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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rubiadin
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Accession:CHEBI:69533 term browser browse the term
Definition:A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 3 and a methyl group at position 2. It has been isolated from Rubia yunnanensis.
Synonyms:exact_synonym: 1,3-dihydroxy-2-methylanthracene-9,10-dione
 related_synonym: Formula=C15H10O4;   InChI=1S/C15H10O4/c1-7-11(16)6-10-12(13(7)17)15(19)9-5-3-2-4-8(9)14(10)18/h2-6,16-17H,1H3;   InChIKey=IRZTUXPRIUZXMP-UHFFFAOYSA-N;   SMILES=Cc1c(O)cc2C(=O)c3ccccc3C(=O)c2c1O
 alt_id: CHEBI:8906
 xref: CAS:117-02-2;   KEGG:C10402;   KNApSAcK:C00002862
 xref_mesh: MESH:C072500
 xref: PMID:10410466;   PMID:16213120;   PMID:19793347;   PMID:20965744;   PMID:21973054;   PMID:22822668;   PMID:24062780;   PMID:9425750;   Patent:KR20120033699;   Reaxys:1885558


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rubiadin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcr calcitonin receptor decreases expression EXP rubiadin results in decreased expression of CALCR mRNA CTD PMID:21945525 NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
JBrowse link
G Car2 carbonic anhydrase 2 decreases expression EXP rubiadin results in decreased expression of CA2 mRNA CTD PMID:21945525 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Ctsk cathepsin K increases activity EXP rubiadin results in increased activity of CTSK protein CTD PMID:21945525 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein] CTD PMID:21945525 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression EXP rubiadin results in increased expression of TNFRSF11B mRNA; rubiadin results in increased expression of TNFRSF11B protein CTD PMID:21945525 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions
EXP rubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 protein
rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]
CTD PMID:21945525 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        antioxidant 14211
          rubiadin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        cyclic ketone 13813
                                          quinone 8338
                                            acenoquinone 7497
                                              anthraquinone 469
                                                hydroxyanthraquinones 461
                                                  dihydroxyanthraquinone 320
                                                    rubiadin 6
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