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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cannabigerol
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Accession:CHEBI:69477 term browser browse the term
Definition:A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species.
Synonyms:exact_synonym: 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-5-pentylbenzene-1,3-diol
 related_synonym: (E)-2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-1,3-benzenediol;   (E)-2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-resorcinol;   Formula=C21H32O2;   InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+;   InChIKey=QXACEHWTBCFNSA-SFQUDFHCSA-N;   SMILES=C1(=C(C=C(CCCCC)C=C1O)O)C/C=C(/CCC=C(C)C)\\C
 xref: CAS:25654-31-3;   CAS:2808-33-5;   DrugBank:DB14734;   KEGG:C20219
 xref_mesh: MESH:C037036
 xref: PMID:20614687;   PMID:21902175;   PMID:23415610;   PMID:25269802;   PMID:27503475;   PMID:28343385;   PMID:29427593;   PMID:29977202;   PMID:31035309;   PMID:31941059;   PMID:7153877;   Patent:EP2175848;   Wikipedia:Cannabigerol


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cannabigerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression ISO cannabigerol results in increased expression of ACOX1 mRNA CTD PMID:30611848 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Adcy5 adenylate cyclase 5 increases expression ISO cannabigerol results in increased expression of ADCY5 mRNA CTD PMID:33019509 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adcy9 adenylate cyclase 9 decreases expression ISO cannabigerol results in decreased expression of ADCY9 mRNA CTD PMID:33019509 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression ISO cannabigerol results in increased expression of AKT1 mRNA CTD PMID:33019509 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO cannabigerol results in increased expression of ATF4 mRNA CTD PMID:33019509 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO cannabigerol results in increased expression of BCL2L1 mRNA CTD PMID:33019509 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO cannabigerol results in decreased expression of CAMK2B mRNA CTD PMID:33019509 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Casp8 caspase 8 decreases expression ISO cannabigerol results in decreased expression of CASP8 mRNA CTD PMID:33019509 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:22971837 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Clock clock circadian regulator decreases expression ISO cannabigerol results in decreased expression of CLOCK mRNA CTD PMID:33019509 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO cannabigerol affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein] CTD PMID:22971837 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO cannabigerol results in increased expression of CPT1A mRNA CTD PMID:30611848 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO cannabigerol results in decreased expression of CREB1 mRNA CTD PMID:33019509 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases metabolic processing
multiple interactions		 ISO CYP2J2 protein results in increased metabolism of cannabigerol
cannabigerol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]		 CTD PMID:29689453 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Dlgap1 DLG associated protein 1 increases expression ISO cannabigerol results in increased expression of DLGAP1 mRNA CTD PMID:33019509 NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO cannabigerol results in decreased expression of DRD2 mRNA CTD PMID:33019509 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression ISO cannabigerol results in decreased expression of EIF2AK3 mRNA CTD PMID:33019509 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression ISO cannabigerol results in decreased expression of ERN1 mRNA CTD PMID:33019509 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression		 ISO cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]
cannabigerol results in increased expression of FABP4 mRNA		 CTD PMID:30611848 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Gnai2 G protein subunit alpha i2 increases expression ISO cannabigerol results in increased expression of GNAI2 mRNA CTD PMID:33019509 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnal G protein subunit alpha L decreases expression ISO cannabigerol results in decreased expression of GNAL mRNA CTD PMID:33019509 NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599 		JBrowse link
G Gnb4 G protein subunit beta 4 increases expression ISO cannabigerol results in increased expression of GNB4 mRNA CTD PMID:33019509 NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579 		JBrowse link
G Hap1 huntingtin-associated protein 1 increases expression ISO cannabigerol results in increased expression of HAP1 mRNA CTD PMID:33019509 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:22971837 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:22971837 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA] CTD PMID:30611848 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO cannabigerol results in decreased expression of MAP3K5 mRNA CTD PMID:33019509 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Npy neuropeptide Y decreases expression EXP cannabigerol results in decreased expression of NPY mRNA CTD PMID:31941059 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 decreases expression ISO cannabigerol results in decreased expression of PARP4 mRNA CTD PMID:33019509 NCBI chr15:30,690,503...30,792,868
Ensembl chr15:30,686,613...30,828,810 		JBrowse link
G Pld1 phospholipase D1 decreases expression ISO cannabigerol results in decreased expression of PLD1 mRNA CTD PMID:33019509 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pomc proopiomelanocortin decreases expression EXP cannabigerol results in decreased expression of POMC mRNA CTD PMID:31941059 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO cannabigerol binds to and results in increased activity of PPARA protein CTD PMID:30611848 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
increases expression		 ISO cannabigerol results in decreased expression of PPARG protein
cannabigerol binds to and results in increased activity of PPARG protein; cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]
cannabigerol results in increased expression of PPARG mRNA		 CTD PMID:28853159 PMID:30611848 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression ISO cannabigerol results in decreased expression of PPP3R1 mRNA CTD PMID:33019509 NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907 		JBrowse link
G Prkca protein kinase C, alpha increases expression ISO cannabigerol results in increased expression of PRKCA mRNA CTD PMID:33019509 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta decreases expression ISO cannabigerol results in decreased expression of PRKCB mRNA CTD PMID:33019509 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 decreases expression ISO cannabigerol results in decreased expression of SHANK1 mRNA CTD PMID:33019509 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
G Slc18a1 solute carrier family 18 member A1 decreases expression ISO cannabigerol results in decreased expression of SLC18A1 mRNA CTD PMID:33019509 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases expression ISO cannabigerol results in decreased expression of SLC1A2 mRNA CTD PMID:33019509 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc32a1 solute carrier family 32 member 1 increases expression ISO cannabigerol results in increased expression of SLC32A1 mRNA CTD PMID:33019509 NCBI chr 3:147,267,373...147,271,842
Ensembl chr 3:147,267,373...147,271,844 		JBrowse link
G Slc38a1 solute carrier family 38, member 1 decreases expression ISO cannabigerol results in decreased expression of SLC38A1 mRNA CTD PMID:33019509 NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:22971837 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity		 ISO [cannabigerol results in increased activity of TRPV1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
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                                      resorcinols 4312
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