CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: bergomottin
Accession: CHEBI:70476
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Definition: A furanocoumarin that has formula C21H22O4.
Synonyms: related_synonym: 4-{[(2E)-3,7-Dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one; 5-Geranoxypsoralen; Bergamotine; Bergaptin; Formula=C21H22O4; InChI=1S/C21H22O4/c1-14(2)5-4-6-15(3)9-11-24-21-16-7-8-20(22)25-19(16)13-18-17(21)10-12-23-18/h5,7-10,12-13H,4,6,11H2,1-3H3/b15-9+; InChIKey=DBMJZOMNXBSRED-OQLLNIDSSA-N; SMILES=CC(C)=CCC\\C(C)=C\\COc1c2ccoc2cc2oc(=O)ccc12; bergamottin
xref: CAS:7380-40-7
xref_mesh: MESH:C068337
xref: PMID:20964319
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Abcb1a
ATP-binding cassette, sub-family B member 1A
increases expression
ISO
bergamottin results in increased expression of ABCB1 mRNA; bergamottin results in increased expression of ABCB1 protein
CTD
PMID:19148864
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Ahr
aryl-hydrocarbon receptor
increases activity
ISO
bergamottin results in increased activity of AHR protein
CTD
PMID:15670584 PMID:21924250
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
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Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
decreases expression
ISO
bergamottin results in decreased expression of CD74 mRNA
CTD
PMID:18818744
NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression multiple interactions
EXP ISO
bergamottin results in increased expression of CYP1A1 protein bergamottin results in increased expression of and results in decreased activity of CYP1A1 protein bergamottin results in increased expression of CYP1A1 mRNA
CTD
PMID:15670584 PMID:18692084
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
EXP
bergamottin results in increased expression of CYP1A2 protein
CTD
PMID:18692084
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions decreases activity
ISO
bergamottin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] bergamottin results in decreased activity of CYP1B1 protein; bergamottin results in decreased activity of CYP1B1 protein polymorphism
CTD
PMID:15861043
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
increases expression decreases activity
EXP ISO
bergamottin results in increased expression of CYP2B10 protein bergamottin results in decreased activity of CYP2B6 protein
CTD
PMID:15769884 PMID:18692084
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Cyp3a11
cytochrome P450, family 3, subfamily a, polypeptide 11
increases expression
EXP
bergamottin results in increased expression of CYP3A11 protein
CTD
PMID:18692084
NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
bergamottin results in increased activity of NR1I2 protein
CTD
PMID:21924250
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
bergamottin results in increased activity of NR1I3 protein
CTD
PMID:21924250
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
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Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
increases glucuronidation
ISO
UGT1A1 protein results in increased glucuronidation of bergamottin analog
CTD
PMID:14557274
NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
increases glucuronidation
ISO
UGT1A10 protein results in increased glucuronidation of bergamottin analog
CTD
PMID:14557274
NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726
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Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of bergamottin analog
CTD
PMID:14557274
NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
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