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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:topoisomerase inhibitor
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Accession:CHEBI:70727 term browser browse the term
Definition:An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA).
Synonyms:related_synonym: topoisomerase inhibitors
 xref: Wikipedia:Topoisomerase

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      CHEBI ontology 20072
        role 20024
          biological role 20023
            biochemical role 19658
              enzyme inhibitor 18569
                EC 5.* (isomerase) inhibitor 6702
                  EC 5.99.* (other isomerases) inhibitor 6520
                    EC 5.99.1.* (miscellaneous isomerase) inhibitor 6520
                      topoisomerase inhibitor 6520
                        2,2,3,3-tetrahydroxy-2,3-dihydronaphthalene-1,4-dione 0
                        EC (DNA topoisomerase) inhibitor + 3768
                        EC [DNA topoisomerase (ATP-hydrolysing)] inhibitor + 3910
                        actinodaphnine 0
                        topoisomerase II inhibitor + 4
                        topoisomerase IV inhibitor + 586
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