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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(+)-(S)-ar-turmerone
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Accession:CHEBI:70159 term browser browse the term
Definition:A sesquiterpenoid that is 2-methylhept-2-en-4-one substituted by a 4-methylphenyl group at position 6. It has been isolated from Peltophorum dasyrachis.
Synonyms:exact_synonym: (6S)-2-methyl-6-(4-methylphenyl)hept-2-en-4-one
 related_synonym: Formula=C15H20O;   InChI=1S/C15H20O/c1-11(2)9-15(16)10-13(4)14-7-5-12(3)6-8-14/h5-9,13H,10H2,1-4H3/t13-/m0/s1;   InChIKey=NAAJVHHFAXWBOK-ZDUSSCGKSA-N;   SMILES=C[C@@H](CC(=O)C=C(C)C)c1ccc(C)cc1
 xref: CAS:532-65-0
 xref_mesh: MESH:C078098
 xref: PMID:21189039;   Reaxys:3606512


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(+)-(S)-ar-turmerone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO ar-turmerone results in increased expression of ABCB1 mRNA CTD PMID:22181075 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions		 ISO ar-turmerone results in increased activity of AHR protein
ar-turmerone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]		 CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ar-turmerone results in increased expression of BAX mRNA; ar-turmerone results in increased expression of BAX protein CTD PMID:19250610 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 increases activity ISO ar-turmerone results in increased activity of CASP3 protein CTD PMID:19250610 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO ar-turmerone results in increased expression of CYP1A1 mRNA
ar-turmerone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]		 CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO ar-turmerone binds to PPARG protein CTD PMID:15713005 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO ar-turmerone results in increased expression of TP53 mRNA; ar-turmerone results in increased expression of TP53 protein CTD PMID:19250610 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        biochemical role 19443
          metabolite 19430
            eukaryotic metabolite 19227
              plant metabolite 17860
                (+)-(S)-ar-turmerone 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18799
                                    carbonyl compound 18799
                                      ketone 17108
                                        alpha,beta-unsaturated ketone 9954
                                          enone 9954
                                            (+)-(S)-ar-turmerone 7
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