CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: antileishmanial agent
Accession: CHEBI:70868
browse the term
Definition: An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
Synonyms: related_synonym: antileishmanial agents; antileishmanial drug; antileishmanial drugs
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Cftr
CF transmembrane conductance regulator
multiple interactions
ISO
acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA]
CTD
PMID:14766015
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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Ggt1
gamma-glutamyltransferase 1
multiple interactions decreases activity
ISO
[acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione
CTD
PMID:15629191 PMID:19419996
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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Acta2
actin alpha 2, smooth muscle
decreases expression
ISO
acteoside results in decreased expression of ACTA2 protein
CTD
PMID:33522686
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Ager
advanced glycosylation end product-specific receptor
decreases expression
ISO
acteoside results in decreased expression of AGER protein
CTD
PMID:33522686
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Ahr
aryl hydrocarbon receptor
multiple interactions decreases localization
ISO
acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein] acteoside results in decreased localization of AHR protein
CTD
PMID:21756928
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Arnt
aryl hydrocarbon receptor nuclear translocator
increases localization
ISO
acteoside results in increased localization of ARNT protein
CTD
PMID:21756928
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Ccl2
C-C motif chemokine ligand 2
decreases expression multiple interactions decreases secretion
ISO
acteoside results in decreased expression of CCL2 mRNA acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA] acteoside results in decreased secretion of CCL2 protein
CTD
PMID:21756928 PMID:21967610
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnd1
cyclin D1
decreases expression
ISO
acteoside results in decreased expression of CCND1 protein
CTD
PMID:17634406
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd2
cyclin D2
decreases expression
ISO
acteoside results in decreased expression of CCND2 protein
CTD
PMID:17634406
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Ccnd3
cyclin D3
decreases expression
ISO
acteoside results in decreased expression of CCND3 protein
CTD
PMID:17634406
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccne1
cyclin E1
decreases expression
ISO
acteoside results in decreased expression of CCNE1 protein
CTD
PMID:17634406
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Cdh1
cadherin 1
increases expression
ISO
acteoside results in increased expression of CDH1 protein
CTD
PMID:33522686
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdk2
cyclin dependent kinase 2
multiple interactions
ISO
acteoside results in decreased expression of and results in decreased activity of CDK2 protein
CTD
PMID:17634406
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
decreases activity multiple interactions
ISO
acteoside results in decreased activity of CDK4 protein acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]
CTD
PMID:17634406
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdk6
cyclin-dependent kinase 6
multiple interactions
ISO
acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein
CTD
PMID:17634406
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions
ISO
acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]
CTD
PMID:17634406
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression multiple interactions
ISO
acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]
CTD
PMID:17634406
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cxcl10
C-X-C motif chemokine ligand 10
decreases secretion decreases expression multiple interactions
ISO
acteoside results in decreased secretion of CXCL10 protein acteoside results in decreased expression of CXCL10 mRNA acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]
CTD
PMID:21756928 PMID:21967610
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
acteoside results in increased expression of CYP1A1 mRNA
CTD
PMID:21756928
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
EXP
acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]
CTD
PMID:14672760
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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E2f1
E2F transcription factor 1
multiple interactions
ISO
[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]
CTD
PMID:17634406
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Egfr
epidermal growth factor receptor
decreases phosphorylation multiple interactions
ISO
acteoside results in decreased phosphorylation of EGFR protein acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]
CTD
PMID:21756928 PMID:21967610
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Hmgb1
high mobility group box 1
decreases expression
ISO
acteoside results in decreased expression of HMGB1 protein
CTD
PMID:33522686
NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
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Icam1
intercellular adhesion molecule 1
decreases expression
ISO
acteoside results in decreased expression of ICAM1 mRNA
CTD
PMID:21371465
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifng
interferon gamma
decreases expression multiple interactions
ISO
acteoside results in decreased expression of IFNG mRNA acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
CTD
PMID:21371465 PMID:21756928
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il6
interleukin 6
multiple interactions decreases expression
ISO
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] acteoside results in decreased expression of IL6 mRNA
CTD
PMID:21756928
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgb2
integrin subunit beta 2
multiple interactions
ISO
acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]
CTD
PMID:16393473
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions decreases phosphorylation
ISO
acteoside results in increased phosphorylation of MAPK1 protein acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] acteoside results in decreased phosphorylation of MAPK1 protein
CTD
PMID:21756928 PMID:23527233
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation multiple interactions increases phosphorylation
ISO
acteoside results in decreased phosphorylation of MAPK3 protein acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] acteoside results in increased phosphorylation of MAPK3 protein
CTD
PMID:21756928 PMID:23527233
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nox1
NADPH oxidase 1
decreases activity
ISO
acteoside results in decreased activity of NOX1 protein
CTD
PMID:16393473
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Ptgds
prostaglandin D2 synthase
affects binding
ISO
acteoside binds to PTGDS protein
CTD
PMID:26456343
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA
CTD
PMID:21756928
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation multiple interactions
ISO
acteoside results in decreased phosphorylation of RB1 protein [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]
CTD
PMID:17634406
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rela
RELA proto-oncogene, NF-kB subunit
increases phosphorylation multiple interactions decreases phosphorylation
ISO
acteoside results in increased phosphorylation of RELA protein acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] acteoside results in decreased phosphorylation of RELA protein
CTD
PMID:21756928 PMID:23527233
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Smad2
SMAD family member 2
increases phosphorylation
ISO
acteoside results in increased phosphorylation of SMAD2 protein
CTD
PMID:17634406
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Smad3
SMAD family member 3
increases phosphorylation
ISO
acteoside results in increased phosphorylation of SMAD3 protein
CTD
PMID:17634406
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Smad7
SMAD family member 7
increases expression
ISO
acteoside results in increased expression of SMAD7 protein
CTD
PMID:33522686
NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
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Snai1
snail family transcriptional repressor 1
decreases expression
ISO
acteoside results in decreased expression of SNAI1 protein
CTD
PMID:33522686
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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Snai2
snail family transcriptional repressor 2
decreases expression
ISO
acteoside results in decreased expression of SNAI2 protein
CTD
PMID:33522686
NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
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Sod2
superoxide dismutase 2
decreases expression
ISO
acteoside results in decreased expression of SOD2 mRNA
CTD
PMID:21371465
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Tgfa
transforming growth factor alpha
multiple interactions
ISO
[acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]
CTD
PMID:21756928 PMID:21967610
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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Tgfb1
transforming growth factor, beta 1
increases expression
ISO
acteoside results in increased expression of TGFB1 mRNA
CTD
PMID:17634406
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfbr1
transforming growth factor, beta receptor 1
decreases expression
ISO
acteoside results in decreased expression of TGFBR1 protein
CTD
PMID:33522686
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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Tgfbr2
transforming growth factor, beta receptor 2
decreases expression
ISO
acteoside results in decreased expression of TGFBR2 protein
CTD
PMID:33522686
NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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Tnf
tumor necrosis factor
multiple interactions
ISO
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
CTD
PMID:21756928
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Vcam1
vascular cell adhesion molecule 1
decreases expression
ISO
acteoside results in decreased expression of VCAM1 mRNA
CTD
PMID:21371465
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Ercc6
