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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GW 7647
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Accession:CHEBI:70778 term browser browse the term
Definition:A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.
Synonyms:exact_synonym: 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid
 related_synonym: 2-((4-(2-(1-cyclohexylbutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid;   2-(4-(2-(1-(4-cyclohexylbutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid;   2-(4-(2-(1-(cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid;   2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid;   Formula=C29H46N2O3S;   GW7647;   InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33);   InChIKey=PKNYXWMTHFMHKD-UHFFFAOYSA-N;   SMILES=CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O
 xref: CAS:265129-71-3;   KEGG:C15622;   LINCS:LSM-4172
 xref_mesh: MESH:C453899
 xref: PMID:14654352;   PMID:16839165;   PMID:17434479;   PMID:21443859;   PMID:21742490;   PMID:22465071;   PMID:23008696;   Reaxys:8955332


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GW 7647 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases expression
ISO
EXP
GW 7647 results in increased expression of ABCB1 mRNA
GW 7647 results in decreased expression of ABCB1A mRNA
CTD PMID:31628012 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression
multiple interactions
ISO GW 7647 results in increased expression of ACAA1 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACAA1 mRNA
CTD PMID:30611723 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression
multiple interactions
ISO GW 7647 results in increased expression of ACAA2 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACAA2 mRNA
CTD PMID:30611723 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of ACADL mRNA CTD PMID:30611723 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO
EXP
GW 7647 results in increased expression of ACADM mRNA CTD PMID:30611723, PMID:31628012 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of ACADS mRNA
GW 7647 results in increased expression of ACADS mRNA
CTD PMID:30611723 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain increases expression
multiple interactions
ISO GW 7647 results in increased expression of ACADVL mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACADVL mRNA
CTD PMID:30611723 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO GW 7647 results in increased expression of ACOT1 mRNA CTD PMID:30611723 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acot12 acyl-CoA thioesterase 12 multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of ACOT12 mRNA
GW 7647 results in increased expression of ACOT12 mRNA
CTD PMID:30611723 NCBI chr 2:20,857,056...20,901,656
Ensembl chr 2:20,857,202...20,901,659
JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression
multiple interactions
ISO GW 7647 results in increased expression of ACOT4 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACOT4 mRNA
CTD PMID:30611723 NCBI chr 6:107,517,668...107,522,952
Ensembl chr 6:107,517,668...107,522,952
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
multiple interactions
ISO GW 7647 results in increased expression of ACOX1 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA
GW 6471 inhibits the reaction [GW 7647 results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [GW 7647 results in increased expression of ACOX1 mRNA]
CTD PMID:21324916, PMID:23014847, PMID:30611723, PMID:31437187 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acox2 acyl-CoA oxidase 2 multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of ACOX2 mRNA
GW 7647 results in increased expression of ACOX2 mRNA
CTD PMID:30611723 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression EXP GW 7647 results in increased expression of ACSL1 mRNA CTD PMID:31628012 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression ISO GW 7647 results in increased expression of ACSL3 mRNA CTD PMID:30611723 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression
multiple interactions
ISO GW 7647 results in increased expression of ACSL4 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACSL4 mRNA
CTD PMID:30611723 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions
decreases expression
increases expression
ISO
EXP
[GW 7647 co-treated with Oleic Acid] results in increased expression of ACSL5 mRNA
GW 7647 results in decreased expression of ACSL5 mRNA
GW 7647 results in increased expression of ACSL5 mRNA
CTD PMID:30611723, PMID:31628012 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO GW 6471 inhibits the reaction [[GW 7647 co-treated with PPARA protein] results in increased expression of ADIPOQ mRNA] CTD PMID:21324916 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 increases expression ISO GW 7647 results in increased expression of AGPAT1 mRNA CTD PMID:30611723 NCBI chr20:4,369,399...4,378,272
Ensembl chr20:4,369,178...4,378,269
