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ONTOLOGY REPORT - ANNOTATIONS


Term:microcystin-LR
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Accession:CHEBI:6925 term browser browse the term
Definition:A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Synonyms:exact_synonym: cyclo[D-alanyl-L-leucyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylalanyl]
 related_synonym: 1,7-anhydro[D-alanyl-L-leucyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylalanine];   Formula=C49H74N10O12;   InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1;   InChIKey=ZYZCGGRZINLQBL-GWRQVWKTSA-N;   Microcystis aeruginosa toxin;   SMILES=C([C@H](OC)[C@@H](C)/C=C(\\C)/C=C/[C@@]1(NC([C@H](CCCNC(=N)N)NC([C@H]([C@H](C(O)=O)NC([C@H](CC(C)C)NC([C@@H](C)NC(C(N(C(CC[C@@H](NC([C@H]1C)=O)C(O)=O)=O)C)=C)=O)=O)=O)C)=O)=O)[H])C=2C=CC=CC2;   cyanoginosin LR;   cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl];   toxin-LR
 xref: Beilstein:4779759 "ChemIDplus";   CAS:101043-37-2 "ChemIDplus";   CAS:101043-37-2 "KEGG COMPOUND";   KEGG:C05371
 xref_mesh: MESH:C057862
 xref: PMID:10903983 "Europe PMC";   PMID:17125460 "Europe PMC";   PMID:18246549 "Europe PMC";   PMID:21489775 "Europe PMC";   PMID:22071605 "Europe PMC";   PMID:22301162 "Europe PMC";   PMID:22837451 "Europe PMC";   PMID:22956115 "Europe PMC";   PMID:23131420 "Europe PMC";   PMID:23506857 "Europe PMC";   PMID:23586662 "Europe PMC";   PMID:23999063 "Europe PMC";   PMID:24268348 "Europe PMC";   PMID:24280256 "Europe PMC";   PMID:24318164 "Europe PMC";   PMID:24462717 "Europe PMC";   PMID:24631598 "Europe PMC";   PMID:28648727 "Europe PMC";   Reaxys:4779759 "Reaxys";   Wikipedia:Microcystin-LR


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microcystin-LR term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca8b ATP-binding cassette, sub-family A (ABC1), member 8b JBrowse link 11 109,932,206 109,996,274 RGD:6480464
G Abcb10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 JBrowse link 8 123,952,459 123,983,122 RGD:6480464
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 JBrowse link 19 43,782,308 43,838,332 RGD:6480464
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 JBrowse link 16 20,331,303 20,426,428 RGD:6480464
G Acaa1b acetyl-Coenzyme A acyltransferase 1B JBrowse link 9 119,148,043 119,157,093 RGD:6480464
G Acaca acetyl-Coenzyme A carboxylase alpha JBrowse link 11 84,129,635 84,401,651 RGD:6480464
G Acad10 acyl-Coenzyme A dehydrogenase family, member 10 JBrowse link 5 121,621,026 121,660,603 RGD:6480464
G Acad11 acyl-Coenzyme A dehydrogenase family, member 11 JBrowse link 9 104,063,724 104,127,656 RGD:6480464
G Acadl acyl-Coenzyme A dehydrogenase, long-chain JBrowse link 1 66,830,839 66,863,309 RGD:6480464
G Acadm acyl-Coenzyme A dehydrogenase, medium chain JBrowse link 3 153,922,353 153,944,643 RGD:6480464
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain JBrowse link 11 70,010,183 70,015,428 RGD:6480464
G Acat2 acetyl-Coenzyme A acetyltransferase 2 JBrowse link 17 12,943,042 12,960,725 RGD:6480464
G Acox3 acyl-Coenzyme A oxidase 3, pristanoyl JBrowse link 5 35,582,981 35,614,208 RGD:6480464
G Actb actin, beta JBrowse link 5 142,903,115 142,907,976 RGD:6480464
G Afm afamin JBrowse link 5 90,518,949 90,553,544 RGD:6480464
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) JBrowse link 6 34,303,930 34,317,489 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Akt3 thymoma viral proto-oncogene 3 JBrowse link 1 177,020,076 177,261,781 RGD:6480464
G Alb albumin JBrowse link 5 90,460,870 90,476,602 RGD:6480464
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 JBrowse link 6 90,550,768 90,599,171 RGD:6480464
G Alpi alkaline phosphatase, intestinal JBrowse link 1 87,098,002 87,101,606 RGD:6480464
G Alyref Aly/REF export factor JBrowse link 11 120,594,504 120,598,399 RGD:6480464
G Anxa2 annexin A2 JBrowse link 9 69,453,683 69,491,792 RGD:6480464
G Anxa4 annexin A4 JBrowse link 6 86,736,840 86,793,634 RGD:6480464
G Anxa5 annexin A5 JBrowse link 3 36,448,923 36,475,887 RGD:6480464
G Anxa7 annexin A7 JBrowse link 14 20,455,261 20,480,133 RGD:6480464
G Apex1 apurinic/apyrimidinic endonuclease 1 JBrowse link 14 50,924,949 50,927,188 RGD:6480464
