CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: mometasone
Accession: CHEBI:6970
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Definition: A chlorinated steroid that has formula C22H28Cl2O4.
Synonyms: exact_synonym: 9,21-dichloro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
related_synonym: Formula=C22H28Cl2O4; InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1; InChIKey=QLIIKPVHVRXHRI-CXSFZGCWSA-N; SMILES=[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C; mometasona; mometasonum
xref: CAS:105102-22-5; DrugBank:DB00764; KEGG:C07816; KEGG:D08227
G
Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon]
CTD
PMID:16442095
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions increases activity
ISO
Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone] Mometasone Furoate results in increased activity of ABCG2 protein
CTD
PMID:16442095
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Csf2
colony stimulating factor 2
multiple interactions
ISO
Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
CTD
PMID:10460758
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
decreases activity
ISO
Mometasone Furoate results in decreased activity of CYP2C8 protein
CTD
PMID:15601807
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F3
coagulation factor III, tissue factor
increases expression
ISO
Mometasone Furoate results in increased expression of F3 protein
CTD
PMID:25569083
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Hsf1
heat shock transcription factor 1
increases activity
ISO
Mometasone Furoate results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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Il10
interleukin 10
decreases secretion
ISO
Mometasone Furoate results in decreased secretion of IL10 protein
CTD
PMID:9819297
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il12b
interleukin 12B
multiple interactions
ISO
Mometasone Furoate inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL12B protein]
CTD
PMID:19422381
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il1b
interleukin 1 beta
multiple interactions
ISO
Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
CTD
PMID:10460758
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects binding
EXP ISO
Mometasone Furoate binds to NR3C1 protein
CTD
PMID:16507850 PMID:19422381
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
affects binding
ISO
Mometasone Furoate binds to NR3C2 protein
CTD
PMID:19422381
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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Pgr
progesterone receptor
multiple interactions affects binding
ISO
Mometasone Furoate binds to and results in increased activity of PGR protein Mometasone Furoate binds to PGR protein
CTD
PMID:15189034 PMID:19422381
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Spp1
secreted phosphoprotein 1
increases expression
ISO
Mometasone Furoate results in increased expression of SPP1 protein
CTD
PMID:21885873
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Tat
tyrosine aminotransferase
increases activity
ISO
Mometasone Furoate results in increased activity of TAT protein
CTD
PMID:19422381
NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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Tgm2
transglutaminase 2
increases expression
ISO
Mometasone Furoate results in increased expression of TGM2 protein
CTD
PMID:21885873
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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Tnf
tumor necrosis factor
multiple interactions decreases secretion
ISO
Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] Mometasone Furoate results in decreased secretion of TNF protein
CTD
PMID:9819297 PMID:10100995
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD
PMID:10100995
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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