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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17-hydroxyjolkinolide B
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Accession:CHEBI:69828 term browser browse the term
Definition:A diterpene lactone that has formula C20H26O5.
Synonyms:related_synonym: (4aR,6aS,7aR,10aR,11aR,11bR,11cR)-8-(Hydroxymethyl)-4,4,11c-trimethyl-1,2,3,4,4a,5,6,11a,11b,11c-decahydrobisoxireno[3,4:1,10a]phenanthro[3,2-b]furan-9(7aH)-one;   Formula=C20H26O5;   InChI=1S/C20H26O5/c1-17(2)6-4-7-18(3)11(17)5-8-19-13(18)15-20(24-15)12(14(19)23-19)10(9-21)16(22)25-20/h11,13-15,21H,4-9H2,1-3H3/t11-,13+,14-,15-,18-,19+,20-/m1/s1;   InChIKey=ORPHDWFMIUUKJM-MCDHERAVSA-N;   SMILES=[H][C@]12O[C@]11CC[C@]3([H])C(C)(C)CCC[C@@]3(C)[C@]1([H])[C@@]1([H])O[C@]11OC(=O)C(CO)=C21
 xref_mesh: MESH:C057916
 xref: PMID:21534540



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17-hydroxyjolkinolide B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 multiple interactions ISO 17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; 17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]] CTD PMID:22080918 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22080918 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22080918 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22080918 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:22080918 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22080918 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22080918 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of RELA protein] CTD PMID:22080918 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 17-hydroxyjolkinolide B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:22080918 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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  CHEBI ontology 19715
    role 19690
      biological role 19688
        biochemical role 19395
          metabolite 19380
            17-hydroxyjolkinolide B 9
Path 2
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  CHEBI ontology 19715
    subatomic particle 19713
      composite particle 19713
        hadron 19713
          baryon 19713
            nucleon 19713
              atomic nucleus 19713
                atom 19713
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19606
                        carbon atom 19603
                          organic molecular entity 19603
                            organic group 18792
                              organic divalent group 18777
                                organodiyl group 18777
                                  carbonyl group 18743
                                    carbonyl compound 18743
                                      carboxylic ester 15915
                                        lactone 11285
                                          terpene lactone 1791
                                            diterpene lactone 233
                                              17-hydroxyjolkinolide B 9
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