Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpinumisoflavone
go back to main search page
Accession:CHEBI:69746 term browser browse the term
Definition:An isoflavanone that has formula C20H16O5.
Synonyms:related_synonym: 5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethylpyrano[3,2-g]chromen-6-one;   Formula=C20H16O5;   InChI=1S/C20H16O5/c1-20(2)8-7-13-15(25-20)9-16-17(18(13)22)19(23)14(10-24-16)11-3-5-12(21)6-4-11/h3-10,21-22H,1-2H3;   InChIKey=RQAMSFTXEFSBPK-UHFFFAOYSA-N;   SMILES=CC1(C)Oc2cc3occ(-c4ccc(O)cc4)c(=O)c3c(O)c2C=C1
 xref: CAS:34086-50-5
 xref_mesh: MESH:C000154
 xref: PMID:21619045


show annotations for term's descendants           Sort by:
 
alpinumisoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects localization ISO alpinumisoflavone affects the localization of BAX protein CTD PMID:23850732 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO alpinumisoflavone results in decreased expression of BCL2 protein CTD PMID:23850732 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO alpinumisoflavone results in decreased expression of BID protein CTD PMID:23850732 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein
alpinumisoflavone results in increased cleavage of CASP3 protein
CTD PMID:23850732 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO alpinumisoflavone results in increased cleavage of CASP9 protein
[alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein
CTD PMID:23850732 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO alpinumisoflavone results in decreased expression of CHUK protein CTD PMID:23850732 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO alpinumisoflavone affects the localization of CYCS protein CTD PMID:23850732 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein; [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein CTD PMID:23850732 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19091749 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alpinumisoflavone results in increased cleavage of PARP1 protein CTD PMID:23850732 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO alpinumisoflavone results in decreased expression of RELA protein CTD PMID:23850732 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT3 protein CTD PMID:23850732 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:23850732 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT6 protein CTD PMID:23850732 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            alpinumisoflavone 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  oxacycle 17185
                                    benzopyran 10135
                                      1-benzopyran 9851
                                        isoflavonoid 3793
                                          isoflavans 220
                                            isoflavanones 184
                                              alpinumisoflavone 14
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.