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ONTOLOGY REPORT - ANNOTATIONS


Term:monocrotaline
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Accession:CHEBI:6980 term browser browse the term
Definition:A pyrrolizidine alkaloid that has formula C16H23NO6.
Synonyms:exact_synonym: (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
 related_synonym: (13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione;   Formula=C16H23NO6;   InChI=1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1;   InChIKey=QVCMHGGNRFRMAD-XFGHUUIASA-N;   Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate;   SMILES=[H][C@]12CCN3CC=C(COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O1)[C@]23[H];   Testosterone oenanthate
 xref: CAS:315-22-0;   KEGG:C10350;   KNApSAcK:C00002101;   LINCS:LSM-6637
 xref_mesh: MESH:D016686


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monocrotaline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 JBrowse link 11 105,967,948 105,989,964 RGD:6480464
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 JBrowse link X 164,139,342 164,188,418 RGD:6480464
G Acta2 actin, alpha 2, smooth muscle, aorta JBrowse link 19 34,240,336 34,255,585 RGD:6480464
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,706 RGD:6480464
G Agtr1a angiotensin II receptor, type 1a JBrowse link 13 30,336,356 30,382,867 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Anxa5 annexin A5 JBrowse link 3 36,448,923 36,475,887 RGD:6480464
G Atm ataxia telangiectasia mutated JBrowse link 9 53,437,122 53,536,828 RGD:6480464
G Atp6v0e2 ATPase, H+ transporting, lysosomal V0 subunit E2 JBrowse link 6 48,537,569 48,541,801 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcl2l1 BCL2-like 1 JBrowse link 2 152,758,732 152,833,803 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 11 117,849,237 117,855,743 RGD:6480464
G Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) JBrowse link 1 59,764,279 59,878,081 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Cav1 caveolin 1, caveolae protein JBrowse link 6 17,306,335 17,341,328 RGD:6480464
G Cav2 caveolin 2 JBrowse link 6 17,281,185 17,289,130 RGD:6480464
G Cavin1 caveolae associated 1 JBrowse link 11 100,956,736 100,970,617 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,831 RGD:6480464
G Ccng1 cyclin G1 JBrowse link 11 40,748,552 40,755,309 RGD:6480464
G Cdh2 cadherin 2 JBrowse link 18 16,588,877 16,809,246 RGD:6480464
G Cdh5 cadherin 5 JBrowse link 8 104,101,613 104,144,504 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) JBrowse link 17 29,090,979 29,100,722 RGD:6480464
G Chek2 checkpoint kinase 2 JBrowse link 5 110,839,800 110,874,140 RGD:6480464
G Col1a1 collagen, type I, alpha 1 JBrowse link 11 94,936,224 94,953,042 RGD:6480464
G Ctnnb1 catenin (cadherin associated protein), beta 1 JBrowse link 9 120,933,400 120,960,507 RGD:6480464
G Cxcl10 chemokine (C-X-C motif) ligand 10 JBrowse link 5 92,346,638 92,348,889 RGD:6480464
G Cxcl16 chemokine (C-X-C motif) ligand 16 JBrowse link 11 70,454,389 70,459,984 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 5 90,786,101 90,788,093 RGD:6480464
G Cybb cytochrome b-245, beta polypeptide JBrowse link X 9,435,252 9,487,766 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 17 79,706,940 79,715,061 RGD:6480464
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 JBrowse link 7 26,835,339 26,843,264 RGD:6480464
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 JBrowse link 7 25,897,658 25,926,624 RGD:6480464
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 JBrowse link 7 26,173,350 26,210,661 RGD:6480464
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 JBrowse link 19 39,389,556 39,463,103 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Cyp3a44 cytochrome P450, family 3, subfamily a, polypeptide 44 JBrowse link 5 145,773,983 145,805,891 RGD:6480464
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 JBrowse link 4 115,518,287 115,533,649 RGD:6480464
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 JBrowse link 4 115,486,200 115,496,158 RGD:6480464
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 JBrowse link 4 6,265,612 6,275,632 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 10 127,290,793 127,296,291 RGD:6480464
