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ONTOLOGY REPORT - ANNOTATIONS


Term:monocrotaline
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Accession:CHEBI:6980 term browser browse the term
Definition:A pyrrolizidine alkaloid that has formula C16H23NO6.
Synonyms:exact_synonym: (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
 related_synonym: (13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione;   Formula=C16H23NO6;   InChI=1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1;   InChIKey=QVCMHGGNRFRMAD-XFGHUUIASA-N;   Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate;   SMILES=[H][C@]12CCN3CC=C(COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O1)[C@]23[H];   Testosterone oenanthate
 xref: CAS:315-22-0;   KEGG:C10350;   KNApSAcK:C00002101;   LINCS:LSM-6637
 xref_mesh: MESH:D016686


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monocrotaline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACE angiotensin I converting enzyme JBrowse link 17 63,477,061 63,498,373 RGD:6480464
G ACE2 angiotensin I converting enzyme 2 JBrowse link X 15,494,520 15,602,158 RGD:6480464
G ACTA2 actin alpha 2, smooth muscle JBrowse link 10 88,935,074 88,991,397 RGD:6480464
G AGT angiotensinogen JBrowse link 1 230,702,523 230,714,122 RGD:6480464
G AGTR1 angiotensin II receptor type 1 JBrowse link 3 148,697,871 148,743,003 RGD:6480464
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6480464
G ANXA5 annexin A5 JBrowse link 4 121,667,946 121,696,994 RGD:6480464
G ATM ATM serine/threonine kinase JBrowse link 11 108,222,484 108,369,102 RGD:6480464
G ATP6V0E2 ATPase H+ transporting V0 subunit e2 JBrowse link 7 149,872,964 149,880,713 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BCL2L1 BCL2 like 1 JBrowse link 20 31,664,452 31,723,963 RGD:6480464
G BIRC5 baculoviral IAP repeat containing 5 JBrowse link 17 78,214,253 78,225,635 RGD:6480464
G BMPR2 bone morphogenetic protein receptor type 2 JBrowse link 2 202,376,310 202,567,751 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CAT catalase JBrowse link 11 34,438,934 34,472,060 RGD:6480464
G CAV1 caveolin 1 JBrowse link 7 116,525,009 116,561,185 RGD:6480464
G CAV2 caveolin 2 JBrowse link 7 116,499,738 116,508,541 RGD:6480464
G CAVIN1 caveolae associated protein 1 JBrowse link 17 42,402,449 42,423,269 RGD:6480464
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 34,255,285 34,257,203 RGD:6480464
G CCL5 C-C motif chemokine ligand 5 JBrowse link 17 35,871,491 35,880,360 RGD:6480464
G CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6480464
G CCNG1 cyclin G1 JBrowse link 5 163,437,571 163,448,199 RGD:6480464
G CDH2 cadherin 2 JBrowse link 18 27,932,878 28,177,130 RGD:6480464
G CDH5 cadherin 5 JBrowse link 16 66,366,657 66,404,784 RGD:6480464
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,463 36,687,332 RGD:6480464
G CHEK2 checkpoint kinase 2 JBrowse link 22 28,687,743 28,741,866 RGD:6480464
G COL1A1 collagen type I alpha 1 chain JBrowse link 17 50,184,096 50,201,649 RGD:6480464
G CTNNB1 catenin beta 1 JBrowse link 3 41,199,422 41,240,445 RGD:6480464
G CXCL1 C-X-C motif chemokine ligand 1 JBrowse link 4 73,869,393 73,871,308 RGD:6480464
G CXCL10 C-X-C motif chemokine ligand 10 JBrowse link 4 76,021,118 76,023,497 RGD:6480464
G CXCL16 C-X-C motif chemokine ligand 16 JBrowse link 17 4,733,533 4,739,928 RGD:6480464
G CYBB cytochrome b-245 beta chain JBrowse link X 37,780,059 37,813,461 RGD:6480464
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 JBrowse link 2 38,067,603 38,076,181 RGD:6480464
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 JBrowse link 19 41,088,451 41,096,195 RGD:6480464
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 JBrowse link 19 40,991,282 41,018,398 RGD:6480464
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 JBrowse link 10 94,762,681 94,855,547 RGD:6480464
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 JBrowse link 7 99,756,967 99,784,184 RGD:6480464
