CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Actein
Accession: CHEBI:70241
browse the term
Definition: A triterpenoid that has formula C37H56O11.
Synonyms: related_synonym: Formula=C37H56O11; InChI=1S/C37H56O11/c1-17-12-37(29-34(7,47-29)30(42)48-37)46-20-13-32(5)22-9-8-21-31(3,4)23(45-28-27(41)26(40)19(39)15-43-28)10-11-35(21)16-36(22,35)14-24(44-18(2)38)33(32,6)25(17)20/h17,19-30,39-42H,8-16H2,1-7H3/t17-,19-,20+,21+,22+,23+,24-,25+,26+,27-,28+,29-,30+,32+,33-,34+,35-,36+,37-/m1/s1; InChIKey=NEWMWGLPJQHSSQ-PSDKAYTQSA-N; SMILES=[H][C@]1(OC[C@@H](O)[C@H](O)[C@H]1O)O[C@H]1CC[C@]23C[C@]22C[C@@H](OC(C)=O)[C@]4(C)[C@@]5([H])[C@H](C)C[C@]6(O[C@H](O)[C@@]7(C)O[C@@]67[H])O[C@@]5([H])C[C@@]4(C)[C@]2([H])CC[C@@]3([H])C1(C)C
xref_mesh: MESH:C096064
xref: PMID:21082802
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A2m
alpha-2-macroglobulin
increases expression
EXP
actein results in increased expression of A2M mRNA; actein results in increased expression of A2M protein
CTD
PMID:19527300 PMID:29969672
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Acox1
acyl-CoA oxidase 1
decreases expression
EXP
actein results in decreased expression of ACOX1 mRNA
CTD
PMID:19527300
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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Acox2
acyl-CoA oxidase 2
increases expression
EXP
actein results in increased expression of ACOX2 protein
CTD
PMID:29969672
NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein]
CTD
PMID:28836330
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ahrr
aryl-hydrocarbon receptor repressor
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR protein]
CTD
PMID:28836330
NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
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Alox15
arachidonate 15-lipoxygenase
increases expression
EXP
actein results in increased expression of ALOX15 protein
CTD
PMID:29969672
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL protein]
CTD
PMID:28836330
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Apcs
amyloid P component, serum
decreases expression
EXP
actein results in decreased expression of APCS mRNA
CTD
PMID:19527300
NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298
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Ascl1
achaete-scute family bHLH transcription factor 1
decreases expression
EXP
actein results in decreased expression of ASCL1 protein
CTD
PMID:29969672
NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993
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Atp5me
ATP synthase membrane subunit e
decreases expression
EXP
actein results in decreased expression of ATP5ME mRNA
CTD
PMID:19527300
NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
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C4bpa
complement component 4 binding protein, alpha
increases expression
EXP
actein results in increased expression of C4BPA mRNA
CTD
PMID:19527300
NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
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C4bpb
complement component 4 binding protein, beta
increases expression
EXP
actein results in increased expression of C4BPB mRNA
CTD
PMID:19527300
NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
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C5
complement C5
increases expression
EXP
actein results in increased expression of C5 mRNA
CTD
PMID:19527300
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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Car3
carbonic anhydrase 3
increases expression
EXP
actein results in increased expression of CA3 protein
CTD
PMID:29969672
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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Ccnd1
cyclin D1
affects expression decreases expression
EXP ISO
actein affects the expression of CCND1 mRNA actein results in decreased expression of CCND1 mRNA; actein results in decreased expression of CCND1 protein
CTD
PMID:14758092 PMID:19527300 PMID:29969672
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cd44
CD44 molecule
increases expression
EXP
actein results in increased expression of CD44 mRNA
CTD
PMID:19527300
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
actein results in decreased expression of CDK4 protein
CTD
PMID:14758092
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
actein results in increased expression of CDKN1A protein
CTD
PMID:14758092
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Ces1d
carboxylesterase 1D
decreases expression
EXP
actein results in decreased expression of CES1 protein
CTD
PMID:29969672
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Cxcl1
C-X-C motif chemokine ligand 1
increases expression
EXP
actein results in increased expression of CXCL1 mRNA
CTD
PMID:19527300
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl2
C-X-C motif chemokine ligand 2
increases expression
EXP
actein results in increased expression of CXCL2 protein
CTD
PMID:29969672
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
CTD
PMID:28836330
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2c22
cytochrome P450, family 2, subfamily c, polypeptide 22
decreases expression
EXP
actein results in decreased expression of CYP2C22 mRNA
CTD
PMID:19527300
NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
decreases expression
EXP
actein results in decreased expression of CYP2J9 protein
CTD
PMID:29969672
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
increases expression
EXP
actein results in increased expression of CYP7A1 mRNA
CTD
PMID:19527300
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Dipk1c
divergent protein kinase domain 1C
decreases expression
EXP
actein results in decreased expression of DIPK1C protein
CTD
PMID:29969672
NCBI chr18:78,087,972...78,109,910
Ensembl chr18:78,087,991...78,109,904
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Epo
erythropoietin
decreases expression
EXP
actein results in decreased expression of EPO mRNA
CTD
PMID:19527300
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Fas
Fas cell surface death receptor
increases expression
EXP
actein results in increased expression of FAS mRNA
CTD
PMID:19527300
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fdps
farnesyl diphosphate synthase
increases expression
EXP
actein results in increased expression of FDPS mRNA
CTD
PMID:19527300
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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Flt1
Fms related receptor tyrosine kinase 1
increases expression
EXP
actein results in increased expression of FLT1 mRNA
CTD
PMID:19527300
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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Fmo1
flavin containing dimethylaniline monoxygenase 1
increases expression
EXP
actein results in increased expression of FMO1 protein
CTD
PMID:29969672
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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Gpd2
glycerol-3-phosphate dehydrogenase 2
decreases expression
EXP
actein results in decreased expression of GPD2 mRNA
CTD
PMID:19527300
NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
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Hamp
hepcidin antimicrobial peptide
decreases expression
EXP
actein results in decreased expression of HAMP protein
CTD
PMID:29969672
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
affects expression
EXP
actein affects the expression of HMGCR mRNA
CTD
PMID:19527300
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
affects expression increases expression
EXP
actein affects the expression of HMGCS1 mRNA actein results in increased expression of HMGCS1 mRNA
CTD
PMID:19527300
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
affects expression
EXP
actein affects the expression of HSD17B7 mRNA
CTD
PMID:19527300
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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Ibsp
integrin-binding sialoprotein
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IBSP mRNA]
CTD
PMID:28836330
NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
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Id1
inhibitor of DNA binding 1
decreases expression
EXP
actein results in decreased expression of ID1 protein
CTD
PMID:29969672
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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Id3
inhibitor of DNA binding 3
affects expression
EXP
actein affects the expression of ID3 mRNA
CTD
PMID:19527300
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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Idi1
isopentenyl-diphosphate delta isomerase 1
increases expression
EXP
actein results in increased expression of IDI1 protein
CTD
PMID:29969672
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Isg15
ISG15 ubiquitin-like modifier
increases expression
EXP
actein results in increased expression of ISG15 protein
CTD
PMID:29969672
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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Lcn2
lipocalin 2
increases expression
EXP
actein results in increased expression of LCN2 protein
CTD
PMID:29969672
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Lgalsl
galectin-like
decreases expression
EXP
actein results in decreased expression of LGALSL protein
CTD
PMID:29969672
NCBI chr14:94,996,991...95,004,499
Ensembl chr14:94,996,990...95,004,980
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA]
CTD
PMID:28836330
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Me1
malic enzyme 1
decreases expression
EXP
actein results in decreased expression of ME1 mRNA
CTD
PMID:19527300
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Mx1
MX dynamin like GTPase 1
increases expression
EXP
actein results in increased expression of MX1 protein
CTD
PMID:29969672
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA]
CTD
PMID:28836330
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Noct
nocturnin
decreases expression
EXP
actein results in decreased expression of NOCT protein
CTD
PMID:29969672
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
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Npas2
neuronal PAS domain protein 2
decreases expression
EXP
actein results in decreased expression of NPAS2 protein
CTD
PMID:29969672
NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
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Nqo1
NAD(P)H quinone dehydrogenase 1
affects expression increases expression
EXP