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of AGPAT2 mRNA
GW 7647 results in increased expression of AGPAT2 mRNA
CTD PMID:30611723 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806
JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO GW 7647 results in increased expression of APOA1 mRNA; GW 7647 results in increased expression of APOA1 protein CTD PMID:19445040, PMID:31676336 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa5 apolipoprotein A5 increases expression
multiple interactions
ISO GW 7647 results in increased expression of APOA5 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of APOA5 mRNA
CTD PMID:30611723 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of APOB mRNA CTD PMID:30611723 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoc4 apolipoprotein C4 decreases expression
multiple interactions
ISO GW 7647 results in decreased expression of APOC4 mRNA
[GW 7647 co-treated with Oleic Acid] results in decreased expression of APOC4 mRNA
CTD PMID:30611723 NCBI chr 1:80,595,339...80,599,525
Ensembl chr 1:80,595,326...80,599,572
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of APOE mRNA CTD PMID:30611723 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression
increases expression
EXP
ISO
GW 7647 results in decreased expression of AVPR1A mRNA
GW 7647 results in increased expression of AVPR1A mRNA
CTD PMID:31628012 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO GW 7647 inhibits the reaction [IFNG results in increased expression of CCL2 mRNA] CTD PMID:21268089 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of CD36 mRNA
GW 7647 results in increased expression of CD36 mRNA
CTD PMID:30611723 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 increases expression ISO GW 7647 results in increased expression of COX10 mRNA CTD PMID:30611723 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression
multiple interactions
EXP
ISO
GW 7647 results in increased expression of CPT1A mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of CPT1A mRNA
CTD PMID:19631232, PMID:27226639, PMID:30611723, PMID:31676336 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions
increases expression
ISO GW 6471 inhibits the reaction [GW 7647 results in increased expression of CPT1B mRNA]; GW 7647 promotes the reaction [PPARA protein binds to CPT1B promoter]; PPARA protein promotes the reaction [GW 7647 results in increased expression of CPT1B mRNA] CTD PMID:21324916 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of CPT2 mRNA
GW 7647 results in increased expression of CPT2 mRNA
CTD PMID:30611723 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP GW 7647 promotes the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:19631232 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of CYP2B6 mRNA
GW 7647 results in increased expression of CYP2B6 mRNA
CTD PMID:30611723, PMID:31676336 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP GW 7647 results in increased expression of CYP4A1 mRNA CTD PMID:23315828 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 increases expression ISO GW 7647 results in increased expression of DGAT2 mRNA CTD PMID:30611723 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dhdds dehydrodolichyl diphosphate synthase subunit multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of DHDDS mRNA
GW 7647 results in increased expression of DHDDS mRNA
CTD PMID:30611723 NCBI chr 5:152,200,681...152,227,669
Ensembl chr 5:152,199,584...152,227,677
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity
multiple interactions
ISO GW 7647 results in increased activity of DIO2 protein
PPARG protein promotes the reaction [GW 7647 results in increased activity of DIO2 protein]
CTD PMID:19036883 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G E2f5 E2F transcription factor 5 decreases expression EXP GW 7647 results in decreased expression of E2F5 mRNA CTD PMID:31628012 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO GW 7647 results in increased expression of ECH1 mRNA CTD PMID:30611723 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 increases expression ISO GW 7647 results in increased expression of ECHS1 mRNA CTD PMID:30611723 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO GW 7647 results in increased expression of EHHADH mRNA CTD PMID:30611723 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 increases expression ISO GW 7647 results in increased expression of ELOVL1 mRNA CTD PMID:30611723 NCBI chr 5:137,255,868...137,260,486
Ensembl chr 5:137,255,908...137,260,483
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 increases expression ISO GW 7647 results in increased expression of ELOVL5 mRNA CTD PMID:30611723 NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases activity ISO GW 7647 results in decreased activity of EPHX2 protein CTD PMID:15798002 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression EXP GW 7647 results in decreased expression of ETS1 mRNA CTD PMID:31628012 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Fa2h fatty acid 2-hydroxylase increases expression ISO GW 7647 results in increased expression of FA2H mRNA CTD PMID:23535410 NCBI chr19:43,545,380...43,596,788
