CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cannabigerol
Accession: CHEBI:69477
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Definition: A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species.
Synonyms: exact_synonym: 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-5-pentylbenzene-1,3-diol
related_synonym: (E)-2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-1,3-benzenediol; (E)-2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-resorcinol; Formula=C21H32O2; InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+; InChIKey=QXACEHWTBCFNSA-SFQUDFHCSA-N; SMILES=C1(=C(C=C(CCCCC)C=C1O)O)C/C=C(/CCC=C(C)C)\\C
xref: CAS:25654-31-3; CAS:2808-33-5; DrugBank:DB14734; KEGG:C20219
xref_mesh: MESH:C037036
xref: PMID:20614687; PMID:21902175; PMID:23415610; PMID:25269802; PMID:27503475; PMID:28343385; PMID:29427593; PMID:29977202; PMID:31035309; PMID:31941059; PMID:7153877; Patent:EP2175848; Wikipedia:Cannabigerol
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Acox1
acyl-CoA oxidase 1
increases expression
ISO
cannabigerol results in increased expression of ACOX1 mRNA
CTD
PMID:30611848
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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Adcy5
adenylate cyclase 5
increases expression
ISO
cannabigerol results in increased expression of ADCY5 mRNA
CTD
PMID:33019509
NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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Adcy9
adenylate cyclase 9
decreases expression
ISO
cannabigerol results in decreased expression of ADCY9 mRNA
CTD
PMID:33019509
NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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Akt1
AKT serine/threonine kinase 1
increases expression
ISO
cannabigerol results in increased expression of AKT1 mRNA
CTD
PMID:33019509
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Atf4
activating transcription factor 4
increases expression
ISO
cannabigerol results in increased expression of ATF4 mRNA
CTD
PMID:33019509
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Bcl2l1
Bcl2-like 1
increases expression
ISO
cannabigerol results in increased expression of BCL2L1 mRNA
CTD
PMID:33019509
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
decreases expression
ISO
cannabigerol results in decreased expression of CAMK2B mRNA
CTD
PMID:33019509
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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Casp8
caspase 8
decreases expression
ISO
cannabigerol results in decreased expression of CASP8 mRNA
CTD
PMID:33019509
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Ccl3
C-C motif chemokine ligand 3
multiple interactions
EXP
cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]
CTD
PMID:22971837
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Clock
clock circadian regulator
decreases expression
ISO
cannabigerol results in decreased expression of CLOCK mRNA
CTD
PMID:33019509
NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
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Cnr2
cannabinoid receptor 2
multiple interactions
ISO
cannabigerol affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]
CTD
PMID:22971837
NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
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Cpt1a
carnitine palmitoyltransferase 1A
increases expression
ISO
cannabigerol results in increased expression of CPT1A mRNA
CTD
PMID:30611848
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Creb1
cAMP responsive element binding protein 1
decreases expression
ISO
cannabigerol results in decreased expression of CREB1 mRNA
CTD
PMID:33019509
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
increases metabolic processing multiple interactions
ISO
CYP2J2 protein results in increased metabolism of cannabigerol cannabigerol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]
CTD
PMID:29689453
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Dlgap1
DLG associated protein 1
increases expression
ISO
cannabigerol results in increased expression of DLGAP1 mRNA
CTD
PMID:33019509
NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817
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Drd2
dopamine receptor D2
decreases expression
ISO
cannabigerol results in decreased expression of DRD2 mRNA
CTD
PMID:33019509
NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
decreases expression
ISO
cannabigerol results in decreased expression of EIF2AK3 mRNA
CTD
PMID:33019509
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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Ern1
endoplasmic reticulum to nucleus signaling 1
decreases expression
ISO
cannabigerol results in decreased expression of ERN1 mRNA
CTD
PMID:33019509
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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Fabp4
fatty acid binding protein 4
multiple interactions increases expression
ISO
cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA] cannabigerol results in increased expression of FABP4 mRNA
CTD
PMID:30611848
NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
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Gnai2
G protein subunit alpha i2
increases expression
ISO
cannabigerol results in increased expression of GNAI2 mRNA
CTD
PMID:33019509
