Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:muscimol
go back to main search page
Accession:CHEBI:7035 term browser browse the term
Definition:A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Synonyms:exact_synonym: 5-(aminomethyl)-1,2-oxazol-3(2H)-one
 related_synonym: 5-(aminomethyl)-3(2H)-isoxazolone;   Formula=C4H6N2O2;   InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7);   InChIKey=ZJQHPWUVQPJPQT-UHFFFAOYSA-N;   SMILES=NCc1cc(=O)[nH]o1
 xref: Beilstein:774694;   CAS:2763-96-4;   KEGG:C08311;   KNApSAcK:C00001423
 xref_mesh: MESH:D009118
 xref: PMID:18599311;   PMID:21427702;   PMID:21751026;   PMID:2181052;   PMID:22049436;   PMID:24259680;   PMID:24316475;   PMID:24473816;   Reaxys:774694;   Wikipedia:Muscimol


show annotations for term's descendants           Sort by:
 
muscimol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Muscimol inhibits the reaction [decamethrin results in increased expression of BDNF exon] CTD PMID:22079160 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein] CTD PMID:29044621 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit multiple interactions ISO Muscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein] CTD PMID:8388298 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit multiple interactions ISO Muscimol binds to and results in increased activity of [CHRNA5 protein co-treated with CHRNB1 protein] CTD PMID:8388298 NCBI chr10:56,390,671...56,403,255
Ensembl chr10:56,390,671...56,403,188
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased phosphorylation of ERN1 protein] CTD PMID:29044621 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Muscimol inhibits the reaction [Cocaine results in increased expression of FOS protein] CTD PMID:16930414 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
affects binding
ISO GABRA1 protein affects the reaction [Muscimol results in increased uptake of Chlorides]
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD PMID:12490572, PMID:22029276 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 affects binding EXP Muscimol binds to GABRB1 protein CTD PMID:9661255 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions
affects binding
ISO
EXP
GABRB2 protein affects the reaction [Muscimol results in increased uptake of Chlorides]
GABRB2 protein binds to Muscimol; Muscimol binds to GABRB2 protein
alphaxalone promotes the reaction [Muscimol binds to GABRB2 protein]; Pentobarbital affects the reaction [GABRB2 protein binds to Muscimol]; Pentobarbital promotes the reaction [Muscimol binds to GABRB2 protein]
CTD PMID:8397295, PMID:10591412, PMID:12490572 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
affects binding
EXP
ISO
alphaxalone promotes the reaction [Muscimol binds to GABRB3 protein]; Pentobarbital promotes the reaction [Muscimol binds to GABRB3 protein]
Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD PMID:8397295, PMID:22029276 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:22029276 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 increases activity EXP Muscimol results in increased activity of GABRR3 protein CTD PMID:10635063 NCBI chr11:43,046,987...43,099,754
Ensembl chr11:43,046,987...43,099,412
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP Muscimol affects the reaction [bisphenol A affects the secretion of GNRH1 protein] CTD PMID:26950200 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:29044621 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased expression of MAP3K5 protein] CTD PMID:29044621 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Muscimol promotes the reaction [methyl tert-butyl ether results in decreased phosphorylation of MAPK1 protein] CTD PMID:19344668 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Muscimol promotes the reaction [methyl tert-butyl ether results in decreased phosphorylation of MAPK3 protein] CTD PMID:19344668 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Muscimol inhibits the reaction [Ethanol results in increased expression of MAPK8 protein] CTD PMID:29044621 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Pomc proopiomelanocortin multiple interactions
decreases expression
EXP Muscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA]
Muscimol results in decreased expression of POMC mRNA
CTD PMID:7937335 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Syn1 synapsin I decreases expression EXP Muscimol results in decreased expression of SYN1 protein CTD PMID:21920406 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            alkaloid 5350
              muscimol 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  heteroarene 16447
                                    monocyclic heteroarene 13303
                                      azole 12471
                                        oxazole 3299
                                          isoxazoles 3079
                                            muscimol 20
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.