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ONTOLOGY REPORT - ANNOTATIONS


Term:GW 7647
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Accession:CHEBI:70778 term browser browse the term
Definition:A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.
Synonyms:exact_synonym: 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid
 related_synonym: 2-((4-(2-(1-cyclohexylbutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid;   2-(4-(2-(1-(4-cyclohexylbutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid;   2-(4-(2-(1-(cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid;   2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid;   Formula=C29H46N2O3S;   GW7647;   InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33);   InChIKey=PKNYXWMTHFMHKD-UHFFFAOYSA-N;   SMILES=CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O
 xref: CAS:265129-71-3 "ChemIDplus";   CAS:265129-71-3 "KEGG COMPOUND";   KEGG:C15622;   LINCS:LSM-4172
 xref_mesh: MESH:C453899
 xref: PMID:14654352 "Europe PMC";   PMID:16839165 "Europe PMC";   PMID:17434479 "Europe PMC";   PMID:21443859 "Europe PMC";   PMID:21742490 "Europe PMC";   PMID:22465071 "Europe PMC";   PMID:23008696 "Europe PMC";   Reaxys:8955332 "Reaxys"


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GW 7647 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa1a acetyl-CoA acyltransferase 1A JBrowse link 8 128,027,880 128,036,471 RGD:6480464
G Acaa2 acetyl-CoA acyltransferase 2 JBrowse link 18 70,733,872 70,762,395 RGD:6480464
G Acadl acyl-CoA dehydrogenase, long chain JBrowse link 9 73,833,368 73,871,857 RGD:6480464
G Acadm acyl-CoA dehydrogenase medium chain JBrowse link 2 260,124,418 260,148,589 RGD:6480464
G Acads acyl-CoA dehydrogenase short chain JBrowse link 12 47,254,503 47,263,747 RGD:6480464
G Acadvl acyl-CoA dehydrogenase, very long chain JBrowse link 10 56,619,321 56,624,468 RGD:6480464
G Acot1 acyl-CoA thioesterase 1 JBrowse link 6 107,485,088 107,493,082 RGD:6480464
G Acot12 acyl-CoA thioesterase 12 JBrowse link 2 20,857,056 20,901,656 RGD:6480464
G Acot4 acyl-CoA thioesterase 4 JBrowse link 6 107,517,668 107,522,952 RGD:6480464
G Acox1 acyl-CoA oxidase 1 JBrowse link 10 104,724,534 104,748,003 RGD:6480464
G Acox2 acyl-CoA oxidase 2 JBrowse link 15 18,449,304 18,481,472 RGD:6480464
G Acsl3 acyl-CoA synthetase long-chain family member 3 JBrowse link 9 84,569,601 84,593,565 RGD:6480464
G Acsl4 acyl-CoA synthetase long-chain family member 4 JBrowse link X 113,596,247 113,660,024 RGD:6480464
G Acsl5 acyl-CoA synthetase long-chain family member 5 JBrowse link 1 276,240,703 276,290,012 RGD:6480464
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 JBrowse link 20 4,369,399 4,378,272 RGD:6480464
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 JBrowse link 3 4,044,741 4,055,384 RGD:6480464
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:6480464
G Apoa5 apolipoprotein A5 JBrowse link 8 50,559,079 50,561,720 RGD:6480464
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:6480464
G Apoc4 apolipoprotein C4 JBrowse link 1 80,595,339 80,599,525 RGD:6480464
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6480464
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 JBrowse link 10 50,439,778 50,563,920 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1A JBrowse link 1 218,568,157 218,629,679 RGD:6480464
G Cpt1b carnitine palmitoyltransferase 1B JBrowse link 7 130,395,211 130,404,731 RGD:6480464
G Cpt2 carnitine palmitoyltransferase 2 JBrowse link 5 127,505,646 127,523,016 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6480464
G Dgat2 diacylglycerol O-acyltransferase 2 JBrowse link 1 164,113,459 164,143,818 RGD:6480464
G Dhdds dehydrodolichyl diphosphate synthase subunit JBrowse link 5 152,200,681 152,227,669 RGD:6480464
G Dio2 iodothyronine deiodinase 2 JBrowse link 6 114,475,156 114,489,443 RGD:6480464
G Ech1 enoyl-CoA hydratase 1 JBrowse link 1 87,009,798 87,015,996 RGD:6480464
G Echs1 enoyl-CoA hydratase, short chain 1 JBrowse link 1 212,570,213 212,579,040 RGD:6480464
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase JBrowse link 11 82,945,104 82,978,364 RGD:6480464
G Elovl1 ELOVL fatty acid elongase 1 JBrowse link 5 137,255,868 137,260,486 RGD:6480464
G Elovl5 ELOVL fatty acid elongase 5 JBrowse link 8 85,220,941 85,287,449 RGD:6480464
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:6480464
G Fa2h fatty acid 2-hydroxylase JBrowse link 19 43,545,380 43,596,788 RGD:6480464
G Fabp1 fatty acid binding protein 1 JBrowse link 4 99,063,181 99,066,957 RGD:6480464
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fgf21 fibroblast growth factor 21 JBrowse link 1 101,595,579 101,596,822 RGD:6480464
G Fnta farnesyltransferase, CAAX box, alpha JBrowse link 16 70,834,957 70,854,724 RGD:6480464
G Gpat3 glycerol-3-phosphate acyltransferase 3 JBrowse link 14 10,343,287 10,396,565 RGD:6480464
G Hadh hydroxyacyl-CoA dehydrogenase JBrowse link 2 236,353,445 236,395,067 RGD:6480464
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha JBrowse link 6 27,589,840 27,628,921 RGD:6480464
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta JBrowse link 6 27,555,408 27,589,539 RGD:6480464
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:6480464
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 JBrowse link 2 200,452,623 200,480,785 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Mecr mitochondrial trans-2-enoyl-CoA reductase JBrowse link 5 150,001,281 150,027,407 RGD:6480464
G Mlxipl MLX interacting protein-like JBrowse link 12 24,590,645 24,619,639 RGD:6480464
G Mttp microsomal triglyceride transfer protein JBrowse link 2 243,366,181 243,407,608 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6480464
G Pecr peroxisomal trans-2-enoyl-CoA reductase JBrowse link 9 79,601,937 79,630,547 RGD:6480464
G Plin2 perilipin 2 JBrowse link 5 104,984,413 105,010,863 RGD:6480464
G Plpp6 phospholipid phosphatase 6 JBrowse link 1 247,084,228 247,087,080 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ppard peroxisome proliferator-activated receptor delta JBrowse link 20 7,818,289 7,883,482 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6480464
G Slc25a20 solute carrier family 25 member 20 JBrowse link 8 117,455,308 117,476,762 RGD:6480464
G Slc27a1 solute carrier family 27 member 1 JBrowse link 16 19,997,823 20,016,193 RGD:6480464
G Slc27a2 solute carrier family 27 member 2 JBrowse link 3 119,014,620 119,052,531 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Ucp3 uncoupling protein 3 JBrowse link 1 165,482,912 165,495,895 RGD:6480464
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        pharmacological role 18680
          agonist 18011
            PPARalpha agonist 3096
              GW 7647 76
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        carboacyl group 16941
                                          univalent carboacyl group 16941
                                            carbamoyl group 16621
                                              carboxamide 16621
                                                monocarboxylic acid amide 13181
                                                  urea 4932
                                                    ureas 4929
                                                      GW 7647 76
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.