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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rubiadin
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Accession:CHEBI:69533 term browser browse the term
Definition:A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 3 and a methyl group at position 2. It has been isolated from Rubia yunnanensis.
Synonyms:exact_synonym: 1,3-dihydroxy-2-methylanthracene-9,10-dione
 related_synonym: Formula=C15H10O4;   InChI=1S/C15H10O4/c1-7-11(16)6-10-12(13(7)17)15(19)9-5-3-2-4-8(9)14(10)18/h2-6,16-17H,1H3;   InChIKey=IRZTUXPRIUZXMP-UHFFFAOYSA-N;   SMILES=Cc1c(O)cc2C(=O)c3ccccc3C(=O)c2c1O
 alt_id: CHEBI:8906
 xref: CAS:117-02-2;   KEGG:C10402;   KNApSAcK:C00002862
 xref_mesh: MESH:C072500
 xref: PMID:10410466;   PMID:16213120;   PMID:19793347;   PMID:20965744;   PMID:21973054;   PMID:22822668;   PMID:24062780;   PMID:9425750;   Patent:KR20120033699;   Reaxys:1885558



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rubiadin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcr calcitonin receptor decreases expression EXP rubiadin results in decreased expression of CALCR mRNA CTD PMID:21945525 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
JBrowse link
G Car2 carbonic anhydrase 2 decreases expression EXP rubiadin results in decreased expression of CA2 mRNA CTD PMID:21945525 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Ctsk cathepsin K increases activity EXP rubiadin results in increased activity of CTSK protein CTD PMID:21945525 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein] CTD PMID:21945525 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression EXP rubiadin results in increased expression of TNFRSF11B mRNA; rubiadin results in increased expression of TNFRSF11B protein CTD PMID:21945525 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions
EXP rubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 protein
rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]
CTD PMID:21945525 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      chemical role 19356
        antioxidant 15686
          rubiadin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      ketone 17109
                                        cyclic ketone 15669
                                          quinone 8533
                                            acenoquinone 7605
                                              anthraquinone 509
                                                hydroxyanthraquinones 498
                                                  dihydroxyanthraquinone 341
                                                    rubiadin 6
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