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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Bergenin
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Accession:CHEBI:69499 term browser browse the term
Definition:A trihydroxybenzoic acid that has formula C14H16O9.
Synonyms:related_synonym: (2R,3S,4S,4aR,10bS)-3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one;   Cuscutin;   Formula=C14H16O9;   InChI=1S/C14H16O9/c1-21-11-5(16)2-4-7(9(11)18)12-13(23-14(4)20)10(19)8(17)6(3-15)22-12/h2,6,8,10,12-13,15-19H,3H2,1H3/t6-,8-,10+,12+,13-/m1/s1;   InChIKey=YWJXCIXBAKGUKZ-HJJNZUOJSA-N;   SMILES=[H][C@]12OC(=O)c3cc(O)c(OC)c(O)c3[C@]1([H])O[C@H](CO)[C@@H](O)[C@@H]2O
 alt_id: CHEBI:3069
 xref: CAS:477-90-7;   KEGG:C09919;   KEGG:D01040;   KNApSAcK:C00002981
 xref_mesh: MESH:C006741
 xref: PMID:21939182


show annotations for term's descendants           Sort by:
Bergenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein] CTD PMID:31369791 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO bergenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein] CTD PMID:29148590 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA] CTD PMID:31369791 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased cleavage of CASP1 protein] CTD PMID:30365937 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp4 caspase 4 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased cleavage of CASP4 protein] CTD PMID:30365937 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Cat catalase multiple interactions ISO bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; PPARG protein promotes the reaction [bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]] CTD PMID:34499403 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP bergenin inhibits the reaction [Iron-Dextran Complex results in increased phosphorylation of FOS protein] CTD PMID:36207002 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:29148590 PMID:31369791 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO bergenin inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein] CTD PMID:29148590 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifng interferon gamma multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein] CTD PMID:30365937 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein] CTD PMID:30365937 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL18 protein] CTD PMID:30365937 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of IL1B protein]; bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein] CTD PMID:30365937 PMID:36207002 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO bergenin inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein] CTD PMID:29148590 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA] CTD PMID:31369791 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA CTD PMID:31369791 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:30365937 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO bergenin affects the reaction [Pyruvaldehyde affects the expression of NFE2L2 protein] CTD PMID:29148590 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO		 bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFKBIA protein]
bergenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]		 CTD PMID:30365937 PMID:34499403 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NLRP3 protein] CTD PMID:30365937 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] CTD PMID:30365937 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA] CTD PMID:31369791 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO
EXP		 bergenin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARG protein]; PPARG protein promotes the reaction [bergenin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]
bergenin inhibits the reaction [Iron-Dextran Complex results in decreased expression of PPARG protein]		 CTD PMID:34499403 PMID:36207002 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of PTGS2 protein]; bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein] CTD PMID:30365937 PMID:36207002 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 bergenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]
bergenin inhibits the reaction [Iron-Dextran Complex affects the localization of and results in increased expression of RELA protein]		 CTD PMID:34499403 PMID:36207002 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein] CTD PMID:30365937 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of TNF protein] CTD PMID:36207002 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA] CTD PMID:31369791 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Trip4 thyroid hormone receptor interactor 4 multiple interactions EXP bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TRIP4 protein] CTD PMID:30365937 NCBI chr 8:66,351,861...66,439,679
Ensembl chr 8:66,353,248...66,439,774 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        biochemical role 19501
          metabolite 19486
            Bergenin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        aromatic carboxylic acid 11830
                                          benzoic acids 11805
                                            benzoic acid 4374
                                              hydroxybenzoic acid 3784
                                                trihydroxybenzoic acid 2714
                                                  Bergenin 29
paths to the root