Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Bergenin
go back to main search page
Accession:CHEBI:69499 term browser browse the term
Definition:A trihydroxybenzoic acid that has formula C14H16O9.
Synonyms:related_synonym: (2R,3S,4S,4aR,10bS)-3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one;   Cuscutin;   Formula=C14H16O9;   InChI=1S/C14H16O9/c1-21-11-5(16)2-4-7(9(11)18)12-13(23-14(4)20)10(19)8(17)6(3-15)22-12/h2,6,8,10,12-13,15-19H,3H2,1H3/t6-,8-,10+,12+,13-/m1/s1;   InChIKey=YWJXCIXBAKGUKZ-HJJNZUOJSA-N;   SMILES=[H][C@]12OC(=O)c3cc(O)c(OC)c(O)c3[C@]1([H])O[C@H](CO)[C@@H](O)[C@@H]2O
 alt_id: CHEBI:3069
 xref: CAS:477-90-7;   KEGG:C09919;   KEGG:D01040;   KNApSAcK:C00002981
 xref_mesh: MESH:C006741
 xref: PMID:21939182



show annotations for term's descendants           Sort by:
Bergenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP [bergenin co-treated with 2,2-bis(4-glycidyloxyphenyl)propane] inhibits the reaction [Sodium Azide results in increased activity of ACHE protein]; [bergenin co-treated with Sodium Azide] results in increased activity of ACHE protein CTD PMID:36249784 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein] CTD PMID:31369791 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein] CTD PMID:37482253 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO bergenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein] CTD PMID:29148590 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA] CTD PMID:31369791 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [bergenin affects the reaction [Sodium Azide results in increased expression of APP protein]]; bergenin affects the reaction [Sodium Azide results in increased expression of APP protein] CTD PMID:36249784 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP bergenin inhibits the reaction [Cadmium results in increased expression of BAX protein] CTD PMID:37949422 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP bergenin inhibits the reaction [Cadmium results in decreased expression of BCL2 protein] CTD PMID:37949422 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp1 caspase 1 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased cleavage of CASP1 protein] CTD PMID:30365937 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp4 caspase 4 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased cleavage of CASP4 protein] CTD PMID:30365937 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Cat catalase multiple interactions ISO
EXP
bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; PPARG protein promotes the reaction [bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]
bergenin inhibits the reaction [Cadmium results in decreased activity of CAT protein]
bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]
CTD PMID:34499403 PMID:37482253 PMID:37949422 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased secretion of CCL2 protein] CTD PMID:37482253 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP bergenin inhibits the reaction [Iron-Dextran Complex results in increased phosphorylation of FOS protein] CTD PMID:36207002 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:29148590 PMID:31369791 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of GOT1 protein] CTD PMID:37482253 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of GPT protein] CTD PMID:37482253 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of GPX1 protein] CTD PMID:37482253 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP bergenin inhibits the reaction [Cadmium results in increased expression of HAVCR1 protein] CTD PMID:37949422 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
bergenin inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
[Cadmium co-treated with bergenin] results in increased expression of HMOX1 protein
CTD PMID:29148590 PMID:37949422 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein] CTD PMID:30365937 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein] CTD PMID:30365937 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL18 protein] CTD PMID:30365937 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[bergenin co-treated with 2,2-bis(4-glycidyloxyphenyl)propane] inhibits the reaction [Sodium Azide results in increased expression of IL1B protein]; [Sodium Azide co-treated with bergenin] results in increased expression of IL1B protein; bergenin inhibits the reaction [Cadmium results in increased expression of IL1B protein]; bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of IL1B protein]; bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased secretion of IL1B protein]
CTD PMID:30365937 PMID:36207002 PMID:36249784 PMID:37482253 PMID:37949422 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased secretion of IL6 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein] CTD PMID:29148590 PMID:37482253 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA] CTD PMID:31369791 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA CTD PMID:31369791 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [bergenin co-treated with 2,2-bis(4-glycidyloxyphenyl)propane] inhibits the reaction [Sodium Azide results in increased activity of MPO protein]; [Sodium Azide co-treated with bergenin] results in increased activity of MPO protein; bergenin inhibits the reaction [Cadmium results in increased activity of MPO protein]; bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:30365937 PMID:36249784 PMID:37949422 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of MYD88 mRNA]; bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of MYD88 protein] CTD PMID:37482253 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP
bergenin affects the reaction [Pyruvaldehyde affects the expression of NFE2L2 protein]
[Cadmium co-treated with bergenin] results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:29148590 PMID:37949422 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFKBIA protein]
bergenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]
CTD PMID:30365937 PMID:34499403 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NLRP3 protein] CTD PMID:30365937 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] CTD PMID:30365937 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Cadmium co-treated with bergenin] results in increased expression of NQO1 protein CTD PMID:37949422 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA] CTD PMID:31369791 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO
EXP
bergenin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARG protein]; PPARG protein promotes the reaction [bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]
bergenin inhibits the reaction [Iron-Dextran Complex results in decreased expression of PPARG protein]
CTD PMID:34499403 PMID:36207002 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of PTGS2 protein]; bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein] CTD PMID:30365937 PMID:36207002 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
bergenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]
bergenin inhibits the reaction [Cadmium results in increased acetylation of and affects the localization of RELA protein]; bergenin inhibits the reaction [Iron-Dextran Complex affects the localization of and results in increased expression of RELA protein]
bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of RELA mRNA]; bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of RELA protein]
CTD PMID:34499403 PMID:36207002 PMID:37482253 PMID:37949422 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP bergenin inhibits the reaction [Cadmium results in decreased expression of SIRT1 protein] CTD PMID:37949422 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] CTD PMID:37482253 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein] CTD PMID:30365937 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TLR4 mRNA]; bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TLR4 protein] CTD PMID:37482253 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[bergenin co-treated with 2,2-bis(4-glycidyloxyphenyl)propane] inhibits the reaction [Sodium Azide results in increased expression of TNF protein]; [Sodium Azide co-treated with bergenin] results in increased expression of TNF protein; bergenin inhibits the reaction [Cadmium results in increased expression of TNF protein]; bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of TNF protein]
bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased secretion of TNF protein]
CTD PMID:36207002 PMID:36249784 PMID:37482253 PMID:37949422 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA] CTD PMID:31369791 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO bergenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TRAF6 mRNA] CTD PMID:37482253 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trip4 thyroid hormone receptor interactor 4 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TRIP4 protein] CTD PMID:30365937 NCBI chr 8:66,351,861...66,439,679
Ensembl chr 8:66,353,248...66,439,774
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            Bergenin 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        aromatic carboxylic acid 12279
                                          benzoic acids 12254
                                            benzoic acid 5331
                                              hydroxybenzoic acid 4798
                                                trihydroxybenzoic acid 2734
                                                  Bergenin 45
paths to the root