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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Actein
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Accession:CHEBI:70241 term browser browse the term
Definition:A triterpenoid that has formula C37H56O11.
Synonyms:related_synonym: Formula=C37H56O11;   InChI=1S/C37H56O11/c1-17-12-37(29-34(7,47-29)30(42)48-37)46-20-13-32(5)22-9-8-21-31(3,4)23(45-28-27(41)26(40)19(39)15-43-28)10-11-35(21)16-36(22,35)14-24(44-18(2)38)33(32,6)25(17)20/h17,19-30,39-42H,8-16H2,1-7H3/t17-,19-,20+,21+,22+,23+,24-,25+,26+,27-,28+,29-,30+,32+,33-,34+,35-,36+,37-/m1/s1;   InChIKey=NEWMWGLPJQHSSQ-PSDKAYTQSA-N;   SMILES=[H][C@]1(OC[C@@H](O)[C@H](O)[C@H]1O)O[C@H]1CC[C@]23C[C@]22C[C@@H](OC(C)=O)[C@]4(C)[C@@]5([H])[C@H](C)C[C@]6(O[C@H](O)[C@@]7(C)O[C@@]67[H])O[C@@]5([H])C[C@@]4(C)[C@]2([H])CC[C@@]3([H])C1(C)C
 xref_mesh: MESH:C096064
 xref: PMID:21082802


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Actein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP actein results in increased expression of A2M mRNA; actein results in increased expression of A2M protein CTD PMID:19527300 PMID:29969672 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression EXP actein results in decreased expression of ACOX1 mRNA CTD PMID:19527300 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acox2 acyl-CoA oxidase 2 increases expression EXP actein results in increased expression of ACOX2 protein CTD PMID:29969672 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein] CTD PMID:28836330 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR protein] CTD PMID:28836330 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP actein results in increased expression of ALOX15 protein CTD PMID:29969672 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL protein] CTD PMID:28836330 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Apcs amyloid P component, serum decreases expression EXP actein results in decreased expression of APCS mRNA CTD PMID:19527300 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP actein results in decreased expression of ASCL1 protein CTD PMID:29969672 NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993
JBrowse link
G Atp5me ATP synthase membrane subunit e decreases expression EXP actein results in decreased expression of ATP5ME mRNA CTD PMID:19527300 NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
JBrowse link
G C4bpa complement component 4 binding protein, alpha increases expression EXP actein results in increased expression of C4BPA mRNA CTD PMID:19527300 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta increases expression EXP actein results in increased expression of C4BPB mRNA CTD PMID:19527300 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G C5 complement C5 increases expression EXP actein results in increased expression of C5 mRNA CTD PMID:19527300 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP actein results in increased expression of CA3 protein CTD PMID:29969672 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Ccnd1 cyclin D1 affects expression
decreases expression
EXP
ISO
actein affects the expression of CCND1 mRNA
actein results in decreased expression of CCND1 protein
actein results in decreased expression of CCND1 mRNA; actein results in decreased expression of CCND1 protein
CTD PMID:14758092 PMID:19527300 PMID:29969672 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP actein results in increased expression of CD44 mRNA CTD PMID:19527300 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO actein results in decreased expression of CDK4 protein CTD PMID:14758092 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO actein results in increased expression of CDKN1A protein CTD PMID:14758092 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces1d carboxylesterase 1D decreases expression EXP actein results in decreased expression of CES1 protein CTD PMID:29969672 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP actein results in increased expression of CXCL1 mRNA CTD PMID:19527300 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP actein results in increased expression of CXCL2 protein CTD PMID:29969672 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:28836330 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP actein results in decreased expression of CYP2C22 mRNA CTD PMID:19527300 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP actein results in decreased expression of CYP2J9 protein CTD PMID:29969672 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP actein results in increased expression of CYP7A1 mRNA CTD PMID:19527300 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Dipk1c divergent protein kinase domain 1C decreases expression EXP actein results in decreased expression of DIPK1C protein CTD PMID:29969672 NCBI chr18:78,087,972...78,109,910
Ensembl chr18:78,087,991...78,109,904
JBrowse link
G Epo erythropoietin decreases expression EXP actein results in decreased expression of EPO mRNA CTD PMID:19527300 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP actein results in increased expression of FAS mRNA CTD PMID:19527300 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP actein results in increased expression of FDPS mRNA CTD PMID:19527300 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression EXP actein results in increased expression of FLT1 mRNA CTD PMID:19527300 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP actein results in increased expression of FMO1 protein CTD PMID:29969672 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 decreases expression EXP actein results in decreased expression of GPD2 mRNA CTD PMID:19527300 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP actein results in decreased expression of HAMP protein CTD PMID:29969672 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase affects expression EXP actein affects the expression of HMGCR mRNA CTD PMID:19527300 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 affects expression
