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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:morusin
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Accession:CHEBI:7005 term browser browse the term
Definition:An extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2' and 4', a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8.
Synonyms:exact_synonym: 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-en-1-yl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
 related_synonym: Formula=C25H24O6;   InChI=1S/C25H24O6/c1-13(2)5-7-17-22(29)21-19(28)12-20-16(9-10-25(3,4)31-20)24(21)30-23(17)15-8-6-14(26)11-18(15)27/h5-6,8-12,26-28H,7H2,1-4H3;   InChIKey=XFFOMNJIDRDDLQ-UHFFFAOYSA-N;   SMILES=CC(C)=CCc1c(oc2c3C=CC(C)(C)Oc3cc(O)c2c1=O)-c1ccc(O)cc1O
 xref: CAS:62596-29-6;   HMDB:HMDB0036631;   KEGG:C10106;   KNApSAcK:C00001070
 xref_mesh: MESH:C057451
 xref: PMID:25237377;   PMID:25476160;   PMID:25628938;   Reaxys:1442330


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morusin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 increases expression ISO morusin results in increased expression of CDH1 protein CTD PMID:25476160 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein] CTD PMID:28108223 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Ctsb cathepsin B decreases metabolic processing ISO morusin results in decreased metabolism of CTSB protein CTD PMID:29421517 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D decreases metabolic processing ISO morusin results in decreased metabolism of CTSD protein CTD PMID:29421517 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of DDIT3 protein] CTD PMID:29421517 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO morusin results in increased expression of ERN1 protein CTD PMID:29421517 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of HSPA5 protein] CTD PMID:29421517 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO morusin results in decreased expression of ITGA2 protein CTD PMID:25476160 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO morusin results in decreased expression of ITGA6 protein CTD PMID:25476160 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO morusin results in decreased expression of ITGB1 protein CTD PMID:25476160 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:28108223 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO morusin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:25476160 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO morusin results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:25476160 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression
multiple interactions
ISO morusin results in decreased expression of PDCD6IP protein
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in decreased expression of PDCD6IP protein]
CTD PMID:29421517 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:28108223 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation
multiple interactions
ISO morusin results in decreased phosphorylation of RELA protein
morusin results in decreased phosphorylation of and affects the localization of RELA protein
morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]
CTD PMID:25476160, PMID:28108223 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO morusin results in increased expression of SQSTM1 protein
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of SQSTM1 protein]
CTD PMID:29421517 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO morusin results in decreased phosphorylation of and affects the localization of STAT3 protein
morusin results in decreased phosphorylation of STAT3 protein
CTD PMID:25476160 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO morusin results in decreased expression of VIM protein
morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]
CTD PMID:25476160, PMID:28108223 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            antineoplastic agent 16982
              morusin 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  oxacycle 17181
                                    benzopyran 10132
                                      1-benzopyran 9848
                                        flavonoid 6372
                                          flavones 4166
                                            hydroxyflavone 4154
                                              trihydroxyflavone 338
                                                morusin 19
paths to the root

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