Ensembl chr19:43,545,378...43,596,801
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions
ISO
EXP
GW 7647 results in increased expression of FABP1 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of FABP1 mRNA
CTD PMID:30611723, PMID:31628012, PMID:31676336 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO GW 6471 inhibits the reaction [PPARA protein promotes the reaction [GW 7647 results in increased expression of FABP4 mRNA]]; GW 7647 promotes the reaction [PPARA protein binds to FABP4 promoter]; PPARA protein promotes the reaction [GW 7647 results in increased expression of FABP4 mRNA] CTD PMID:21324916, PMID:31437187 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of FASN mRNA
GW 7647 results in increased expression of FASN mRNA
CTD PMID:30611723, PMID:31437187 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions
increases expression
ISO indolo(3,2-b)carbazole inhibits the reaction [GW 7647 results in increased expression of FGF21 mRNA] CTD PMID:27226639 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Fhl3 four and a half LIM domains 3 decreases expression EXP GW 7647 results in decreased expression of FHL3 mRNA CTD PMID:31628012 NCBI chr 5:142,688,962...142,696,330
Ensembl chr 5:142,689,026...142,696,383
JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha increases expression ISO GW 7647 results in increased expression of FNTA mRNA CTD PMID:30611723 NCBI chr16:70,834,957...70,854,724
Ensembl chr16:70,834,957...70,854,724
JBrowse link
G Gng12 G protein subunit gamma 12 increases expression
decreases expression
ISO
EXP
GW 7647 results in increased expression of GNG12 mRNA
GW 7647 results in decreased expression of GNG12 mRNA
CTD PMID:31628012 NCBI chr 4:97,634,925...97,763,478
Ensembl chr 4:97,657,671...97,760,102
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of GPAT3 mRNA
GW 7647 results in increased expression of GPAT3 mRNA
CTD PMID:30611723 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP GW 7647 results in increased expression of GPT protein CTD PMID:31628012 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
decreases expression
ISO
EXP
GW 7647 results in increased expression of GPX3 mRNA
GW 7647 results in decreased expression of GPX3 mRNA
CTD PMID:31628012 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression
decreases expression
EXP
ISO
GW 7647 results in increased expression of GSTA1 mRNA
GW 7647 results in decreased expression of GSTA1 mRNA
CTD PMID:31628012 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression ISO GW 7647 results in increased expression of HADH mRNA CTD PMID:30611723 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
multiple interactions
ISO GW 7647 results in increased expression of HADHA mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of HADHA mRNA; GW 7647 promotes the reaction [Oleic Acid results in increased expression of HADHA mRNA]
CTD PMID:30611723 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of HADHB mRNA; GW 7647 promotes the reaction [Oleic Acid results in increased expression of HADHB mRNA]; Oleic Acid promotes the reaction [GW 7647 results in increased expression of HADHB mRNA] CTD PMID:30611723 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression EXP GW 7647 results in decreased expression of HES6 mRNA CTD PMID:31628012 NCBI chr 9:98,549,698...98,551,438
Ensembl chr 9:98,549,705...98,551,438
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of HMGCR mRNA CTD PMID:30611723 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP
ISO
GW 7647 results in increased expression of HMGCS2 mRNA CTD PMID:23315828, PMID:31437187, PMID:31628012, PMID:31676336 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Ifng interferon gamma multiple interactions ISO GW 7647 inhibits the reaction [IFNG results in increased expression of CCL2 mRNA] CTD PMID:21268089 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of IL6 mRNA
GW 7647 results in decreased expression of IL6 mRNA
CTD PMID:30611723 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]
PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]]
CTD PMID:21324916 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO GW 7647 results in increased expression of INSIG1 mRNA CTD PMID:31437187 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Lpl lipoprotein lipase increases expression ISO GW 7647 results in increased expression of LPL mRNA CTD PMID:31437187 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase increases expression ISO GW 7647 results in increased expression of MECR mRNA CTD PMID:30611723 NCBI chr 5:150,001,281...150,027,407
Ensembl chr 5:150,001,281...150,027,049
JBrowse link
G Mid1 midline 1 decreases expression
increases expression
EXP
ISO
GW 7647 results in decreased expression of MID1 mRNA
GW 7647 results in increased expression of MID1 mRNA