actein affects the expression of NQO1 mRNA actein results in increased expression of NQO1 mRNA
CTD
PMID:19527300
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
decreases expression
EXP
actein results in decreased expression of NR0B2 protein
CTD
PMID:29969672
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Oas1a
2'-5' oligoadenylate synthetase 1A
increases expression
EXP
actein results in increased expression of OAS1 protein
CTD
PMID:29969672
NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
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Oasl
2'-5'-oligoadenylate synthetase-like
increases expression
EXP
actein results in increased expression of OASL protein
CTD
PMID:29969672
NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
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Pcsk9
proprotein convertase subtilisin/kexin type 9
increases expression
EXP
actein results in increased expression of PCSK9 protein
CTD
PMID:29969672
NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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Psmb10
proteasome 20S subunit beta 10
increases expression
EXP
actein results in increased expression of PSMB10 mRNA
CTD
PMID:19527300
NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626
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Rb1
RB transcriptional corepressor 1
decreases expression
ISO
actein results in decreased expression of RB1 protein
CTD
PMID:14758092
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rgs5
regulator of G-protein signaling 5
increases expression
EXP
actein results in increased expression of RGS5 protein
CTD
PMID:29969672
NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518
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S100a8
S100 calcium binding protein A8
increases expression
EXP
actein results in increased expression of S100A8 protein
CTD
PMID:29969672
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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S100a9
S100 calcium binding protein A9
increases expression affects expression
EXP
actein results in increased expression of S100A9 mRNA; actein results in increased expression of S100A9 protein actein affects the expression of S100A9 mRNA
CTD
PMID:19527300 PMID:29969672
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Scd
stearoyl-CoA desaturase
decreases expression
EXP
actein results in decreased expression of SCD protein; actein results in decreased expression of SCD1 mRNA
CTD
PMID:19527300 PMID:29969672
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Sdf2l1
stromal cell-derived factor 2-like 1
increases expression
EXP
actein results in increased expression of SDF2L1 protein
CTD
PMID:29969672
NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
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Slc25a30
solute carrier family 25, member 30
decreases expression
EXP
actein results in decreased expression of SLC25A30 protein
CTD
PMID:29969672
NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
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Sod2
superoxide dismutase 2
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOD2 mRNA]
CTD
PMID:28836330
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sod3
superoxide dismutase 3
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SOD3 mRNA]
CTD
PMID:28836330
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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Sp7
Sp7 transcription factor
multiple interactions
ISO
actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SP7 mRNA]
CTD
PMID:28836330
NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
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Sqle
squalene epoxidase
increases expression
EXP
actein results in increased expression of SQLE protein
CTD
PMID:29969672
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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Tfrc
transferrin receptor
increases expression
EXP
actein results in increased expression of TFRC mRNA
CTD
PMID:19527300
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tsku
tsukushi, small leucine rich proteoglycan
decreases expression
EXP
actein results in decreased expression of TSKU protein
CTD
PMID:29969672
NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
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Tspo
translocator protein
increases expression
EXP
actein results in increased expression of TSPO mRNA
CTD
PMID:19527300
NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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Usp18
ubiquitin specific peptidase 18
increases expression
EXP
actein results in increased expression of USP18 protein
CTD
PMID:29969672
NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
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Usp2
ubiquitin specific peptidase 2
decreases expression
EXP
actein results in decreased expression of USP2 protein
CTD
PMID:29969672
NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
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Zfp354a
zinc finger protein 354A
decreases expression
EXP
actein results in decreased expression of ZNF354A protein
CTD
PMID:29969672
NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
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