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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(+)-conocarpan
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Accession:CHEBI:69251 term browser browse the term
Definition:A member of the class of benzofurans that is 2,3-dihydro-1-benzofuran substituted by a methyl group at position 3, a prop-1-en-1-yl group at position 5 and a 4-hydroxyphenyl group at position 2. It is a lignan derivative isolated from the roots of Krameria lappacea.
Synonyms:exact_synonym: 4-{(2S,3S)-3-methyl-5-[(1E)-prop-1-en-1-yl]-2,3-dihydro-1-benzofuran-2-yl}phenol
 related_synonym: Formula=C18H18O2;   InChI=1S/C18H18O2/c1-3-4-13-5-10-17-16(11-13)12(2)18(20-17)14-6-8-15(19)9-7-14/h3-12,18-19H,1-2H3/b4-3+/t12-,18-/m0/s1;   InChIKey=GXJSAHXNLJFDPO-OFXNJDNMSA-N;   SMILES=C\\C=C\\c1ccc2O[C@@H]([C@@H](C)c2c1)c1ccc(O)cc1
 xref_mesh: MESH:C447284
 xref: PMID:21800856;   Reaxys:8268058


show annotations for term's descendants           Sort by:
(+)-conocarpan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO SAR7334 inhibits the reaction [conocarpan results in increased cleavage of CASP3 protein] CTD PMID:31054997 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases activity
multiple interactions		 ISO conocarpan results in increased activity of TRPC6 protein
SAR7334 inhibits the reaction [conocarpan results in increased activity of TRPC6 protein]		 CTD PMID:31054997 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      application 19720
        anti-inflammatory agent 16695
          (+)-conocarpan 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            organic molecule 19735
                              organic cyclic compound 19528
                                organic heterocyclic compound 18895
                                  oxacycle 17921
                                    benzofurans 3332
                                      (+)-conocarpan 2
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