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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpinumisoflavone
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Accession:CHEBI:69746 term browser browse the term
Definition:An isoflavanone that has formula C20H16O5.
Synonyms:related_synonym: 5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethylpyrano[3,2-g]chromen-6-one;   Formula=C20H16O5;   InChI=1S/C20H16O5/c1-20(2)8-7-13-15(25-20)9-16-17(18(13)22)19(23)14(10-24-16)11-3-5-12(21)6-4-11/h3-10,21-22H,1-2H3;   InChIKey=RQAMSFTXEFSBPK-UHFFFAOYSA-N;   SMILES=CC1(C)Oc2cc3occ(-c4ccc(O)cc4)c(=O)c3c(O)c2C=C1
 xref: CAS:34086-50-5
 xref_mesh: MESH:C000154
 xref: PMID:21619045


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alpinumisoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects localization ISO alpinumisoflavone affects the localization of BAX protein CTD PMID:23850732 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO alpinumisoflavone results in decreased expression of BCL2 protein CTD PMID:23850732 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO alpinumisoflavone results in decreased expression of BID protein CTD PMID:23850732 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein
alpinumisoflavone results in increased cleavage of CASP3 protein		 CTD PMID:23850732 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO alpinumisoflavone results in increased cleavage of CASP9 protein
[alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein		 CTD PMID:23850732 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO alpinumisoflavone results in decreased expression of CHUK protein CTD PMID:23850732 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO alpinumisoflavone affects the localization of CYCS protein CTD PMID:23850732 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein; [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein CTD PMID:23850732 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19091749 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alpinumisoflavone results in increased cleavage of PARP1 protein CTD PMID:23850732 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO alpinumisoflavone results in decreased expression of RELA protein CTD PMID:23850732 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT3 protein CTD PMID:23850732 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:23850732 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT6 protein CTD PMID:23850732 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
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  CHEBI ontology 19812
    role 19784
      biological role 19782
        biochemical role 19495
          metabolite 19480
            alpinumisoflavone 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic molecule 19651
                              organic cyclic compound 19457
                                organic heterocyclic compound 18816
                                  oxacycle 17773
                                    benzopyran 11699
                                      1-benzopyran 11461
                                        isoflavonoid 3793
                                          isoflavans 127
                                            isoflavanones 86
                                              alpinumisoflavone 14
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