CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cannabigerol
Accession: CHEBI:69477
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Definition: A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species.
Synonyms: exact_synonym: 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-5-pentylbenzene-1,3-diol
related_synonym: (E)-2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-1,3-benzenediol; (E)-2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-resorcinol; Formula=C21H32O2; InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+; InChIKey=QXACEHWTBCFNSA-SFQUDFHCSA-N; SMILES=C1(=C(C=C(CCCCC)C=C1O)O)C/C=C(/CCC=C(C)C)\\C
xref: CAS:25654-31-3; CAS:2808-33-5; DrugBank:DB14734; KEGG:C20219
xref_mesh: MESH:C037036
xref: PMID:20614687; PMID:21902175; PMID:23415610; PMID:25269802; PMID:27503475; PMID:28343385; PMID:29427593; PMID:29977202; PMID:31035309; PMID:31941059; PMID:7153877; Patent:EP2175848; Wikipedia:Cannabigerol
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Acox1
acyl-CoA oxidase 1
increases expression
ISO
cannabigerol results in increased expression of ACOX1 mRNA
CTD
PMID:30611848
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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Adcy5
adenylate cyclase 5
increases expression
ISO
cannabigerol results in increased expression of ADCY5 mRNA
CTD
PMID:33019509
NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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Adcy9
adenylate cyclase 9
decreases expression
ISO
cannabigerol results in decreased expression of ADCY9 mRNA
CTD
PMID:33019509
NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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Akt1
AKT serine/threonine kinase 1
increases expression
ISO
cannabigerol results in increased expression of AKT1 mRNA
CTD
PMID:33019509
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Atf4
activating transcription factor 4
increases expression
ISO
cannabigerol results in increased expression of ATF4 mRNA
CTD
PMID:33019509
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Bcl2l1
Bcl2-like 1
increases expression
ISO
cannabigerol results in increased expression of BCL2L1 mRNA
CTD
PMID:33019509
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
decreases expression
ISO
cannabigerol results in decreased expression of CAMK2B mRNA
CTD
PMID:33019509
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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Casp8
caspase 8
decreases expression
ISO
cannabigerol results in decreased expression of CASP8 mRNA
CTD
PMID:33019509
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Ccl3
C-C motif chemokine ligand 3
multiple interactions
EXP
cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]
CTD
PMID:22971837
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Clock
clock circadian regulator
decreases expression
ISO
cannabigerol results in decreased expression of CLOCK mRNA
CTD
PMID:33019509
NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
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Cnr2
cannabinoid receptor 2
multiple interactions
ISO
cannabigerol affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]
CTD
PMID:22971837
NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
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Cpt1a
carnitine palmitoyltransferase 1A
increases expression
ISO
cannabigerol results in increased expression of CPT1A mRNA
CTD
PMID:30611848
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Creb1
cAMP responsive element binding protein 1
decreases expression
ISO
cannabigerol results in decreased expression of CREB1 mRNA
CTD
PMID:33019509
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
increases metabolic processing multiple interactions
ISO
CYP2J2 protein results in increased metabolism of cannabigerol cannabigerol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]
CTD
PMID:29689453
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Dlgap1
DLG associated protein 1
increases expression
ISO
cannabigerol results in increased expression of DLGAP1 mRNA
CTD
PMID:33019509
NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817
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Drd2
dopamine receptor D2
decreases expression
ISO
cannabigerol results in decreased expression of DRD2 mRNA
CTD
PMID:33019509
NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
decreases expression
ISO
cannabigerol results in decreased expression of EIF2AK3 mRNA
CTD
PMID:33019509
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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Ern1
endoplasmic reticulum to nucleus signaling 1
decreases expression
ISO
cannabigerol results in decreased expression of ERN1 mRNA
CTD
PMID:33019509
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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Fabp4
fatty acid binding protein 4
multiple interactions increases expression
ISO
cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA] cannabigerol results in increased expression of FABP4 mRNA
CTD
PMID:30611848
NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
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Gnai2
G protein subunit alpha i2
increases expression
ISO
cannabigerol results in increased expression of GNAI2 mRNA
CTD
PMID:33019509
