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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:morusin
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Accession:CHEBI:7005 term browser browse the term
Definition:An extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2' and 4', a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8.
Synonyms:exact_synonym: 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-en-1-yl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
 related_synonym: Formula=C25H24O6;   InChI=1S/C25H24O6/c1-13(2)5-7-17-22(29)21-19(28)12-20-16(9-10-25(3,4)31-20)24(21)30-23(17)15-8-6-14(26)11-18(15)27/h5-6,8-12,26-28H,7H2,1-4H3;   InChIKey=XFFOMNJIDRDDLQ-UHFFFAOYSA-N;   SMILES=CC(C)=CCc1c(oc2c3C=CC(C)(C)Oc3cc(O)c2c1=O)-c1ccc(O)cc1O
 xref: CAS:62596-29-6;   HMDB:HMDB0036631;   KEGG:C10106;   KNApSAcK:C00001070
 xref_mesh: MESH:C057451
 xref: PMID:25237377;   PMID:25476160;   PMID:25628938;   Reaxys:1442330


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morusin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [morusin results in decreased phosphorylation of AKT1 protein] CTD PMID:33035517 PMID:37443484 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO morusin results in increased expression of BAX protein CTD PMID:33035517 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO morusin results in decreased expression of BCL2 protein CTD PMID:33035517 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO morusin results in decreased expression of BCL2L1 protein CTD PMID:33035517 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [morusin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [morusin results in increased cleavage of CASP3 protein] CTD PMID:33035517 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO morusin results in increased cleavage of CASP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP9 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [morusin results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of CASP9 protein]; U 0126 inhibits the reaction [morusin results in increased cleavage of CASP9 protein]		 CTD PMID:33035517 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO morusin results in increased expression of CDH1 protein CTD PMID:25476160 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein] CTD PMID:28108223 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Ctsb cathepsin B decreases metabolic processing ISO morusin results in decreased metabolism of CTSB protein CTD PMID:29421517 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsd cathepsin D decreases metabolic processing ISO morusin results in decreased metabolism of CTSD protein CTD PMID:29421517 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of DDIT3 protein] CTD PMID:29421517 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO morusin results in increased expression of ERN1 protein CTD PMID:29421517 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of HSPA5 protein] CTD PMID:29421517 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO morusin results in decreased expression of ITGA2 protein CTD PMID:25476160 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO morusin results in decreased expression of ITGA6 protein CTD PMID:25476160 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO morusin results in decreased expression of ITGB1 protein CTD PMID:25476160 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:28108223 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [morusin results in increased phosphorylation of MAPK1 protein] CTD PMID:33035517 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [morusin results in increased phosphorylation of MAPK3 protein] CTD PMID:33035517 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO morusin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:25476160 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO morusin results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:25476160 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [morusin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [morusin results in increased cleavage of PARP1 protein] CTD PMID:33035517 PMID:37443484 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression
multiple interactions		 ISO morusin results in decreased expression of PDCD6IP protein
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in decreased expression of PDCD6IP protein]		 CTD PMID:29421517 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases phosphorylation ISO morusin results in decreased phosphorylation of PIK3CA protein CTD PMID:37443484 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:28108223 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation
multiple interactions		 ISO morusin results in decreased phosphorylation of RELA protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in decreased phosphorylation of RELA protein]; morusin results in decreased phosphorylation of and affects the localization of RELA protein
morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]		 CTD PMID:25476160 PMID:28108223 PMID:33035517 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
decreases expression		 ISO morusin results in increased expression of SQSTM1 protein
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [morusin results in decreased expression of SQSTM1 protein]; U 0126 inhibits the reaction [morusin results in decreased expression of SQSTM1 protein]		 CTD PMID:29421517 PMID:33035517 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation		 ISO morusin results in decreased phosphorylation of and affects the localization of STAT3 protein
morusin results in decreased phosphorylation of STAT3 protein		 CTD PMID:25476160 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO morusin results in decreased expression of VIM protein
morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]		 CTD PMID:25476160 PMID:28108223 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        pharmaceutical 19491
          drug 19491
            antineoplastic agent 17757
              morusin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  oxacycle 17838
                                    benzopyran 11965
                                      1-benzopyran 11716
                                        flavonoid 7192
                                          anthoxanthin 4540
                                            flavones 4540
                                              hydroxyflavone 4518
                                                trihydroxyflavone 428
                                                  morusin 29
paths to the root