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Term:topoisomerase inhibitor
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Accession:CHEBI:70727 term browser browse the term
Definition:An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA).
Synonyms:related_synonym: topoisomerase inhibitors
 xref: Wikipedia:Topoisomerase

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  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          enzyme inhibitor 17977
            EC 5.* (isomerase) inhibitor 5729
              EC 5.99.* (other isomerases) inhibitor 5542
                EC 5.99.1.* (miscellaneous isomerase) inhibitor 5542
                  topoisomerase inhibitor 5542
                    2,2,3,3-tetrahydroxy-2,3-dihydronaphthalene-1,4-dione 0
                    EC (DNA topoisomerase) inhibitor + 3719
                    EC [DNA topoisomerase (ATP-hydrolysing)] inhibitor + 2760
                    actinodaphnine 0
                    topoisomerase IV inhibitor + 552
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.