G Apoa1 apolipoprotein A-I JBrowse link 9 46,228,630 46,230,469 RGD:6480464
G Apob apolipoprotein B JBrowse link 12 7,977,629 8,016,839 RGD:6480464
G Apoc3 apolipoprotein C-III JBrowse link 9 46,233,050 46,235,636 RGD:6480464
G Apoe apolipoprotein E JBrowse link 7 19,696,244 19,701,310 RGD:6480464
G Ar androgen receptor JBrowse link X 98,148,757 98,323,218 RGD:6480464
G Arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 JBrowse link 3 88,593,105 88,649,532 RGD:6480464
G Asns asparagine synthetase JBrowse link 6 7,675,165 7,693,209 RGD:6480464
G Ass1 argininosuccinate synthetase 1 JBrowse link 2 31,470,270 31,520,670 RGD:6480464
G Atf2 activating transcription factor 2 JBrowse link 2 73,816,509 73,892,677 RGD:6480464
G Atox1 antioxidant 1 copper chaperone JBrowse link 11 55,446,637 55,461,208 RGD:6480464
G Bad BCL2-associated agonist of cell death JBrowse link 19 6,941,861 6,951,905 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bbc3 BCL2 binding component 3 JBrowse link 7 16,308,398 16,318,334 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) JBrowse link 2 128,126,038 128,162,547 RGD:6480464
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 9 7,847,468 7,873,205 RGD:6480464
G Blvrb biliverdin reductase B (flavin reductase (NADPH)) JBrowse link 7 27,447,978 27,465,981 RGD:6480464
G Bmp5 bone morphogenetic protein 5 JBrowse link 9 75,775,365 75,900,316 RGD:6480464
G Bsg basigin JBrowse link 10 79,704,358 79,711,979 RGD:6480464
G C9 complement component 9 JBrowse link 15 6,445,346 6,498,825 RGD:6480464
G Cables1 CDK5 and Abl enzyme substrate 1 JBrowse link 18 11,839,274 11,945,627 RGD:6480464
G Calm2 calmodulin 2 JBrowse link 17 87,433,401 87,446,935 RGD:6480464
G Calm3 calmodulin 3 JBrowse link 7 16,915,379 16,924,032 RGD:6480464
G Camk1 calcium/calmodulin-dependent protein kinase I JBrowse link 6 113,334,124 113,343,922 RGD:6480464
G Capn2 calpain 2 JBrowse link 1 182,467,253 182,517,610 RGD:6480464
G Capns1 calpain, small subunit 1 JBrowse link 7 30,186,934 30,198,883 RGD:6480464
G Capzb capping protein (actin filament) muscle Z-line, beta JBrowse link 4 139,192,899 139,291,820 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6480464
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6480464
G Cast calpastatin JBrowse link 13 74,692,366 74,808,874 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Cbr1 carbonyl reductase 1 JBrowse link 16 93,607,837 93,610,349 RGD:6480464
G Cbr3 carbonyl reductase 3 JBrowse link 16 93,683,219 93,690,991 RGD:6480464
G Ccdc180 coiled-coil domain containing 180 JBrowse link 4 45,890,303 45,950,774 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,937 RGD:6480464
G Ccnf cyclin F JBrowse link 17 24,223,230 24,251,409 RGD:6480464
G Ccng1 cyclin G1 JBrowse link 11 40,748,552 40,755,309 RGD:6480464
G Cd2ap CD2-associated protein JBrowse link 17 42,748,887 42,876,707 RGD:6480464
G Cdc42 cell division cycle 42 JBrowse link 4 137,319,696 137,357,759 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 8 106,603,350 106,670,247 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 10 69,335,146 69,352,912 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 10 127,063,535 127,067,288 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 5 3,341,004 3,531,008 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) JBrowse link 17 29,090,979 29,100,722 RGD:6480464
G Cebpd CCAAT/enhancer binding protein (C/EBP), delta JBrowse link 16 15,887,286 15,889,545 RGD:6480464
G Coro1c coronin, actin binding protein 1C JBrowse link 5 113,842,439 113,908,706 RGD:6480464
G Creb3 cAMP responsive element binding protein 3 JBrowse link 4 43,562,658 43,567,061 RGD:6480464
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) JBrowse link 11 54,247,270 54,249,899 RGD:6480464
G Cspg4 chondroitin sulfate proteoglycan 4 JBrowse link 9 56,865,104 56,899,870 RGD:6480464
G Cstb cystatin B JBrowse link 10 78,425,670 78,427,622 RGD:6480464
G Ctnnb1 catenin (cadherin associated protein), beta 1 JBrowse link 9 120,933,400 120,960,507 RGD:6480464
G Ctsl cathepsin L JBrowse link 13 64,361,890 64,370,772 RGD:6480464
G Ctsz cathepsin Z JBrowse link 2 174,427,494 174,439,039 RGD:6480464
