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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:topoisomerase inhibitor
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Accession:CHEBI:70727 term browser browse the term
Definition:An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA).
Synonyms:related_synonym: topoisomerase inhibitors
 xref: Wikipedia:Topoisomerase

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  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          enzyme inhibitor 18150
            EC 5.* (isomerase) inhibitor 6623
              EC 5.99.* (other isomerases) inhibitor 6440
                EC 5.99.1.* (miscellaneous isomerase) inhibitor 6440
                  topoisomerase inhibitor 6440
                    2,2,3,3-tetrahydroxy-2,3-dihydronaphthalene-1,4-dione 0
                    EC (DNA topoisomerase) inhibitor + 3720
                    EC [DNA topoisomerase (ATP-hydrolysing)] inhibitor + 3866
                    actinodaphnine 0
                    topoisomerase II inhibitor + 0
                    topoisomerase IV inhibitor + 554
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.