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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:minoxidil
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Accession:CHEBI:6942 term browser browse the term
Definition:A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.
Synonyms:exact_synonym: 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide
 related_synonym: Alostil;   Apo-Gain;   Formula=C9H15N5O;   InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12);   InChIKey=ZFMITUMMTDLWHR-UHFFFAOYSA-N;   Lonolox;   Minoximen;   Normoxidil;   Regaine;   Rogaine;   SMILES=Nc1cc(nc(N)[n+]1[O-])N1CCCCC1;   Tricoxidil;   minoxidilum
 alt_id: CHEBI:49774
 xref: CAS:38304-91-5;   DrugBank:DB00350;   Drug_Central:1814;   HMDB:HMDB0014494;   KEGG:D00418
 xref_mesh: MESH:D008914
 xref: PMID:24742982;   PMID:26024233;   PMID:7755612;   Patent:AU2012316063;   Patent:NL6615385;   Patent:RU2012112099;   Patent:US3382247;   Reaxys:886240;   Wikipedia:Minoxidil


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minoxidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ereg epiregulin decreases expression ISO Minoxidil results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Il24 interleukin 24 decreases expression ISO Minoxidil results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Minoxidil results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Ren renin affects expression
multiple interactions
increases activity
increases expression		 ISO
EXP		 Minoxidil affects the expression of REN protein
Minoxidil binds to and results in decreased activity of REN protein
Minoxidil results in increased activity of REN protein
Minoxidil results in increased expression of REN protein		 CTD PMID:28811 PMID:145319 PMID:790007 PMID:8238566 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Minoxidil results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP		 SULT1A1 protein results in increased sulfation of Minoxidil CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19886
      application 19720
        pharmaceutical 19548
          drug 19548
            cardiovascular drug 8602
              vasodilator agent 5986
                minoxidil 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19856
                    main group molecular entity 19856
                      s-block molecular entity 19687
                        hydrogen molecular entity 19676
                          hydrides 19153
                            inorganic hydride 18131
                              pnictogen hydride 18120
                                nitrogen hydride 18026
                                  azane 17825
                                    ammonia 17824
                                      organic amino compound 17824
                                        aromatic amine 15427
                                          aminopyrimidine 1734
                                            minoxidil 6
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