CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: perampanel
Accession: CHEBI:71013
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Definition: A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.
Synonyms: exact_synonym: 2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile
related_synonym: 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one; E 2007; E2007; ER-155055-90; Formula=C23H15N3O; Fycompa; InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H; InChIKey=PRMWGUBFXWROHD-UHFFFAOYSA-N; SMILES=O=c1c(cc(cn1-c1ccccc1)-c1ccccn1)-c1ccccc1C#N; perampanelum
xref: CAS:380917-97-5; Drug_Central:4684; KEGG:D08964
xref_mesh: MESH:C551441
xref: PMID:21635236; PMID:21686307; PMID:21883097; PMID:22161845; PMID:22222634; PMID:22433907; PMID:22517103; PMID:22650169; PMID:22776828; PMID:22788917; PMID:22843280; PMID:22905857; PMID:22905878; PMID:22913800; PMID:23093905; PMID:23114872; Patent:EP1875912; Patent:US2008108603; Patent:US2009088574; Patent:WO2006107859; Patent:WO2008111590; Reaxys:11343244; Wikipedia:Perampanel
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases metabolic processing
ISO
CYP1A2 protein results in increased metabolism of perampanel
CTD
PMID:35200000
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Hmgb1
high mobility group box 1
multiple interactions
ISO
perampanel inhibits the reaction [Kainic Acid results in increased expression of and affects the localization of HMGB1 protein]
CTD
PMID:36669621
NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
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Il1b
interleukin 1 beta
multiple interactions
ISO
perampanel inhibits the reaction [Kainic Acid results in increased expression of IL1B protein]
CTD
PMID:36669621
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Tlr4
toll-like receptor 4
multiple interactions
ISO
perampanel inhibits the reaction [Kainic Acid results in increased expression of TLR4 protein]
CTD
PMID:36669621
NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
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