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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:topoisomerase inhibitor
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Accession:CHEBI:70727 term browser browse the term
Definition:An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA).
Synonyms:related_synonym: topoisomerase inhibitors
 xref: Wikipedia:Topoisomerase


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      CHEBI ontology 19911
        role 19854
          biological role 19852
            biochemical role 19582
              enzyme inhibitor 18776
                EC 5.* (isomerase) inhibitor 7962
                  EC 5.99.* (other isomerases) inhibitor 7532
                    EC 5.99.1.* (miscellaneous isomerase) inhibitor 7532
                      topoisomerase inhibitor 7532
                        2,2,3,3-tetrahydroxy-2,3-dihydronaphthalene-1,4-dione 0
                        EC 5.99.1.2 (DNA topoisomerase) inhibitor + 4040
                        EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor + 4044
                        actinodaphnine 0
                        topoisomerase II inhibitor + 10
                        topoisomerase IV inhibitor + 2072
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