ERCC excision repair 6, chromatin remodeling factor
affects response to substance
ISO
ERCC6 protein affects the susceptibility to ascaridole
CTD
PMID:22280988
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
affects response to substance
ISO
XPC protein affects the susceptibility to ascaridole
CTD
PMID:22280988
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation multiple interactions
ISO
flavokawain B results in decreased phosphorylation of AKT1 protein TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein]
CTD
PMID:30025493
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Atf4
activating transcription factor 4
multiple interactions increases expression
ISO
4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of ATF4 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein]
CTD
PMID:30025493
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Atg5
autophagy related 5
multiple interactions affects response to substance
ISO
[ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]
CTD
PMID:30025493
NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Atg7
autophagy related 7
affects response to substance multiple interactions
ISO
ATG7 protein affects the susceptibility to flavokawain B [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]
CTD
PMID:30025493
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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Casp3
caspase 3
multiple interactions
ISO
[ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein
CTD
PMID:30025493
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein
CTD
PMID:30025493
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Ddit3
DNA-damage inducible transcript 3
multiple interactions increases expression
ISO
4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]
CTD
PMID:30025493
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases phosphorylation
ISO
flavokawain B results in increased phosphorylation of EIF2AK3 protein
CTD
PMID:30025493
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases phosphorylation
ISO
flavokawain B results in increased phosphorylation of EIF2S1 protein
CTD
PMID:30025493
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Glb1
galactosidase, beta 1
multiple interactions increases expression
ISO
[ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein flavokawain B results in increased expression of GLB1 protein
CTD
PMID:30025493
NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
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H2ax
H2A.X variant histone
increases phosphorylation
ISO
flavokawain B results in increased phosphorylation of H2AX protein
CTD
PMID:30025493
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
flavokawain B results in increased expression of HSPA5 protein
CTD
PMID:30025493
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions increases expression
ISO
3-methyladenine inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]
CTD
PMID:30025493
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Mki67
marker of proliferation Ki-67
multiple interactions
ISO
[ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein
CTD
PMID:30025493
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mtor
mechanistic target of rapamycin kinase
multiple interactions decreases phosphorylation
ISO
TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein]
CTD
PMID:30025493
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
[ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [flavokawain B co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein
CTD
PMID:30025493
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Rps6kb1
ribosomal protein S6 kinase B1
decreases phosphorylation multiple interactions
ISO
flavokawain B results in decreased phosphorylation of RPS6KB1 protein TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein]
CTD
PMID:30025493
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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Sqstm1
sequestosome 1
increases expression
ISO
flavokawain B results in increased expression of SQSTM1 protein
CTD
PMID:30025493
NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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Trib3
tribbles pseudokinase 3
multiple interactions increases expression
ISO
ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein]
CTD
PMID:30025493
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Akr1b10
aldo-keto reductase family 1 member B10
increases chemical synthesis
ISO
AKR1B10 protein results in increased chemical synthesis of geranylgeraniol
CTD
PMID:21187079
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akr1c3
aldo-keto reductase family 1, member C3
increases chemical synthesis
ISO
AKR1C3 protein results in increased chemical synthesis of geranylgeraniol
CTD
PMID:21187079
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Casp3
caspase 3
increases activity
ISO
geranylgeraniol results in increased activity of CASP3 protein
CTD
PMID:9175767
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cav1
caveolin 1
multiple interactions
ISO
geranylgeraniol inhibits the reaction [rosiglitazone results in increased expression of CAV1 mRNA]
CTD
PMID:15314095
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
G
Ccn1
cellular communication network factor 1
multiple interactions
ISO
geranylgeraniol inhibits the reaction [Zoledronic Acid results in decreased expression of CCN1 protein]
CTD
PMID:19530242
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
G
Egf
epidermal growth factor
multiple interactions
ISO
geranylgeraniol analog inhibits the reaction [EGF protein results in increased phosphorylation of RHOA protein]
CTD
PMID:24587105
NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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F3
coagulation factor III, tissue factor
multiple interactions
ISO
geranylgeraniol inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]; geranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3]
CTD
PMID:9081680 PMID:12753293
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions decreases activity
ISO
[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein; [MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to geranylgeraniol; MVK gene mutant form promotes the reaction [geranylgeraniol results in decreased activity of HMGCR protein]
CTD
PMID:12477733 PMID:19819230
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Ibsp
integrin-binding sialoprotein
multiple interactions
ISO
geranylgeraniol inhibits the reaction [zoledronic acid results in increased expression of IBSP mRNA]
CTD
PMID:15324309
NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
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Il1b
interleukin 1 beta
multiple interactions
ISO
geranylgeraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein] geranylgeraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
CTD
PMID:20304105
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Itga2
integrin subunit alpha 2
multiple interactions
ISO EXP
geranylgeraniol inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]
CTD
PMID:12500026
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
G
Itgb1
integrin subunit beta 1
multiple interactions
ISO EXP
geranylgeraniol inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]
CTD
PMID:12500026
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Mvk
mevalonate kinase
multiple interactions
ISO
[MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to geranylgeraniol; geranylgeraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; geranylgeraniol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]; MVK gene mutant form promotes the reaction [geranylgeraniol results in decreased activity of HMGCR protein]
CTD
PMID:12477733 PMID:20304105
NCBI chr12:42,141,391...42,158,858
Ensembl chr12:42,141,384...42,158,882
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Myl9
myosin light chain 9
multiple interactions
ISO
geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein]
CTD
PMID:24587105
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
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Plat
plasminogen activator, tissue type
multiple interactions
ISO
geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT]
CTD
PMID:12371961 PMID:12753293
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
CTD
PMID:11779144
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
G
Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
multiple interactions
EXP
geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]
CTD
PMID:24449418
NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
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Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
multiple interactions
EXP
geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]
CTD
PMID:24449418
NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
G
Rac1
Rac family small GTPase 1
multiple interactions
ISO
geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
CTD
PMID:12933658
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
G
Rap1a
RAP1A, member of RAS oncogene family
multiple interactions
ISO
[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified form; geranylgeraniol inhibits the reaction [zoledronic acid results in decreased geranoylation of RAP1A protein]
CTD
PMID:16539721 PMID:19819230
NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
G
Rhoa
ras homolog family member A
multiple interactions
ISO EXP
geranylgeraniol analog inhibits the reaction [EGF protein results in increased phosphorylation of RHOA protein]; geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]; geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Zoledronic Acid results in decreased expression of and affects the localization of RHOA protein] geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]
CTD
PMID:9398081 PMID:12477733 PMID:12933658 PMID:15324309 PMID:24449418 PMID:24587105 More...
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
G
Rhoc
ras homolog family member C
multiple interactions
ISO
geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein]
CTD
PMID:24587105
NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306
G
Rxra
retinoid X receptor alpha
multiple interactions
ISO
geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
CTD
PMID:11779144
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
G
Sele
