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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aucubin
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Accession:CHEBI:69796 term browser browse the term
Definition:An organic molecular entity that has formula C15H22O9.
Synonyms:related_synonym: (1S,4aR,5S,7aS)-5-Hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl beta-D-glucopyranoside;   Formula=C15H22O9;   InChI=1S/C15H22O9/c16-4-6-3-8(18)7-1-2-22-14(10(6)7)24-15-13(21)12(20)11(19)9(5-17)23-15/h1-3,7-21H,4-5H2/t7-,8+,9+,10+,11+,12-,13+,14-,15-/m0/s1;   InChIKey=RJWJHRPNHPHBRN-FKVJWERZSA-N;   Rhinanthin;   SMILES=[H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)O[C@@H]1OC=C[C@@]2([H])[C@H](O)C=C(CO)[C@@]12[H]
 alt_id: CHEBI:2919
 xref: CAS:479-98-1;   KEGG:C09771;   KNApSAcK:C00003073
 xref_mesh: MESH:C006650
 xref: PMID:21568305


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aucubin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO aucubin results in increased phosphorylation of AKT1 protein
aucubin inhibits the reaction [Cisplatin results in increased phosphorylation of AKT1 protein]
CTD PMID:29408431, PMID:32504734 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO aucubin results in increased expression of BGLAP protein CTD PMID:29408431 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO aucubin results in increased expression of BMP2 protein CTD PMID:29408431 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Casp3 caspase 3 multiple interactions ISO aucubin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:32504734 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO aucubin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:32504734 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO aucubin inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein] CTD PMID:32504734 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO aucubin inhibits the reaction [Cisplatin results in increased expression of and results in increased phosphorylation of FOXO3 protein] CTD PMID:32504734 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO aucubin inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein] CTD PMID:32504734 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Itgb1 integrin subunit beta 1 increases expression ISO aucubin results in increased expression of ITGB1 protein CTD PMID:29408431 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO aucubin results in increased phosphorylation of MAPK1 protein
aucubin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]
CTD PMID:29408431, PMID:32504734 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO aucubin results in increased phosphorylation of MAPK14 protein CTD PMID:29408431 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO aucubin results in increased phosphorylation of MAPK3 protein
aucubin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]
CTD PMID:29408431, PMID:32504734 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation ISO aucubin results in increased phosphorylation of MTOR protein CTD PMID:29408431 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO aucubin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:32504734 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aucubin inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:32504734 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO aucubin results in increased phosphorylation of RPS6KB1 protein CTD PMID:29408431 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Smad1 SMAD family member 1 increases expression ISO aucubin results in increased expression of SMAD1 protein CTD PMID:29408431 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad5 SMAD family member 5 increases expression ISO aucubin results in increased expression of SMAD5 protein CTD PMID:29408431 NCBI chr17:8,307,448...8,336,996
Ensembl chr17:8,311,796...8,331,032
JBrowse link
G Smad9 SMAD family member 9 increases expression ISO aucubin results in increased expression of SMAD9 protein CTD PMID:29408431 NCBI chr 2:143,951,725...144,002,025
Ensembl chr 2:144,191,846...144,212,138
Ensembl chr 2:144,191,846...144,212,138
JBrowse link
G Sp7 Sp7 transcription factor increases expression ISO aucubin results in increased expression of SP7 protein CTD PMID:29408431 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO aucubin results in increased expression of SPP1 protein CTD PMID:29408431 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO aucubin inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein] CTD PMID:32504734 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO aucubin inhibits the reaction [Cisplatin results in increased expression of TNF protein] CTD PMID:32504734 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biochemical role 19304
          metabolite 19285
            aucubin 23
              agnuside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      p-block molecular entity 19696
                        carbon group molecular entity 19599
                          organic molecular entity 19588
                            aucubin 23
                              agnuside 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.