CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Bergenin
Accession: CHEBI:69499
browse the term
Definition: A trihydroxybenzoic acid that has formula C14H16O9.
Synonyms: related_synonym: (2R,3S,4S,4aR,10bS)-3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one; Cuscutin; Formula=C14H16O9; InChI=1S/C14H16O9/c1-21-11-5(16)2-4-7(9(11)18)12-13(23-14(4)20)10(19)8(17)6(3-15)22-12/h2,6,8,10,12-13,15-19H,3H2,1H3/t6-,8-,10+,12+,13-/m1/s1; InChIKey=YWJXCIXBAKGUKZ-HJJNZUOJSA-N; SMILES=[H][C@]12OC(=O)c3cc(O)c(OC)c(O)c3[C@]1([H])O[C@H](CO)[C@@H](O)[C@@H]2O
alt_id: CHEBI:3069
xref: CAS:477-90-7; KEGG:C09919; KEGG:D01040; KNApSAcK:C00002981
xref_mesh: MESH:C006741
xref: PMID:21939182
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Acp5
acid phosphatase 5, tartrate resistant
multiple interactions
ISO
bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]
CTD
PMID:31369791
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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Ager
advanced glycosylation end product-specific receptor
multiple interactions
ISO
bergenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]
CTD
PMID:29148590
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Akt2
AKT serine/threonine kinase 2
multiple interactions
ISO
bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA]
CTD
PMID:31369791
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Casp1
caspase 1
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased cleavage of CASP1 protein]
CTD
PMID:30365937
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp4
caspase 4
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased cleavage of CASP4 protein]
CTD
PMID:30365937
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Cat
catalase
multiple interactions
ISO
bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; PPARG protein promotes the reaction [bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]
CTD
PMID:34499403
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Glo1
glyoxalase 1
multiple interactions
ISO
bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
CTD
PMID:29148590 PMID:31369791
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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Hmox1
heme oxygenase 1
multiple interactions
ISO
bergenin inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
CTD
PMID:29148590
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Ifng
interferon gamma
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]
CTD
PMID:30365937
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]
CTD
PMID:30365937
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il18
interleukin 18
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL18 protein]
CTD
PMID:30365937
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
CTD
PMID:30365937
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
bergenin inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
CTD
PMID:29148590
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]
CTD
PMID:31369791
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
[TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA
CTD
PMID:31369791
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD
PMID:30365937
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
bergenin affects the reaction [Pyruvaldehyde affects the expression of NFE2L2 protein]
CTD
PMID:29148590
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia
NFKB inhibitor alpha
multiple interactions
EXP ISO
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFKBIA protein] bergenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]
CTD
PMID:30365937 PMID:34499403
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NLRP3 protein]
CTD
PMID:30365937
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]
CTD
PMID:30365937
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ostm1
osteoclastogenesis associated transmembrane protein 1
multiple interactions
ISO
bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA]
CTD
PMID:31369791
NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
bergenin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARG protein]; PPARG protein promotes the reaction [bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]
CTD
PMID:34499403
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]
CTD
PMID:30365937
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
bergenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]
CTD
PMID:34499403
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Stat3
signal transducer and activator of transcription 3
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]
CTD
PMID:30365937
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tnfsf11
TNF superfamily member 11
multiple interactions
ISO
[TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA]
CTD
PMID:31369791
NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
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Trip4
thyroid hormone receptor interactor 4
multiple interactions
EXP
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TRIP4 protein]
CTD
PMID:30365937
NCBI chr 8:66,351,861...66,439,679
Ensembl chr 8:66,353,248...66,439,774
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