selectin E
multiple interactions
ISO
geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]]
CTD
PMID:16740276
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
G
Tnf
tumor necrosis factor
multiple interactions
ISO
geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]]
CTD
PMID:16740276
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
quercitrin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
CTD
PMID:34217736
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcc4
ATP binding cassette subfamily C member 4
decreases expression
ISO
quercitrin results in decreased expression of ABCC4 mRNA
CTD
PMID:25193878
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
G
Abcf2
ATP binding cassette subfamily F member 2
increases expression
ISO
quercitrin results in increased expression of ABCF2 mRNA
CTD
PMID:25193878
NCBI chr 4:10,594,802...10,607,606
Ensembl chr 4:10,594,907...10,607,606
G
Acbd6
acyl-CoA binding domain containing 6
decreases expression
ISO
quercitrin results in decreased expression of ACBD6 mRNA
CTD
PMID:25193878
NCBI chr13:67,726,786...67,863,392
Ensembl chr13:67,726,786...67,862,311
G
Acbd7
acyl-CoA binding domain containing 7
increases expression
ISO
quercitrin results in increased expression of ACBD7 mRNA
CTD
PMID:25193878
NCBI chr17:74,903,936...74,909,977
Ensembl chr17:74,903,177...74,905,811
G
Actn1
actinin, alpha 1
affects expression
ISO
quercitrin affects the expression of ACTN1 mRNA
CTD
PMID:25193878
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
G
Actn4
actinin alpha 4
affects expression
ISO
quercitrin affects the expression of ACTN4 mRNA
CTD
PMID:25193878
NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847
G
Adgrb1
adhesion G protein-coupled receptor B1
decreases expression
ISO
quercitrin results in decreased expression of ADGRB1 mRNA
CTD
PMID:25193878
NCBI chr 7:106,404,844...106,476,902
Ensembl chr 7:106,404,958...106,476,902
G
Adgrf1
adhesion G protein-coupled receptor F1
decreases expression
ISO
quercitrin results in decreased expression of ADGRF1 mRNA
CTD
PMID:25193878
NCBI chr 9:17,661,258...17,696,359
Ensembl chr 9:17,660,930...17,711,704
G
Adgrg1
adhesion G protein-coupled receptor G1
decreases expression
ISO
quercitrin results in decreased expression of ADGRG1 mRNA
CTD
PMID:25193878
NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108
G
Adgrg6
adhesion G protein-coupled receptor G6
decreases expression
ISO
quercitrin results in decreased expression of ADGRG6 mRNA
CTD
PMID:25193878
NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123
G
Adgrg7
adhesion G protein-coupled receptor G7
increases expression
ISO
quercitrin results in increased expression of ADGRG7 mRNA
CTD
PMID:25193878
NCBI chr11:43,808,101...43,877,539
Ensembl chr11:43,813,801...43,876,316
G
Adgrv1
adhesion G protein-coupled receptor V1
increases expression
ISO
quercitrin results in increased expression of ADGRV1 mRNA
CTD
PMID:25193878
NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688
G
Adk
adenosine kinase
decreases expression
ISO
quercitrin results in decreased expression of ADK mRNA
CTD
PMID:25193878
NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
G
Adra2c
adrenoceptor alpha 2C
increases expression
ISO
quercitrin results in increased expression of ADRA2C mRNA
CTD
PMID:25193878
NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846
G
Ahnak2
AHNAK nucleoprotein 2
increases expression
ISO
quercitrin results in increased expression of AHNAK2 mRNA
CTD
PMID:25193878
NCBI chr 6:131,830,668...131,876,311
G
Alkbh7
alkB homolog 7
increases expression
ISO
quercitrin results in increased expression of ALKBH7 mRNA
CTD
PMID:25193878
NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044
G
Anapc15
anaphase promoting complex subunit 15
decreases expression
ISO
quercitrin results in decreased expression of ANAPC15 mRNA
CTD
PMID:25193878
NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145
G
Ar
androgen receptor
increases expression
ISO
quercitrin results in increased expression of AR mRNA
CTD
PMID:25193878
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
increases expression
ISO
quercitrin results in increased expression of ARAP2 mRNA
CTD
PMID:25193878
NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154
G
Asb6
ankyrin repeat and SOCS box-containing 6
increases expression
ISO
quercitrin results in increased expression of ASB6 mRNA
CTD
PMID:25193878
NCBI chr 3:14,110,628...14,115,276
Ensembl chr 3:14,110,628...14,115,242
G
Atg7
autophagy related 7
decreases expression
ISO
quercitrin results in decreased expression of ATG7 mRNA
CTD
PMID:25193878
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
G
Baiap2
BAR/IMD domain containing adaptor protein 2
affects expression
ISO
quercitrin affects the expression of BAIAP2 mRNA
CTD
PMID:25193878
NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]
CTD
PMID:23138875
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bdkrb1
bradykinin receptor B1
decreases expression
ISO
quercitrin results in decreased expression of BDKRB1 mRNA
CTD
PMID:25193878
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
G
Camk2b
calcium/calmodulin-dependent protein kinase II beta
decreases expression
ISO
quercitrin results in decreased expression of CAMK2B mRNA
CTD
PMID:25193878
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
G
Casp3
caspase 3
increases activity multiple interactions
ISO EXP
quercitrin results in increased activity of CASP3 protein quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]
CTD
PMID:23138875 PMID:25193878
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases expression
ISO
quercitrin results in increased expression of CASP8 mRNA
CTD
PMID:25193878
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Ccr9
C-C motif chemokine receptor 9
decreases expression
ISO
quercitrin results in decreased expression of CCR9 mRNA
CTD
PMID:25193878
NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969
G
Ccrl2
C-C motif chemokine receptor like 2
increases expression
ISO
quercitrin results in increased expression of CCRL2 mRNA
CTD
PMID:25193878
NCBI chr 8:111,034,279...111,036,914
Ensembl chr 8:111,034,279...111,036,664
G
Cd302
CD302 molecule
decreases expression
ISO
quercitrin results in decreased expression of CD302 mRNA
CTD
PMID:25193878
NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:44,722,325...44,756,045
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Cd38
CD38 molecule
decreases expression
ISO
quercitrin results in decreased expression of CD38 mRNA
CTD
PMID:25193878
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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Cd74
CD74 molecule
affects expression
ISO
quercitrin affects the expression of CD74 mRNA
CTD
PMID:25193878
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
G
Cdh1
cadherin 1
decreases expression
ISO
quercitrin results in decreased expression of CDH1 mRNA
CTD
PMID:25193878
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cdkn3
cyclin-dependent kinase inhibitor 3
decreases expression
ISO
quercitrin results in decreased expression of CDKN3 mRNA
CTD
PMID:25193878
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
G
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
increases expression
ISO
quercitrin results in increased expression of CELSR3 mRNA
CTD
PMID:25193878
NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354
G
Cep95
centrosomal protein 95
increases expression
ISO
quercitrin results in increased expression of CEP95 mRNA
CTD
PMID:25193878
NCBI chr10:91,732,111...91,760,095
Ensembl chr10:91,732,111...91,760,092
G
Cers5
ceramide synthase 5
increases expression
ISO
quercitrin results in increased expression of CERS5 mRNA
CTD
PMID:25193878
NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947
G
Cfap298
cilia and flagella associated protein 298
decreases expression
ISO
quercitrin results in decreased expression of CFAP298 mRNA
CTD
PMID:25193878
NCBI chr11:30,181,916...30,191,302
Ensembl chr11:30,181,905...30,191,346
G
Chd2
chromodomain helicase DNA binding protein 2
decreases expression
ISO
quercitrin results in decreased expression of CHD2 mRNA
CTD
PMID:25193878
NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502
G
Cldn10
claudin 10
affects expression
ISO
quercitrin affects the expression of CLDN10 mRNA
CTD
PMID:25193878
NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526
G
Cldn23
claudin 23
affects expression
ISO
quercitrin affects the expression of CLDN23 mRNA
CTD
PMID:25193878
NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523
G
Cldn4
claudin 4
affects expression
ISO
quercitrin affects the expression of CLDN4 mRNA
CTD
PMID:25193878
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
G
Cldn8
claudin 8
affects expression
ISO
quercitrin affects the expression of CLDN8 mRNA
CTD
PMID:25193878
NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513
G
Col3a1
collagen type III alpha 1 chain
decreases expression
ISO
quercitrin results in decreased expression of COL3A1 mRNA
CTD
PMID:25193878
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
G
Coq3
coenzyme Q3 methyltransferase
decreases expression
ISO
quercitrin results in decreased expression of COQ3 mRNA
CTD
PMID:25193878
NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607
G
Crisp1
cysteine-rich secretory protein 1
decreases expression
ISO
quercitrin results in decreased expression of CRISP1 mRNA
CTD
PMID:25193878
NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796
G
Cryzl1
crystallin zeta like 1
decreases expression
ISO
quercitrin results in decreased expression of CRYZL1 mRNA
CTD
PMID:25193878
NCBI chr11:30,933,140...30,977,936
Ensembl chr11:30,933,144...30,977,867
G
Csnk2a1
casein kinase 2 alpha 1
affects expression
ISO
quercitrin affects the expression of CSNK2A1 mRNA
CTD
PMID:25193878
NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
G
Csnk2a2
casein kinase 2 alpha 2
affects expression
ISO
quercitrin affects the expression of CSNK2A2 mRNA
CTD
PMID:25193878
NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080
G
Ctdspl2
CTD small phosphatase like 2
decreases expression
ISO
quercitrin results in decreased expression of CTDSPL2 mRNA
CTD
PMID:25193878
NCBI chr 3:108,914,650...108,970,620
Ensembl chr 3:108,915,280...108,967,227
G
Ctsb
cathepsin B
affects expression
ISO
quercitrin affects the expression of CTSB mRNA
CTD
PMID:25193878
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
quercitrin results in decreased activity of CYP1A1 protein
CTD