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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Gnal
G protein subunit alpha L
decreases expression
ISO
cannabigerol results in decreased expression of GNAL mRNA
CTD
PMID:33019509
NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599
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Gnb4
G protein subunit beta 4
increases expression
ISO
cannabigerol results in increased expression of GNB4 mRNA
CTD
PMID:33019509
NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579
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Hap1
huntingtin-associated protein 1
increases expression
ISO
cannabigerol results in increased expression of HAP1 mRNA
CTD
PMID:33019509
NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126
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Il1b
interleukin 1 beta
multiple interactions
EXP
cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:22971837
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
EXP
cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:22971837
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ins2
insulin 2
multiple interactions
ISO
cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]
CTD
PMID:30611848
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Map3k5
mitogen-activated protein kinase kinase kinase 5
decreases expression
ISO
cannabigerol results in decreased expression of MAP3K5 mRNA
CTD
PMID:33019509
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Npy
neuropeptide Y
decreases expression
EXP
cannabigerol results in decreased expression of NPY mRNA
CTD
PMID:31941059
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Parp4
poly (ADP-ribose) polymerase family, member 4
decreases expression
ISO
cannabigerol results in decreased expression of PARP4 mRNA
CTD
PMID:33019509
NCBI chr15:30,690,503...30,792,868
Ensembl chr15:30,686,613...30,828,810
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Pld1
phospholipase D1
decreases expression
ISO
cannabigerol results in decreased expression of PLD1 mRNA
CTD
PMID:33019509
NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
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Pomc
proopiomelanocortin
decreases expression
EXP
cannabigerol results in decreased expression of POMC mRNA
CTD
PMID:31941059
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
cannabigerol binds to and results in increased activity of PPARA protein
CTD
PMID:30611848
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
decreases expression increases expression multiple interactions
ISO
cannabigerol results in decreased expression of PPARG protein cannabigerol results in increased expression of PPARG mRNA cannabigerol binds to and results in increased activity of PPARG protein cannabigerol binds to and results in increased activity of PPARG protein; cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]
CTD
PMID:28853159 PMID:30611848
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha
decreases expression
ISO
cannabigerol results in decreased expression of PPP3R1 mRNA
CTD
PMID:33019509
NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907
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Prkca
protein kinase C, alpha
increases expression
ISO
cannabigerol results in increased expression of PRKCA mRNA
CTD
PMID:33019509
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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Prkcb
protein kinase C, beta
decreases expression
ISO
cannabigerol results in decreased expression of PRKCB mRNA
CTD
PMID:33019509
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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Shank1
SH3 and multiple ankyrin repeat domains 1
decreases expression
ISO
cannabigerol results in decreased expression of SHANK1 mRNA
CTD
PMID:33019509
NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824
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Slc18a1
solute carrier family 18 member A1
decreases expression
ISO
cannabigerol results in decreased expression of SLC18A1 mRNA
CTD
PMID:33019509
NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051
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Slc1a2
solute carrier family 1 member 2
decreases expression
ISO
cannabigerol results in decreased expression of SLC1A2 mRNA
CTD
PMID:33019509
NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
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Slc32a1
solute carrier family 32 member 1
increases expression
ISO
cannabigerol results in increased expression of SLC32A1 mRNA
CTD
PMID:33019509
NCBI chr 3:147,267,373...147,271,842
Ensembl chr 3:147,267,373...147,271,844
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Slc38a1
solute carrier family 38, member 1
decreases expression
ISO
cannabigerol results in decreased expression of SLC38A1 mRNA
CTD
PMID:33019509
NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218
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Tnf
tumor necrosis factor
multiple interactions
EXP
cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:22971837
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions increases activity
ISO
[cannabigerol results in increased activity of TRPV1 protein] which results in increased uptake of Calcium
CTD
PMID:31096838
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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