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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Actein
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Accession:CHEBI:70241 term browser browse the term
Definition:A triterpenoid that has formula C37H56O11.
Synonyms:related_synonym: Formula=C37H56O11;   InChI=1S/C37H56O11/c1-17-12-37(29-34(7,47-29)30(42)48-37)46-20-13-32(5)22-9-8-21-31(3,4)23(45-28-27(41)26(40)19(39)15-43-28)10-11-35(21)16-36(22,35)14-24(44-18(2)38)33(32,6)25(17)20/h17,19-30,39-42H,8-16H2,1-7H3/t17-,19-,20+,21+,22+,23+,24-,25+,26+,27-,28+,29-,30+,32+,33-,34+,35-,36+,37-/m1/s1;   InChIKey=NEWMWGLPJQHSSQ-PSDKAYTQSA-N;   SMILES=[H][C@]1(OC[C@@H](O)[C@H](O)[C@H]1O)O[C@H]1CC[C@]23C[C@]22C[C@@H](OC(C)=O)[C@]4(C)[C@@]5([H])[C@H](C)C[C@]6(O[C@H](O)[C@@]7(C)O[C@@]67[H])O[C@@]5([H])C[C@@]4(C)[C@]2([H])CC[C@@]3([H])C1(C)C
 xref_mesh: MESH:C096064
 xref: PMID:21082802


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Actein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP actein results in increased expression of A2M mRNA; actein results in increased expression of A2M protein CTD PMID:19527300, PMID:29969672 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression EXP actein results in decreased expression of ACOX1 mRNA CTD PMID:19527300 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acox2 acyl-CoA oxidase 2 increases expression EXP actein results in increased expression of ACOX2 protein CTD PMID:29969672 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein] CTD PMID:28836330 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR protein] CTD PMID:28836330 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP actein results in increased expression of ALOX15 protein CTD PMID:29969672 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL protein] CTD PMID:28836330 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Apcs amyloid P component, serum decreases expression EXP actein results in decreased expression of APCS mRNA CTD PMID:19527300 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP actein results in decreased expression of ASCL1 protein CTD PMID:29969672 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Atp5me ATP synthase membrane subunit e decreases expression EXP actein results in decreased expression of ATP5ME mRNA CTD PMID:19527300 NCBI chr14:2,325,308...2,326,436
Ensembl chr14:2,325,308...2,326,436
JBrowse link
G C4bpa complement component 4 binding protein, alpha increases expression EXP actein results in increased expression of C4BPA mRNA CTD PMID:19527300 NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703
JBrowse link
G C4bpb complement component 4 binding protein, beta increases expression EXP actein results in increased expression of C4BPB mRNA CTD PMID:19527300 NCBI chr13:47,387,173...47,398,115
Ensembl chr13:47,387,173...47,397,890
JBrowse link
G C5 complement C5 increases expression EXP actein results in increased expression of C5 mRNA CTD PMID:19527300 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP actein results in increased expression of CA3 protein CTD PMID:29969672 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Ccnd1 cyclin D1 affects expression
decreases expression
EXP
ISO
actein affects the expression of CCND1 mRNA
actein results in decreased expression of CCND1 protein
actein results in decreased expression of CCND1 mRNA; actein results in decreased expression of CCND1 protein
CTD PMID:14758092, PMID:19527300, PMID:29969672 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP actein results in increased expression of CD44 mRNA CTD PMID:19527300 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO actein results in decreased expression of CDK4 protein CTD PMID:14758092 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO actein results in increased expression of CDKN1A protein CTD PMID:14758092 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ces1d carboxylesterase 1D decreases expression EXP actein results in decreased expression of CES1 protein CTD PMID:29969672 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP actein results in increased expression of CXCL1 mRNA CTD PMID:19527300 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP actein results in increased expression of CXCL2 protein CTD PMID:29969672 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:28836330 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP actein results in decreased expression of CYP2C22 mRNA CTD PMID:19527300 NCBI chr 1:259,257,658...259,297,270
Ensembl chr 1:259,257,657...259,287,684
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP actein results in decreased expression of CYP2J9 protein CTD PMID:29969672 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP actein results in increased expression of CYP7A1 mRNA CTD PMID:19527300 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dipk1c divergent protein kinase domain 1C decreases expression EXP actein results in decreased expression of DIPK1C protein CTD PMID:29969672 NCBI chr18:81,569,693...81,591,683
Ensembl chr18:81,569,910...81,590,887
JBrowse link
G Epo erythropoietin decreases expression EXP actein results in decreased expression of EPO mRNA CTD PMID:19527300 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP actein results in increased expression of FAS mRNA CTD PMID:19527300 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP actein results in increased expression of FDPS mRNA CTD PMID:19527300 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression EXP actein results in increased expression of FLT1 mRNA CTD PMID:19527300 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP actein results in increased expression of FMO1 protein CTD PMID:29969672 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 decreases expression EXP actein results in decreased expression of GPD2 mRNA CTD PMID:19527300 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP actein results in decreased expression of HAMP protein CTD PMID:29969672 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase affects expression EXP actein affects the expression of HMGCR mRNA CTD PMID:19527300 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 affects expression
increases expression
EXP actein affects the expression of HMGCS1 mRNA
actein results in increased expression of HMGCS1 mRNA
