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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kalopanaxsaponin A
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Accession:CHEBI:69370 term browser browse the term
Definition:A triterpenoid saponin that is hederagenin attached to a 2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage. It has been isolated from the stem bark of Kalopanax pictus.
Synonyms:exact_synonym: 3beta-{[2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl]oxy}-23-hydroxyolean-12-en-28-oic acid
 related_synonym: 3-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl hederagenin;   Formula=C41H66O12;   InChI=1S/C41H66O12/c1-21-28(44)30(46)31(47)33(51-21)53-32-29(45)24(43)19-50-34(32)52-27-11-12-37(4)25(38(27,5)20-42)10-13-40(7)26(37)9-8-22-23-18-36(2,3)14-16-41(23,35(48)49)17-15-39(22,40)6/h8,21,23-34,42-47H,9-20H2,1-7H3,(H,48,49)/t21-,23-,24-,25+,26+,27-,28-,29-,30+,31+,32+,33-,34-,37-,38-,39+,40+,41-/m0/s1;   InChIKey=KEOITPILCOILGM-LLJOFIFVSA-N;   SMILES=C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)CO[C@H]2O[C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC=C3[C@@H]5CC(C)(C)CC[C@@]5(CC[C@@]43C)C(O)=O)[C@]2(C)CO)[C@H](O)[C@H](O)[C@H]1O;   akebiasaponin PD;   akeboside Stc;   alpha-hederin;   glycoside L-E1;   hederoside C;   helixin;   kizutasaponin K6;   koronaroside A;   prosapogenin CP3b;   sapindoside A;   tauroside E
 xref: CAS:27013-91-8;   KEGG:C08954;   KNApSAcK:C00003528
 xref_mesh: MESH:C010177
 xref: PMID:21870831;   Reaxys:76156


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kalopanaxsaponin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO alpha-hederin inhibits the reaction [[Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] which results in increased expression of CYP1A1 mRNA] CTD PMID:10378784 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
decreases activity
ISO alpha-hederin inhibits the reaction [[Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] which results in increased expression of CYP1A1 mRNA]; alpha-hederin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; alpha-hederin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
alpha-hederin results in decreased expression of CYP1A1 mRNA
alpha-hederin results in decreased activity of CYP1A1 protein
CTD PMID:9861456, PMID:10378784 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
decreases expression
ISO alpha-hederin results in decreased activity of CYP1A2 protein
alpha-hederin results in decreased expression of CYP1A2 mRNA
CTD PMID:9861456 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression ISO alpha-hederin results in decreased expression of CYP2B1 mRNA CTD PMID:9861456 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alpha-hederin results in decreased activity of CYP2E1 protein CTD PMID:9861456 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link

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  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          kalopanaxsaponin A 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organooxygen compound 18778
                                  carbohydrates and carbohydrate derivatives 12180
                                    carbohydrate 12180
                                      carbohydrate derivative 11804
                                        glycosyl compound 10848
                                          glycoside 9204
                                            saponin 373
                                              triterpenoid saponin 319
                                                kalopanaxsaponin A 5
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