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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:omacetaxine mepesuccinate
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Accession:CHEBI:71019 term browser browse the term
Definition:A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
Synonyms:related_synonym: (2'R,3S,4S,5R)-(-)-homoharringtonine;   CGX-635;   Formula=C29H39NO9;   Homoharringtonine;   InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1;   InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N;   SMILES=[H][C@@]12[C@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21;   Synribo;   mepesuccinate d'omacetaxine;   mepesuccinato de omacetaxina;   omacetaxini mepesuccinas
 xref: Beilstein:5687925;   CAS:26833-87-4;   Drug_Central:4677;   KEGG:D08956;   LINCS:LSM-3716
 xref_mesh: MESH:C001652
 xref: PDBeChem:HMT;   PMID:20971952;   PMID:21152934;   PMID:21258877;   PMID:21294709;   PMID:21415308;   PMID:21418889;   PMID:21468038;   PMID:21509439;   PMID:21845438;   PMID:21916787;   PMID:22040954;   PMID:22054289;   PMID:22075327;   PMID:22289991;   PMID:22391162;   PMID:22580751;   PMID:22714632;   PMID:22896000;   PMID:22898909;   PMID:22917222;   PMID:22967374;   PMID:23053254;   PMID:23059828;   PMID:23086639;   PMID:23109844;   PMID:23456623;   Patent:US2010240887;   Patent:WO2007089878;   Reaxys:5687925;   Wikipedia:Omacetaxine_mepesuccinate



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omacetaxine mepesuccinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 increases expression ISO Homoharringtonine results in increased expression of AHI1 protein alternative form CTD PMID:19379585 NCBI chr 1:15,768,047...15,886,744
Ensembl chr 1:15,762,462...15,891,041
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of AKT1 protein CTD PMID:31726078 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Homoharringtonine results in increased expression of BAD protein CTD PMID:31726078 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Homoharringtonine results in increased expression of BAX protein CTD PMID:31726078 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Homoharringtonine results in decreased expression of BCL2 protein CTD PMID:23980369 PMID:31726078 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO Homoharringtonine results in increased expression of CASP3 protein
Homoharringtonine results in increased cleavage of CASP3 protein
CTD PMID:23980369 PMID:31726078 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases cleavage ISO Homoharringtonine results in increased cleavage of CASP7 protein CTD PMID:31726078 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage
ISO Homoharringtonine results in increased expression of CASP9 protein
Homoharringtonine results in increased cleavage of CASP9 protein
CTD PMID:23980369 PMID:31726078 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Homoharringtonine results in decreased expression of CCNA2 protein CTD PMID:31726078 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Homoharringtonine results in decreased expression of CCNB1 protein CTD PMID:31726078 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Homoharringtonine results in increased expression of CCNE1 protein CTD PMID:31726078 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd34 CD34 molecule multiple interactions
decreases expression
ISO Arsenic Trioxide promotes the reaction [Homoharringtonine results in decreased expression of CD34 mRNA] CTD PMID:31307525 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cd38 CD38 molecule increases expression
multiple interactions
ISO Homoharringtonine results in increased expression of CD38 mRNA
[Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of CD38 mRNA
CTD PMID:31307525 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Cd96 CD96 molecule multiple interactions ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of CD96 mRNA CTD PMID:31307525 NCBI chr11:54,702,290...54,776,618
Ensembl chr11:54,702,290...54,776,621
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Homoharringtonine results in increased expression of CDK1 protein CTD PMID:31726078 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Homoharringtonine results in increased expression of CDK2 protein CTD PMID:31726078 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
increases phosphorylation
ISO Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]; crenigacestat inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein] CTD PMID:31307525 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Ephb4 EPH receptor B4 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein] CTD PMID:31726078 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK1 protein CTD PMID:31726078 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK3 protein CTD PMID:31726078 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Homoharringtonine results in decreased expression of MCL1 protein CTD PMID:23980369 PMID:31726078 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Homoharringtonine results in decreased expression of MKI67 protein CTD PMID:31726078 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MTOR protein CTD PMID:31726078 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions
increases expression
ISO Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NFKB2 protein] CTD PMID:31307525 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Notch1 notch receptor 1 multiple interactions
increases expression
ISO Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NOTCH1 protein] CTD PMID:31307525 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Notch2 notch receptor 2 multiple interactions ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of NOTCH2 protein CTD PMID:31307525 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Homoharringtonine results in decreased expression of PIK3CA protein CTD PMID:31726078 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Homoharringtonine results in increased expression of PTEN protein CTD PMID:31726078 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of RELA protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of RELA protein] CTD PMID:31307525 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression
multiple interactions
ISO Homoharringtonine results in increased expression of RELB protein
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of RELB protein]
CTD PMID:31307525 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO [Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of TP53 protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of TP53 protein] CTD PMID:31307525 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tyr tyrosinase increases expression ISO Homoharringtonine results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          apoptosis inducer 13312
            omacetaxine mepesuccinate 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterobicyclic compound 16859
                                      benzazepine 542
                                        benzazepine alkaloid 40
                                          cephalotaxine 32
                                            omacetaxine mepesuccinate 32
paths to the root