PMID:16271822
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
quercitrin results in decreased activity of CYP1B1 protein
CTD
PMID:16271822
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
increases expression
ISO
quercitrin results in increased expression of CYP26B1 mRNA
CTD
PMID:25193878
NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
G
Dcun1d5
defective in cullin neddylation 1 domain containing 5
decreases expression
ISO
quercitrin results in decreased expression of DCUN1D5 mRNA
CTD
PMID:25193878
NCBI chr 8:4,412,266...4,433,380
Ensembl chr 8:4,412,221...4,433,367
G
Ddx19b
DEAD-box helicase 19B
decreases expression
ISO
quercitrin results in decreased expression of DDX19B mRNA
CTD
PMID:25193878
NCBI chr19:38,968,215...38,998,907
Ensembl chr19:38,968,215...38,997,259
G
Dele1
DAP3 binding cell death enhancer 1
decreases expression
ISO
quercitrin results in decreased expression of DELE1 mRNA
CTD
PMID:25193878
NCBI chr18:30,085,093...30,098,105
Ensembl chr18:30,085,126...30,098,756
G
Dgkq
diacylglycerol kinase, theta
affects expression
ISO
quercitrin affects the expression of DGKQ mRNA
CTD
PMID:25193878
NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131
G
Dhrs11
dehydrogenase/reductase 11
decreases activity
ISO
quercitrin results in decreased activity of DHRS11 protein
CTD
PMID:30926317
NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
G
Dtwd1
DTW domain containing 1
decreases expression
ISO
quercitrin results in decreased expression of DTWD1 mRNA
CTD
PMID:25193878
NCBI chr 3:113,392,402...113,409,322
Ensembl chr 3:113,392,457...113,408,105
G
Egr2
early growth response 2
increases expression
ISO
quercitrin results in increased expression of EGR2 mRNA
CTD
PMID:25193878
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
G
Epas1
endothelial PAS domain protein 1
increases expression
ISO
quercitrin results in increased expression of EPAS1 mRNA
CTD
PMID:25193878
NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
G
Ercc1
ERCC excision repair 1, endonuclease non-catalytic subunit
decreases expression
ISO
quercitrin results in decreased expression of ERCC1 mRNA
CTD
PMID:25193878
NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
G
Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
decreases expression
ISO
quercitrin results in decreased expression of ERCC2 mRNA
CTD
PMID:25193878
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
G
Eri2
ERI1 exoribonuclease family member 2
increases expression
ISO
quercitrin results in increased expression of ERI2 mRNA
CTD
PMID:25193878
NCBI chr 1:174,140,831...174,168,757
Ensembl chr 1:174,141,993...174,168,665
G
Eva1a
eva-1 homolog A, regulator of programmed cell death
decreases expression
ISO
quercitrin results in decreased expression of EVA1A mRNA
CTD
PMID:25193878
NCBI chr 4:114,593,773...114,643,011
Ensembl chr 4:114,593,341...114,643,011
G
F11r
F11 receptor
affects expression
ISO
quercitrin affects the expression of F11R mRNA
CTD
PMID:25193878
NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
G
F2rl1
F2R like trypsin receptor 1
increases expression
ISO
quercitrin results in increased expression of F2RL1 mRNA
CTD
PMID:25193878
NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
G
F2rl2
coagulation factor II (thrombin) receptor-like 2
decreases expression
ISO
quercitrin results in decreased expression of F2RL2 mRNA
CTD
PMID:25193878
NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098
G
F3
coagulation factor III, tissue factor
increases expression
ISO
quercitrin results in increased expression of F3 mRNA
CTD
PMID:25193878
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
G
Faim
Fas apoptotic inhibitory molecule
increases expression
ISO
quercitrin results in increased expression of FAIM mRNA
CTD
PMID:25193878
NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562
G
Fam102a
family with sequence similarity 102, member A
increases expression
ISO
quercitrin results in increased expression of FAM102A mRNA
CTD
PMID:25193878
NCBI chr 3:15,823,147...15,854,651
Ensembl chr 3:15,823,144...15,854,643
G
Fam216a
family with sequence similarity 216, member A
decreases expression
ISO
quercitrin results in decreased expression of FAM216A mRNA
CTD
PMID:25193878
NCBI chr12:34,198,526...34,207,673
Ensembl chr12:34,198,526...34,207,665
G
Fam3c
FAM3 metabolism regulating signaling molecule C
increases expression
ISO
quercitrin results in increased expression of FAM3C mRNA
CTD
PMID:25193878
NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078
G
Fam43a
family with sequence similarity 43, member A
increases expression
ISO
quercitrin results in increased expression of FAM43A mRNA
CTD
PMID:25193878
NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401
G
Fam50a
family with sequence similarity 50, member A
increases expression
ISO
quercitrin results in increased expression of FAM50A mRNA
CTD
PMID:25193878
NCBI chr X:152,095,245...152,102,362
Ensembl chr X:152,095,245...152,102,362
G
Fas
Fas cell surface death receptor
increases expression
ISO
quercitrin results in increased expression of FAS mRNA
CTD
PMID:25193878
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fdcsp
follicular dendritic cell secreted protein
decreases expression
ISO
quercitrin results in decreased expression of FDCSP mRNA
CTD
PMID:25193878
NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983
G
Flg
filaggrin
increases expression
ISO
quercitrin results in increased expression of FLG mRNA
CTD
PMID:25193878
NCBI chr 2:178,888,688...178,912,731
G
Fzd4
frizzled class receptor 4
increases expression
ISO
quercitrin results in increased expression of FZD4 mRNA
CTD
PMID:25193878
NCBI chr 1:143,280,065...143,288,799
Ensembl chr 1:143,280,065...143,285,724
G
Gabbr2
gamma-aminobutyric acid type B receptor subunit 2
increases expression
ISO
quercitrin results in increased expression of GABBR2 mRNA
CTD
PMID:25193878
NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
affects expression
ISO
quercitrin affects the expression of GADD45 mRNA
CTD
PMID:25193878
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Galk2
galactokinase 2
increases expression
ISO
quercitrin results in increased expression of GALK2 mRNA
CTD
PMID:25193878
NCBI chr 3:113,110,057...113,243,014
Ensembl chr 3:113,110,030...113,233,306
G
Galr3
galanin receptor 3
increases expression
ISO
quercitrin results in increased expression of GALR3 mRNA
CTD
PMID:25193878
NCBI chr 7:110,603,525...110,608,429
Ensembl chr 7:110,605,226...110,607,685
G
Gimap6
GTPase, IMAP family member 6
increases expression
ISO
quercitrin results in increased expression of GIMAP6 mRNA
CTD
PMID:25193878
NCBI chr 4:77,653,703...77,659,112
Ensembl chr 4:77,652,610...77,659,116
G
Glipr1
GLI pathogenesis-related 1
decreases expression
ISO
quercitrin results in decreased expression of GLIPR1 mRNA
CTD
PMID:25193878
NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429
G
Golim4
golgi integral membrane protein 4
increases expression
ISO
quercitrin results in increased expression of GOLIM4 mRNA
CTD
PMID:25193878
NCBI chr 2:160,640,932...160,733,475
Ensembl chr 2:160,640,938...160,733,253
G
Gpr137b
G protein-coupled receptor 137B
increases expression
ISO
quercitrin results in increased expression of GPR137B mRNA
CTD
PMID:25193878
NCBI chr17:86,003,630...86,041,841
Ensembl chr17:85,966,921...86,041,835
G
Gpr173
G-protein coupled receptor 173
increases expression
ISO
quercitrin results in increased expression of GPR173 mRNA
CTD
PMID:25193878
NCBI chr X:21,446,261...21,471,497
Ensembl chr X:21,447,361...21,471,498
G
Gpr174
G protein-coupled receptor 174
increases expression
ISO
quercitrin results in increased expression of GPR174 mRNA
CTD
PMID:25193878
NCBI chr X:72,355,452...72,396,146
Ensembl chr X:72,355,033...72,397,658
G
Gpr19
G protein-coupled receptor 19
increases expression
ISO
quercitrin results in increased expression of GPR19 mRNA
CTD
PMID:25193878
NCBI chr 4:167,710,944...167,739,232
Ensembl chr 4:167,710,666...167,741,036
G
Gpr4
G protein-coupled receptor 4
increases expression
ISO
quercitrin results in increased expression of GPR4 mRNA
CTD
PMID:25193878
NCBI chr 1:78,865,376...78,877,126
Ensembl chr 1:78,865,409...78,876,599
G
Gpr63
G protein-coupled receptor 63
increases expression
ISO
quercitrin results in increased expression of GPR63 mRNA
CTD
PMID:25193878
NCBI chr 5:38,672,548...38,727,224
Ensembl chr 5:38,635,472...38,727,677
G
Gpr83
G protein-coupled receptor 83
increases expression
ISO
quercitrin results in increased expression of GPR83 mRNA
CTD
PMID:25193878
NCBI chr 8:11,693,540...11,704,028
Ensembl chr 8:11,693,540...11,704,028
G
Gstp1
glutathione S-transferase pi 1
decreases expression
ISO
quercitrin results in decreased expression of GSTP1 mRNA
CTD
PMID:25193878
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Havcr2
hepatitis A virus cellular receptor 2
increases expression
ISO
quercitrin results in increased expression of HAVCR2 mRNA
CTD
PMID:25193878
NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
G
Hgf
hepatocyte growth factor
increases expression
ISO
quercitrin results in increased expression of HGF mRNA
CTD
PMID:25193878
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Hmga2
high mobility group AT-hook 2
increases expression
ISO
quercitrin results in increased expression of HMGA2 mRNA
CTD
PMID:25193878
NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
G
Hmgb2
high mobility group box 2
decreases expression
ISO
quercitrin results in decreased expression of HMGB2 mRNA
CTD
PMID:25193878
NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
G
Hnf4a
hepatocyte nuclear factor 4, alpha
decreases expression
ISO
quercitrin results in decreased expression of HNF4A mRNA
CTD
PMID:25193878
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
affects expression
ISO
quercitrin affects the expression of HSP90AA1 mRNA
CTD
PMID:25193878
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hspa1l
heat shock protein family A (Hsp70) member 1 like
affects expression
ISO
quercitrin affects the expression of HSPA1L mRNA
CTD
PMID:25193878
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
G
Hspa8
heat shock protein family A (Hsp70) member 8
affects expression
ISO
quercitrin affects the expression of HSPA8 mRNA
CTD
PMID:25193878
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Ifna1
interferon, alpha 1
affects expression
ISO
quercitrin affects the expression of IFNA1 mRNA
CTD
PMID:25193878
NCBI chr 5:103,095,767...103,098,260