increases expression
EXP actein affects the expression of HMGCS1 mRNA
actein results in increased expression of HMGCS1 mRNA
CTD PMID:19527300 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 affects expression EXP actein affects the expression of HSD17B7 mRNA CTD PMID:19527300 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IBSP mRNA] CTD PMID:28836330 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression EXP actein results in decreased expression of ID1 protein CTD PMID:29969672 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein affects expression EXP actein affects the expression of ID3 mRNA CTD PMID:19527300 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP actein results in increased expression of IDI1 protein CTD PMID:29969672 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression EXP actein results in increased expression of ISG15 protein CTD PMID:29969672 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP actein results in increased expression of LCN2 protein CTD PMID:29969672 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lgalsl galectin-like decreases expression EXP actein results in decreased expression of LGALSL protein CTD PMID:29969672 NCBI chr14:94,996,991...95,004,499
Ensembl chr14:94,996,990...95,004,980
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA] CTD PMID:28836330 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Me1 malic enzyme 1 decreases expression EXP actein results in decreased expression of ME1 mRNA CTD PMID:19527300 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression EXP actein results in increased expression of MX1 protein CTD PMID:29969672 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA] CTD PMID:28836330 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Noct nocturnin decreases expression EXP actein results in decreased expression of NOCT protein CTD PMID:29969672 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Npas2 neuronal PAS domain protein 2 decreases expression EXP actein results in decreased expression of NPAS2 protein CTD PMID:29969672 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression
increases expression
EXP actein affects the expression of NQO1 mRNA
actein results in increased expression of NQO1 mRNA
CTD PMID:19527300 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP actein results in decreased expression of NR0B2 protein CTD PMID:29969672 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression EXP actein results in increased expression of OAS1 protein CTD PMID:29969672 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP actein results in increased expression of OASL protein CTD PMID:29969672 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP actein results in increased expression of PCSK9 protein CTD PMID:29969672 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression EXP actein results in increased expression of PSMB10 mRNA CTD PMID:19527300 NCBI chr19:33,830,958...33,833,442 JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO actein results in decreased expression of RB1 protein CTD PMID:14758092 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rgs5 regulator of G-protein signaling 5 increases expression EXP actein results in increased expression of RGS5 protein CTD PMID:29969672 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP actein results in increased expression of S100A8 protein CTD PMID:29969672 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression
affects expression
EXP actein results in increased expression of S100A9 mRNA; actein results in increased expression of S100A9 protein
actein affects the expression of S100A9 mRNA
CTD PMID:19527300 PMID:29969672 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP actein results in decreased expression of SCD protein; actein results in decreased expression of SCD1 mRNA CTD PMID:19527300 PMID:29969672 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP actein results in increased expression of SDF2L1 protein CTD PMID:29969672 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP actein results in decreased expression of SLC25A30 protein CTD PMID:29969672 NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOD2 mRNA] CTD PMID:28836330 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SOD3 mRNA] CTD PMID:28836330 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SP7 mRNA] CTD PMID:28836330 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Sqle squalene epoxidase increases expression EXP actein results in increased expression of SQLE protein CTD PMID:29969672 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Tfrc transferrin receptor increases expression EXP actein results in increased expression of TFRC mRNA CTD PMID:19527300 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan decreases expression EXP actein results in decreased expression of TSKU protein CTD PMID:29969672 NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
JBrowse link
G Tspo translocator protein increases expression EXP actein results in increased expression of TSPO mRNA CTD PMID:19527300 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression EXP actein results in increased expression of USP18 protein CTD PMID:29969672 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression EXP actein results in decreased expression of USP2 protein CTD PMID:29969672 NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
JBrowse link
G Zfp354a zinc finger protein 354A decreases expression EXP actein results in decreased expression of ZNF354A protein CTD PMID:29969672 NCBI chr10:35,396,242...35,408,065
Ensembl chr10:35,396,231...35,408,068
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            Actein 72
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  terpene 12711
                                    triterpene 737
                                      triterpenoid 732
                                        Actein 72
paths to the root