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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cannabigerol
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Accession:CHEBI:69477 term browser browse the term
Definition:A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species.
Synonyms:exact_synonym: 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-5-pentylbenzene-1,3-diol
 related_synonym: (E)-2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-1,3-benzenediol;   (E)-2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-resorcinol;   Formula=C21H32O2;   InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+;   InChIKey=QXACEHWTBCFNSA-SFQUDFHCSA-N;   SMILES=C1(=C(C=C(CCCCC)C=C1O)O)C/C=C(/CCC=C(C)C)\\C
 xref: CAS:25654-31-3;   CAS:2808-33-5;   DrugBank:DB14734;   KEGG:C20219
 xref_mesh: MESH:C037036
 xref: PMID:20614687;   PMID:21902175;   PMID:23415610;   PMID:25269802;   PMID:27503475;   PMID:28343385;   PMID:29427593;   PMID:29977202;   PMID:31035309;   PMID:31941059;   PMID:7153877;   Patent:EP2175848;   Wikipedia:Cannabigerol


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cannabigerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression ISO cannabigerol results in increased expression of ACOX1 mRNA CTD PMID:30611848 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Adcy5 adenylate cyclase 5 increases expression ISO cannabigerol results in increased expression of ADCY5 mRNA CTD PMID:33019509 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adcy9 adenylate cyclase 9 decreases expression ISO cannabigerol results in decreased expression of ADCY9 mRNA CTD PMID:33019509 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression ISO cannabigerol results in increased expression of AKT1 mRNA CTD PMID:33019509 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO cannabigerol results in increased expression of ATF4 mRNA CTD PMID:33019509 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO cannabigerol results in increased expression of BCL2L1 mRNA CTD PMID:33019509 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO cannabigerol results in decreased expression of CAMK2B mRNA CTD PMID:33019509 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Casp8 caspase 8 decreases expression ISO cannabigerol results in decreased expression of CASP8 mRNA CTD PMID:33019509 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:22971837 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Clock clock circadian regulator decreases expression ISO cannabigerol results in decreased expression of CLOCK mRNA CTD PMID:33019509 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO cannabigerol affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein] CTD PMID:22971837 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO cannabigerol results in increased expression of CPT1A mRNA CTD PMID:30611848 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO cannabigerol results in decreased expression of CREB1 mRNA CTD PMID:33019509 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases metabolic processing
multiple interactions		 ISO CYP2J2 protein results in increased metabolism of cannabigerol
cannabigerol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]		 CTD PMID:29689453 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Dlgap1 DLG associated protein 1 increases expression ISO cannabigerol results in increased expression of DLGAP1 mRNA CTD PMID:33019509 NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO cannabigerol results in decreased expression of DRD2 mRNA CTD PMID:33019509 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression ISO cannabigerol results in decreased expression of EIF2AK3 mRNA CTD PMID:33019509 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression ISO cannabigerol results in decreased expression of ERN1 mRNA CTD PMID:33019509 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression		 ISO cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]
cannabigerol results in increased expression of FABP4 mRNA		 CTD PMID:30611848 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Gnai2 G protein subunit alpha i2 increases expression ISO cannabigerol results in increased expression of GNAI2 mRNA CTD PMID:33019509 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnal G protein subunit alpha L decreases expression ISO cannabigerol results in decreased expression of GNAL mRNA CTD PMID:33019509 NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599 		JBrowse link
G Gnb4 G protein subunit beta 4 increases expression ISO cannabigerol results in increased expression of GNB4 mRNA CTD PMID:33019509 NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579 		JBrowse link
G Hap1 huntingtin-associated protein 1 increases expression ISO cannabigerol results in increased expression of HAP1 mRNA CTD PMID:33019509 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:22971837 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:22971837 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA] CTD PMID:30611848 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO cannabigerol results in decreased expression of MAP3K5 mRNA CTD PMID:33019509 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Npy neuropeptide Y decreases expression EXP cannabigerol results in decreased expression of NPY mRNA CTD PMID:31941059 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 decreases expression ISO cannabigerol results in decreased expression of PARP4 mRNA CTD PMID:33019509 NCBI chr15:30,690,503...30,792,868
Ensembl chr15:30,686,613...30,828,810 		JBrowse link
G Pld1 phospholipase D1 decreases expression ISO cannabigerol results in decreased expression of PLD1 mRNA CTD PMID:33019509 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pomc proopiomelanocortin decreases expression EXP cannabigerol results in decreased expression of POMC mRNA CTD PMID:31941059 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO cannabigerol binds to and results in increased activity of PPARA protein CTD PMID:30611848 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
increases expression
multiple interactions		 ISO cannabigerol results in decreased expression of PPARG protein
cannabigerol results in increased expression of PPARG mRNA
cannabigerol binds to and results in increased activity of PPARG protein
cannabigerol binds to and results in increased activity of PPARG protein; cannabigerol promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]		 CTD PMID:28853159 PMID:30611848 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression ISO cannabigerol results in decreased expression of PPP3R1 mRNA CTD PMID:33019509 NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907 		JBrowse link
G Prkca protein kinase C, alpha increases expression ISO cannabigerol results in increased expression of PRKCA mRNA CTD PMID:33019509 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta decreases expression ISO cannabigerol results in decreased expression of PRKCB mRNA CTD PMID:33019509 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 decreases expression ISO cannabigerol results in decreased expression of SHANK1 mRNA CTD PMID:33019509 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
G Slc18a1 solute carrier family 18 member A1 decreases expression ISO cannabigerol results in decreased expression of SLC18A1 mRNA CTD PMID:33019509 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases expression ISO cannabigerol results in decreased expression of SLC1A2 mRNA CTD PMID:33019509 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc32a1 solute carrier family 32 member 1 increases expression ISO cannabigerol results in increased expression of SLC32A1 mRNA CTD PMID:33019509 NCBI chr 3:147,267,373...147,271,842
Ensembl chr 3:147,267,373...147,271,844 		JBrowse link
G Slc38a1 solute carrier family 38, member 1 decreases expression ISO cannabigerol results in decreased expression of SLC38A1 mRNA CTD PMID:33019509 NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:22971837 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity		 ISO [cannabigerol results in increased activity of TRPV1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
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