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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ergosta-4,6,8(14),22-tetraen-3-one
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Accession:CHEBI:69431 term browser browse the term
Definition:An ergostanoid that is (22E)-ergosta-4,6,8(14),22-tetraene substituted by an oxo group at position 3. It has been isolated from the mycelia of Cordyceps sinensis.
Synonyms:exact_synonym: (22E)-ergosta-4,6,8(14),22-tetraen-3-one
 related_synonym: 24-methylcholesta-4,6,8(14),22-tetraen-3-one;   Formula=C28H40O;   InChI=1S/C28H40O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,17-20,24,26H,11-16H2,1-6H3/b8-7+/t19-,20+,24+,26-,27-,28+/m0/s1;   InChIKey=OIMXTYUHMBQQJM-HSVWHVBGSA-N;   SMILES=CC(C)[C@@H](C)\\C=C\\[C@@H](C)[C@H]1CCC2=C3C=CC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
 alt_id: CHEBI:68084
 xref: CAS:19254-69-4
 xref_mesh: MESH:C015860
 xref: PMID:21043476;   PMID:21226488;   PMID:21428374;   PMID:21848266;   Reaxys:3223568


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ergosta-4,6,8(14),22-tetraen-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of ACTA2 protein] CTD PMID:28578904 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of VIM protein]
ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of SYNPO protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
CTD PMID:28578904 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of CCL2 protein] CTD PMID:28578904 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of CDH1 protein] CTD PMID:28578904 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of COL3A1 protein] CTD PMID:28578904 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein] CTD PMID:28578904 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein] CTD PMID:28578904 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein] CTD PMID:28578904 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein] CTD PMID:28578904 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein] CTD PMID:28578904 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Podxl podocalyxin-like multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of PODXL protein] CTD PMID:28578904 NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:28578904 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of SNAI1 protein] CTD PMID:28578904 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Synpo synaptopodin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of SYNPO protein] CTD PMID:28578904 NCBI chr18:55,863,081...55,921,412
Ensembl chr18:55,865,467...55,916,220
JBrowse link
G Vim vimentin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of VIM protein] CTD PMID:28578904 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wt1 WT1 transcription factor multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of WT1 protein] CTD PMID:28578904 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      group 19687
        organic group 18602
          3-oxo-Delta(4)-steroid group 8406
            3-oxo-Delta(4) steroid 8406
              ergosta-4,6,8(14),22-tetraen-3-one 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      ketone 16825
                                        oxo steroid 9710
                                          3-oxo steroid 9267
                                            3-oxo-Delta(4) steroid 8406
                                              ergosta-4,6,8(14),22-tetraen-3-one 16
paths to the root