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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Paeonol
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Accession:CHEBI:69581 term browser browse the term
Definition:A methoxybenzene that has formula C9H10O3.
Synonyms:related_synonym: 1-(2-Hydroxy-4-methoxyphenyl)ethanone;   4-O-Methylresacetophenone;   Formula=C9H10O3;   InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3;   InChIKey=UILPJVPSNHJFIK-UHFFFAOYSA-N;   SMILES=COc1ccc(C(C)=O)c(O)c1
 alt_id: CHEBI:7890
 xref: CAS:552-41-0;   KEGG:C10712;   KNApSAcK:C00002704;   LINCS:LSM-24937
 xref_mesh: MESH:C013638
 xref: PMID:21954959


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Paeonol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
paeonol inhibits the reaction [Epirubicin results in decreased phosphorylation of AKT1 protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein; paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]
CTD PMID:26646421 PMID:29505745 PMID:32344236 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg5 autophagy related 5 multiple interactions EXP paeonol inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein] CTD PMID:29505745 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased expression of BAX protein] CTD PMID:26646421 PMID:29505745 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
paeonol inhibits the reaction [Epirubicin results in decreased expression of BCL2 protein]
[Doxorubicin co-treated with paeonol] results in increased expression of BCL2 mRNA
CTD PMID:26646421 PMID:29505745 PMID:31307187 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 multiple interactions EXP paeonol inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein] CTD PMID:29505745 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased cleavage of CASP3 protein] CTD PMID:26646421 PMID:29505745 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in decreased activity of CAT protein] CTD PMID:26646421 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP paeonol inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA] CTD PMID:31307187 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of NFKB1 protein; [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein; paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of [CHUK protein binds to IKBKB protein]] CTD PMID:22542583 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA CTD PMID:32344236 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP paeonol inhibits the reaction [Doxorubicin results in increased expression of FN1 mRNA] CTD PMID:31307187 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression EXP paeonol results in increased expression of HES1 mRNA CTD PMID:31307187 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions
increases expression
EXP paeonol affects the reaction [Doxorubicin affects the expression of HEY1 mRNA]
paeonol results in increased expression of HEY1 mRNA
CTD PMID:31307187 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of NFKB1 protein; [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein; paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of [CHUK protein binds to IKBKB protein]] CTD PMID:22542583 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of IL1B protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein
CTD PMID:22542583 PMID:32344236 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 protein] CTD PMID:26646421 PMID:29505745 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
paeonol inhibits the reaction [Epirubicin results in increased expression of IL6 mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of IL6 protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein
CTD PMID:22542583 PMID:26646421 PMID:32344236 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klf4 Kruppel like factor 4 increases expression
multiple interactions
EXP paeonol results in increased expression of KLF4 mRNA
paeonol inhibits the reaction [Doxorubicin results in decreased expression of KLF4 mRNA]
CTD PMID:31307187 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Maoa monoamine oxidase A decreases activity EXP paeonol results in decreased activity of MAOA protein CTD PMID:15120460 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B decreases activity EXP paeonol results in decreased activity of MAOB protein CTD PMID:15120460 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mir1 microRNA 1 multiple interactions EXP paeonol inhibits the reaction [Epirubicin results in decreased expression of MIR1 mRNA] CTD PMID:29505745 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein CTD PMID:32344236 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA; paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein] CTD PMID:29505745 PMID:32344236 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein CTD PMID:32344236 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA CTD PMID:32344236 NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP paeonol inhibits the reaction [Doxorubicin results in increased expression of MYH7 mRNA] CTD PMID:31307187 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myocd myocardin increases expression
multiple interactions
EXP paeonol results in increased expression of MYOCD mRNA
paeonol affects the reaction [Doxorubicin results in decreased expression of MYOCD mRNA]
CTD PMID:31307187 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of NFKB1 protein; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of NFKB1 protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NFKB1 protein] CTD PMID:22542583 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
[paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of NFKB1 protein; [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein; paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NFKBIA protein]
paeonol inhibits the reaction [Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein]
CTD PMID:22542583 PMID:29505745 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein] CTD PMID:22542583 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 increases expression
increases cleavage
multiple interactions
EXP paeonol results in increased expression of NOTCH1 mRNA
paeonol results in increased cleavage of NOTCH1 protein
paeonol affects the reaction [Doxorubicin results in decreased expression of NOTCH1 mRNA]
CTD PMID:31307187 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased cleavage of PARP1 protein] CTD PMID:26646421 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] CTD PMID:22542583 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
[paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of RELA protein]
paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of RELA protein]
CTD PMID:22542583 PMID:29505745 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP paeonol inhibits the reaction [Epirubicin results in increased expression of SQSTM1 protein] CTD PMID:29505745 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP paeonol inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA] CTD PMID:31307187 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein CTD PMID:32344236 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
paeonol inhibits the reaction [Epirubicin results in increased expression of TNF mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of TNF protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein
CTD PMID:22542583 PMID:26646421 PMID:29505745 PMID:32344236 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            Paeonol 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                carbocyclic compound 18309
                                  benzenoid aromatic compound 17453
                                    benzenes 17233
                                      methoxybenzenes 1891
                                        Paeonol 38
paths to the root