Ensembl chr 5:103,097,356...103,097,925
G
Ifng
interferon gamma
multiple interactions
EXP
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:23138875
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Igf1r
insulin-like growth factor 1 receptor
affects expression
ISO
quercitrin affects the expression of IGF1R mRNA
CTD
PMID:25193878
NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
G
Il15
interleukin 15
decreases expression
ISO
quercitrin results in decreased expression of IL15 mRNA
CTD
PMID:25193878
NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
G
Il1b
interleukin 1 beta
multiple interactions
EXP
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:23138875
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Ino80c
INO80 complex subunit C
decreases expression
ISO
quercitrin results in decreased expression of INO80C mRNA
CTD
PMID:25193878
NCBI chr18:15,378,764...15,398,574
Ensembl chr18:15,378,770...15,393,403
G
Inpp4a
inositol polyphosphate-4-phosphatase type I A
affects expression
ISO
quercitrin affects the expression of INPP4A mRNA
CTD
PMID:25193878
NCBI chr 9:39,528,245...39,650,574
Ensembl chr 9:39,528,674...39,646,581
G
Inpp5d
inositol polyphosphate-5-phosphatase D
affects expression
ISO
quercitrin affects the expression of INPP5D mRNA
CTD
PMID:25193878
NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
G
Insr
insulin receptor
affects expression
ISO
quercitrin affects the expression of INSR mRNA
CTD
PMID:25193878
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
G
Irf2bp2
interferon regulatory factor 2 binding protein 2
increases expression
ISO
quercitrin results in increased expression of IRF2BP2 mRNA
CTD
PMID:25193878
NCBI chr19:54,559,409...54,564,714
Ensembl chr19:54,560,128...54,566,642
G
Itgb1
integrin subunit beta 1
affects expression
ISO
quercitrin affects the expression of ITGB1 mRNA
CTD
PMID:25193878
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Jaml
junction adhesion molecule like
increases expression
ISO
quercitrin results in increased expression of JAML mRNA
CTD
PMID:25193878
NCBI chr 8:45,384,836...45,415,459
Ensembl chr 8:45,383,495...45,416,565
G
Jpt2
Jupiter microtubule associated homolog 2
increases expression
ISO
quercitrin results in increased expression of JPT2 mRNA
CTD
PMID:25193878
NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170
G
Kat5
lysine acetyltransferase 5
affects expression
ISO
quercitrin affects the expression of KAT5 mRNA
CTD
PMID:25193878
NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458
G
Kdm3a
lysine demethylase 3A
increases expression
ISO
quercitrin results in increased expression of KDM3A mRNA
CTD
PMID:25193878
NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073
G
Kdr
kinase insert domain receptor
increases expression
ISO
quercitrin results in increased expression of KDR mRNA
CTD
PMID:25193878
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
G
Keap1
Kelch-like ECH-associated protein 1
increases expression
ISO
quercitrin results in increased expression of KEAP1 mRNA
CTD
PMID:25193878
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
G
Klhl28
kelch-like family member 28
increases expression
ISO
quercitrin results in increased expression of KLHL28 mRNA
CTD
PMID:25193878
NCBI chr 6:82,987,360...83,018,971
Ensembl chr 6:82,990,945...83,016,164
G
Krt81
keratin 81
decreases expression
ISO
quercitrin results in decreased expression of KRT81 mRNA
CTD
PMID:25193878
NCBI chr 7:132,577,112...132,582,238
Ensembl chr 7:132,576,492...132,582,170
G
Lef1
lymphoid enhancer binding factor 1
affects expression
ISO
quercitrin affects the expression of LEF1 mRNA
CTD
PMID:25193878
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
G
LOC100911237
zinc finger protein 420-like
increases expression
ISO
quercitrin results in increased expression of ZNF502 mRNA
CTD
PMID:25193878
NCBI chr 1:28,884,390...28,908,726
G
LOC102552569
P2Y purinoceptor 11-like
increases expression
ISO
quercitrin results in increased expression of P2RY11 mRNA
CTD
PMID:25193878
G
LOC686035
similar to heat shock 70kDa protein 6 (HSP70B)
affects expression
ISO
quercitrin affects the expression of HSPA6 mRNA
CTD
PMID:25193878
NCBI chr13:83,271,340...83,275,267
G
Lpar3
lysophosphatidic acid receptor 3
increases expression
ISO
quercitrin results in increased expression of LPAR3 mRNA
CTD
PMID:25193878
NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357
G
Lpar5
lysophosphatidic acid receptor 5
increases expression
ISO
quercitrin results in increased expression of LPAR5 mRNA
CTD
PMID:25193878
NCBI chr 4:157,870,493...157,883,970
Ensembl chr 4:157,881,796...157,882,950
G
Lpar6
lysophosphatidic acid receptor 6
decreases expression
ISO
quercitrin results in decreased expression of LPAR6 mRNA
CTD
PMID:25193878
NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331
G
Mat2a
methionine adenosyltransferase 2A
increases expression
ISO
quercitrin results in increased expression of MAT2A mRNA
CTD
PMID:25193878
NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
G
Mc1r
melanocortin 1 receptor
increases expression
ISO
quercitrin results in increased expression of MC1R mRNA
CTD
PMID:25193878
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
G
Mcts1
MCTS1, re-initiation and release factor
decreases expression
ISO
quercitrin results in decreased expression of MCTS1 mRNA
CTD
PMID:25193878
NCBI chr X:117,350,723...117,362,504
Ensembl chr X:117,350,889...117,362,504
G
Mrpl12
mitochondrial ribosomal protein L12
decreases expression
ISO
quercitrin results in decreased expression of MRPL12 mRNA
CTD
PMID:25193878
NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913
G
Mrpl22
mitochondrial ribosomal protein L22
decreases expression
ISO
quercitrin results in decreased expression of MRPL22 mRNA
CTD
PMID:25193878
NCBI chr10:42,345,446...42,355,779
Ensembl chr10:42,342,776...42,355,779
G
Msn
moesin
affects expression
ISO
quercitrin affects the expression of MSN mRNA
CTD
PMID:25193878
NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628
G
Myl2
myosin light chain 2
affects expression
ISO
quercitrin affects the expression of MYL2 mRNA
CTD
PMID:25193878
NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
G
Myl9
myosin light chain 9
affects expression
ISO
quercitrin affects the expression of MYL9 mRNA
CTD
PMID:25193878
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
G
Myom2
myomesin 2
increases expression
ISO
quercitrin results in increased expression of MYOM2 mRNA
CTD
PMID:25193878
NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772
G
Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
decreases expression
ISO
quercitrin results in decreased expression of LSMD1 mRNA
CTD
PMID:25193878
NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
EXP
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]
CTD
PMID:23138875
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nfrkb
nuclear factor related to kappa B binding protein
increases expression
ISO
quercitrin results in increased expression of NFRKB mRNA
CTD
PMID:25193878
NCBI chr 8:29,831,802...29,863,360
Ensembl chr 8:29,831,812...29,863,359
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Nmur1
neuromedin U receptor 1
decreases expression
ISO
quercitrin results in decreased expression of NMUR1 mRNA
CTD
PMID:25193878
NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:23138875
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Npbwr1
neuropeptides B and W receptor 1
increases expression
ISO
quercitrin results in increased expression of NPBWR1 mRNA
CTD
PMID:25193878
NCBI chr 5:13,495,426...13,496,415
Ensembl chr 5:13,495,426...13,496,415
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Npffr2
neuropeptide FF receptor 2
decreases expression
ISO
quercitrin results in decreased expression of NPFFR2 mRNA
CTD
PMID:25193878
NCBI chr14:18,513,277...18,521,919
Ensembl chr14:18,513,277...18,521,919
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Npy5r
neuropeptide Y receptor Y5
increases expression
ISO
quercitrin results in increased expression of NPY5R mRNA
CTD
PMID:25193878
NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382
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Nuak2
NUAK family kinase 2
decreases expression
ISO
quercitrin results in decreased expression of NUAK2 mRNA
CTD
PMID:25193878
NCBI chr13:43,753,454...43,770,604
Ensembl chr13:43,753,832...43,770,604
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Ocln
occludin
affects expression
ISO
quercitrin affects the expression of OCLN mRNA
CTD
PMID:25193878
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Odc1
ornithine decarboxylase 1
increases expression
ISO
quercitrin results in increased expression of ODC1 mRNA
CTD
PMID:25193878
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
G
Oga
O-GlcNAcase
increases expression
ISO
quercitrin results in increased expression of OGA mRNA
CTD
PMID:25193878
NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
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Ogfod2
2-oxoglutarate and iron-dependent oxygenase domain containing 2
increases expression
ISO
quercitrin results in increased expression of OGFOD2 mRNA
CTD
PMID:25193878
NCBI chr12:32,482,377...32,485,687
Ensembl chr12:32,482,377...32,485,673
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Oma1
OMA1 zinc metallopeptidase
increases expression
ISO
quercitrin results in increased expression of OMA1 mRNA
CTD
PMID:25193878
NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
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P2rx2
purinergic receptor P2X 2
increases expression
ISO
quercitrin results in increased expression of P2RX2 mRNA
CTD
PMID:25193878
NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891
G
P2rx3
purinergic receptor P2X 3
increases expression
ISO
quercitrin results in increased expression of P2RX3 mRNA
CTD
PMID:25193878
NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178
G
P2ry6
pyrimidinergic receptor P2Y6
decreases expression
ISO
quercitrin results in decreased expression of P2RY6 mRNA
CTD
PMID:25193878
NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
EXP
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]
CTD
PMID:23138875
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Patz1
POZ (BTB) and AT hook containing zinc finger 1
decreases expression
ISO
quercitrin results in decreased expression of PATZ1 mRNA
CTD
PMID:25193878
NCBI chr14:78,154,590...78,173,032
Ensembl chr14:78,152,516...78,173,032
