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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dienogest
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Accession:CHEBI:70708 term browser browse the term
Definition:A steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive.
Synonyms:exact_synonym: [(17beta)-17-hydroxy-3-oxoestra-4,9-dien-17-yl]acetonitrile
 related_synonym: (17-hydroxy-3-oxoestra-4,9-dien-17beta-yl)acetonitrile;   17alpha-Cyanomethyl-17beta-hydroxyestra-4,9(10)-dien-3-one;   Dienogestum;   Formula=C20H25NO2;   InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1;   InChIKey=AZFLJNIPTRTECV-FUMNGEBKSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)CCC3=C1CC[C@@]1(C)[C@@]2([H])CC[C@@]1(O)CC#N
 xref: CAS:65928-58-7;   Drug_Central:871;   KEGG:D03799
 xref_mesh: MESH:C023635
 xref: PMID:21681516;   PMID:22003899;   PMID:22067805;   PMID:22130322;   PMID:22149760;   PMID:22160205;   PMID:22169052;   PMID:22264663;   PMID:22322156;   PMID:22364708;   PMID:22366992;   PMID:22413833;   PMID:22445438;   PMID:22459918;   PMID:22515510;   PMID:22571602;   PMID:22876102;   PMID:22878119;   PMID:23003209;   Patent:EP1935898;   Patent:US2008214512;   Patent:US2010298585;   Patent:US6670350;   Patent:WO2008116890;   Patent:WO2011132045;   Reaxys:5763925;   Wikipedia:Dienogest


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dienogest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 decreases expression ISO dienogest results in decreased expression of AKR1C2 mRNA CTD PMID:23183084 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein] CTD PMID:22014880 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd4 Cd4 molecule multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of CD4 protein CTD PMID:10813102 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Crp C-reactive protein multiple interactions ISO [Estradiol co-treated with dienogest] results in increased expression of CRP protein CTD PMID:15970291 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO dienogest results in decreased expression of CYP19A1 mRNA; dienogest results in decreased expression of CYP19A1 protein CTD PMID:22130322 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G F2 coagulation factor II multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of F2 protein CTD PMID:15288212 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F7 coagulation factor VII multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of F7 protein CTD PMID:15288212 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:15288212 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:15288212 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:15288212 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO dienogest results in decreased expression of FSHB protein CTD PMID:11994349 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression ISO dienogest results in decreased expression of HSD17B2 mRNA CTD PMID:23183084 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of IGF1 protein CTD PMID:11172797 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il6 interleukin 6 multiple interactions ISO dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein] CTD PMID:22014880 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO dienogest results in decreased expression of LHB protein CTD PMID:11994349 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization
ISO dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]
dienogest affects the localization of NFKB1 protein
CTD PMID:15866594 PMID:22130322 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PLAT protein CTD PMID:15288212 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased activity of PROC protein CTD PMID:15288212 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Pros1 protein S multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PROS1 protein CTD PMID:15288212 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO dienogest results in decreased expression of PTGS2 mRNA; dienogest results in decreased expression of PTGS2 protein CTD PMID:22130322 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased activity of SERPINC1 protein CTD PMID:15288212 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of SERPINE1 protein CTD PMID:15288212 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein] CTD PMID:15866594 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        molecular messenger 18316
          hormone 18081
            steroid hormone 7802
              dienogest 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        oxo steroid 9720
                                          3-oxo steroid 9279
                                            3-oxo-Delta(4) steroid 8420
                                              dienogest 25
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