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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:minoxidil
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Accession:CHEBI:6942 term browser browse the term
Definition:A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.
Synonyms:exact_synonym: 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide
 related_synonym: Alostil;   Apo-Gain;   Formula=C9H15N5O;   InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12);   InChIKey=ZFMITUMMTDLWHR-UHFFFAOYSA-N;   Lonolox;   Minoximen;   Normoxidil;   Regaine;   Rogaine;   SMILES=Nc1cc(nc(N)[n+]1[O-])N1CCCCC1;   Tricoxidil;   minoxidilum
 alt_id: CHEBI:49774
 xref: CAS:38304-91-5;   DrugBank:DB00350;   Drug_Central:1814;   HMDB:HMDB0014494;   KEGG:D00418
 xref_mesh: MESH:D008914
 xref: PMID:24742982;   PMID:26024233;   PMID:7755612;   Patent:AU2012316063;   Patent:NL6615385;   Patent:RU2012112099;   Patent:US3382247;   Reaxys:886240;   Wikipedia:Minoxidil


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minoxidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ren renin affects expression
multiple interactions
increases activity
increases expression
ISO
EXP
Minoxidil affects the expression of REN protein
Minoxidil binds to and results in decreased activity of REN protein
Minoxidil results in increased activity of REN protein
Minoxidil results in increased expression of REN protein
CTD PMID:28811, PMID:145319, PMID:790007, PMID:8238566 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of Minoxidil CTD PMID:11181495 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            cardiovascular drug 7613
              vasodilator agent 5729
                minoxidil 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        aromatic amine 13616
                                          aminopyrimidine 1103
                                            minoxidil 2
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