Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Moxonidine
go back to main search page
Accession:CHEBI:7009 term browser browse the term
Definition:A pyrimidine that has formula C9H12ClN5O.
Synonyms:related_synonym: Formula=C9H12ClN5O;   InChI=1S/C9H12ClN5O/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9/h3-4H2,1-2H3,(H2,11,12,15);   InChIKey=WPNJAUFVNXKLIM-UHFFFAOYSA-N;   SMILES=COc1nc(C)nc(Cl)c1NC1=NCCN1;   moxonidin;   normoxocin
 xref: CAS:75438-57-2;   Drug_Central:1856;   HMDB:HMDB0041938;   KEGG:C07451;   KEGG:D05087;   LINCS:LSM-3743
 xref_mesh: MESH:C043482


show annotations for term's descendants           Sort by:
 
Moxonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor multiple interactions EXP ADORA2A protein affects the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO moxonidine binds to and results in increased activity of ADRA2A protein CTD PMID:10217548 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Ins2 insulin 2 decreases expression
decreases secretion
ISO
EXP
moxonidine results in decreased expression of INS protein
moxonidine results in decreased secretion of INS protein
CTD PMID:15071362, PMID:16700870 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Nisch nischarin multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]; [moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol; ADORA2A protein affects the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]; Caffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO moxonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO moxonidine results in increased activity of TAAR1 protein
[moxonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        polyatomic entity 19695
          heteroatomic molecular entity 19620
            halide 17977
              organohalogen compound 17713
                Moxonidine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteromonocyclic compound 16444
                                    diazines 12138
                                      pyrimidines 11955
                                        Moxonidine 6
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.