G Cttn cortactin JBrowse link 7 144,435,724 144,471,560 RGD:6480464
G Cxcl15 chemokine (C-X-C motif) ligand 15 JBrowse link 5 90,794,534 90,803,067 RGD:6480464
G Cybb cytochrome b-245, beta polypeptide JBrowse link X 9,435,252 9,487,766 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 9 54,165,937 54,268,164 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 9 57,676,937 57,683,655 RGD:6480464
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 19 37,697,738 37,701,536 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 7 140,763,819 140,774,990 RGD:6480464
G Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 JBrowse link 9 121,914,356 121,916,305 RGD:6480464
G Dap3 death associated protein 3 JBrowse link 3 88,920,803 88,951,213 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 10 127,290,793 127,296,291 RGD:6480464
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 10 59,949,675 59,951,770 RGD:6480464
G Ddit4l DNA-damage-inducible transcript 4-like JBrowse link 3 137,623,672 137,628,332 RGD:6480464
G Decr2 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal JBrowse link 17 26,081,208 26,090,322 RGD:6480464
G Dgat1 diacylglycerol O-acyltransferase 1 JBrowse link 15 76,502,012 76,512,021 RGD:6480464
G Dio2 deiodinase, iodothyronine, type II JBrowse link 12 90,724,552 90,739,038 RGD:6480464
G Dnmt3a DNA methyltransferase 3A JBrowse link 12 3,801,559 3,914,443 RGD:6480464
G Dnmt3b DNA methyltransferase 3B JBrowse link 2 153,649,411 153,687,730 RGD:6480464
G Dusp10 dual specificity phosphatase 10 JBrowse link 1 184,034,381 184,075,636 RGD:6480464
G Eef1d eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) JBrowse link 15 75,894,796 75,909,784 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 11 16,752,203 16,913,907 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 34,861,207 34,864,956 RGD:6480464
G Eif4a3 eukaryotic translation initiation factor 4A3 JBrowse link 11 119,288,363 119,300,043 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 8 27,260,327 27,275,656 RGD:6480464
G Epo erythropoietin JBrowse link 5 137,483,020 137,485,816 RGD:6480464
G Esr1 estrogen receptor 1 (alpha) JBrowse link 10 4,611,989 5,005,633 RGD:6480464
G Etv5 ets variant 5 JBrowse link 16 22,381,313 22,439,570 RGD:6480464
G Ezr ezrin JBrowse link 17 6,738,131 6,782,780 RGD:6480464
G Fabp1 fatty acid binding protein 1, liver JBrowse link 6 71,199,879 71,205,034 RGD:6480464
G Fabp2 fatty acid binding protein 2, intestinal JBrowse link 3 122,895,072 122,899,506 RGD:6480464
G Fads1 fatty acid desaturase 1 JBrowse link 19 10,182,877 10,196,874 RGD:6480464
G Fads2 fatty acid desaturase 2 JBrowse link 19 10,062,765 10,101,503 RGD:6480464
G Fasn fatty acid synthase JBrowse link 11 120,805,958 120,825,166 RGD:6480464
G Fgf13 fibroblast growth factor 13 JBrowse link X 59,062,139 59,585,572 RGD:6480464
G Fgf21 fibroblast growth factor 21 JBrowse link 7 45,613,890 45,615,490 RGD:6480464
G Fhdc1 FH2 domain containing 1 JBrowse link 3 84,442,191 84,480,439 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 1 71,585,473 71,653,280 RGD:6480464
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6480464
G Ftl1 ferritin light polypeptide 1 JBrowse link 7 45,457,944 45,459,886 RGD:6480464
G G6pc glucose-6-phosphatase, catalytic JBrowse link 11 101,367,716 101,377,903 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha JBrowse link 6 67,035,096 67,037,407 RGD:6480464
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma JBrowse link 13 51,846,675 51,848,475 RGD:6480464
G Gas1 growth arrest specific 1 JBrowse link 13 60,174,405 60,177,535 RGD:6480464
G Gbp5 guanylate binding protein 5 JBrowse link 3 142,496,934 142,522,344 RGD:6480464
G Gck glucokinase JBrowse link 11 5,900,816 5,950,081 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 9 77,754,535 77,794,489 RGD:6480464
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 10 75,561,076 75,586,193 RGD:6480464
G Gipc2 GIPC PDZ domain containing family, member 2 JBrowse link 3 152,093,839 152,165,900 RGD:6480464
G Glrx3 glutaredoxin 3 JBrowse link 7 137,437,573 137,469,631 RGD:6480464
G Gm10639 predicted gene 10639 JBrowse link 9 78,289,928 78,305,525 RGD:6480464
