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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(+)-conocarpan
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Accession:CHEBI:69251 term browser browse the term
Definition:A member of the class of benzofurans that is 2,3-dihydro-1-benzofuran substituted by a methyl group at position 3, a prop-1-en-1-yl group at position 5 and a 4-hydroxyphenyl group at position 2. It is a lignan derivative isolated from the roots of Krameria lappacea.
Synonyms:exact_synonym: 4-{(2S,3S)-3-methyl-5-[(1E)-prop-1-en-1-yl]-2,3-dihydro-1-benzofuran-2-yl}phenol
 related_synonym: Formula=C18H18O2;   InChI=1S/C18H18O2/c1-3-4-13-5-10-17-16(11-13)12(2)18(20-17)14-6-8-15(19)9-7-14/h3-12,18-19H,1-2H3/b4-3+/t12-,18-/m0/s1;   InChIKey=GXJSAHXNLJFDPO-OFXNJDNMSA-N;   SMILES=C\\C=C\\c1ccc2O[C@@H]([C@@H](C)c2c1)c1ccc(O)cc1
 xref_mesh: MESH:C447284
 xref: PMID:21800856;   Reaxys:8268058


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(+)-conocarpan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO SAR7334 inhibits the reaction [conocarpan results in increased cleavage of CASP3 protein] CTD PMID:31054997 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases activity
multiple interactions
ISO conocarpan results in increased activity of TRPC6 protein
SAR7334 inhibits the reaction [conocarpan results in increased activity of TRPC6 protein]
CTD PMID:31054997 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      application 19411
        anti-inflammatory agent 15758
          (+)-conocarpan 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  oxacycle 17539
                                    benzofurans 3224
                                      (+)-conocarpan 2
paths to the root