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link 4 40,722,468 40,734,965 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 2 154,559,400 154,569,892 RGD:6480464
G Edn1 endothelin 1 JBrowse link 13 42,301,476 42,307,990 RGD:6480464
G Ednra endothelin receptor type A JBrowse link 8 77,663,029 77,724,452 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 34,861,207 34,864,956 RGD:6480464
G F3 coagulation factor III JBrowse link 3 121,723,537 121,735,052 RGD:6480464
G Fasl Fas ligand (TNF superfamily, member 6) JBrowse link 1 161,780,691 161,788,495 RGD:6480464
G Fbxo32 F-box protein 32 JBrowse link 15 58,175,879 58,214,892 RGD:6480464
G Fmo1 flavin containing monooxygenase 1 JBrowse link 1 162,829,561 162,866,610 RGD:6480464
G Fmo4 flavin containing monooxygenase 4 JBrowse link 1 162,793,188 162,816,072 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 1 71,585,473 71,653,280 RGD:6480464
G Foxo3 forkhead box O3 JBrowse link 10 42,181,845 42,276,695 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha JBrowse link 6 67,035,096 67,037,407 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 9 77,754,535 77,794,489 RGD:6480464
G Gclm glutamate-cysteine ligase, modifier subunit JBrowse link 3 122,245,487 122,267,215 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 11 102,887,336 102,897,200 RGD:6480464
G Gpt glutamic pyruvic transaminase, soluble JBrowse link 15 76,696,726 76,699,675 RGD:6480464
G Gpx2 glutathione peroxidase 2 JBrowse link 12 76,792,335 76,795,554 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 16 38,089,001 38,246,084 RGD:6480464
G Gsr glutathione reductase JBrowse link 8 33,653,238 33,698,162 RGD:6480464
G Gstm1 glutathione S-transferase, mu 1 JBrowse link 3 108,012,250 108,017,973 RGD:6480464
G Gstm5 glutathione S-transferase, mu 5 JBrowse link 3 107,895,854 107,898,685 RGD:6480464
G Hmgb1 high mobility group box 1 JBrowse link 5 149,046,702 149,053,057 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Hspa1l heat shock protein 1-like JBrowse link 17 34,972,703 34,979,228 RGD:6480464
G Hspa8 heat shock protein 8 JBrowse link 9 40,801,276 40,805,202 RGD:6480464
G Hspb1 heat shock protein 1 JBrowse link 5 135,887,919 135,889,563 RGD:6480464
G Hspd1 heat shock protein 1 (chaperonin) JBrowse link 1 55,077,833 55,088,243 RGD:6480464
G Hspe1 heat shock protein 1 (chaperonin 10) JBrowse link 1 55,088,148 55,091,317 RGD:6480464
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A JBrowse link 14 74,640,874 74,706,859 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,940 21,028,814 RGD:6480464
G Id1 inhibitor of DNA binding 1, HLH protein JBrowse link 2 152,736,251 152,737,410 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il18 interleukin 18 JBrowse link 9 50,554,700 50,581,841 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 2 129,299,609 129,310,186 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Itgb1 integrin beta 1 (fibronectin receptor beta) JBrowse link 8 128,685,654 128,733,579 RGD:6480464
G Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 JBrowse link 6 126,532,551 126,535,555 RGD:6480464
G Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 JBrowse link 2 167,095,969 167,190,072 RGD:6480464
G Lep leptin JBrowse link 6 29,060,221 29,073,876 RGD:6480464
G Lgals3 lectin, galactose binding, soluble 3 JBrowse link 14 47,373,860 47,386,167 RGD:6480464
G Limd2 LIM domain containing 2 JBrowse link 11 106,156,254 106,160,729 RGD:6480464
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 JBrowse link 7 110,850,607 110,862,953 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mdm2 transformed mouse 3T3 cell double minute 2 JBrowse link 10 117,688,875 117,710,758 RGD:6480464
G Mgat5b mannoside acetylglucosaminyltransferase 5, isoenzyme B JBrowse link 11 116,918,853 116,986,944 RGD:6480464
G Mir122 microRNA 122 JBrowse link 18 65,248,861 65,248,926 RGD:6480464
G Mir132 microRNA 132 JBrowse link 11 75,173,682 75,173,747 RGD:6480464
G Mir138-1 microRNA 138-1 JBrowse link 9 122,682,876 122,682,974 RGD:6480464
G Mir1894 microRNA 1894 JBrowse link 17 35,917,889 35,917,969 RGD:6480464
