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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:morusin
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Accession:CHEBI:7005 term browser browse the term
Definition:An extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2' and 4', a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8.
Synonyms:exact_synonym: 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-en-1-yl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
 related_synonym: Formula=C25H24O6;   InChI=1S/C25H24O6/c1-13(2)5-7-17-22(29)21-19(28)12-20-16(9-10-25(3,4)31-20)24(21)30-23(17)15-8-6-14(26)11-18(15)27/h5-6,8-12,26-28H,7H2,1-4H3;   InChIKey=XFFOMNJIDRDDLQ-UHFFFAOYSA-N;   SMILES=CC(C)=CCc1c(oc2c3C=CC(C)(C)Oc3cc(O)c2c1=O)-c1ccc(O)cc1O
 xref: CAS:62596-29-6;   HMDB:HMDB0036631;   KEGG:C10106;   KNApSAcK:C00001070
 xref_mesh: MESH:C057451
 xref: PMID:25237377;   PMID:25476160;   PMID:25628938;   Reaxys:1442330


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morusin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [morusin results in decreased phosphorylation of AKT1 protein] CTD PMID:33035517 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO morusin results in increased expression of BAX protein CTD PMID:33035517 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO morusin results in decreased expression of BCL2 protein CTD PMID:33035517 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO morusin results in decreased expression of BCL2L1 protein CTD PMID:33035517 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [morusin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [morusin results in increased cleavage of CASP3 protein] CTD PMID:33035517 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO morusin results in increased cleavage of CASP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP9 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [morusin results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of CASP9 protein]; U 0126 inhibits the reaction [morusin results in increased cleavage of CASP9 protein]
CTD PMID:33035517 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdh1 cadherin 1 increases expression ISO morusin results in increased expression of CDH1 protein CTD PMID:25476160 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein] CTD PMID:28108223 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Ctsb cathepsin B decreases metabolic processing ISO morusin results in decreased metabolism of CTSB protein CTD PMID:29421517 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D decreases metabolic processing ISO morusin results in decreased metabolism of CTSD protein CTD PMID:29421517 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of DDIT3 protein] CTD PMID:29421517 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO morusin results in increased expression of ERN1 protein CTD PMID:29421517 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of HSPA5 protein] CTD PMID:29421517 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO morusin results in decreased expression of ITGA2 protein CTD PMID:25476160 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO morusin results in decreased expression of ITGA6 protein CTD PMID:25476160 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO morusin results in decreased expression of ITGB1 protein CTD PMID:25476160 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:28108223 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [morusin results in increased phosphorylation of MAPK1 protein] CTD PMID:33035517 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [morusin results in increased phosphorylation of MAPK3 protein] CTD PMID:33035517 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO morusin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:25476160 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO morusin results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:25476160 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [morusin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [morusin results in increased cleavage of PARP1 protein] CTD PMID:33035517 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression
multiple interactions
ISO morusin results in decreased expression of PDCD6IP protein
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in decreased expression of PDCD6IP protein]
CTD PMID:29421517 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:28108223 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation
multiple interactions
ISO morusin results in decreased phosphorylation of RELA protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in decreased phosphorylation of RELA protein]; morusin results in decreased phosphorylation of and affects the localization of RELA protein
morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]
CTD PMID:25476160 PMID:28108223 PMID:33035517 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sqstm1 sequestosome 1 increases expression
decreases expression
multiple interactions
ISO morusin results in increased expression of SQSTM1 protein
morusin results in decreased expression of SQSTM1 protein
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [morusin results in decreased expression of SQSTM1 protein]; U 0126 inhibits the reaction [morusin results in decreased expression of SQSTM1 protein]
CTD PMID:29421517 PMID:33035517 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO morusin results in decreased phosphorylation of and affects the localization of STAT3 protein
morusin results in decreased phosphorylation of STAT3 protein
CTD PMID:25476160 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO morusin results in decreased expression of VIM protein
morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]
CTD PMID:25476160 PMID:28108223 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              morusin 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  oxacycle 17587
                                    benzopyran 10402
                                      1-benzopyran 10129
                                        flavonoid 6513
                                          flavones 4203
                                            hydroxyflavone 4191
                                              trihydroxyflavone 352
                                                morusin 28
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