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ONTOLOGY REPORT - ANNOTATIONS


Term:ceftaroline fosamil
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Accession:CHEBI:70718 term browser browse the term
Definition:A cephalosporin having [4-(1-methylpyridinium-4-yl)-1,3-thiazol-2-yl]sulfanyl and {(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino side groups located at positions 3 and 7 respectively. The N-phospho prodrug of ceftaroline, a broad-spectrum antibiotic active against methicillin-resistant Staphylococcus aureus (MRSA). It is used for the treatment of adults with acute bacterial skin and skin structure infections.
Synonyms:exact_synonym: 7-({(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methylpyridinium-4-yl)-1,3-thiazol-2-yl]sulfanyl}-3,4-didehydrocepham-4-carboxylate
 related_synonym: (6R,7R)-7-({(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methylpyridinium-4-yl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;   Formula=C22H21N8O8PS4;   InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/b26-13-/t14-,19-/m1/s1;   InChIKey=ZCCUWMICIWSJIX-NQJJCJBVSA-N;   SMILES=[H][C@]12SCC(Sc3nc(cs3)-c3cc[n+](C)cc3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC)\\c1nsc(NP(O)(O)=O)n1)C([O-])=O;   ceftarolina fosamilo;   ceftarolinum fosamilum
 xref: CAS:229016-73-3 "ChemIDplus";   Drug_Central:4169 "DrugCentral";   PMID:21076711 "Europe PMC";   PMID:21115453 "Europe PMC";   PMID:21115454 "Europe PMC";   PMID:21115455 "Europe PMC";   PMID:21115456 "Europe PMC";   PMID:21162631 "Europe PMC";   PMID:21252841 "Europe PMC";   PMID:21393213 "Europe PMC";   PMID:21482565 "Europe PMC";   PMID:21482566 "Europe PMC";   PMID:21482568 "Europe PMC";   PMID:21482570 "Europe PMC";   PMID:21548186 "Europe PMC";   PMID:21897727 "Europe PMC";   PMID:22058102 "Europe PMC";   PMID:22314524 "Europe PMC";   PMID:22330908 "Europe PMC";   PMID:22354289 "Europe PMC";   PMID:22355258 "Europe PMC";   PMID:22594846 "Europe PMC";   PMID:22779432 "Europe PMC";   PMID:22903949 "Europe PMC";   PMID:22985880 "Europe PMC";   PMID:29017833 "Europe PMC";   Patent:MX2012003411;   Reaxys:9535806 "Reaxys";   Wikipedia:Ceftaroline_fosamil


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  CHEBI ontology 19716
    role 19663
      biological role 19661
        antimicrobial agent 17199
          ceftaroline fosamil 0
            ceftaroline fosamil acetate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        carboacyl group 16948
                                          univalent carboacyl group 16948
                                            carbamoyl group 16630
                                              carboxamide 16630
                                                lactam 2976
                                                  beta-lactam 786
                                                    beta-lactam antibiotic 774
                                                      cephem 538
                                                        cephalosporin 537
                                                          ceftaroline 0
                                                            ceftaroline fosamil 0
                                                              ceftaroline fosamil acetate + 0
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