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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Gnal
G protein subunit alpha L
decreases expression
ISO
cannabigerol results in decreased expression of GNAL mRNA
CTD
PMID:33019509
NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599
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Gnb4
G protein subunit beta 4
increases expression
ISO
cannabigerol results in increased expression of GNB4 mRNA
CTD
PMID:33019509
NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579
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Hap1
huntingtin-associated protein 1
increases expression
ISO
cannabigerol results in increased expression of HAP1 mRNA
CTD
PMID:33019509
NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126
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Il1b
interleukin 1 beta
multiple interactions
EXP
cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:22971837
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
EXP
cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:22971837
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ins2
insulin 2
multiple interactions
ISO
cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]
CTD
PMID:30611848
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Map3k5
mitogen-activated protein kinase kinase kinase 5
decreases expression
ISO
cannabigerol results in decreased expression of MAP3K5 mRNA
CTD
PMID:33019509
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Npy
neuropeptide Y
decreases expression
EXP
cannabigerol results in decreased expression of NPY mRNA
CTD
PMID:31941059
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Parp4
poly (ADP-ribose) polymerase family, member 4
decreases expression
ISO
cannabigerol results in decreased expression of PARP4 mRNA
CTD
PMID:33019509
NCBI chr15:30,690,503...30,792,868
Ensembl chr15:30,686,613...30,828,810
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Pld1
phospholipase D1
decreases expression
ISO
cannabigerol results in decreased expression of PLD1 mRNA
CTD
PMID:33019509
NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
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Pomc
proopiomelanocortin
decreases expression
EXP
cannabigerol results in decreased expression of POMC mRNA
CTD
PMID:31941059
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
cannabigerol binds to and results in increased activity of PPARA protein
CTD
PMID:30611848
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
decreases expression multiple interactions increases expression
ISO
cannabigerol results in decreased expression of PPARG protein cannabigerol binds to and results in increased activity of PPARG protein; cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA] cannabigerol results in increased expression of PPARG mRNA
CTD
PMID:28853159 PMID:30611848
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha
decreases expression
ISO
cannabigerol results in decreased expression of PPP3R1 mRNA
CTD
PMID:33019509
NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907
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Prkca
protein kinase C, alpha
increases expression
ISO
cannabigerol results in increased expression of PRKCA mRNA
CTD
PMID:33019509
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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Prkcb
protein kinase C, beta
decreases expression
ISO
cannabigerol results in decreased expression of PRKCB mRNA
CTD
PMID:33019509
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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Shank1
SH3 and multiple ankyrin repeat domains 1
decreases expression
ISO
cannabigerol results in decreased expression of SHANK1 mRNA
CTD
PMID:33019509
NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824
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Slc18a1
solute carrier family 18 member A1
decreases expression
ISO
cannabigerol results in decreased expression of SLC18A1 mRNA
CTD
PMID:33019509
NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051
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Slc1a2
solute carrier family 1 member 2
decreases expression
ISO
cannabigerol results in decreased expression of SLC1A2 mRNA
CTD
PMID:33019509
NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
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Slc32a1
solute carrier family 32 member 1
increases expression
ISO
cannabigerol results in increased expression of SLC32A1 mRNA
CTD
PMID:33019509
NCBI chr 3:147,267,373...147,271,842
Ensembl chr 3:147,267,373...147,271,844
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Slc38a1
solute carrier family 38, member 1
decreases expression
ISO
cannabigerol results in decreased expression of SLC38A1 mRNA
CTD
PMID:33019509
NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218
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Tnf
tumor necrosis factor
multiple interactions
EXP
cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:22971837
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions increases activity
ISO
[cannabigerol results in increased activity of TRPV1 protein] which results in increased uptake of Calcium
CTD
PMID:31096838
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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