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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:AMPA receptor antagonist
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Accession:CHEBI:71014 term browser browse the term
Definition:An antagonist at the AMPA receptor.
Synonyms:related_synonym: AMPA receptor antagonists;   alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist;   alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists
 xref: Wikipedia:AMPA_receptor


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perampanel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of perampanel CTD PMID:35200000 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO perampanel inhibits the reaction [Kainic Acid results in increased expression of and affects the localization of HMGB1 protein] CTD PMID:36669621 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO perampanel inhibits the reaction [Kainic Acid results in increased expression of IL1B protein] CTD PMID:36669621 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO perampanel inhibits the reaction [Kainic Acid results in increased expression of TLR4 protein] CTD PMID:36669621 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        pharmacological role 19771
          antagonist 17511
            AMPA receptor antagonist 4
              ZCAN262 0
              perampanel + 4
              perampanel hydrate 0
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