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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rubiadin
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Accession:CHEBI:69533 term browser browse the term
Definition:A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 3 and a methyl group at position 2. It has been isolated from Rubia yunnanensis.
Synonyms:exact_synonym: 1,3-dihydroxy-2-methylanthracene-9,10-dione
 related_synonym: Formula=C15H10O4;   InChI=1S/C15H10O4/c1-7-11(16)6-10-12(13(7)17)15(19)9-5-3-2-4-8(9)14(10)18/h2-6,16-17H,1H3;   InChIKey=IRZTUXPRIUZXMP-UHFFFAOYSA-N;   SMILES=Cc1c(O)cc2C(=O)c3ccccc3C(=O)c2c1O
 alt_id: CHEBI:8906
 xref: CAS:117-02-2;   KEGG:C10402;   KNApSAcK:C00002862
 xref_mesh: MESH:C072500
 xref: PMID:10410466;   PMID:16213120;   PMID:19793347;   PMID:20965744;   PMID:21973054;   PMID:22822668;   PMID:24062780;   PMID:9425750;   Patent:KR20120033699;   Reaxys:1885558



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rubiadin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcr calcitonin receptor decreases expression EXP rubiadin results in decreased expression of CALCR mRNA CTD PMID:21945525 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
JBrowse link
G Car2 carbonic anhydrase 2 decreases expression EXP rubiadin results in decreased expression of CA2 mRNA CTD PMID:21945525 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Ctsk cathepsin K increases activity EXP rubiadin results in increased activity of CTSK protein CTD PMID:21945525 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO rubiadin results in decreased activity of CYP1A2 protein CTD PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity ISO rubiadin results in decreased activity of CYP2C9 protein CTD PMID:33438235 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO rubiadin results in decreased activity of CYP2C19 protein CTD PMID:33438235 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO rubiadin results in decreased activity of CYP2D6 protein CTD PMID:33438235 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein] CTD PMID:21945525 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression EXP rubiadin results in increased expression of TNFRSF11B mRNA; rubiadin results in increased expression of TNFRSF11B protein CTD PMID:21945525 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions
EXP rubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 protein
rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]
CTD PMID:21945525 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      chemical role 19512
        antioxidant 16062
          rubiadin 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      ketone 17210
                                        cyclic ketone 15715
                                          quinone 8655
                                            acenoquinone 7728
                                              anthraquinone 515
                                                hydroxyanthraquinones 503
                                                  dihydroxyanthraquinone 351
                                                    rubiadin 10
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