CTD PMID:31628012 NCBI chr  X:25,458,782...25,839,941
Ensembl chr  X:25,458,771...25,628,272
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of MLXIPL mRNA CTD PMID:30611723 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of MTTP mRNA CTD PMID:30611723 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Mxd4 Max dimerization protein 4 decreases expression EXP GW 7647 results in decreased expression of MXD4 mRNA CTD PMID:31628012 NCBI chr14:81,819,415...81,833,456
Ensembl chr14:81,819,415...81,833,456
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO GW 7647 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; GW 7647 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; lactacystin inhibits the reaction [GW 7647 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:17891158 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
decreases expression
ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of NR0B2 mRNA
GW 7647 results in decreased expression of NR0B2 mRNA
CTD PMID:30611723 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO GW 7647 results in decreased expression of NR1H4 mRNA CTD PMID:30611723 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
multiple interactions
EXP
ISO
GW 7647 results in increased expression of NR1I3 mRNA
[GW 7647 co-treated with Oleic Acid] results in decreased expression of NR1I3 mRNA
GW 7647 promotes the reaction [Phenobarbital results in increased expression of NR1I3 mRNA]
CTD PMID:19631232, PMID:30611723 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nrip3 nuclear receptor interacting protein 3 decreases expression EXP GW 7647 results in decreased expression of NRIP3 mRNA CTD PMID:31628012 NCBI chr 1:174,385,424...174,411,141
Ensembl chr 1:174,385,424...174,411,141
JBrowse link
G Onecut1 one cut homeobox 1 decreases expression EXP GW 7647 results in decreased expression of ONECUT1 mRNA CTD PMID:31628012 NCBI chr 8:81,765,779...81,799,894
Ensembl chr 8:81,766,041...81,793,577
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions
ISO GW 7647 results in increased expression of PCK1 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of PCK1 mRNA
CTD PMID:30611723 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO GW 7647 results in increased expression of PDK4 mRNA CTD PMID:31437187 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of PECR mRNA CTD PMID:30611723 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 decreases expression EXP GW 7647 results in decreased expression of PIAS3 mRNA CTD PMID:31628012 NCBI chr 2:198,821,377...198,831,533
Ensembl chr 2:198,823,366...198,836,372
JBrowse link
G Pla1a phospholipase A1 member A decreases expression
increases expression
EXP
ISO
GW 7647 results in decreased expression of PLA1A mRNA
GW 7647 results in increased expression of PLA1A mRNA
CTD PMID:31628012 NCBI chr11:64,882,024...64,919,714
Ensembl chr11:64,882,288...64,919,579
JBrowse link
G Pla2g15 phospholipase A2, group XV decreases expression EXP GW 7647 results in decreased expression of PLA2G15 mRNA CTD PMID:31628012 NCBI chr19:38,129,666...38,146,958
Ensembl chr19:38,129,584...38,146,956
JBrowse link
G Plin2 perilipin 2 multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in increased expression of PLIN2 mRNA
GW 7647 results in increased expression of PLIN2 mRNA
CTD PMID:30611723, PMID:31676336 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Plpp6 phospholipid phosphatase 6 multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of PLPP6 mRNA CTD PMID:30611723 NCBI chr 1:247,084,228...247,087,080
Ensembl chr 1:247,084,228...247,087,077
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects binding
increases expression
increases activity
ISO
EXP
Acetaldehyde inhibits the reaction [GW 7647 results in increased activity of PPARA protein]; Ethanol inhibits the reaction [GW 7647 results in increased activity of PPARA protein]; GW 7647 binds to and results in increased activity of PPARA protein; norathyriol inhibits the reaction [GW 7647 results in increased activity of PPARA protein]; Quercetin inhibits the reaction [GW 7647 results in increased activity of PPARA protein]
GW 7647 binds to PPARA protein
[GW 7647 results in increased activity of PPARA protein] promotes the reaction [Phenobarbital results in increased degradation of Triiodothyronine]; GW 7647 binds to and results in increased activity of PPARA protein
GW 7647 results in increased expression of PPARA mRNA
