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ONTOLOGY REPORT - ANNOTATIONS


Term:dabigatran
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Accession:CHEBI:70752 term browser browse the term
Definition:An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-beta-alanine. The active metabolite of the prodrug dabigatran etexilate, it acts as an anticoagulant which is used for the prevention of stroke and systemic embolism.
Synonyms:related_synonym: Formula=C25H25N7O3;   InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34);   InChIKey=YBSJFWOBGCMAKL-UHFFFAOYSA-N;   SMILES=Cn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)C(=O)N(CCC(O)=O)c1ccccn1
 xref: CAS:211914-51-1 "KEGG DRUG";   KEGG:D09707
 xref_mesh: MESH:D000069604
 xref: PMID:21956605 "Europe PMC";   PMID:22215856 "Europe PMC";   PMID:22227958 "Europe PMC";   PMID:22314599 "Europe PMC";   PMID:22378612 "Europe PMC";   PMID:22411291 "Europe PMC";   PMID:22413715 "Europe PMC";   PMID:22431533 "Europe PMC";   PMID:22458575 "Europe PMC";   PMID:22494098 "Europe PMC";   PMID:22595629 "Europe PMC";   PMID:22612026 "Europe PMC";   PMID:22645678 "Europe PMC";   PMID:22700854 "Europe PMC";   PMID:22722043 "Europe PMC";   PMID:22740145 "Europe PMC";   PMID:22786838 "Europe PMC";   PMID:22834159 "Europe PMC";   PMID:22854367 "Europe PMC";   PMID:23020832 "Europe PMC";   PMID:23476049 "Europe PMC";   Patent:US2006222640;   Patent:US2008015176;   Patent:US6087380;   Patent:WO2004014894;   Patent:WO2006004575;   Patent:WO2006103206;   Patent:WO2008009638;   Patent:WO2008009639;   Reaxys:9168207 "Reaxys";   Wikipedia:Dabigatran


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dabigatran term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:6480464
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:6480464
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Mertk MER proto-oncogene, tyrosine kinase JBrowse link 3 121,235,230 121,340,932 RGD:6480464
G Plp1 proteolipid protein 1 JBrowse link X 107,494,326 107,511,355 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        inhibitor 18070
          beta-alanine 35
            beta-alanine derivative 35
              dabigatran 8
                N-(4-aminobutyl)dabigatranamide 0
                dabigatran etexilate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic group 18351
                              organic divalent group 18340
                                organodiyl group 18340
                                  carbonyl group 18225
                                    carbonyl compound 18225
                                      carboxylic acid 17930
                                        amino acid 12314
                                          non-proteinogenic amino acid 1725
                                            beta-amino acid 172
                                              beta-alanine 35
                                                beta-alanine derivative 35
                                                  dabigatran 8
                                                    N-(4-aminobutyl)dabigatranamide 0
                                                    dabigatran etexilate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.