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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor
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Accession:CHEBI:70722 term browser browse the term
Definition:An EC 6.4.1.* (C-C bond-forming ligase) inhibitor that interferes with the action of acetyl-CoA carboxylase (EC 6.4.1.2).
Synonyms:related_synonym: ACC inhibitor;   ACC inhibitors;   ACCase inhibitor;   ACCase inhibitors;   EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitors;   EC 6.4.1.2 inhibitor;   EC 6.4.1.2 inhibitors;   acetyl coenzyme A carboxylase inhibitor;   acetyl coenzyme A carboxylase inhibitors;   acetyl-CoA carboxylase inhibitor;   acetyl-CoA carboxylase inhibitors;   acetyl-CoA:carbon-dioxide ligase (ADP-forming) inhibitor;   acetyl-CoA:carbon-dioxide ligase (ADP-forming) inhibitors
 xref: PMID:19552511;   PMID:22560583;   PMID:22677317;   Patent:US2009270435;   Wikipedia:Acetyl_CoA_carboxylase



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5-(tetradecyloxy)-2-furoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO 5-(tetradecyloxy)-2-furancarboxylic acid inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
9-oxononanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases activity EXP 9-oxononanoic acid results in decreased activity of ACACA protein CTD PMID:2892534 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
diclofop-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP [dichlorfop-methyl co-treated with difenoconazole] results in decreased activity of ACHE protein CTD PMID:25419412 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin affects binding ISO dichlorfop-methyl binds to ALB protein CTD PMID:32278049 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cat catalase increases activity EXP dichlorfop-methyl results in increased activity of CAT protein CTD PMID:11275354 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO dichlorfop-methyl binds to and results in increased activity of PPARA protein CTD PMID:17084873 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
fluazifop-butyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 increases activity ISO fluazifop-butyl results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO fluazifop-butyl results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
quizalofop-ethyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases activity
increases expression
multiple interactions
EXP quizalofop-ethyl analog results in increased activity of ACOX1 protein
quizalofop-ethyl analog results in increased expression of ACOX1 mRNA
PPARA protein affects the reaction [quizalofop-ethyl analog results in increased activity of ACOX1 protein]; PPARA protein affects the reaction [quizalofop-ethyl analog results in increased expression of ACOX1 mRNA]
CTD PMID:29626562 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Cat catalase increases activity EXP quizalofop-ethyl analog results in increased activity of CAT protein CTD PMID:29626562 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases response to substance
multiple interactions
EXP PPARA protein results in increased susceptibility to quizalofop-ethyl analog
PPARA protein affects the reaction [quizalofop-ethyl analog results in increased activity of ACOX1 protein]; PPARA protein affects the reaction [quizalofop-ethyl analog results in increased expression of ACOX1 mRNA]
CTD PMID:29626562 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO quizalofop-ethyl results in increased activity of PPARG protein CTD PMID:31086981 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
spirotetramat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxo1 forkhead box O1 increases expression ISO spirotetramat results in increased expression of FOXO1 mRNA CTD PMID:27917277 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Vnn1 vanin 1 decreases expression ISO spirotetramat results in decreased expression of VNN1 mRNA CTD PMID:27917277 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        biochemical role 19630
          enzyme inhibitor 18576
            EC 6.* (ligase) inhibitor 4409
              EC 6.4.* (C-C bond-forming ligase) inhibitor 1170
                EC 6.4.1.* (carboxylase) inhibitor 1170
                  EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor 12
                    (5s,8s)-3-(2,5-dimethylphenyl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one 0
                    5-(tetradecyloxy)-2-furoic acid 1
                    9-oxononanoate 0
                    9-oxononanoic acid + 1
                    MEDICA 16 0
                    clethodim 0
                    clodinafop + 0
                    clodinafop-propargyl 0
                    cycloxydim 0
                    diclofop-methyl 4
                    fluazifop 0
                    fluazifop-P + 2
                    fluazifop-P-butyl + 2
                    fluazifop-butyl 2
                    haloxyfop + 0
                    haloxyfop-P + 0
                    haloxyfop-P-methyl + 0
                    haloxyfop-etotyl 0
                    haloxyfop-methyl 0
                    haloxyfop-sodium 0
                    metamifop + 0
                    pinoxaden 0
                    pinoxaden acid + 0
                    profoxydim 0
                    quizalofop-P + 4
                    soraphen A 0
                    spiropidion 0
                    spirotetramat 2
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