G Gna13 guanine nucleotide binding protein, alpha 13 JBrowse link 11 109,362,794 109,401,369 RGD:6480464
G Gnb1 guanine nucleotide binding protein (G protein), beta 1 JBrowse link 4 155,491,300 155,559,269 RGD:6480464
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial JBrowse link 19 55,067,635 55,127,319 RGD:6480464
G Gpx1 glutathione peroxidase 1 JBrowse link 9 108,339,080 108,340,342 RGD:6480464
G Gpx2 glutathione peroxidase 2 JBrowse link 12 76,792,335 76,795,554 RGD:6480464
G Gpx3 glutathione peroxidase 3 JBrowse link 11 54,902,854 54,910,387 RGD:6480464
G Gpx4 glutathione peroxidase 4 JBrowse link 10 80,047,166 80,056,439 RGD:6480464
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 7 25,228,258 25,237,851 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 16 38,089,001 38,246,084 RGD:6480464
G Gsn gelsolin JBrowse link 2 35,256,359 35,307,902 RGD:6480464
G Gsr glutathione reductase JBrowse link 8 33,653,238 33,698,162 RGD:6480464
G Gss glutathione synthetase JBrowse link 2 155,563,181 155,592,810 RGD:6480464
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) JBrowse link 9 78,331,018 78,347,192 RGD:6480464
G Gsta3 glutathione S-transferase, alpha 3 JBrowse link 1 21,240,565 21,265,575 RGD:6480464
G Gstk1 glutathione S-transferase kappa 1 JBrowse link 6 42,245,935 42,250,441 RGD:6480464
G Gstm1 glutathione S-transferase, mu 1 JBrowse link 3 108,012,250 108,017,979 RGD:6480464
G Gstm2 glutathione S-transferase, mu 2 JBrowse link 3 107,981,702 107,986,420 RGD:6480464
G Gstm4 glutathione S-transferase, mu 4 JBrowse link 3 108,030,571 108,045,179 RGD:6480464
G Gstm5 glutathione S-transferase, mu 5 JBrowse link 3 107,895,854 107,898,685 RGD:6480464
G Gstm6 glutathione S-transferase, mu 6 JBrowse link 3 107,938,847 107,953,641 RGD:6480464
G Gstp1 glutathione S-transferase, pi 1 JBrowse link 19 4,035,411 4,037,912 RGD:6480464
G Gstt1 glutathione S-transferase, theta 1 JBrowse link 10 75,783,813 75,798,584 RGD:6480464
G Gtpbp4 GTP binding protein 4 JBrowse link 13 8,972,070 8,996,116 RGD:6480464
G Gys1 glycogen synthase 1, muscle JBrowse link 7 45,434,839 45,456,617 RGD:6480464
G H2-D1 histocompatibility 2, D region locus 1 JBrowse link 17 35,263,094 35,267,497 RGD:6480464
G H2bc1 H2B clustered histone 1 JBrowse link 13 23,933,725 23,934,156 RGD:6480464
G Hadh hydroxyacyl-Coenzyme A dehydrogenase JBrowse link 3 131,233,419 131,272,101 RGD:6480464
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta JBrowse link 5 30,155,253 30,184,593 RGD:6480464
G Hephl1 hephaestin-like 1 JBrowse link 9 15,051,841 15,112,170 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 6 82,725,025 82,774,454 RGD:6480464
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase JBrowse link 13 96,648,962 96,670,936 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Hnf4a hepatic nuclear factor 4, alpha JBrowse link 2 163,506,811 163,572,907 RGD:6480464
G Hpx hemopexin JBrowse link 7 105,591,611 105,600,116 RGD:6480464
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 JBrowse link 3 98,618,636 98,645,534 RGD:6480464
G Hspa8 heat shock protein 8 JBrowse link 9 40,801,276 40,805,202 RGD:6480464
G Hspb1 heat shock protein 1 JBrowse link 5 135,887,919 135,889,563 RGD:6480464
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble JBrowse link 1 65,158,616 65,186,479 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Igbp1 immunoglobulin (CD79A) binding protein 1 JBrowse link X 100,494,291 100,516,125 RGD:6480464
G Igfbp1 insulin-like growth factor binding protein 1 JBrowse link 11 7,197,787 7,202,546 RGD:6480464
G Igkc immunoglobulin kappa constant JBrowse link 6 70,726,435 70,726,754 RGD:6480464
G Igtp interferon gamma induced GTPase JBrowse link 11 58,199,556 58,207,592 RGD:6480464
G Iigp1 interferon inducible GTPase 1 JBrowse link 18 60,373,616 60,392,634 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:6480464
G Il3 interleukin 3 JBrowse link 11 54,265,085 54,267,279 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Inmt indolethylamine N-methyltransferase JBrowse link 6 55,170,627 55,174,990 RGD:6480464
G Ins1 insulin I JBrowse link 19 52,264,297 52,265,015 RGD:6480464
