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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:minoxidil
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Accession:CHEBI:6942 term browser browse the term
Definition:A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.
Synonyms:exact_synonym: 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide
 related_synonym: Alostil;   Apo-Gain;   Formula=C9H15N5O;   InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12);   InChIKey=ZFMITUMMTDLWHR-UHFFFAOYSA-N;   Lonolox;   Minoximen;   Normoxidil;   Regaine;   Rogaine;   SMILES=Nc1cc(nc(N)[n+]1[O-])N1CCCCC1;   Tricoxidil;   minoxidilum
 alt_id: CHEBI:49774
 xref: CAS:38304-91-5;   DrugBank:DB00350;   Drug_Central:1814;   HMDB:HMDB0014494;   KEGG:D00418
 xref_mesh: MESH:D008914
 xref: PMID:24742982;   PMID:26024233;   PMID:7755612;   Patent:AU2012316063;   Patent:NL6615385;   Patent:RU2012112099;   Patent:US3382247;   Reaxys:886240;   Wikipedia:Minoxidil



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minoxidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ereg epiregulin decreases expression ISO Minoxidil results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il24 interleukin 24 decreases expression ISO Minoxidil results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Minoxidil results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Ren renin affects expression
multiple interactions
increases activity
increases expression
ISO
EXP
Minoxidil affects the expression of REN protein
Minoxidil binds to and results in decreased activity of REN protein
Minoxidil results in increased activity of REN protein
Minoxidil results in increased expression of REN protein
CTD PMID:28811 PMID:145319 PMID:790007 PMID:8238566 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Minoxidil results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of Minoxidil CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            cardiovascular drug 7726
              vasodilator agent 5846
                minoxidil 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            inorganic hydride 17901
                              pnictogen hydride 17884
                                nitrogen hydride 17773
                                  azane 17503
                                    ammonia 17521
                                      organic amino compound 17521
                                        aromatic amine 14915
                                          aminopyrimidine 1688
                                            minoxidil 6
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