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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perampanel
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Accession:CHEBI:71013 term browser browse the term
Definition:A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.
Synonyms:exact_synonym: 2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile
 related_synonym: 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one;   E 2007;   E2007;   ER-155055-90;   Formula=C23H15N3O;   Fycompa;   InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H;   InChIKey=PRMWGUBFXWROHD-UHFFFAOYSA-N;   SMILES=O=c1c(cc(cn1-c1ccccc1)-c1ccccn1)-c1ccccc1C#N;   perampanelum
 xref: CAS:380917-97-5;   Drug_Central:4684;   KEGG:D08964
 xref_mesh: MESH:C551441
 xref: PMID:21635236;   PMID:21686307;   PMID:21883097;   PMID:22161845;   PMID:22222634;   PMID:22433907;   PMID:22517103;   PMID:22650169;   PMID:22776828;   PMID:22788917;   PMID:22843280;   PMID:22905857;   PMID:22905878;   PMID:22913800;   PMID:23093905;   PMID:23114872;   Patent:EP1875912;   Patent:US2008108603;   Patent:US2009088574;   Patent:WO2006107859;   Patent:WO2008111590;   Reaxys:11343244;   Wikipedia:Perampanel



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perampanel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of perampanel CTD PMID:35200000 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO perampanel inhibits the reaction [Kainic Acid results in increased expression of and affects the localization of HMGB1 protein] CTD PMID:36669621 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO perampanel inhibits the reaction [Kainic Acid results in increased expression of IL1B protein] CTD PMID:36669621 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO perampanel inhibits the reaction [Kainic Acid results in increased expression of TLR4 protein] CTD PMID:36669621 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22188
    chemical entity 22187
      group 22082
        pseudohalo group 4677
          cyano group 4677
            nitrile 4677
              perampanel 4
                perampanel hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon atom 21840
                          organic molecular entity 21840
                            organic molecule 21654
                              organic cyclic compound 21259
                                carbocyclic compound 19665
                                  benzenoid aromatic compound 18767
                                    benzenes 18558
                                      benzonitrile 8
                                        perampanel 4
                                          perampanel hydrate 0
paths to the root