CTD PMID:19527300 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 affects expression EXP actein affects the expression of HSD17B7 mRNA CTD PMID:19527300 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988
JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IBSP mRNA] CTD PMID:28836330 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression EXP actein results in decreased expression of ID1 protein CTD PMID:29969672 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein affects expression EXP actein affects the expression of ID3 mRNA CTD PMID:19527300 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP actein results in increased expression of IDI1 protein CTD PMID:29969672 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression EXP actein results in increased expression of ISG15 protein CTD PMID:29969672 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP actein results in increased expression of LCN2 protein CTD PMID:29969672 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lgalsl galectin-like decreases expression EXP actein results in decreased expression of LGALSL protein CTD PMID:29969672 NCBI chr14:105,047,915...105,055,421
Ensembl chr14:105,047,919...105,055,421
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA] CTD PMID:28836330 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Me1 malic enzyme 1 decreases expression EXP actein results in decreased expression of ME1 mRNA CTD PMID:19527300 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mx2 MX dynamin like GTPase 2 increases expression EXP actein results in increased expression of MX1 protein CTD PMID:29969672 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA] CTD PMID:28836330 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Noct nocturnin decreases expression EXP actein results in decreased expression of NOCT protein CTD PMID:29969672 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
JBrowse link
G Npas2 neuronal PAS domain protein 2 decreases expression EXP actein results in decreased expression of NPAS2 protein CTD PMID:29969672 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression
increases expression
EXP actein affects the expression of NQO1 mRNA
actein results in increased expression of NQO1 mRNA
CTD PMID:19527300 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP actein results in decreased expression of NR0B2 protein CTD PMID:29969672 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression EXP actein results in increased expression of OAS1 protein CTD PMID:29969672 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP actein results in increased expression of OASL protein CTD PMID:29969672 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP actein results in increased expression of PCSK9 protein CTD PMID:29969672 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression EXP actein results in increased expression of PSMB10 mRNA CTD PMID:19527300 NCBI chr19:37,909,543...37,912,027
Ensembl chr19:37,909,546...37,912,027
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO actein results in decreased expression of RB1 protein CTD PMID:14758092 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rgs5 regulator of G-protein signaling 5 increases expression EXP actein results in increased expression of RGS5 protein CTD PMID:29969672 NCBI chr13:87,966,820...88,002,831
Ensembl chr13:87,966,758...88,003,035
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP actein results in increased expression of S100A8 protein CTD PMID:29969672 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression
affects expression
EXP actein results in increased expression of S100A9 mRNA; actein results in increased expression of S100A9 protein
actein affects the expression of S100A9 mRNA
CTD PMID:19527300, PMID:29969672 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP actein results in decreased expression of SCD protein; actein results in decreased expression of SCD1 mRNA CTD PMID:19527300, PMID:29969672 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP actein results in increased expression of SDF2L1 protein CTD PMID:29969672 NCBI chr11:88,122,271...88,124,513
Ensembl chr11:88,122,271...88,124,513
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP actein results in decreased expression of SLC25A30 protein CTD PMID:29969672 NCBI chr15:57,811,612...57,834,173
Ensembl chr15:57,813,356...57,834,173
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOD2 mRNA] CTD PMID:28836330 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SOD3 mRNA] CTD PMID:28836330 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SP7 mRNA] CTD PMID:28836330 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Sqle squalene epoxidase increases expression EXP actein results in increased expression of SQLE protein CTD PMID:29969672 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Tfrc transferrin receptor increases expression EXP actein results in increased expression of TFRC mRNA CTD PMID:19527300 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan decreases expression EXP actein results in decreased expression of TSKU protein CTD PMID:29969672 NCBI chr 1:163,317,281...163,328,697
Ensembl chr 1:163,317,282...163,328,591
JBrowse link
G Tspo translocator protein increases expression EXP actein results in increased expression of TSPO mRNA CTD PMID:19527300 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression EXP actein results in increased expression of USP18 protein CTD PMID:29969672 NCBI chr 4:153,812,312...153,834,374
Ensembl chr 4:153,805,993...153,834,430
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression EXP actein results in decreased expression of USP2 protein CTD PMID:29969672 NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885
JBrowse link
G Zfp354a zinc finger protein 354A decreases expression EXP actein results in decreased expression of ZNF354A protein CTD PMID:29969672 NCBI chr10:36,586,495...36,600,172
Ensembl chr10:36,589,181...36,600,469
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            Actein 72
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  terpene 9593
                                    triterpene 665
                                      triterpenoid 661
                                        Actein 72
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.