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 8 58,490,178 58,500,163 RGD:6480464
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 57,516,588 57,520,517 RGD:6480464
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link 9 33,025,203 33,039,907 RGD:6480464
G E2F1 E2F transcription factor 1 JBrowse link 20 33,675,477 33,686,385 RGD:6480464
G EDN1 endothelin 1 JBrowse link 6 12,256,463 12,297,194 RGD:6480464
G EDNRA endothelin receptor type A JBrowse link 4 147,480,917 147,544,954 RGD:6480464
G EGR1 early growth response 1 JBrowse link 5 138,465,479 138,469,303 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 1 94,529,173 94,541,857 RGD:6480464
G FASLG Fas ligand JBrowse link 1 172,659,008 172,666,876 RGD:6480464
G FBXO32 F-box protein 32 JBrowse link 8 123,497,887 123,541,206 RGD:6480464
G FMO1 flavin containing dimethylaniline monoxygenase 1 JBrowse link 1 171,248,471 171,285,978 RGD:6480464
G FMO4 flavin containing dimethylaniline monoxygenase 4 JBrowse link 1 171,314,131 171,342,084 RGD:6480464
G FN1 fibronectin 1 JBrowse link 2 215,360,440 215,436,167 RGD:6480464
G FOXO3 forkhead box O3 JBrowse link 6 108,559,825 108,684,774 RGD:6480464
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 1 67,685,201 67,688,334 RGD:6480464
G GCLC glutamate-cysteine ligase catalytic subunit JBrowse link 6 53,497,341 53,545,101 RGD:6480464
G GCLM glutamate-cysteine ligase modifier subunit JBrowse link 1 93,885,199 93,910,370 RGD:6480464
G GFAP glial fibrillary acidic protein JBrowse link 17 44,903,159 44,915,552 RGD:6480464
G GPT glutamic--pyruvic transaminase JBrowse link 8 144,502,217 144,507,174 RGD:6480464
G GPX2 glutathione peroxidase 2 JBrowse link 14 64,939,158 64,942,745 RGD:6480464
G GSK3B glycogen synthase kinase 3 beta JBrowse link 3 119,821,321 120,095,823 RGD:6480464
G GSR glutathione-disulfide reductase JBrowse link 8 30,678,061 30,727,999 RGD:6480464
G GSTM1 glutathione S-transferase mu 1 JBrowse link 1 109,687,817 109,693,745 RGD:6480464
G GSTM3 glutathione S-transferase mu 3 JBrowse link 1 109,733,932 109,741,038 RGD:6480464
G HMGB1 high mobility group box 1 JBrowse link 13 30,456,704 30,617,597 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G HSPA1L heat shock protein family A (Hsp70) member 1 like JBrowse link 6 31,809,619 31,815,283 RGD:6480464
G HSPA8 heat shock protein family A (Hsp70) member 8 JBrowse link 11 123,057,489 123,062,366 RGD:6480464
G HSPB1 heat shock protein family B (small) member 1 JBrowse link 7 76,302,673 76,304,292 RGD:6480464
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 2 197,486,584 197,500,274 RGD:6480464
G HSPE1 heat shock protein family E (Hsp10) member 1 JBrowse link 2 197,500,379 197,503,449 RGD:6480464
G HTR2A 5-hydroxytryptamine receptor 2A JBrowse link 13 46,831,542 46,897,076 RGD:6480464
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:6480464
G ID1 inhibitor of DNA binding 1, HLH protein JBrowse link 20 31,605,289 31,606,510 RGD:6480464
G IL10 interleukin 10 JBrowse link 1 206,767,602 206,772,494 RGD:6480464
G IL18 interleukin 18 JBrowse link 11 112,143,251 112,164,104 RGD:6480464
G IL1A interleukin 1 alpha JBrowse link 2 112,773,925 112,784,493 RGD:6480464
G IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:6480464
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:6480464
G ITGB1 integrin subunit beta 1 JBrowse link 10 32,900,318 32,958,230 RGD:6480464
G KCNA5 potassium voltage-gated channel subfamily A member 5 JBrowse link 12 5,043,879 5,046,788 RGD:6480464
G KCNB1 potassium voltage-gated channel subfamily B member 1 JBrowse link 20 49,363,877 49,484,033 RGD:6480464
G LEP leptin JBrowse link 7 128,241,201 128,257,629 RGD:6480464
G LGALS3 galectin 3 JBrowse link 14 55,129,252 55,145,430 RGD:6480464
G LIMD2 LIM domain containing 2 JBrowse link 17 63,695,888 63,701,227 RGD:6480464
G LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 JBrowse link 11 10,556,966 10,568,665 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G MDM2 MDM2 proto-oncogene JBrowse link 12 68,808,149 68,850,686 RGD:6480464
