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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Moxonidine
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Accession:CHEBI:7009 term browser browse the term
Definition:A pyrimidine that has formula C9H12ClN5O.
Synonyms:related_synonym: Formula=C9H12ClN5O;   InChI=1S/C9H12ClN5O/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9/h3-4H2,1-2H3,(H2,11,12,15);   InChIKey=WPNJAUFVNXKLIM-UHFFFAOYSA-N;   SMILES=COc1nc(C)nc(Cl)c1NC1=NCCN1;   moxonidin;   normoxocin
 xref: CAS:75438-57-2;   Drug_Central:1856;   HMDB:HMDB0041938;   KEGG:C07451;   KEGG:D05087;   LINCS:LSM-3743
 xref_mesh: MESH:C043482


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Moxonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor multiple interactions EXP ADORA2A protein affects the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO moxonidine binds to and results in increased activity of ADRA2A protein CTD PMID:10217548 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Ins2 insulin 2 decreases expression
decreases secretion		 ISO
EXP		 moxonidine results in decreased expression of INS protein
moxonidine results in decreased secretion of INS protein		 CTD PMID:15071362 PMID:16700870 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Nisch nischarin multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]; [moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol; ADORA2A protein affects the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]; Caffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr16:6,364,370...6,400,675
Ensembl chr16:6,364,374...6,400,668 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO moxonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO moxonidine results in increased activity of TAAR1 protein
[moxonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      molecular entity 19829
        polyatomic entity 19787
          heteroatomic molecular entity 19743
            halide 18635
              organohalogen compound 18507
                Moxonidine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteromonocyclic compound 17794
                                    diazines 13228
                                      pyrimidines 13094
                                        Moxonidine 6
paths to the root