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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:midodrine
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Accession:CHEBI:6933 term browser browse the term
Definition:An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Synonyms:exact_synonym: rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide
 related_synonym: (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide;   1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol;   2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide;   DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid;   Formula=C12H18N2O4;   InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);   InChIKey=PTKSEFOSCHHMPD-UHFFFAOYSA-N;   SMILES=COc1ccc(OC)c(c1)C(O)CNC(=O)CN;   midodrina;   midodrinum
 xref: Beilstein:2384653;   CAS:42794-76-3;   DrugBank:DB00211;   Drug_Central:1803;   HMDB:HMDB0014356;   KEGG:C07890;   KEGG:D08220;   LINCS:LSM-1815
 xref_mesh: MESH:D008879
 xref: PMID:11096750;   PMID:15273244;   PMID:16676655;   PMID:17901021;   PMID:18410283;   PMID:18840368;   PMID:19522958;   PMID:20376815;   PMID:20844343;   PMID:21343575;   PMID:21801220;   PMID:22436941;   PMID:23051063;   Patent:GB1003659;   Patent:US3340298;   Reaxys:2384653;   Wikipedia:Midodrine
 cyclic_relationship: is_conjugate_base_of CHEBI:73243


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midodrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Midodrine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Midodrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pro-agent 10095
          prodrug 9899
            midodrine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        amino acid 14873
                                          alpha-amino acid 12852
                                            L-alpha-amino acid 11559
                                              serine family amino acid 2498
                                                glycine 1519
                                                  glycine derivative 1506
                                                    glycinamide 80
                                                      midodrine 2
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