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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dienogest
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Accession:CHEBI:70708 term browser browse the term
Definition:A steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive.
Synonyms:exact_synonym: [(17beta)-17-hydroxy-3-oxoestra-4,9-dien-17-yl]acetonitrile
 related_synonym: (17-hydroxy-3-oxoestra-4,9-dien-17beta-yl)acetonitrile;   17alpha-Cyanomethyl-17beta-hydroxyestra-4,9(10)-dien-3-one;   Dienogestum;   Formula=C20H25NO2;   InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1;   InChIKey=AZFLJNIPTRTECV-FUMNGEBKSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)CCC3=C1CC[C@@]1(C)[C@@]2([H])CC[C@@]1(O)CC#N
 xref: CAS:65928-58-7;   Drug_Central:871;   KEGG:D03799
 xref_mesh: MESH:C023635
 xref: PMID:21681516;   PMID:22003899;   PMID:22067805;   PMID:22130322;   PMID:22149760;   PMID:22160205;   PMID:22169052;   PMID:22264663;   PMID:22322156;   PMID:22364708;   PMID:22366992;   PMID:22413833;   PMID:22445438;   PMID:22459918;   PMID:22515510;   PMID:22571602;   PMID:22876102;   PMID:22878119;   PMID:23003209;   Patent:EP1935898;   Patent:US2008214512;   Patent:US2010298585;   Patent:US6670350;   Patent:WO2008116890;   Patent:WO2011132045;   Reaxys:5763925;   Wikipedia:Dienogest


show annotations for term's descendants           Sort by:
dienogest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1 member C1 decreases expression EXP dienogest results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283 		JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 decreases expression EXP dienogest results in decreased expression of AKR1C2 mRNA CTD PMID:23183084 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein] CTD PMID:22014880 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CD4 CD4 molecule multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of CD4 protein CTD PMID:10813102 NCBI chr12:6,789,528...6,820,799
Ensembl chr12:6,786,858...6,820,799 		JBrowse link
G CRP C-reactive protein multiple interactions EXP [Estradiol co-treated with dienogest] results in increased expression of CRP protein CTD PMID:15970291 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein] CTD PMID:15866594 PMID:22014880 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases expression EXP dienogest results in decreased expression of CYP19A1 mRNA; dienogest results in decreased expression of CYP19A1 protein CTD PMID:22130322 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in increased expression of F2 protein CTD PMID:15288212 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506 		JBrowse link
G F7 coagulation factor VII multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in increased expression of F7 protein CTD PMID:15288212 NCBI chr13:113,105,788...113,120,685
Ensembl chr13:113,105,788...113,120,685 		JBrowse link
G FGA fibrinogen alpha chain multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:15288212 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,126...154,590,742 		JBrowse link
G FGB fibrinogen beta chain multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:15288212 NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807 		JBrowse link
G FGG fibrinogen gamma chain multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:15288212 NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967 		JBrowse link
G FSHB follicle stimulating hormone subunit beta decreases expression EXP dienogest results in decreased expression of FSHB protein CTD PMID:11994349 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G HMGB1 high mobility group box 1 multiple interactions EXP dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 decreases expression EXP dienogest results in decreased expression of HSD17B2 mRNA CTD PMID:23183084 NCBI chr16:82,035,253...82,098,534
Ensembl chr16:82,035,004...82,098,534 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of IGF1 protein CTD PMID:11172797 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein] CTD PMID:22014880 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G LHB luteinizing hormone subunit beta decreases expression EXP dienogest results in decreased expression of LHB protein CTD PMID:11994349 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
affects localization		 EXP dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]
dienogest affects the localization of NFKB1 protein		 CTD PMID:15866594 PMID:22130322 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G PLAT plasminogen activator, tissue type multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PLAT protein CTD PMID:15288212 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in increased activity of PROC protein CTD PMID:15288212 NCBI chr 2:127,418,427...127,429,242
Ensembl chr 2:127,418,427...127,429,242 		JBrowse link
G PROS1 protein S multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PROS1 protein CTD PMID:15288212 NCBI chr 3:93,873,051...93,973,896
Ensembl chr 3:93,873,051...93,980,003 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP dienogest results in decreased expression of PTGS2 mRNA; dienogest results in decreased expression of PTGS2 protein CTD PMID:22130322 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SERPINC1 serpin family C member 1 multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in decreased activity of SERPINC1 protein CTD PMID:15288212 NCBI chr 1:173,903,800...173,917,327
Ensembl chr 1:173,903,800...173,917,327 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions EXP [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of SERPINE1 protein CTD PMID:15288212 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein] CTD PMID:15866594 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      biological role 25936
        molecular messenger 20284
          hormone 19899
            steroid hormone 8402
              dienogest 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbonyl compound 23569
                                    ketone 19358
                                      oxo steroid 11055
                                        3-oxo steroid 10452
                                          3-oxo-Delta(4) steroid 9663
                                            dienogest 27
paths to the root