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Pex16
peroxisomal biogenesis factor 16
decreases expression
ISO
quercitrin results in decreased expression of PEX16 mRNA
CTD
PMID:25193878
NCBI chr 3:78,347,212...78,352,603
Ensembl chr 3:78,343,164...78,353,207
G
Pidd1
p53-induced death domain protein 1
increases expression
ISO
quercitrin results in increased expression of PIDD1 mRNA
CTD
PMID:25193878
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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Pik3c2a
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
affects expression
ISO
quercitrin affects the expression of PIK3C2A mRNA
CTD
PMID:25193878
NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
affects expression
ISO
quercitrin affects the expression of PIK3R1 mRNA
CTD
PMID:25193878
NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
G
Plcb2
phospholipase C, beta 2
affects expression
ISO
quercitrin affects the expression of PLCB2 mRNA
CTD
PMID:25193878
NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302
G
Plce1
phospholipase C, epsilon 1
affects expression
ISO
quercitrin affects the expression of PLCE1 mRNA
CTD
PMID:25193878
NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
G
Plgrkt
plasminogen receptor with a C-terminal lysine
decreases expression
ISO
quercitrin results in decreased expression of PLGRKT mRNA
CTD
PMID:25193878
NCBI chr 1:227,099,005...227,111,277
Ensembl chr 1:227,099,015...227,111,194
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Poc1a
POC1 centriolar protein A
decreases expression
ISO
quercitrin results in decreased expression of POC1A mRNA
CTD
PMID:25193878
NCBI chr 8:106,922,058...106,991,678
Ensembl chr 8:106,922,978...106,991,089
G
Polh
DNA polymerase eta
increases expression
ISO
quercitrin results in increased expression of POLH mRNA
CTD
PMID:25193878
NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
G
Polrmt
RNA polymerase mitochondrial
decreases expression
ISO
quercitrin results in decreased expression of POLRMT mRNA
CTD
PMID:25193878
NCBI chr 7:9,959,532...9,969,791
Ensembl chr 7:9,959,576...9,969,791
G
Pomt2
protein-O-mannosyltransferase 2
increases expression
ISO
quercitrin results in increased expression of POMT2 mRNA
CTD
PMID:25193878
NCBI chr 6:106,755,462...106,794,849
Ensembl chr 6:106,755,462...106,794,849
G
Pou5f2
POU domain class 5, transcription factor 2
decreases expression
ISO
quercitrin results in decreased expression of POU5F2 mRNA
CTD
PMID:25193878
NCBI chr 2:7,907,504...7,908,738
G
Prkcb
protein kinase C, beta
affects expression
ISO
quercitrin affects the expression of PRKCB mRNA
CTD
PMID:25193878
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
G
Prr3
proline rich 3
decreases expression
ISO
quercitrin results in decreased expression of PRR3 mRNA
CTD
PMID:25193878
NCBI chr20:2,792,868...2,799,865
Ensembl chr20:2,792,860...2,799,865
G
Psd4
pleckstrin and Sec7 domain containing 4
increases expression
ISO
quercitrin results in increased expression of PSD4 mRNA
CTD
PMID:25193878
NCBI chr 3:7,137,069...7,173,571
Ensembl chr 3:7,137,155...7,173,571
G
Psma6
proteasome 20S subunit alpha 6
decreases expression
ISO
quercitrin results in decreased expression of PSMA6 mRNA
CTD
PMID:25193878
NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554
G
Psma8
proteasome 20S subunit alpha 8
decreases expression
ISO
quercitrin results in decreased expression of PSMA8 mRNA
CTD
PMID:25193878
NCBI chr18:5,863,594...5,928,226
Ensembl chr18:5,863,608...5,928,226
G
Psmb6
proteasome 20S subunit beta 6
decreases expression
ISO
quercitrin results in decreased expression of PSMB6 mRNA
CTD
PMID:25193878
NCBI chr10:55,239,274...55,241,581
Ensembl chr10:55,239,241...55,241,586
G
Psmb9
proteasome 20S subunit beta 9
decreases expression
ISO
quercitrin results in decreased expression of PSMB9 mRNA
CTD
PMID:25193878
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
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Ptgdr2
prostaglandin D2 receptor 2
increases expression
ISO
quercitrin results in increased expression of PTGDR2 mRNA
CTD
PMID:25193878
NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213
G
Ptk2b
protein tyrosine kinase 2 beta
affects expression
ISO
quercitrin affects the expression of PTK2B mRNA
CTD
PMID:25193878
NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
G
Ptpru
protein tyrosine phosphatase, receptor type, U
decreases expression
ISO
quercitrin results in decreased expression of PTPRU mRNA
CTD
PMID:25193878
NCBI chr 5:143,950,542...144,024,791
Ensembl chr 5:143,950,965...144,024,768
G
Rac3
Rac family small GTPase 3
affects expression
ISO
quercitrin affects the expression of RAC3 mRNA
CTD
PMID:25193878
NCBI chr10:106,002,808...106,005,244
Ensembl chr10:105,993,087...106,005,260
G
Rap1a
RAP1A, member of RAS oncogene family
affects expression
ISO
quercitrin affects the expression of RAP1A mRNA
CTD
PMID:25193878
NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
G
Rbak
RB-associated KRAB zinc finger
increases expression
ISO
quercitrin results in increased expression of RBAK mRNA
CTD
PMID:25193878
NCBI chr12:11,375,314...11,388,937
Ensembl chr12:11,375,318...11,388,934
G
Rbks
ribokinase
decreases expression
ISO
quercitrin results in decreased expression of RBKS mRNA
CTD
PMID:25193878
NCBI chr 6:24,747,651...24,824,290
Ensembl chr 6:24,747,293...24,824,290
G
Rbm15b
RNA binding motif protein 15B
increases expression
ISO
quercitrin results in increased expression of RBM15B mRNA
CTD
PMID:25193878
NCBI chr 8:107,543,542...107,548,195
Ensembl chr 8:107,525,898...107,551,696
G
Rbm38
RNA binding motif protein 38
increases expression
ISO
quercitrin results in increased expression of RBM38 mRNA
CTD
PMID:25193878
NCBI chr 3:161,801,550...161,814,381
Ensembl chr 3:161,801,577...161,814,381
G
Rbm39
RNA binding motif protein 39
increases expression
ISO
quercitrin results in increased expression of RBM39 mRNA
CTD
PMID:25193878
NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
G
Rchy1
ring finger and CHY zinc finger domain containing 1
decreases expression
ISO
quercitrin results in decreased expression of RCHY1 mRNA
CTD
PMID:25193878
NCBI chr14:16,113,263...16,129,017
Ensembl chr14:16,113,224...16,129,167
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]
CTD
PMID:23138875
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
RGD1310553
similar to expressed sequence AI597479
decreases expression
ISO
quercitrin results in decreased expression of C2ORF49 mRNA
CTD
PMID:25193878
NCBI chr 9:45,371,396...45,382,123
Ensembl chr 9:45,371,430...45,382,120
G
Riok1
RIO kinase 1
increases expression
ISO
quercitrin results in increased expression of RIOK1 mRNA
CTD
PMID:25193878
NCBI chr17:26,767,440...26,789,900
Ensembl chr17:26,766,947...26,789,900
G
Rnf14
ring finger protein 14
decreases expression
ISO
quercitrin results in decreased expression of RNF14 mRNA
CTD
PMID:25193878
NCBI chr18:30,131,627...30,155,686
Ensembl chr18:30,131,691...30,155,685
G
Rock1
Rho-associated coiled-coil containing protein kinase 1
affects expression
ISO
quercitrin affects the expression of ROCK1 mRNA
CTD
PMID:25193878
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
G
RT1-A2
RT1 class Ia, locus A2
affects expression
ISO
quercitrin affects the expression of HLA-E mRNA
CTD
PMID:25193878
NCBI chr20:4,870,939...4,910,183
G
RT1-Ba
RT1 class II, locus Ba
affects expression
ISO
quercitrin affects the expression of HLA-DQA1 mRNA
CTD
PMID:25193878
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
G
Sap18
Sin3A associated protein 18
increases expression
ISO
quercitrin results in increased expression of SAP18 mRNA
CTD
PMID:25193878
NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038
G
Sat1
spermidine/spermine N1-acetyl transferase 1
decreases expression
ISO
quercitrin results in decreased expression of SAT1 mRNA
CTD
PMID:25193878
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
G
Sertad1
SERTA domain containing 1
increases expression
ISO
quercitrin results in increased expression of SERTAD1 mRNA
CTD
PMID:25193878
NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
G
Sf3b1
splicing factor 3b, subunit 1
decreases expression
ISO
quercitrin results in decreased expression of SF3B1 mRNA
CTD
PMID:25193878
NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300
G
Slc16a13
solute carrier family 16, member 13
decreases expression
ISO
quercitrin results in decreased expression of SLC16A13 mRNA
CTD
PMID:25193878
NCBI chr10:54,925,973...54,937,860
Ensembl chr10:54,926,760...54,937,788
G
Slc16a4
solute carrier family 16, member 4
decreases expression
ISO
quercitrin results in decreased expression of SLC16A4 mRNA
CTD
PMID:25193878
NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
G
Slc22a18
solute carrier family 22, member 18
decreases expression
ISO
quercitrin results in decreased expression of SLC22A18 mRNA
CTD
PMID:25193878
NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975
G
Slc25a40
solute carrier family 25, member 40
decreases expression
ISO
quercitrin results in decreased expression of SLC25A40 mRNA
CTD
PMID:25193878
NCBI chr 4:25,620,007...25,676,422
Ensembl chr 4:25,589,360...25,676,472
G
Slc39a8
solute carrier family 39 member 8
decreases expression
ISO
quercitrin results in decreased expression of SLC39A8 mRNA
CTD
PMID:25193878
NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129
G
Slc7a9
solute carrier family 7 member 9
increases expression
ISO
quercitrin results in increased expression of SLC7A9 mRNA
CTD
PMID:25193878
NCBI chr 1:88,109,517...88,132,653
Ensembl chr 1:88,110,644...88,132,641
G
Slfnl1
schlafen-like 1
increases expression
ISO
quercitrin results in increased expression of SLFNL1 mRNA
CTD
PMID:25193878
NCBI chr 5:134,117,634...134,122,105
Ensembl chr 5:133,990,520...134,122,105
G
Smad3
SMAD family member 3
increases expression
ISO
quercitrin results in increased expression of SMAD3 mRNA
CTD
PMID:25193878
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
G
Smpd1
sphingomyelin phosphodiesterase 1
increases expression
ISO
quercitrin results in increased expression of SMPD1 mRNA
CTD
PMID:25193878
NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
G
Snai2
snail family transcriptional repressor 2
affects expression
ISO
quercitrin affects the expression of SNAI2 mRNA
CTD
PMID:25193878
NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
G
Sorbs1
sorbin and SH3 domain containing 1
affects expression
ISO
quercitrin affects the expression of SORBS1 mRNA
CTD
PMID:25193878
NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169
G
Sorl1
sortilin related receptor 1
decreases expression
ISO
quercitrin results in decreased expression of SORL1 mRNA
CTD
PMID:25193878
NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
G
Sp4
Sp4 transcription factor
increases expression
ISO
quercitrin results in increased expression of SP4 mRNA
CTD
PMID:25193878
NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126
G
Spata18
spermatogenesis associated 18
increases expression
ISO
quercitrin results in increased expression of SPATA18 mRNA
CTD
PMID:25193878
NCBI chr14:34,531,931...34,558,671
Ensembl chr14:34,531,061...34,558,687
G
Src
SRC proto-oncogene, non-receptor tyrosine kinase
affects expression
ISO
quercitrin affects the expression of SRC mRNA
CTD
PMID:25193878
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
G
Srd5a3
steroid 5 alpha-reductase 3
increases expression
ISO
quercitrin results in increased expression of SRD5A3 mRNA
CTD
PMID:25193878
NCBI chr14:32,046,415...32,060,796
Ensembl chr14:32,046,408...32,060,747
G
Srrm2
serine/arginine repetitive matrix 2
increases expression
ISO
quercitrin results in increased expression of SRRM2 mRNA
CTD
PMID:25193878
NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751
G
Sugct
succinylCoA:glutarate-CoA transferase
increases expression
ISO
quercitrin results in increased expression of SUGCT mRNA
CTD
PMID:25193878
NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376
G
Sugp1
SURP and G patch domain containing 1
increases expression
ISO
quercitrin results in increased expression of SUGP1 mRNA
CTD
PMID:25193878
NCBI chr16:19,352,659...19,383,533
Ensembl chr16:19,351,793...19,383,756
G
Tcea1
transcription elongation factor A1
decreases expression
ISO
quercitrin results in decreased expression of TCEA1 mRNA
CTD
PMID:25193878
NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745
G
Tcea2
transcription elongation factor A2
decreases expression
ISO
quercitrin results in decreased expression of TCEA2 mRNA
CTD
PMID:25193878
NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116
G
Tcf7
transcription factor 7
affects expression
ISO
quercitrin affects the expression of TCF7 mRNA
CTD
PMID:25193878
NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
G
Tfb1m
transcription factor B1, mitochondrial
decreases expression
ISO
quercitrin results in decreased expression of TFB1M mRNA
CTD
PMID:25193878
NCBI chr 1:44,115,240...44,161,737
Ensembl chr 1:44,119,166...44,161,709
G
Tgif2
TGFB-induced factor homeobox 2
decreases expression
ISO
quercitrin results in decreased expression of TGIF2 mRNA
CTD
PMID:25193878
NCBI chr 3:145,333,152...145,348,599
Ensembl chr 3:145,333,418...145,348,596
G
Tgm2
transglutaminase 2
decreases expression
ISO
quercitrin results in decreased expression of TGM2 mRNA
CTD
PMID:25193878
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
G
Thsd1
thrombospondin type 1 domain containing 1
increases expression
ISO
quercitrin results in increased expression of THSD1 mRNA
CTD
PMID:25193878
NCBI chr16:69,771,408...69,804,844
Ensembl chr16:69,771,408...69,801,504
G
Tmem160
transmembrane protein 160
decreases expression
ISO
quercitrin results in decreased expression of TMEM160 mRNA
CTD
PMID:25193878
NCBI chr 1:77,164,448...77,167,156
Ensembl chr 1:77,164,448...77,167,156
G
Tmem208
transmembrane protein 208
decreases expression
ISO
quercitrin results in decreased expression of TMEM208 mRNA
CTD
PMID:25193878
NCBI chr19:33,203,587...33,206,287
Ensembl chr19:33,203,587...33,212,183
G
Tmem242
transmembrane protein 242
increases expression
ISO
quercitrin results in increased expression of TMEM242 mRNA
CTD
PMID:25193878
NCBI chr 1:45,992,713...46,019,684
Ensembl chr 1:45,992,713...46,019,626
G
Tmx1
thioredoxin-related transmembrane protein 1
decreases expression
ISO
quercitrin results in decreased expression of TMX1 mRNA
CTD
PMID:25193878
NCBI chr 6:88,960,724...88,971,301
Ensembl chr 6:88,960,695...88,971,301
G
Tnf
tumor necrosis factor
multiple interactions
EXP
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:23138875
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf1a
TNF receptor superfamily member 1A
decreases expression
ISO
quercitrin results in decreased expression of TNFRSF1A mRNA
CTD
PMID:25193878
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tnfrsf1b
TNF receptor superfamily member 1B
decreases expression
ISO
quercitrin results in decreased expression of TNFRSF1B mRNA
CTD
PMID:25193878
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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Tp63
tumor protein p63
decreases expression
ISO
quercitrin results in decreased expression of TP63 mRNA
CTD
PMID:25193878
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
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Tspan14
tetraspanin 14
decreases expression
ISO
quercitrin results in decreased expression of TSPAN14 mRNA
CTD
PMID:25193878
NCBI chr16:16,784,242...16,841,368
Ensembl chr16:16,783,234...16,841,400
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U2af2
U2 small nuclear RNA auxiliary factor 2
increases expression
ISO
quercitrin results in increased expression of U2AF2 mRNA
CTD
PMID:25193878
NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492
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Uts2r
urotensin 2 receptor
increases expression
ISO
quercitrin results in increased expression of UTS2R mRNA
CTD
PMID:25193878
NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252
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Vom1r51
vomeronasal 1 receptor 51
increases expression
ISO
quercitrin results in increased expression of VN1R1 mRNA
CTD
PMID:25193878
G
Vwa8
von Willebrand factor A domain containing 8
decreases expression
ISO
quercitrin results in decreased expression of VWA8 mRNA
CTD
PMID:25193878
NCBI chr15:54,252,703...54,576,871
Ensembl chr15:54,252,584...54,576,870
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Was
WASP actin nucleation promoting factor
affects expression
ISO
quercitrin affects the expression of WAS mRNA
CTD
PMID:25193878
NCBI chr X:14,405,096...14,413,850
Ensembl chr X:14,405,124...14,413,849
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Wdr33
WD repeat domain 33
decreases expression
ISO
quercitrin results in decreased expression of WDR33 mRNA
CTD
PMID:25193878
NCBI chr18:23,432,233...23,535,460
Ensembl chr18:23,432,191...23,468,597
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Wwox
WW domain-containing oxidoreductase
decreases expression
ISO
quercitrin results in decreased expression of WWOX mRNA
CTD
PMID:25193878
NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
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Zan
zonadhesin
increases expression
ISO
quercitrin results in increased expression of ZAN mRNA
CTD
PMID:25193878
NCBI chr12:19,215,018...19,322,789
Ensembl chr12:19,215,102...19,271,240
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Zcchc14
zinc finger CCHC-type containing 14
increases expression
ISO
quercitrin results in increased expression of ZCCHC14 mRNA
CTD
PMID:25193878
NCBI chr19:49,674,185...49,718,004
Ensembl chr19:49,674,195...49,718,029
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
rocaglamide results in increased expression of BAX protein
CTD
PMID:31433962
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
rocaglamide results in decreased expression of BCL2 protein
CTD
PMID:31433962
NCBI chr13:22,689,783...22,853,920
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
decreases expression
ISO
rocaglamide results in decreased expression of CHUK protein
CTD
PMID:31433962
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Cycs
cytochrome c, somatic
increases expression
ISO
rocaglamide results in increased expression of CYCS protein
CTD
PMID:31433962
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
decreases expression
ISO
rocaglamide results in decreased expression of IKBKB protein
CTD
PMID:31433962
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Nfkb1
nuclear factor kappa B subunit 1
decreases expression
ISO
rocaglamide results in decreased expression of NFKB1 protein
CTD
PMID:31433962
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Parp1
poly (ADP-ribose) polymerase 1
decreases expression
ISO
rocaglamide results in decreased expression of PARP1 protein
CTD
PMID:31433962
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Rela
RELA proto-oncogene, NF-kB subunit
decreases expression
ISO
rocaglamide results in decreased expression of RELA protein
CTD
PMID:31433962
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions
ISO
[Lovastatin results in decreased activity of ABCC1 protein] which results in increased susceptibility to Antimony Sodium Gluconate
CTD
PMID:18056276
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Bcl6
BCL6, transcription repressor
decreases expression
ISO
Antimony Sodium Gluconate results in decreased expression of BCL6 protein
CTD
PMID:27546522
NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
Antimony Sodium Gluconate results in decreased expression of CCL2 mRNA
CTD
PMID:20102417
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Epo
erythropoietin
decreases expression
ISO
Antimony Sodium Gluconate results in decreased expression of EPO mRNA; Antimony Sodium Gluconate results in decreased expression of EPO protein
CTD
PMID:9531339
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Icam1
intercellular adhesion molecule 1
affects response to substance
ISO
ICAM1 protein affects the susceptibility to Antimony Sodium Gluconate
CTD
PMID:11035738
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifng
interferon gamma
decreases expression multiple interactions affects response to substance
ISO
Antimony Sodium Gluconate results in decreased expression of IFNG mRNA [IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL10 mRNA; [IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL4 mRNA; [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of IL12B mRNA; [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of NOS2 mRNA; IFNG protein affects the reaction [IL10RA protein affects the susceptibility to Antimony Sodium Gluconate] IFNG protein affects the susceptibility to Antimony Sodium Gluconate [Antimony Sodium Gluconate co-treated with Amphotericin B] results in increased expression of IFNG protein
CTD
PMID:9234779 PMID:9498473 PMID:10603400 PMID:12870129 PMID:17911647 PMID:20102417 More...