G Ins2 insulin II JBrowse link 7 142,678,656 142,679,726 RGD:6480464
G Insig1 insulin induced gene 1 JBrowse link 5 28,071,412 28,078,662 RGD:6480464
G Ints2 integrator complex subunit 2 JBrowse link 11 86,210,681 86,257,609 RGD:6480464
G Irs1 insulin receptor substrate 1 JBrowse link 1 82,233,105 82,291,439 RGD:6480464
G Irs2 insulin receptor substrate 2 JBrowse link 8 10,984,681 11,008,929 RGD:6480464
G Jak1 Janus kinase 1 JBrowse link 4 101,151,974 101,265,282 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Jund jun D proto-oncogene JBrowse link 8 70,697,739 70,700,616 RGD:6480464
G Keap1 kelch-like ECH-associated protein 1 JBrowse link 9 21,229,730 21,239,332 RGD:6480464
G Kif5b kinesin family member 5B JBrowse link 18 6,201,005 6,241,524 RGD:6480464
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 5 75,574,987 75,656,722 RGD:6480464
G Kpna4 karyopherin (importin) alpha 4 JBrowse link 3 69,072,221 69,127,092 RGD:6480464
G Krt18 keratin 18 JBrowse link 15 102,028,216 102,032,026 RGD:6480464
G Krt8 keratin 8 JBrowse link 15 101,996,711 102,004,342 RGD:6480464
G Ldlr low density lipoprotein receptor JBrowse link 9 21,723,576 21,749,919 RGD:6480464
G Lgals1 lectin, galactose binding, soluble 1 JBrowse link 15 78,926,725 78,930,465 RGD:6480464
G Lgals3 lectin, galactose binding, soluble 3 JBrowse link 14 47,373,860 47,386,167 RGD:6480464
G Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein JBrowse link 11 118,392,747 118,401,959 RGD:6480464
G Lpin2 lipin 2 JBrowse link 17 71,183,532 71,249,818 RGD:6480464
G Lrp1 low density lipoprotein receptor-related protein 1 JBrowse link 10 127,538,157 127,621,148 RGD:6480464
G Lypla2 lysophospholipase 2 JBrowse link 4 135,968,224 135,972,612 RGD:6480464
G Maged1 melanoma antigen, family D, 1 JBrowse link X 94,535,474 94,542,025 RGD:6480464
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 13 111,746,428 111,818,269 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 15 89,142,482 89,149,606 RGD:6480464
G Mapk14 mitogen-activated protein kinase 14 JBrowse link 17 28,691,342 28,748,405 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 14 33,377,898 33,447,353 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 11 49,846,728 49,886,421 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 11 104,229,409 104,332,090 RGD:6480464
G Mcat malonyl CoA:ACP acyltransferase (mitochondrial) JBrowse link 15 83,546,797 83,555,759 RGD:6480464
G Mdm2 transformed mouse 3T3 cell double minute 2 JBrowse link 10 117,688,875 117,710,758 RGD:6480464
G Met met proto-oncogene JBrowse link 6 17,463,349 17,573,980 RGD:6480464
G Mfge8 milk fat globule-EGF factor 8 protein JBrowse link 7 79,133,768 79,149,060 RGD:6480464
G Mir100 microRNA 100 JBrowse link 9 41,531,425 41,531,504 RGD:6480464
G Mir1247 microRNA 1247 JBrowse link 12 110,278,048 110,278,129 RGD:6480464
G Mir137 microRNA 137 JBrowse link 3 118,433,857 118,433,929 RGD:6480464
G Mir181a-2 microRNA 181a-2 JBrowse link 2 38,852,735 38,852,810 RGD:6480464
G Mir19a microRNA 19a JBrowse link 14 115,044,000 115,044,081 RGD:6480464
G Mir204 microRNA 204 JBrowse link 19 22,750,605 22,750,672 RGD:6480464
G Mir27a microRNA 27a JBrowse link 8 84,208,672 84,208,758 RGD:6480464
G Mir30b microRNA 30b JBrowse link 15 68,337,415 68,337,510 RGD:6480464
G Mir31 microRNA 31 JBrowse link 4 88,910,557 88,910,662 RGD:6480464
G Mir320 microRNA 320 JBrowse link 14 70,443,510 70,443,591 RGD:6480464
G Mir33 microRNA 33 JBrowse link 15 82,198,122 82,198,190 RGD:6480464
G Mir331 microRNA 331 JBrowse link 10 93,963,768 93,963,863 RGD:6480464
G Mir338 microRNA 338 JBrowse link 11 120,014,765 120,014,862 RGD:6480464
G Mir342 microRNA 342 JBrowse link 12 108,658,620 108,658,718 RGD:6480464
G Mki67 antigen identified by monoclonal antibody Ki 67 JBrowse link 7 135,689,784 135,716,450 RGD:6480464
G Mmgt1 membrane magnesium transporter 1 JBrowse link X 56,585,512 56,597,944 RGD:6480464
G Mmp13 matrix metallopeptidase 13 JBrowse link 9 7,272,514 7,283,333 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 8 92,827,290 92,853,421 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:6480464
G Mrps7 mitchondrial ribosomal protein S7 JBrowse link 11 115,604,140 115,608,036 RGD:6480464
G Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D JBrowse link 19 11,586,606 11,604,804 RGD:6480464
G Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 JBrowse link 19 11,321,039 11,336,146 RGD:6480464
G Msn moesin JBrowse link X 96,096,045 96,168,553 RGD:6480464
G Msrb1 methionine sulfoxide reductase B1 JBrowse link 17 24,736,593 24,742,778 RGD:6480464
G mt-Atp6 ATP synthase 6, mitochondrial JBrowse link MT 7,927 8,607 RGD:6480464
G mt-Atp8 ATP synthase 8, mitochondrial JBrowse link MT 7,766 7,969 RGD:6480464
G mt-Co1 cytochrome c oxidase I, mitochondrial JBrowse link MT 5,328 6,872 RGD:6480464
G mt-Co2 cytochrome c oxidase II, mitochondrial JBrowse link MT 7,013 7,696 RGD:6480464
G mt-Co3 cytochrome c oxidase III, mitochondrial JBrowse link MT 8,607 9,390 RGD:6480464
G mt-Nd1 NADH dehydrogenase 1, mitochondrial JBrowse link MT 2,751 3,707 RGD:6480464
G mt-Nd3 NADH dehydrogenase 3, mitochondrial JBrowse link MT 9,459 9,806 RGD:6480464
G mt-Nd6 NADH dehydrogenase 6, mitochondrial JBrowse link MT 13,552 14,070 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 8 94,178,883 94,180,327 RGD:6480464
G Mt2 metallothionein 2 JBrowse link 8 94,172,618 94,173,567 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 4 148,448,582 148,557,685 RGD:6480464
G Mttp microsomal triglyceride transfer protein JBrowse link 3 138,089,855 138,143,418 RGD:6480464
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6480464
G Mylk3 myosin light chain kinase 3 JBrowse link 8 85,324,928 85,386,340 RGD:6480464
G Naip2 NLR family, apoptosis inhibitory protein 2 JBrowse link 13 100,144,063 100,202,122 RGD:6480464
G Nalcn sodium leak channel, non-selective JBrowse link 14 123,275,678 123,627,330 RGD:6480464
G Necap1 NECAP endocytosis associated 1 JBrowse link 6 122,874,557 122,888,943 RGD:6480464
G Net1 neuroepithelial cell transforming gene 1 JBrowse link 13 3,882,018 3,918,220 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Nox4 NADPH oxidase 4 JBrowse link 7 87,244,430 87,398,710 RGD:6480464
G Nqo1 NAD(P)H dehydrogenase, quinone 1 JBrowse link 8 107,388,225 107,403,205 RGD:6480464
G Nras neuroblastoma ras oncogene JBrowse link 3 103,058,285 103,067,914 RGD:6480464
G Nupr1 nuclear protein transcription regulator 1 JBrowse link 7 126,623,246 126,625,470 RGD:6480464
G Ocln occludin JBrowse link 13 100,496,504 100,552,718 RGD:6480464
G Olfr1029 olfactory receptor 1029 JBrowse link 2 85,975,213 85,976,273 RGD:6480464
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 7 97,788,541 97,912,381 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:6480464
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine JBrowse link 11 120,610,062 120,617,947 RGD:6480464
G Pdgfra platelet derived growth factor receptor, alpha polypeptide JBrowse link 5 75,151,322 75,198,206 RGD:6480464
G Pdia4 protein disulfide isomerase associated 4 JBrowse link 6 47,796,141 47,813,512 RGD:6480464
G Pdpk1 3-phosphoinositide dependent protein kinase 1 JBrowse link 17 24,073,680 24,155,619 RGD:6480464
G Pdzk1 PDZ domain containing 1 JBrowse link 3 96,829,456 96,870,926 RGD:6480464
G Pepd peptidase D JBrowse link 7 34,912,407 35,044,708 RGD:6480464
G Pfn1 profilin 1 JBrowse link 11 70,651,844 70,656,799 RGD:6480464
G Pfn2 profilin 2 JBrowse link 3 57,841,895 57,847,757 RGD:6480464
G Pgd phosphogluconate dehydrogenase JBrowse link 4 149,149,991 149,166,705 RGD:6480464
G Pigr polymeric immunoglobulin receptor JBrowse link 1 130,826,684 130,852,249 RGD:6480464
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 4 116,221,400 116,303,056 RGD:6480464
G Pitrm1 pitrilysin metallepetidase 1 JBrowse link 13 6,548,122 6,580,158 RGD:6480464
G Plin3 perilipin 3 JBrowse link 17 56,278,962 56,290,511 RGD:6480464
G Plk1 polo like kinase 1 JBrowse link 7 122,159,435 122,169,884 RGD:6480464
G Plk3 polo like kinase 3 JBrowse link 4 117,128,655 117,133,963 RGD:6480464
G Pmpcb peptidase (mitochondrial processing) beta JBrowse link 5 21,737,160 21,757,152 RGD:6480464
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform JBrowse link 11 52,098,824 52,122,749 RGD:6480464
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha JBrowse link 17 20,945,454 20,965,905 RGD:6480464
