoharringtonine results in increased expression of BAD protein CTD PMID:31726078 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 decreases expression ISO Homoharringtonine results in decreased expression of BAK1 mRNA CTD PMID:32431164 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Homoharringtonine results in increased expression of BAX protein CTD PMID:31726078 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Homoharringtonine results in increased expression of BBC3 mRNA CTD PMID:32431164 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Homoharringtonine results in decreased expression of BCL2 mRNA; Homoharringtonine results in decreased expression of BCL2 protein CTD PMID:23980369 PMID:31726078 PMID:32431164 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage 		ISO Homoharringtonine results in increased expression of CASP3 protein
Homoharringtonine results in increased cleavage of CASP3 protein 		CTD PMID:23980369 PMID:31726078 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO Homoharringtonine results in increased cleavage of CASP7 protein CTD PMID:31726078 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage 		ISO Homoharringtonine results in increased expression of CASP9 protein
Homoharringtonine results in increased cleavage of CASP9 protein 		CTD PMID:23980369 PMID:31726078 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Homoharringtonine results in decreased expression of CCNA2 protein CTD PMID:31726078 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Homoharringtonine results in decreased expression of CCNB1 protein CTD PMID:31726078 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO Homoharringtonine results in increased expression of CCNE1 protein CTD PMID:31726078 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cd34 CD34 molecule multiple interactions
decreases expression 		ISO Arsenic Trioxide promotes the reaction [Homoharringtonine results in decreased expression of CD34 mRNA] CTD PMID:31307525 NCBI chr13:106,480,313...106,500,844
Ensembl chr13:109,008,623...109,029,315 		JBrowse link
G Cd38 CD38 molecule increases expression
multiple interactions 		ISO Homoharringtonine results in increased expression of CD38 mRNA
[Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of CD38 mRNA 		CTD PMID:31307525 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505 		JBrowse link
G Cd96 CD96 molecule multiple interactions ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of CD96 mRNA CTD PMID:31307525 NCBI chr11:54,702,290...54,776,618
Ensembl chr11:68,164,872...68,241,937 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Homoharringtonine results in increased expression of CDK1 protein CTD PMID:31726078 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Homoharringtonine results in increased expression of CDK2 protein CTD PMID:31726078 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Homoharringtonine results in increased expression of CDKN1A mRNA CTD PMID:32431164 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
increases phosphorylation 		ISO Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]; crenigacestat inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein] CTD PMID:31307525 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression ISO Homoharringtonine results in increased expression of CYP2C19 mRNA CTD PMID:32431164 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Homoharringtonine results in increased expression of CYP2E1 mRNA CTD PMID:32431164 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO Homoharringtonine results in increased expression of EIF2AK3 mRNA CTD PMID:32431164 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Ephb4 EPH receptor B4 multiple interactions
decreases expression 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein] CTD PMID:31726078 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:24,963,174...24,988,388 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Homoharringtonine results in increased expression of ERN1 mRNA CTD PMID:32431164 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Id4 inhibitor of DNA binding 4 increases expression ISO Homoharringtonine results in increased expression of ID4 mRNA CTD PMID:32431164 NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK1 protein CTD PMID:31726078 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK3 protein CTD PMID:31726078 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Homoharringtonine results in decreased expression of MCL1 protein CTD PMID:23980369 PMID:31726078 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Homoharringtonine results in decreased expression of MKI67 protein CTD PMID:31726078 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MTOR protein CTD PMID:31726078 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Homoharringtonine results in increased expression of NFKB1 mRNA CTD PMID:32431164 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions
increases expression 		ISO Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NFKB2 protein] CTD PMID:31307525 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:255,107,374...255,114,637 		JBrowse link
G Notch1 notch receptor 1 multiple interactions
increases expression 		ISO Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NOTCH1 protein] CTD PMID:31307525 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Notch2 notch receptor 2 multiple interactions ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of NOTCH2 protein CTD PMID:31307525 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Homoharringtonine results in decreased expression of PIK3CA protein CTD PMID:31726078 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Homoharringtonine results in increased expression of PTEN protein CTD PMID:31726078 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression 		ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of RELA protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of RELA protein] CTD PMID:31307525 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression
multiple interactions 		ISO Homoharringtonine results in increased expression of RELB protein
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of RELB protein] 		CTD PMID:31307525 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:88,385,717...88,413,420 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Homoharringtonine results in increased expression of TNF mRNA CTD PMID:32431164 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of TP53 protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of TP53 protein] CTD PMID:31307525 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression ISO Homoharringtonine results in increased expression of TRAF2 mRNA CTD PMID:32431164 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:28,740,098...28,764,691 		JBrowse link
G Tyr tyrosinase increases expression ISO Homoharringtonine results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          apoptosis inducer 13731
            omacetaxine mepesuccinate 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterobicyclic compound 17545
                                      benzazepine 2525
                                        benzazepine alkaloid 60
                                          cephalotaxine 43
                                            omacetaxine mepesuccinate 43
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