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ONTOLOGY REPORT - ANNOTATIONS


Term:midodrine
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Accession:CHEBI:6933 term browser browse the term
Definition:An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Synonyms:exact_synonym: rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide
 related_synonym: (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide;   1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol;   2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide;   DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid;   Formula=C12H18N2O4;   InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);   InChIKey=PTKSEFOSCHHMPD-UHFFFAOYSA-N;   SMILES=COc1ccc(OC)c(c1)C(O)CNC(=O)CN;   midodrina;   midodrinum
 xref: Beilstein:2384653;   CAS:42794-76-3;   DrugBank:DB00211;   Drug_Central:1803;   HMDB:HMDB0014356;   KEGG:C07890;   KEGG:D08220;   LINCS:LSM-1815
 xref_mesh: MESH:D008879
 xref: PMID:11096750;   PMID:15273244;   PMID:16676655;   PMID:17901021;   PMID:18410283;   PMID:18840368;   PMID:19522958;   PMID:20376815;   PMID:20844343;   PMID:21343575;   PMID:21801220;   PMID:22436941;   PMID:23051063;   Patent:GB1003659;   Patent:US3340298;   Reaxys:2384653;   Wikipedia:Midodrine
 cyclic_relationship: is_conjugate_base_of CHEBI:73243


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midodrine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      application 19373
        pro-agent 8838
          prodrug 8627
            midodrine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            organic group 18463
                              organic divalent group 18456
                                organodiyl group 18456
                                  carbonyl group 18356
                                    carbonyl compound 18356
                                      carboxylic acid 18027
                                        amino acid 12478
                                          alpha-amino acid 7713
                                            L-alpha-amino acid 7384
                                              serine family amino acid 1794
                                                glycine 847
                                                  glycine derivative 835
                                                    glycinamide 75
                                                      midodrine 2
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