CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: omacetaxine mepesuccinate
Accession: CHEBI:71019
browse the term
Definition: A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
Synonyms: related_synonym: (2'R,3S,4S,5R)-(-)-homoharringtonine; CGX-635; Formula=C29H39NO9; Homoharringtonine; InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1; InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N; SMILES=[H][C@@]12[C@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21; Synribo; mepesuccinate d'omacetaxine; mepesuccinato de omacetaxina; omacetaxini mepesuccinas
xref: CAS:26833-87-4; Drug_Central:4677; KEGG:D08956; LINCS:LSM-3716
xref_mesh: MESH:C001652
xref: PDBeChem:HMT; PMID:20971952; PMID:21152934; PMID:21258877; PMID:21294709; PMID:21415308; PMID:21418889; PMID:21468038; PMID:21509439; PMID:21845438; PMID:21916787; PMID:22040954; PMID:22054289; PMID:22075327; PMID:22289991; PMID:22391162; PMID:22580751; PMID:22714632; PMID:22896000; PMID:22898909; PMID:22917222; PMID:22967374; PMID:23053254; PMID:23059828; PMID:23086639; PMID:23109844; PMID:23456623; Patent:US2010240887; Patent:WO2007089878; Reaxys:5687925; Wikipedia:Omacetaxine_mepesuccinate
G
Ahi1
Abelson helper integration site 1
increases expression
ISO
Homoharringtonine results in increased expression of AHI1 protein alternative form
CTD
PMID:19379585
NCBI chr 1:15,762,485...15,891,213
Ensembl chr 1:17,582,006...17,711,774
G
Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of AKT1 protein
CTD
PMID:31726078
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
G
Bad
BCL2-associated agonist of cell death
increases expression
ISO
Homoharringtonine results in increased expression of BAD protein
CTD
PMID:31726078
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
G
Bak1
BCL2-antagonist/killer 1
decreases expression
ISO
Homoharringtonine results in decreased expression of BAK1 mRNA
CTD
PMID:32431164
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Homoharringtonine results in increased expression of BAX protein
CTD
PMID:31726078
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
G
Bbc3
Bcl-2 binding component 3
increases expression
ISO
Homoharringtonine results in increased expression of BBC3 mRNA
CTD
PMID:32431164
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Homoharringtonine results in decreased expression of BCL2 mRNA; Homoharringtonine results in decreased expression of BCL2 protein
CTD
PMID:23980369 PMID:31726078 PMID:32431164
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
G
Casp3
caspase 3
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP3 protein Homoharringtonine results in increased cleavage of CASP3 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
G
Casp7
caspase 7
increases cleavage
ISO
Homoharringtonine results in increased cleavage of CASP7 protein
CTD
PMID:31726078
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:265,442,676...265,482,512
G
Casp9
caspase 9
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP9 protein Homoharringtonine results in increased cleavage of CASP9 protein
CTD
PMID:23980369 PMID:31726078
Ensembl chr 5:159,391,188...159,409,648
G
Ccna2
cyclin A2
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNA2 protein
CTD
PMID:31726078
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:121,355,363...121,361,701
G
Ccnb1
cyclin B1
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNB1 protein
CTD
PMID:31726078
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
G
Ccne1
cyclin E1
increases expression
ISO
Homoharringtonine results in increased expression of CCNE1 protein
CTD
PMID:31726078
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:99,918,674...99,927,822
G
Cd34
CD34 molecule
multiple interactions decreases expression
ISO
Arsenic Trioxide promotes the reaction [Homoharringtonine results in decreased expression of CD34 mRNA]
CTD
PMID:31307525
NCBI chr13:106,480,313...106,500,844
Ensembl chr13:109,008,623...109,029,315
G
Cd38
CD38 molecule
increases expression multiple interactions
ISO
Homoharringtonine results in increased expression of CD38 mRNA [Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of CD38 mRNA
CTD
PMID:31307525
NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505
G
Cd96
CD96 molecule
multiple interactions
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of CD96 mRNA
CTD
PMID:31307525
NCBI chr11:54,702,290...54,776,618
Ensembl chr11:68,164,872...68,241,937
G
Cdk1
cyclin-dependent kinase 1
increases expression
ISO
Homoharringtonine results in increased expression of CDK1 protein
CTD
PMID:31726078
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
G
Cdk2
cyclin dependent kinase 2
increases expression
ISO
Homoharringtonine results in increased expression of CDK2 protein
CTD
PMID:31726078
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Homoharringtonine results in increased expression of CDKN1A mRNA
CTD
PMID:32431164