G MGAT5B alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B JBrowse link 17 76,868,404 76,950,393 RGD:6480464
G MIR122 microRNA 122 JBrowse link 18 58,451,074 58,451,158 RGD:6480464
G MIR132 microRNA 132 JBrowse link 17 2,049,908 2,050,008 RGD:6480464
G MIR138-1 microRNA 138-1 JBrowse link 3 44,114,212 44,114,310 RGD:6480464
G MIR219B microRNA 219b JBrowse link 9 128,392,621 128,392,708 RGD:6480464
G MIR301B microRNA 301b JBrowse link 22 21,652,981 21,653,058 RGD:6480464
G MIR325 microRNA 325 JBrowse link X 77,005,404 77,005,501 RGD:6480464
G MIR370 microRNA 370 JBrowse link 14 100,911,139 100,911,213 RGD:6480464
G MIR380 microRNA 380 JBrowse link 14 101,025,017 101,025,077 RGD:6480464
G MIR382 microRNA 382 JBrowse link 14 101,054,306 101,054,381 RGD:6480464
G MIR410 microRNA 410 JBrowse link 14 101,065,912 101,065,991 RGD:6480464
G MIR489 microRNA 489 JBrowse link 7 93,483,936 93,484,019 RGD:6480464
G MIR502 microRNA 502 JBrowse link X 50,014,598 50,014,683 RGD:6480464
G MIR551B microRNA 551b JBrowse link 3 168,551,854 168,551,949 RGD:6480464
G MIR93 microRNA 93 JBrowse link 7 100,093,768 100,093,847 RGD:6480464
G MIR98 microRNA 98 JBrowse link X 53,556,223 53,556,341 RGD:6480464
G MIRLET7B microRNA let-7b JBrowse link 22 46,113,686 46,113,768 RGD:6480464
G MKI67 marker of proliferation Ki-67 JBrowse link 10 128,096,659 128,126,423 RGD:6480464
G MMP2 matrix metallopeptidase 2 JBrowse link 16 55,478,830 55,506,691 RGD:6480464
G MMP9 matrix metallopeptidase 9 JBrowse link 20 46,008,908 46,016,561 RGD:6480464
G MPO myeloperoxidase JBrowse link 17 58,269,855 58,280,935 RGD:6480464
G MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 3 38,138,661 38,143,022 RGD:6480464
G MYH6 myosin heavy chain 6 JBrowse link 14 23,381,987 23,408,273 RGD:6480464
G MYH7 myosin heavy chain 7 JBrowse link 14 23,412,740 23,435,677 RGD:6480464
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:6480464
G NOS2 nitric oxide synthase 2 JBrowse link 17 27,756,766 27,800,529 RGD:6480464
G NOS3 nitric oxide synthase 3 JBrowse link 7 150,991,017 151,014,588 RGD:6480464
G NOX1 NADPH oxidase 1 JBrowse link X 100,843,324 100,874,359 RGD:6480464
G NOX4 NADPH oxidase 4 JBrowse link 11 89,324,353 89,589,557 RGD:6480464
G NPPA natriuretic peptide A JBrowse link 1 11,845,709 11,847,783 RGD:6480464
G NPPB natriuretic peptide B JBrowse link 1 11,857,464 11,858,945 RGD:6480464
G NQO1 NAD(P)H quinone dehydrogenase 1 JBrowse link 16 69,709,401 69,726,560 RGD:6480464
G PECAM1 platelet and endothelial cell adhesion molecule 1 JBrowse link 17 64,319,415 64,413,844 RGD:6480464
G PIGL phosphatidylinositol glycan anchor biosynthesis class L JBrowse link 17 16,217,209 16,351,800 RGD:6480464
G PKNOX1 PBX/knotted 1 homeobox 1 JBrowse link 21 42,974,510 43,033,931 RGD:6480464
G PLVAP plasmalemma vesicle associated protein JBrowse link 19 17,351,455 17,377,342 RGD:6480464
G POSTN periostin JBrowse link 13 37,562,582 37,598,844 RGD:6480464
G PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha JBrowse link 3 48,744,601 48,847,874 RGD:6480464
G PRKDC protein kinase, DNA-activated, catalytic subunit JBrowse link 8 47,773,111 47,960,136 RGD:6480464
G PRKG1 protein kinase cGMP-dependent 1 JBrowse link 10 50,990,888 52,298,350 RGD:6480464
G PSMA1 proteasome 20S subunit alpha 1 JBrowse link 11 14,504,876 14,643,634 RGD:6480464
G PSMA3 proteasome 20S subunit alpha 3 JBrowse link 14 58,244,805 58,272,009 RGD:6480464
G PSMC2 proteasome 26S subunit, ATPase 2 JBrowse link 7 103,344,405 103,369,395 RGD:6480464
G PSMC6 proteasome 26S subunit, ATPase 6 JBrowse link 14 52,707,163 52,728,590 RGD:6480464
G RAD50 RAD50 double strand break repair protein JBrowse link 5 132,556,977 132,646,349 RGD:6480464
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:6480464
G RPS6 ribosomal protein S6 JBrowse link 9 19,375,715 19,380,236 RGD:6480464
