CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dienogest
Accession: CHEBI:70708
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Definition: A steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive.
Synonyms: exact_synonym: [(17beta)-17-hydroxy-3-oxoestra-4,9-dien-17-yl]acetonitrile
related_synonym: (17-hydroxy-3-oxoestra-4,9-dien-17beta-yl)acetonitrile; 17alpha-Cyanomethyl-17beta-hydroxyestra-4,9(10)-dien-3-one; Dienogestum; Formula=C20H25NO2; InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1; InChIKey=AZFLJNIPTRTECV-FUMNGEBKSA-N; SMILES=[H][C@@]12CCC3=CC(=O)CCC3=C1CC[C@@]1(C)[C@@]2([H])CC[C@@]1(O)CC#N
xref: CAS:65928-58-7; Drug_Central:871; KEGG:D03799
xref_mesh: MESH:C023635
xref: PMID:21681516; PMID:22003899; PMID:22067805; PMID:22130322; PMID:22149760; PMID:22160205; PMID:22169052; PMID:22264663; PMID:22322156; PMID:22364708; PMID:22366992; PMID:22413833; PMID:22445438; PMID:22459918; PMID:22515510; PMID:22571602; PMID:22876102; PMID:22878119; PMID:23003209; Patent:EP1935898; Patent:US2008214512; Patent:US2010298585; Patent:US6670350; Patent:WO2008116890; Patent:WO2011132045; Reaxys:5763925; Wikipedia:Dienogest
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Akr1c1
aldo-keto reductase family 1, member C1
decreases expression
ISO
dienogest results in decreased expression of AKR1C1 mRNA
CTD
PMID:23183084
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
decreases expression
ISO
dienogest results in decreased expression of AKR1C2 mRNA
CTD
PMID:23183084
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein]
CTD
PMID:22014880
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cd4
Cd4 molecule
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of CD4 protein
CTD
PMID:10813102
NCBI chr 4:157,668,878...157,695,366
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Crp
C-reactive protein
multiple interactions
ISO
[Estradiol co-treated with dienogest] results in increased expression of CRP protein
CTD
PMID:15970291
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases expression
ISO
dienogest results in decreased expression of CYP19A1 mRNA; dienogest results in decreased expression of CYP19A1 protein
CTD
PMID:22130322
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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F2
coagulation factor II, thrombin
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in increased expression of F2 protein
CTD
PMID:15288212
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F7
coagulation factor VII
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in increased expression of F7 protein
CTD
PMID:15288212
NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
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Fga
fibrinogen alpha chain
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]
CTD
PMID:15288212
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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Fgb
fibrinogen beta chain
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]
CTD
PMID:15288212
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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Fgg
fibrinogen gamma chain
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]
CTD
PMID:15288212
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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Fshb
follicle stimulating hormone subunit beta
decreases expression
ISO
dienogest results in decreased expression of FSHB protein
CTD
PMID:11994349
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Hmgb1
high mobility group box 1
multiple interactions
ISO
dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]
CTD
PMID:22014880
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
decreases expression
ISO
dienogest results in decreased expression of HSD17B2 mRNA
CTD
PMID:23183084
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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Igf1
insulin-like growth factor 1
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of IGF1 protein
CTD
PMID:11172797
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Il6
interleukin 6
multiple interactions
ISO
dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein]
CTD
PMID:22014880
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Lhb
luteinizing hormone subunit beta
decreases expression
ISO
dienogest results in decreased expression of LHB protein
CTD
PMID:11994349
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions affects localization
ISO
dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein] dienogest affects the localization of NFKB1 protein
CTD
PMID:15866594 PMID:22130322
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Plat
plasminogen activator, tissue type
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PLAT protein
CTD
PMID:15288212
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in increased activity of PROC protein
CTD
PMID:15288212
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Pros1
protein S
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PROS1 protein
CTD
PMID:15288212
NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
dienogest results in decreased expression of PTGS2 mRNA; dienogest results in decreased expression of PTGS2 protein
CTD
PMID:22130322
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Serpinc1
serpin family C member 1
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in decreased activity of SERPINC1 protein
CTD
PMID:15288212
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serpine1
serpin family E member 1
multiple interactions
ISO
[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of SERPINE1 protein
CTD
PMID:15288212
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Tlr4
toll-like receptor 4
multiple interactions
ISO
dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]
CTD
PMID:22014880
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf
tumor necrosis factor
multiple interactions
ISO
dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein]
CTD
PMID:15866594
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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