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ifngr1
interferon gamma receptor 1
increases expression
ISO
Antimony Sodium Gluconate results in increased expression of IFNGR1 mRNA; Antimony Sodium Gluconate results in increased expression of IFNGR1 protein
CTD
PMID:12803856
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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Il10
interleukin 10
multiple interactions decreases expression affects response to substance
ISO
[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of IL10 protein Antimony Sodium Gluconate results in decreased expression of IL10 mRNA IL10 protein affects the susceptibility to Antimony Sodium Gluconate [IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL10 mRNA
CTD
PMID:9234779 PMID:9498473 PMID:12379707 PMID:17911647 PMID:20102417
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il10ra
interleukin 10 receptor subunit alpha
multiple interactions affects response to substance
ISO
IFNG protein affects the reaction [IL10RA protein affects the susceptibility to Antimony Sodium Gluconate]
CTD
PMID:12379707 PMID:12870129
NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
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Il12b
interleukin 12B
multiple interactions
ISO
[IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of IL12B mRNA
CTD
PMID:9234779
NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
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Il1b
interleukin 1 beta
decreases expression
ISO
Antimony Sodium Gluconate results in decreased expression of IL1B mRNA
CTD
PMID:20102417
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il4
interleukin 4
decreases expression multiple interactions affects response to substance
ISO
Antimony Sodium Gluconate results in decreased expression of IL4 mRNA [IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL4 mRNA IL4 protein affects the susceptibility to Antimony Sodium Gluconate
CTD
PMID:7960131 PMID:9234779 PMID:11069076 PMID:20102417
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Itgam
integrin subunit alpha M
increases expression
ISO
Antimony Sodium Gluconate results in increased expression of ITGAM protein
CTD
PMID:12399974
NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
[IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of NOS2 mRNA
CTD
PMID:9234779
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ptpn6
protein tyrosine phosphatase, non-receptor type 6
decreases activity
ISO
Antimony Sodium Gluconate results in decreased activity of PTPN6 protein
CTD
PMID:12399974
NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of TGFB1 protein
CTD
PMID:17911647
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
decreases expression
ISO
Antimony Sodium Gluconate results in decreased expression of TNF mRNA
CTD
PMID:20102417
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf18
TNF receptor superfamily member 18
increases response to substance
ISO
TNFRSF18 protein results in increased susceptibility to Antimony Sodium Gluconate
CTD
PMID:20139272
NCBI chr 5:166,618,461...166,622,353
Ensembl chr 5:166,618,969...166,622,353
G
Tnfrsf1a
TNF receptor superfamily member 1A
decreases expression
ISO
Antimony Sodium Gluconate results in decreased expression of TNFRSF1A protein
CTD
PMID:7844400
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
G
Tnfrsf1b
TNF receptor superfamily member 1B
decreases expression
ISO
Antimony Sodium Gluconate results in decreased expression of TNFRSF1B protein
CTD
PMID:7844400
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
CTD
PMID:16891617
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Aifm1
apoptosis inducing factor, mitochondria associated 1
multiple interactions
EXP
calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein]
CTD
PMID:29289695
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Capn1
calpain 1
multiple interactions decreases activity
ISO EXP
calpain inhibitor III inhibits the reaction [CAPN1 protein results in increased susceptibility to Cisplatin] calpain inhibitor III inhibits the reaction [Calcium results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein] calpain inhibitor III results in decreased activity of CAPN1 protein
CTD
PMID:13678654 PMID:20878076 PMID:21985864 PMID:29289695
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Capn2
calpain 2
multiple interactions
EXP
calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]
CTD
PMID:29289695
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD
PMID:16891617
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions
ISO
calpain inhibitor III inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein]
CTD
PMID:19336499
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Il1a
interleukin 1 alpha
affects localization
ISO
calpain inhibitor III affects the localization of IL1A protein
CTD
PMID:24024155
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Nefl
neurofilament light chain
multiple interactions
EXP
calpain inhibitor III inhibits the reaction [Zymosan results in increased degradation of NEFL protein]
CTD
PMID:15275793
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of NOS2 mRNA]
CTD
PMID:15316131
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Sptan1
spectrin, alpha, non-erythrocytic 1
multiple interactions
ISO EXP
calpain inhibitor III inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein] calpain inhibitor III inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]
CTD
PMID:21683092 PMID:21985864
NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
G
Tnf
tumor necrosis factor
multiple interactions
ISO
calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]
CTD
PMID:15316131
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
20056
role
20008
biological role
20007
antimicrobial agent
17793
antimicrobial drug
8738
antiprotozoal drug
7019
antileishmanial agent
339
(-)-coronaridine +
0
(S)-1'-methylbutyl caffeate
0
(S)-1'-methyloctyl caffeate
0
14-norpseurotin A
0
2,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone
0
20-epi-isoiguesterinol
0
22alpha-methoxy-3-beta-O-\{beta-D-Xylp(1->3)-[beta-D-Glcp-(1->2)]-beta-D-Glcp-(1->4)-beta-D-Glcp\}-furost-3beta,26-diol 26-O-beta-D-Glcp
0
3-geranyl-2,4,6-trihydroxybenzophenone
0
5,7,3',4'-tetrahydroxy-2'-(3,3-dimethylallyl)isoflavone
0
5-O-methyl embelin
0
7'-O-demethylisocephaeline
0
GNF6702
0
Z-Val-Phe-H
11
acivicin
2
acteoside
44
ancistrotanzanine A
0
ancistrotanzanine B
0
ascaridole
2
ciliatamide A
0
ciliatamide B
0
combretol
0
dehydroemetine
0
dihydrobetulinic acid
0
flavokawain B
19
geranylgeraniol +
25
grandiflorenic acid
0
guttiferone F
0
hookerianamide J
0
hookerianamide K
0
isoiguesterin
0
kavapyrone
0
klugine
0
methyl 3,4-dihydroxy-5-(3'-methyl-2'-butenyl)benzoate
0
monastrol
0
physalin F
0
quercitrin
243
ravuconazole
0
rocaglamide
8
rohitukine
0
sodium stibogluconate
20
tafenoquine
0
Path 2
CHEBI ontology
20056
role
20008
application
19745
pharmaceutical
19618
drug
19618
antiinfective agent
14207
antiparasitic agent
9336
antiprotozoal drug
7019
antileishmanial agent
339
(-)-coronaridine +
0
(S)-1'-methylbutyl caffeate
0
(S)-1'-methyloctyl caffeate
0
14-norpseurotin A
0
2,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone
0
20-epi-isoiguesterinol
0
22alpha-methoxy-3-beta-O-\{beta-D-Xylp(1->3)-[beta-D-Glcp-(1->2)]-beta-D-Glcp-(1->4)-beta-D-Glcp\}-furost-3beta,26-diol 26-O-beta-D-Glcp
0
3-geranyl-2,4,6-trihydroxybenzophenone
0
5,7,3',4'-tetrahydroxy-2'-(3,3-dimethylallyl)isoflavone
0
5-O-methyl embelin
0
7'-O-demethylisocephaeline
0
GNF6702
0
Z-Val-Phe-H
11
acivicin
2
acteoside
44
ancistrotanzanine A
0
ancistrotanzanine B
0
ascaridole
2
ciliatamide A
0
ciliatamide B
0
combretol
0
dehydroemetine
0
dihydrobetulinic acid
0
flavokawain B
19
geranylgeraniol +
25
grandiflorenic acid
0
guttiferone F
0
hookerianamide J
0
hookerianamide K
0
isoiguesterin
0
kavapyrone
0
klugine
0
methyl 3,4-dihydroxy-5-(3'-methyl-2'-butenyl)benzoate
0
monastrol
0
physalin F
0
quercitrin
243
ravuconazole
0
rocaglamide
8
rohitukine
0
sodium stibogluconate
20
tafenoquine
0