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
G
Chuk
component of inhibitor of nuclear factor kappa B kinase complex
multiple interactions increases phosphorylation
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]; crenigacestat inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]
CTD
PMID:31307525
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:252,908,749...252,944,273
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases expression
ISO
Homoharringtonine results in increased expression of CYP2C19 mRNA
CTD
PMID:32431164
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
ISO
Homoharringtonine results in increased expression of CYP2E1 mRNA
CTD
PMID:32431164
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases expression
ISO
Homoharringtonine results in increased expression of EIF2AK3 mRNA
CTD
PMID:32431164
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:104,363,833...104,425,268
G
Ephb4
EPH receptor B4
multiple interactions decreases expression
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein]
CTD
PMID:31726078
NCBI chr12:19,326,411...19,351,667
Ensembl chr12:24,963,174...24,988,388
G
Ern1
endoplasmic reticulum to nucleus signaling 1
increases expression
ISO
Homoharringtonine results in increased expression of ERN1 mRNA
CTD
PMID:32431164
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,830,428...91,920,791
G
Id4
inhibitor of DNA binding 4
increases expression
ISO
Homoharringtonine results in increased expression of ID4 mRNA
CTD
PMID:32431164
NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK1 protein
CTD
PMID:31726078
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK3 protein
CTD
PMID:31726078
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
G
Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
Homoharringtonine results in decreased expression of MCL1 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
G
Mki67
marker of proliferation Ki-67
decreases expression
ISO
Homoharringtonine results in decreased expression of MKI67 protein
CTD
PMID:31726078
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
G
Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MTOR protein
CTD
PMID:31726078
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
G
Nfkb1
nuclear factor kappa B subunit 1
increases expression
ISO
Homoharringtonine results in increased expression of NFKB1 mRNA
CTD
PMID:32431164
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:226,689,745...226,783,088
G
Nfkb2
nuclear factor kappa B subunit 2
multiple interactions increases expression
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NFKB2 protein]
CTD
PMID:31307525
NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:255,107,374...255,114,637
G
Notch1
notch receptor 1
multiple interactions increases expression
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NOTCH1 protein]
CTD
PMID:31307525
NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613
G
Notch2
notch receptor 2
multiple interactions
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of NOTCH2 protein
CTD
PMID:31307525
NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
decreases expression
ISO
Homoharringtonine results in decreased expression of PIK3CA protein
CTD
PMID:31726078
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411
G
Pten
phosphatase and tensin homolog
increases expression
ISO
Homoharringtonine results in increased expression of PTEN protein
CTD
PMID:31726078
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases expression
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of RELA protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of RELA protein]
CTD
PMID:31307525
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
G
Relb
RELB proto-oncogene, NF-kB subunit
increases expression multiple interactions
ISO
Homoharringtonine results in increased expression of RELB protein Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of RELB protein]
CTD
PMID:31307525
NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:88,385,717...88,413,420
G
Tnf
tumor necrosis factor
increases expression
ISO
Homoharringtonine results in increased expression of TNF mRNA
CTD
PMID:32431164
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
G
Tp53
tumor protein p53
multiple interactions increases expression
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of TP53 protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of TP53 protein]
CTD
PMID:31307525
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
G
Traf2
Tnf receptor-associated factor 2
increases expression
ISO
Homoharringtonine results in increased expression of TRAF2 mRNA
CTD
PMID:32431164
NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:28,740,098...28,764,691
G
Tyr
tyrosinase
increases expression
ISO
Homoharringtonine results in increased expression of TYR mRNA
CTD
PMID:21071833
NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all