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 14 67,014,056 67,072,471 RGD:6480464
G Prkar2b protein kinase, cAMP dependent regulatory, type II beta JBrowse link 12 31,958,450 32,061,648 RGD:6480464
G Prkd3 protein kinase D3 JBrowse link 17 78,949,405 79,020,816 RGD:6480464
G Prune1 prune exopolyphosphatase JBrowse link 3 95,253,674 95,283,506 RGD:6480464
G Pten phosphatase and tensin homolog JBrowse link 19 32,757,577 32,826,160 RGD:6480464
G Rad21 RAD21 cohesin complex component JBrowse link 15 51,962,604 51,993,538 RGD:6480464
G Ralb v-ral simian leukemia viral oncogene B JBrowse link 1 119,470,305 119,504,782 RGD:6480464
G Rbm39 RNA binding motif protein 39 JBrowse link 2 156,147,239 156,180,238 RGD:6480464
G Rdx radixin JBrowse link 9 52,047,150 52,088,738 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Rhob ras homolog family member B JBrowse link 12 8,497,661 8,500,009 RGD:6480464
G Rhoc ras homolog family member C JBrowse link 3 104,789,034 104,794,459 RGD:6480464
G Rhoq ras homolog family member Q JBrowse link 17 86,963,111 87,000,069 RGD:6480464
G Rit1 Ras-like without CAAX 1 JBrowse link 3 88,716,839 88,731,048 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 4 86,854,099 86,857,367 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 JBrowse link 11 86,498,869 86,544,885 RGD:6480464
G S100a11 S100 calcium binding protein A11 JBrowse link 3 93,520,235 93,526,288 RGD:6480464
G Serpinb6a serine (or cysteine) peptidase inhibitor, clade B, member 6a JBrowse link 13 33,917,918 34,002,794 RGD:6480464
G Siah1a siah E3 ubiquitin protein ligase 1A JBrowse link 8 86,720,454 86,746,006 RGD:6480464
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 JBrowse link 12 80,953,185 80,968,705 RGD:6480464
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 JBrowse link 17 46,432,185 46,438,477 RGD:6480464
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 JBrowse link 3 28,697,903 28,728,361 RGD:6480464
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 JBrowse link 3 50,364,936 50,499,087 RGD:6480464
G Slco1a1 solute carrier organic anion transporter family, member 1a1 JBrowse link 6 141,907,281 141,946,962 RGD:6480464
G Slco1a4 solute carrier organic anion transporter family, member 1a4 JBrowse link 6 141,805,438 141,856,284 RGD:6480464
G Slco1b2 solute carrier organic anion transporter family, member 1b2 JBrowse link 6 141,629,452 141,686,646 RGD:6480464
G Slco3a1 solute carrier organic anion transporter family, member 3a1 JBrowse link 7 74,275,418 74,554,780 RGD:6480464
G Slco6b1 solute carrier organic anion transporter family, member 6b1 JBrowse link 1 96,906,176 96,997,560 RGD:6480464
G Smad2 SMAD family member 2 JBrowse link 18 76,241,090 76,311,748 RGD:6480464
G Smoc2 SPARC related modular calcium binding 2 JBrowse link 17 14,279,490 14,404,790 RGD:6480464
G Snai1 snail family zinc finger 1 JBrowse link 2 167,538,195 167,542,814 RGD:6480464
G Sod1 superoxide dismutase 1, soluble JBrowse link 16 90,220,762 90,226,333 RGD:6480464
G Sod2 superoxide dismutase 2, mitochondrial JBrowse link 17 13,007,839 13,018,119 RGD:6480464
G Spint2 serine protease inhibitor, Kunitz type 2 JBrowse link 7 29,256,330 29,282,059 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 11 60,199,084 60,224,186 RGD:6480464
G Srebf2 sterol regulatory element binding factor 2 JBrowse link 15 82,147,269 82,205,379 RGD:6480464
G Stmn1 stathmin 1 JBrowse link 4 134,468,320 134,473,843 RGD:6480464
G Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit JBrowse link 6 95,473,009 95,718,858 RGD:6480464
G Sult1b1 sulfotransferase family 1B, member 1 JBrowse link 5 87,513,339 87,538,195 RGD:6480464
G Syne1 spectrin repeat containing, nuclear envelope 1 JBrowse link 10 5,020,192 5,550,692 RGD:6480464
G Tgfb2 transforming growth factor, beta 2 JBrowse link 1 186,622,787 186,709,697 RGD:6480464
G Tgm2 transglutaminase 2, C polypeptide JBrowse link 2 158,116,405 158,146,392 RGD:6480464
G Thra thyroid hormone receptor alpha JBrowse link 11 98,740,776 98,769,006 RGD:6480464
G Thrsp thyroid hormone responsive JBrowse link 7 97,412,933 97,417,550 RGD:6480464
G Tjp1 tight junction protein 1 JBrowse link 7 65,296,165 65,527,850 RGD:6480464