G SERPINE1 serpin family E member 1 JBrowse link 7 101,127,104 101,139,247 RGD:6480464
G SIRPB1 signal regulatory protein beta 1 JBrowse link 20 1,561,385 1,620,447 RGD:6480464
G SLC22A1 solute carrier family 22 member 1 JBrowse link 6 160,121,808 160,160,590 RGD:6480464
G SLC6A4 solute carrier family 6 member 4 JBrowse link 17 30,194,319 30,235,697 RGD:6480464
G SMAD1 SMAD family member 1 JBrowse link 4 145,481,306 145,559,176 RGD:6480464
G SQSTM1 sequestosome 1 JBrowse link 5 179,806,393 179,838,078 RGD:6480464
G STAT3 signal transducer and activator of transcription 3 JBrowse link 17 42,313,324 42,388,502 RGD:6480464
G TBXA2R thromboxane A2 receptor JBrowse link 19 3,594,507 3,608,749 RGD:6480464
G TBXAS1 thromboxane A synthase 1 JBrowse link 7 139,778,242 140,020,321 RGD:6480464
G TF transferrin JBrowse link 3 133,661,998 133,796,641 RGD:6480464
G TFRC transferrin receptor JBrowse link 3 196,018,694 196,082,123 RGD:6480464
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:6480464
G THY1 Thy-1 cell surface antigen JBrowse link 11 119,415,476 119,424,985 RGD:6480464
G TICAM1 toll like receptor adaptor molecule 1 JBrowse link 19 4,815,932 4,831,712 RGD:6480464
G TIMP1 TIMP metallopeptidase inhibitor 1 JBrowse link X 47,582,408 47,586,789 RGD:6480464
G TLR4 toll like receptor 4 JBrowse link 9 117,704,403 117,724,735 RGD:6480464
G TMED2 transmembrane p24 trafficking protein 2 JBrowse link 12 123,584,552 123,598,582 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G TNFSF10 TNF superfamily member 10 JBrowse link 3 172,505,508 172,523,430 RGD:6480464
G TNN tenascin N JBrowse link 1 175,067,833 175,148,075 RGD:6480464
G TRADD TNFRSF1A associated via death domain JBrowse link 16 67,154,185 67,159,909 RGD:6480464
G TUBB3 tubulin beta 3 class III JBrowse link 16 89,921,925 89,936,097 RGD:6480464
G TXN2 thioredoxin 2 JBrowse link 22 36,467,036 36,481,672 RGD:6480464
G TXNRD1 thioredoxin reductase 1 JBrowse link 12 104,215,779 104,350,307 RGD:6480464
G TXNRD2 thioredoxin reductase 2 JBrowse link 22 19,875,518 19,941,818 RGD:6480464
G UBE2B ubiquitin conjugating enzyme E2 B JBrowse link 5 134,371,569 134,392,108 RGD:6480464
G UBE2G1 ubiquitin conjugating enzyme E2 G1 JBrowse link 17 4,269,217 4,366,674 RGD:6480464
G UNG uracil DNA glycosylase JBrowse link 12 109,097,597 109,110,992 RGD:6480464
G VCAM1 vascular cell adhesion molecule 1 JBrowse link 1 100,719,640 100,739,045 RGD:6480464
G VEGFA vascular endothelial growth factor A JBrowse link 6 43,770,209 43,786,487 RGD:6480464
G VIM vimentin JBrowse link 10 17,228,241 17,237,593 RGD:6480464
G XRCC4 X-ray repair cross complementing 4 JBrowse link 5 83,077,409 83,370,333 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23810
    role 23697
      biological role 23660
        biochemical role 23006
          metabolite 22900
            alkaloid 5485
              pyrrolizidine alkaloid 235
                monocrotaline 163
Path 2
Term Annotations click to browse term
  CHEBI ontology 23810
    subatomic particle 23761
      composite particle 23761
        hadron 23761
          baryon 23761
            nucleon 23761
              atomic nucleus 23761
                atom 23761
                  main group element atom 23578
                    p-block element atom 23578
                      carbon group element atom 23291
                        carbon atom 23245
                          organic molecular entity 23245
                            organic molecule 23109
                              organic cyclic compound 22096
                                organic heterocyclic compound 20740
                                  organic heteropolycyclic compound 19865
                                    organic heterobicyclic compound 17269
                                      pyrrolizidine 235
                                        pyrrolizidine alkaloid 235
                                          monocrotaline 163
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.