G Mir1902 microRNA 1902 JBrowse link 2 104,428,861 104,428,940 RGD:6480464
G Mir1964 microRNA 1964 JBrowse link 7 29,773,294 29,773,376 RGD:6480464
G Mir219b microRNA 219b JBrowse link 2 29,845,647 29,845,711 RGD:6480464
G Mir295 microRNA 295 JBrowse link 7 3,220,773 3,220,841 RGD:6480464
G Mir301b microRNA 301b JBrowse link 16 17,124,400 17,124,496 RGD:6480464
G Mir3058 microRNA 3058 JBrowse link 10 95,559,231 95,559,321 RGD:6480464
G Mir3060 microRNA 3060 JBrowse link 11 4,139,364 4,139,446 RGD:6480464
G Mir325 microRNA 325 JBrowse link X 105,379,082 105,379,179 RGD:6480464
G Mir344b microRNA 344b JBrowse link 7 61,790,519 61,790,581 RGD:6480464
G Mir344f microRNA Mir344f JBrowse link 7 62,046,181 62,046,248 RGD:6480464
G Mir3473d microRNA 3473d JBrowse link 8 111,016,450 111,016,530 RGD:6480464
G Mir370 microRNA 370 JBrowse link 12 109,618,258 109,618,336 RGD:6480464
G Mir380 microRNA 380 JBrowse link 12 109,711,803 109,711,863 RGD:6480464
G Mir382 microRNA 382 JBrowse link 12 109,733,771 109,733,846 RGD:6480464
G Mir3966 microRNA 3966 JBrowse link 10 97,423,478 97,423,562 RGD:6480464
G Mir410 microRNA 410 JBrowse link 12 109,743,715 109,743,795 RGD:6480464
G Mir463 microRNA 463 JBrowse link X 66,799,223 66,799,297 RGD:6480464
G Mir489 microRNA 489 JBrowse link 6 3,721,897 3,722,003 RGD:6480464
G Mir500 microRNA 500 JBrowse link X 7,237,683 7,237,774 RGD:6480464
G Mir547 microRNA 547 JBrowse link X 67,988,374 67,988,451 RGD:6480464
G Mir551b microRNA 551b JBrowse link 3 29,416,823 29,416,920 RGD:6480464
G Mir690 microRNA 690 JBrowse link 16 28,599,935 28,600,043 RGD:6480464
G Mir691 microRNA 691 JBrowse link 16 74,341,990 74,342,067 RGD:6480464
G Mir743 microRNA 743 JBrowse link X 66,776,757 66,776,818 RGD:6480464
G Mir878 microRNA 878 JBrowse link X 66,801,508 66,801,585 RGD:6480464
G Mir93 microRNA 93 JBrowse link 5 138,165,523 138,165,610 RGD:6480464
G Mir98 microRNA 98 JBrowse link X 151,913,214 151,913,321 RGD:6480464
G Mirlet7b microRNA let7b JBrowse link 15 85,707,319 85,707,403 RGD:6480464
G Mki67 antigen identified by monoclonal antibody Ki 67 JBrowse link 7 135,689,784 135,716,450 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 8 92,827,290 92,853,421 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:6480464
G Mpo myeloperoxidase JBrowse link 11 87,793,784 87,804,412 RGD:6480464
G Myd88 myeloid differentiation primary response gene 88 JBrowse link 9 119,335,934 119,340,018 RGD:6480464
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha JBrowse link 14 54,941,921 54,968,017 RGD:6480464
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta JBrowse link 14 54,970,684 54,994,626 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:6480464
G Nox1 NADPH oxidase 1 JBrowse link X 134,086,421 134,137,711 RGD:6480464
G Nox4 NADPH oxidase 4 JBrowse link 7 87,244,430 87,398,710 RGD:6480464
G Nppa natriuretic peptide type A JBrowse link 4 148,000,722 148,002,074 RGD:6480464
G Nppb natriuretic peptide type B JBrowse link 4 147,985,786 147,987,205 RGD:6480464
G Nqo1 NAD(P)H dehydrogenase, quinone 1 JBrowse link 8 107,388,225 107,403,205 RGD:6480464
G Pecam1 platelet/endothelial cell adhesion molecule 1 JBrowse link 11 106,654,213 106,715,281 RGD:6480464
G Pigl phosphatidylinositol glycan anchor biosynthesis, class L JBrowse link 11 62,458,441 62,516,037 RGD:6480464
G Pknox1 Pbx/knotted 1 homeobox JBrowse link 17 31,564,722 31,607,693 RGD:6480464
G Plvap plasmalemma vesicle associated protein JBrowse link 8 71,497,753 71,511,806 RGD:6480464
G Postn periostin, osteoblast specific factor JBrowse link 3 54,359,267 54,391,041 RGD:6480464
G Prkar2a protein kinase, cAMP dependent regulatory, type II alpha JBrowse link 9 108,692,143 108,750,444 RGD:6480464
G Prkdc protein kinase, DNA activated, catalytic polypeptide JBrowse link 16 15,637,444 15,842,239 RGD:6480464
G Prkg1 protein kinase, cGMP-dependent, type I JBrowse link 19 30,564,487 31,765,268 RGD:6480464
G Psma1 proteasome subunit alpha 1 JBrowse link 7 114,264,550 114,276,116 RGD:6480464
G Psma3 proteasome subunit alpha 3 JBrowse link 12 70,969,283 70,995,877 RGD:6480464
G Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 JBrowse link 5 21,785,275 21,803,787 RGD:6480464
G Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 JBrowse link 14 45,329,823 45,349,074 RGD:6480464
G Rad50 RAD50 double strand break repair protein JBrowse link 11 53,649,519 53,707,319 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 4 86,854,099 86,857,367 RGD:6480464
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6480464
G Sirpb1b signal-regulatory protein beta 1B JBrowse link 3 15,495,754 15,575,067 RGD:6480464
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 JBrowse link 17 12,648,874 12,675,838 RGD:6480464
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 JBrowse link 11 76,998,597 77,032,343 RGD:6480464
G Smad1 SMAD family member 1 JBrowse link 8 79,338,395 79,399,428 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 11 50,200,152 50,210,820 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 11 100,886,806 100,939,594 RGD:6480464
G Tbxa2r thromboxane A2 receptor JBrowse link 10 81,328,268 81,335,174 RGD:6480464
G Tbxas1 thromboxane A synthase 1, platelet JBrowse link 6 38,864,159 39,084,590 RGD:6480464
G Tfrc transferrin receptor JBrowse link 16 32,608,896 32,632,794 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Thy1 thymus cell antigen 1, theta JBrowse link 9 44,043,384 44,048,579 RGD:6480464
G Ticam1 toll-like receptor adaptor molecule 1 JBrowse link 17 56,269,462 56,276,767 RGD:6480464
G Timp1 tissue inhibitor of metalloproteinase 1 JBrowse link X 20,870,166 20,874,737 RGD:6480464
G Tlr4 toll-like receptor 4 JBrowse link 4 66,827,551 66,846,581 RGD:6480464
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 5 124,540,791 124,550,503 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 JBrowse link 3 27,317,077 27,339,665 RGD:6480464
G Tnn tenascin N JBrowse link 1 160,085,029 160,153,692 RGD:6480464
G Tradd TNFRSF1A-associated via death domain JBrowse link 8 105,258,575 105,264,594 RGD:6480464
G Trf transferrin JBrowse link 9 103,208,876 103,230,286 RGD:6480464
G Tubb3 tubulin, beta 3 class III JBrowse link 8 123,411,553 123,422,015 RGD:6480464
G Txn2 thioredoxin 2 JBrowse link 15 77,915,051 77,928,994 RGD:6480464
G Txnrd1 thioredoxin reductase 1 JBrowse link 10 82,833,951 82,897,724 RGD:6480464
G Txnrd2 thioredoxin reductase 2 JBrowse link 16 18,426,417 18,479,073 RGD:6480464
G Ube2b ubiquitin-conjugating enzyme E2B JBrowse link 11 51,985,138 52,004,145 RGD:6480464
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 JBrowse link 11 72,607,261 72,686,481 RGD:6480464
G Ung uracil DNA glycosylase JBrowse link 5 114,130,366 114,139,321 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 3 116,110,020 116,129,688 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:6480464
G Vim vimentin JBrowse link 2 13,574,311 13,582,826 RGD:6480464
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 JBrowse link 13 89,848,914 90,089,608 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21309
    role 21296
      biological role 21294
        biochemical role 20358
          metabolite 20298
            alkaloid 5393
              pyrrolizidine alkaloid 266
                monocrotaline 185
Path 2
Term Annotations click to browse term
  CHEBI ontology 21309
    subatomic particle 21305
      composite particle 21305
        hadron 21305
          baryon 21305
            nucleon 21305
              atomic nucleus 21305
                atom 21305
                  main group element atom 21181
                    p-block element atom 21181
                      carbon group element atom 20978
                        carbon atom 20869
                          organic molecular entity 20869
                            organic molecule 20751
                              organic cyclic compound 20236
                                organic heterocyclic compound 19054
                                  organic heteropolycyclic compound 18490
                                    organic heterobicyclic compound 17232
                                      pyrrolizidine 266
                                        pyrrolizidine alkaloid 266
                                          monocrotaline 185
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.