G Tmsb10 thymosin, beta 10 JBrowse link 6 72,957,347 72,958,748 RGD:6480464
G Tmsb4x thymosin, beta 4, X chromosome JBrowse link X 167,207,093 167,213,479 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a JBrowse link 17 23,675,445 23,677,449 RGD:6480464
G Tnp2 transition protein 2 JBrowse link 16 10,787,935 10,788,655 RGD:6480464
G Tnpo1 transportin 1 JBrowse link 13 98,839,019 98,926,384 RGD:6480464
G Tpm1 tropomyosin 1, alpha JBrowse link 9 67,022,590 67,049,672 RGD:6480464
G Treh trehalase (brush-border membrane glycoprotein) JBrowse link 9 44,673,233 44,686,305 RGD:6480464
G Trib3 tribbles pseudokinase 3 JBrowse link 2 152,337,425 152,344,060 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Trrap transformation/transcription domain-associated protein JBrowse link 5 144,767,737 144,859,778 RGD:6480464
G Ttn titin JBrowse link 2 76,703,980 76,982,557 RGD:6480464
G Ttr transthyretin JBrowse link 18 20,664,209 20,674,326 RGD:6480464
G Tub tubby bipartite transcription factor JBrowse link 7 109,010,880 109,034,459 RGD:6480464
G Txndc12 thioredoxin domain containing 12 (endoplasmic reticulum) JBrowse link 4 108,834,678 108,862,120 RGD:6480464
G Txnrd1 thioredoxin reductase 1 JBrowse link 10 82,833,951 82,897,724 RGD:6480464
G Uba2 ubiquitin-like modifier activating enzyme 2 JBrowse link 7 34,140,697 34,168,590 RGD:6480464
G Ugdh UDP-glucose dehydrogenase JBrowse link 5 65,413,207 65,435,842 RGD:6480464
G Ugp2 UDP-glucose pyrophosphorylase 2 JBrowse link 11 21,321,126 21,371,267 RGD:6480464
G Upp2 uridine phosphorylase 2 JBrowse link 2 58,566,317 58,795,846 RGD:6480464
G Usp7 ubiquitin specific peptidase 7 JBrowse link 16 8,688,722 8,757,067 RGD:6480464
G Vasp vasodilator-stimulated phosphoprotein JBrowse link 7 19,256,929 19,271,854 RGD:6480464
G Vdac1 voltage-dependent anion channel 1 JBrowse link 11 52,360,851 52,389,397 RGD:6480464
G Vim vimentin JBrowse link 2 13,574,311 13,582,826 RGD:6480464
G Wee1 WEE 1 homolog 1 (S. pombe) JBrowse link 7 110,122,059 110,143,299 RGD:6480464
G Xylt1 xylosyltransferase 1 JBrowse link 7 117,380,979 117,667,630 RGD:6480464
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide JBrowse link 5 135,908,379 135,934,641 RGD:6480464
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide JBrowse link 5 33,018,816 33,027,966 RGD:6480464
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide JBrowse link 15 36,770,261 36,802,984 RGD:6480464
G Zfp704 zinc finger protein 704 JBrowse link 3 9,427,010 9,610,085 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21038
    role 21018
      biological role 21016
        xenobiotic 18864
          microcystin-LR 362
Path 2
Term Annotations click to browse term
  CHEBI ontology 21038
    subatomic particle 21032
      composite particle 21032
        hadron 21032
          baryon 21032
            nucleon 21032
              atomic nucleus 21032
                atom 21032
                  main group element atom 20874
                    p-block element atom 20874
                      carbon group element atom 20609
                        carbon atom 20586
                          organic molecular entity 20586
                            organic group 19181
                              organic divalent group 19171
                                organodiyl group 19171
                                  carbonyl group 19143
                                    carbonyl compound 19143
                                      carboxylic acid 18821
                                        carboacyl group 17455
                                          univalent carboacyl group 17455
                                            carbamoyl group 17157
                                              carboxamide 17157
                                                peptide 9421
                                                  cyclic peptide 8839
                                                    heterodetic cyclic peptide 1476
                                                      microcystin 480
                                                        microcystin-LR 362
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.