[GW 7647 binds to and results in increased activity of PPARA protein] affects the reaction [Glucose affects the abundance of Calcium]; [GW 7647 binds to and results in increased activity of PPARA protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; [GW 7647 co-treated with PPARA protein] results in increased expression of PPARA mRNA; [PPARA protein co-treated with GW 7647] results in increased expression of PPARG mRNA; GW 6471 inhibits the reaction [[GW 7647 co-treated with PPARA protein] results in increased expression of ADIPOQ mRNA]; GW 6471 inhibits the reaction [[GW 7647 co-treated with PPARA protein] results in increased expression of PPARA mRNA]; GW 6471 inhibits the reaction [PPARA protein promotes the reaction [GW 7647 results in increased expression of FABP4 mRNA]]; GW 7647 binds to and results in increased activity of PPARA protein; GW 7647 promotes the reaction [PPARA protein binds to CPT1B promoter]; GW 7647 promotes the reaction [PPARA protein binds to FABP4 promoter]; PPARA protein inhibits the reaction [GW 7647 results in increased abundance of Triglycerides]; PPARA protein promotes the reaction [[GW 7647 results in increased oxidation of Palmitic Acid] which results in increased abundance of Carbon Dioxide]; PPARA protein promotes the reaction [[GW 7647 results in increased oxidation of Palmitic Acid] which results in increased abundance of Fatty Acids metabolite]; PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]]; PPARA protein promotes the reaction [GW 7647 results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [GW 7647 results in increased expression of CPT1B mRNA]; PPARA protein promotes the reaction [GW 7647 results in increased expression of FABP4 mRNA]; PPARA protein promotes the reaction [GW 7647 results in increased expression of UCP3 mRNA]
CTD PMID:17891158, PMID:18003597, PMID:18393431, PMID:19017711, PMID:19445040, PMID:19631232, PMID:20143881, PMID:20307981, PMID:20516370, PMID:21218783, PMID:21324916, PMID:23391484, PMID:24489787, PMID:28571686, PMID:29421333, PMID:32407875 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases activity ISO GW 7647 results in increased activity of PPARD protein CTD PMID:20143881 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases activity
ISO GW 7647 binds to and results in increased activity of PPARG protein; PPARG protein promotes the reaction [GW 7647 results in increased activity of DIO2 protein]
[PPARA protein co-treated with GW 7647] results in increased expression of PPARG mRNA
GW 7647 results in increased activity of PPARG protein
CTD PMID:19036883, PMID:20143881, PMID:21324916 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K decreases expression ISO
EXP
GW 7647 results in decreased expression of PTPRK mRNA CTD PMID:31628012 NCBI chr 1:17,445,052...18,058,266
Ensembl chr 1:17,446,417...18,058,055
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression
ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of SCD mRNA
GW 7647 results in increased expression of SCD mRNA
CTD PMID:30611723, PMID:31437187 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sec16b SEC16 homolog B, endoplasmic reticulum export factor increases expression
decreases expression
ISO
EXP
GW 7647 results in increased expression of SEC16B mRNA
GW 7647 results in decreased expression of SEC16B mRNA
CTD PMID:31628012 NCBI chr13:75,153,074...75,216,941
Ensembl chr13:75,175,254...75,216,941
JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression
multiple interactions
ISO GW 7647 results in increased expression of SLC25A20 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of SLC25A20 mRNA
CTD PMID:30611723 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of SLC27A1 mRNA CTD PMID:30611723 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression
multiple interactions
ISO GW 7647 results in increased expression of SLC27A2 mRNA
[GW 7647 co-treated with Oleic Acid] results in increased expression of SLC27A2 mRNA
CTD PMID:30611723 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Spns2 sphingolipid transporter 2 decreases expression
increases expression
EXP
ISO
GW 7647 results in decreased expression of SPNS2 mRNA
GW 7647 results in increased expression of SPNS2 mRNA
CTD PMID:31628012 NCBI chr10:59,010,428...59,049,482
Ensembl chr10:59,010,428...59,049,482
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [GW 7647 co-treated with Oleic Acid] results in decreased expression of SREBF1 mRNA CTD PMID:30611723 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tbx15 T-box transcription factor 15 decreases expression EXP GW 7647 results in decreased expression of TBX15 mRNA CTD PMID:31628012 NCBI chr 2:201,289,042...201,390,752
Ensembl chr 2:201,289,357...201,390,745
JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions
increases expression
ISO PPARA protein promotes the reaction [GW 7647 results in increased expression of UCP3 mRNA] CTD PMID:21324916 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression
multiple interactions
EXP GW 7647 results in increased expression of UGT1A3 mRNA
GW 7647 promotes the reaction [Phenobarbital results in increased expression of UGT1A3 mRNA]
CTD PMID:19631232 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          agonist 18191
            PPARalpha agonist 3105
              GW 7647 101
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  urea 4984
                                                    ureas 4982
                                                      GW 7647 101
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.