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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:69345 term browser browse the term
Definition:A sesquiterpene lactone that is decahydroazuleno[6,5-b]furan-2(3H)-one substituted by a hydroxy group at position 5, a methyl group at position 5 and methylidene groups at positions 3 and 8 (the 3aR,4aR,5R,7aS,9aS stereoisomer). Isolated from the aerial parts of Inula hupehensis, it exhibits anti-inflammatory activity.
Synonyms:exact_synonym: (3aR,4aR,5R,7aS,9aS)-5-hydroxy-5-methyl-3,8-dimethylidenedecahydroazuleno[6,5-b]furan-2(3H)-one
 related_synonym: Formula=C15H20O3;   InChI=1S/C15H20O3/c1-8-6-13-11(9(2)14(16)18-13)7-12-10(8)4-5-15(12,3)17/h10-13,17H,1-2,4-7H2,3H3/t10-,11-,12-,13+,15-/m1/s1;   InChIKey=GTYUWNQOOLJZBM-XLFUENPSSA-N;   SMILES=C[C@@]1(O)CC[C@H]2[C@H]1C[C@H]1[C@H](CC2=C)OC(=O)C1=C
 xref_mesh: MESH:C458886
 xref: PMID:11731914;   PMID:17490829;   PMID:21894898;   Reaxys:4234313

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inuviscolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO inuviscolide results in decreased expression of BIRC5 protein CTD PMID:17919456 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases activity ISO inuviscolide results in increased activity of CASP3 protein CTD PMID:17919456 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnb1 cyclin B1 affects expression ISO inuviscolide affects the expression of CCNB1 protein CTD PMID:17919456 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO inuviscolide results in decreased expression of and affects the phosphorylation of CDK1 protein CTD PMID:17919456 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO inuviscolide results in increased expression of CDKN1A protein CTD PMID:17919456 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO inuviscolide results in decreased expression of RELA protein CTD PMID:17919456 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Caffeine inhibits the reaction [inuviscolide results in increased phosphorylation of TP53 protein]; inuviscolide results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:17919456 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 19860
    role 19832
      application 19675
        anti-inflammatory agent 16628
          inuviscolide 7
Path 2
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  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            heteroorganic entity 19494
                              organochalcogen compound 19257
                                organooxygen compound 19173
                                  ester 17473
                                    carboxylic ester 16750
                                      lactone 13242
                                        terpene lactone 2177
                                          sesquiterpene lactone 2031
                                            inuviscolide 7
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