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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:monocrotaline
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Accession:CHEBI:6980 term browser browse the term
Definition:A pyrrolizidine alkaloid that has formula C16H23NO6.
Synonyms:exact_synonym: (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
 related_synonym: (13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione;   Formula=C16H23NO6;   InChI=1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1;   InChIKey=QVCMHGGNRFRMAD-XFGHUUIASA-N;   Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate;   SMILES=[H][C@]12CCN3CC=C(COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O1)[C@]23[H];   Testosterone oenanthate
 xref: CAS:315-22-0;   KEGG:C10350;   KNApSAcK:C00002101;   LINCS:LSM-6637
 xref_mesh: MESH:D016686


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monocrotaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ODC1 ornithine decarboxylase 1 increases activity
increases expression		 EXP Monocrotaline results in increased activity of ODC1 protein
Monocrotaline results in increased expression of ODC1 mRNA		 CTD PMID:9812344 NCBI chr 3:126,087,013...126,095,644
Ensembl chr 3:126,087,242...126,096,051 		JBrowse link
G TNC tenascin C multiple interactions
increases expression		 EXP 1,3-dimethylthiourea inhibits the reaction [Monocrotaline results in increased expression of TNC mRNA] CTD PMID:9251245 NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,533,238...255,630,376 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      biological role 5016
        biochemical role 4938
          metabolite 4926
            alkaloid 74
              pyrrolizidine alkaloid 2
                monocrotaline 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      carbon group element atom 4927
                        carbon atom 4954
                          organic molecular entity 4926
                            organic molecule 4874
                              organic cyclic compound 4812
                                organic heterocyclic compound 4626
                                  organic heteropolycyclic compound 4424
                                    organic heterobicyclic compound 141
                                      pyrrolizidine 2
                                        pyrrolizidine alkaloid 2
                                          monocrotaline 2
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